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$372+ Cheap flights from La Crosse (LSE) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/22. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — STL
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from La Crosse to Missouri

Cheapest flights from La Crosse to Missouri
Explore the most affordable flight options available from La Crosse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:00 pmLSE - STL
1 stop4h 24mAmerican Airlines
Wed 12/105:05 amSTL - LSE
1 stop4h 14mAmerican Airlines
Deal found 11/5$471
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:00 amLSE - MCI
1 stop4h 58mAmerican Airlines
Sun 11/237:42 pmMCI - LSE
1 stop4h 07mAmerican Airlines
Deal found 11/5$536
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/209:50 amLSE - STL
1 stop6h 26mAmerican Airlines
Mon 11/247:58 pmSTL - LSE
1 stop3h 51mAmerican Airlines
Deal found 11/4$560
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:00 amLSE - MCI
1 stop5h 01mAmerican Airlines
Sun 11/307:42 pmMCI - LSE
1 stop5h 31mAmerican Airlines
Deal found 11/5$617

Cheap flight deals from La Crosse to Missouri

Keep the following information in mind while searching for La Crosse to Missouri flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$414
(American Airlines)

One-way from

$372
(American Airlines)
Provider with most accurate pricing for La Crosse-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for La Crosse-Lambert-St Louis flights.
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From La Crosse to Missouri
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One-way flight from La Crosse to Missouri
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from La Crosse to Missouri that are best for you.

Fly from

La Crosse

Fly to

Missouri

Route

Depart

Return

Price

La CrosseColumbia

LSE - COU

LSECOU

La Crosse

Sat 4/4

4:46 pm-7:58 pm

1 stop3h 12m

Columbia Regional

Wed 4/8

5:57 am-10:56 am

1 stop4h 59m

$458

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Sat 4/4

4:46 pm-8:15 pm

1 stop3h 29m

Kansas City

Wed 4/8

7:32 am-10:56 am

1 stop3h 24m

$468

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Sat 4/4

4:46 pm-9:48 pm

1 stop5h 02m

Lambert-St Louis

Tue 4/7

7:50 am-10:56 am

1 stop3h 06m

$468

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Wed 12/3

4:00 pm-8:24 pm

1 stop4h 24m

Lambert-St Louis

Wed 12/10

5:05 am-9:19 am

1 stop4h 14m

$471

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Sat 11/22

6:00 am-10:58 am

1 stop4h 58m

Kansas City

Sun 11/23

7:42 pm-11:49 pm

1 stop4h 07m

$536

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Thu 11/20

9:50 am-4:16 pm

1 stop6h 26m

Lambert-St Louis

Mon 11/24

7:58 pm-11:49 pm

1 stop3h 51m

$560

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Wed 11/26

6:00 am-11:01 am

1 stop5h 01m

Kansas City

Sun 11/30

7:42 pm-1:13 am

1 stop5h 31m

$617

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Sat 11/22

9:50 am-3:01 pm

1 stop5h 11m

$372

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Best time to book a flight from La Crosse to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to Missouri

What is the cheapest month to book a flight from La Crosse to Missouri?

Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in March is currently the most expensive (average of $403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to Missouri?

    Located just 5.4 mi from the city center, La Crosse (LSE) is the airport most travelers will use when flying to Missouri from La Crosse.

  • How long is the flight from La Crosse to Missouri?

    Airlines like American Airlines fly from La Crosse to Missouri in about 3h 12m. The time it takes to get you to your destination can typically vary by up to . La Crosse and Missouri are separated by a distance of 353 mi.

  • What are the most popular routes from La Crosse to Missouri?

    Most travelers choose La Crosse - Lambert-St Louis, La Crosse - Kansas City or La Crosse - Columbia Regional when deciding on the best route from La Crosse to Missouri.

  • Can I find deals for flights from La Crosse to Missouri that include hotel bookings?

    Yes. In addition to deals on La Crosse to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Missouri.

  • Can I find deals for business class flights from La Crosse to Missouri?

    Yes. Cheapflights offers flight deals from La Crosse to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to Missouri?

    Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in March is currently the most expensive (average of $403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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