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$372+ Cheap flights from La Crosse (LSE) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/3. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — STL
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Find flight deals from La Crosse to Missouri

Cheapest flights from La Crosse to Missouri
Explore the most affordable flight options available from La Crosse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This American Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1010:00 amLSE - STL
1 stop6h 50mAmerican Airlines
Sun 12/145:15 amSTL - LSE
1 stop4h 09mAmerican Airlines
Deal found 11/25$517
This American Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:10 pmLSE - STL
1 stop5h 28mAmerican Airlines
Sun 12/141:59 pmSTL - LSE
1 stop3h 39mAmerican Airlines
Deal found 11/25$560
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2110:09 amLSE - STL
1 stop6h 37mAmerican Airlines
Tue 12/235:54 amSTL - LSE
1 stop3h 45mAmerican Airlines
Deal found 11/24$791

Cheap flight deals from La Crosse to Missouri

Keep the following information in mind while searching for La Crosse to Missouri flight deals. Data was last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$458
(American Airlines)

One-way from

$372
(American Airlines)
Provider with most accurate pricing for La Crosse-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for La Crosse-Lambert-St Louis flights.
Search Deals
From La Crosse to Missouri
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One-way flight from La Crosse to Missouri
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from La Crosse to Missouri that are best for you.

Fly from

La Crosse

Fly to

Missouri

Route

Depart

Return

Price

La CrosseColumbia

LSE - COU

LSECOU

La Crosse

Sat 2/7

5:08 pm-9:10 pm

1 stop4h 02m

Columbia Regional

Tue 2/10

11:56 am-4:16 pm

1 stop4h 20m

$458

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Tue 2/3

5:08 pm-10:39 pm

1 stop5h 31m

Kansas City

Sat 2/7

6:34 pm-10:16 pm

1 stop3h 42m

$468

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Wed 1/7

6:00 am-10:20 am

1 stop4h 20m

Lambert-St Louis

Sun 1/11

6:44 pm-10:16 pm

1 stop3h 32m

$468

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Thu 1/1

8:06 pm-11:44 pm

1 stop3h 38m

Lambert-St Louis

Sun 1/4

2:06 pm-7:36 pm

1 stop5h 30m

$468

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Fri 1/2

8:06 pm-11:55 pm

1 stop3h 49m

Lambert-St Louis

Sun 1/4

4:53 pm-11:38 pm

1 stop6h 45m

$468

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Thu 1/8

6:00 am-3:04 pm

2 stops9h 04m

Lambert-St Louis

Sun 1/11

6:44 pm-10:16 pm

1 stop3h 32m

$474

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Wed 12/10

10:00 am-6:43 pm

2 stops8h 43m

Lambert-St Louis

Sun 12/14

9:11 am-5:38 pm

2 stops8h 27m

$528

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Thu 12/11

6:10 pm-11:38 pm

1 stop5h 28m

Lambert-St Louis

Sun 12/14

1:59 pm-5:38 pm

1 stop3h 39m

$560

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Sat 1/3

8:06 pm-1:08 pm

2 stops17h 02m

$559

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/25

Best time to book a flight from La Crosse to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to Missouri

What is the cheapest month to book a flight from La Crosse to Missouri?

Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in November is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 26, 2025.
See what other customers who have flown with American Airlines from La Crosse to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,038 reviews

Comfort

7.2

Crew

8.0

Entertainment

6.9

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.
American Airlines
7.2
Good
11,038 reviews
American Airlines
7.2
Good
11,038 reviews

Comfort

7.2

Crew

8.0

Entertainment

6.9

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to Missouri?

    Located just 5.4 mi from the city center, La Crosse (LSE) is the airport most travelers will use when flying to Missouri from La Crosse.

  • How long is the flight from La Crosse to Missouri?

    Airlines like American Airlines fly from La Crosse to Missouri in about 4h 02m. The time it takes to get you to your destination can typically vary by up to . La Crosse and Missouri are separated by a distance of 353 mi.

  • What are the most popular routes from La Crosse to Missouri?

    Most travelers choose La Crosse - Lambert-St Louis, La Crosse - Columbia Regional or La Crosse - Kansas City when deciding on the best route from La Crosse to Missouri.

  • Can I find deals for flights from La Crosse to Missouri that include hotel bookings?

    Yes. In addition to deals on La Crosse to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Missouri.

  • Can I find deals for business class flights from La Crosse to Missouri?

    Yes. Cheapflights offers flight deals from La Crosse to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to Missouri?

    Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in November is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for La Crosse to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from La Crosse to Missouri

Discover the top airline that operate flights from La Crosse to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$317Average$470FlexibilityNo cancel feeOn-time71%

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