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$372+ Cheap flights from La Crosse (LSE) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — STL
Jan 25 — Feb 11
Sun 1/25
Sun 2/1
1 adult, Economy
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Cheap flight deals from La Crosse to Missouri

Best flights from La Crosse to Missouri
Discover carefully curated flight deals from La Crosse to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 26, 2025.

This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:00 amLSE - STL
1 stop4h 20mAmerican Airlines
Mon 2/162:24 pmSTL - LSE
1 stop3h 15mAmerican Airlines
Deal found 12/26$490
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/96:00 amLSE - STL
1 stop4h 20mAmerican Airlines
Sun 1/116:00 amSTL - LSE
1 stop5h 07mAmerican Airlines
Deal found 12/24$560
This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/176:00 amLSE - MCI
1 stop4h 13mAmerican Airlines
Mon 1/196:00 amMCI - LSE
1 stop5h 07mAmerican Airlines
Deal found 12/25$582

Find flight deals from La Crosse to Missouri

Keep the following information in mind while searching for La Crosse to Missouri flight deals. Data was last updated December 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$490
(American Airlines)

One-way from

$372
(American Airlines)
Provider with most accurate pricing for La Crosse-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for La Crosse-Lambert-St Louis flights.
Search Deals
From La Crosse to Missouri
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One-way flight from La Crosse to Missouri
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from La Crosse to Missouri that are best for you.

Fly from

La Crosse

Fly to

Missouri

Route

Depart

Return

Price

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Sat 2/7

6:00 am-10:20 am

1 stop4h 20m

Lambert-St Louis

Mon 2/16

2:24 pm-5:39 pm

1 stop3h 15m

$490

La CrosseSt. Louis

LSE - STL

LSESTL

La Crosse

Fri 1/9

6:00 am-10:20 am

1 stop4h 20m

Lambert-St Louis

Sun 1/11

6:00 am-11:07 am

1 stop5h 07m

$560

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Sat 1/17

6:00 am-10:13 am

1 stop4h 13m

Kansas City

Mon 1/19

6:00 am-11:07 am

1 stop5h 07m

$582

La CrosseKansas City

LSE - MCI

LSEMCI

La Crosse

Wed 1/14

6:00 am-10:07 am

1 stop4h 07m

$372

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

Best time to book a flight from La Crosse to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to Missouri

What is the cheapest month to book a flight from La Crosse to Missouri?

Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in November is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 26, 2025.
See what other customers who have flown with American Airlines from La Crosse to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,064 reviews

Crew

8.0

Boarding

7.5

Entertainment

6.9

Food

6.5

Overall

7.2

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,064 reviews
American Airlines
7.2
Good
11,064 reviews

Crew

8.0

Boarding

7.5

Entertainment

6.9

Food

6.5

Overall

7.2

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to Missouri?

    Located just 5.4 mi from the city center, La Crosse (LSE) is the airport most travelers will use when flying to Missouri from La Crosse.

  • How long is the flight from La Crosse to Missouri?

    Airlines like American Airlines fly from La Crosse to Missouri in about 4h 20m. The time it takes to get you to your destination can typically vary by up to . La Crosse and Missouri are separated by a distance of 357 mi.

  • What are the most popular routes from La Crosse to Missouri?

    Most travelers choose La Crosse - Lambert-St Louis, La Crosse - Kansas City or La Crosse - Columbia Regional when deciding on the best route from La Crosse to Missouri.

  • Can I find deals for flights from La Crosse to Missouri that include hotel bookings?

    Yes. In addition to deals on La Crosse to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Missouri.

  • Can I find deals for business class flights from La Crosse to Missouri?

    Yes. Cheapflights offers flight deals from La Crosse to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to Missouri?

    Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in November is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top airline flying from La Crosse to Missouri

Discover the top airline that operate flights from La Crosse to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$317Average$470FlexibilityNo cancel feeOn-time71%

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