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$434+ Cheap flights from La Crosse (LSE) to Missouri

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — STL
Nov 19 — Nov 261
Wed 11/19
Wed 11/26
1 adult, Economy
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Find flight deals from La Crosse to Missouri

Cheapest flights from La Crosse to Missouri
Explore the most affordable flight options available from La Crosse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2025.

This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:00 amLSE - MCI
1 stop5h 15mAmerican Airlines
Tue 11/1112:03 pmMCI - LSE
1 stop4h 07mAmerican Airlines
Deal found 10/19$434
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/410:03 amLSE - STL
1 stop4h 59mAmerican Airlines
Sat 11/86:00 amSTL - LSE
1 stop3h 29mAmerican Airlines
Deal found 10/19$434
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/269:50 amLSE - STL
1 stop5h 22mAmerican Airlines
Sun 11/306:00 amSTL - LSE
1 stop3h 20mAmerican Airlines
Deal found 10/19$568
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/26:02 pmLSE - STL
1 stop5h 54mAmerican Airlines
Thu 11/66:00 amSTL - LSE
1 stop3h 20mAmerican Airlines
Deal found 10/18$798

Cheap flight deals from La Crosse to Missouri

Keep the following information in mind while searching for La Crosse to Missouri flight deals. Data was last updated October 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$434
(American Airlines)
Provider with most accurate pricing for La Crosse-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for La Crosse-Lambert-St Louis flights.
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From La Crosse to Missouri
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from La Crosse to Missouri that are best for you.

Fly from

La Crosse

Fly to

Missouri

Route

Depart

Return

Price

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Sat 11/8

6:00 am-11:15 am

1 stop5h 15m

Kansas City

Tue 11/11

12:03 pm-4:10 pm

1 stop4h 07m

$434

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Tue 11/4

10:03 am-3:02 pm

1 stop4h 59m

Lambert-St Louis

Sat 11/8

6:00 am-9:29 am

1 stop3h 29m

$434

La CrosseColumbia

LSE - COU

LSECOU

La Crosse

Sat 4/4

4:46 pm-7:58 pm

1 stop3h 12m

Columbia Regional

Wed 4/8

12:53 pm-3:58 pm

1 stop3h 05m

$458

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Sat 4/4

4:46 pm-8:15 pm

1 stop3h 29m

Kansas City

Wed 4/8

5:47 am-10:56 am

1 stop5h 09m

$468

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Sat 4/4

4:46 pm-9:48 pm

1 stop5h 02m

Lambert-St Louis

Tue 4/7

11:14 am-3:58 pm

1 stop4h 44m

$468

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Wed 11/26

9:50 am-3:12 pm

1 stop5h 22m

Lambert-St Louis

Sun 11/30

6:00 am-9:20 am

1 stop3h 20m

$568

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Sun 11/2

6:02 pm-11:56 pm

1 stop5h 54m

Lambert-St Louis

Thu 11/6

6:00 am-9:20 am

1 stop3h 20m

$798

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/19

Best time to book a flight from La Crosse to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to Missouri

What is the cheapest month to book a flight from La Crosse to Missouri?

Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in March is currently the most expensive (average of $403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to Missouri?

    Located just 5.4 mi from the city center, La Crosse (LSE) is the airport most travelers will use when flying to Missouri from La Crosse.

  • How long is the flight from La Crosse to Missouri?

    Airlines like American Airlines fly from La Crosse to Missouri in about 5h 15m. The time it takes to get you to your destination can typically vary by up to . La Crosse and Missouri are separated by a distance of 363 mi.

  • What are the most popular routes from La Crosse to Missouri?

    Most travelers choose La Crosse - Lambert-St Louis, La Crosse - Kansas City or La Crosse - Columbia Regional when deciding on the best route from La Crosse to Missouri.

  • Can I find deals for flights from La Crosse to Missouri that include hotel bookings?

    Yes. In addition to deals on La Crosse to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Missouri.

  • Can I find deals for business class flights from La Crosse to Missouri?

    Yes. Cheapflights offers flight deals from La Crosse to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to Missouri?

    Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in March is currently the most expensive (average of $403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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