$372+ Cheap flights from La Crosse (LSE) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — STL
Dec 13 — Dec 201
1 adult, Economy
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Cheapest flights from La Crosse to MissouriExplore the most affordable flight options available from La Crosse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.
Explore the most affordable flight options available from La Crosse to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/159:59 amLSE - STL
2 stops9h 30mAmerican Airlines
Tue 11/185:40 pmSTL - LSE
1 stop4h 22mAmerican Airlines
Deal found 11/12![American Airlines logo]()
$480
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:50 amLSE - MCI
1 stop5h 21mAmerican Airlines
Sun 11/167:43 pmMCI - LSE
1 stop4h 06mAmerican Airlines
Deal found 11/12![American Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/269:50 amLSE - STL
1 stop6h 26mAmerican Airlines
Sun 11/307:58 pmSTL - LSE
1 stop5h 15mAmerican Airlines
Deal found 11/11![American Airlines logo]()
$617
This American Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:13 pmLSE - STL
1 stop5h 43mAmerican Airlines
Wed 12/35:40 pmSTL - LSE
1 stop4h 23mAmerican Airlines
Deal found 11/13![American Airlines logo]()
$791
Cheap flight deals from La Crosse to Missouri
Keep the following information in mind while searching for La Crosse to Missouri flight deals. Data was last updated November 13, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $458 (American Airlines) |
One-way from | $372 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from La Crosse to Missouri that are best for you.
Fly from
La Crosse
Fly to
Missouri
Route
Depart
Return
Price
La CrosseColumbia
LSE - COU
LSECOU
La Crosse
Sat 4/4
4:46 pm-7:58 pm
1 stop3h 12m
Columbia Regional
Wed 4/8
5:57 am-10:56 am
1 stop4h 59m
$458
La CrosseKansas City
LSE - MCI
LSEMCI
La Crosse
Sat 4/4
6:14 am-9:41 am
1 stop3h 27m
Kansas City
Wed 4/8
7:32 am-10:56 am
1 stop3h 24m
$468
La CrosseSt. Louis
LSE - STL
LSESTL
La Crosse
Wed 11/26
9:50 am-4:16 pm
1 stop6h 26m
Lambert-St Louis
Sun 11/30
7:58 pm-1:13 am
1 stop5h 15m
$617
La CrosseSt. Louis
LSE - STL
LSESTL
La Crosse
Mon 12/1
6:13 pm-11:56 pm
1 stop5h 43m
Lambert-St Louis
Wed 12/3
5:40 pm-10:03 pm
1 stop4h 23m
$791
La CrosseSt. Louis
LSE - STL
LSESTL
La Crosse
Wed 11/26
6:13 pm-11:56 pm
1 stop5h 43m
$372
Best time to book a flight from La Crosse to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from La Crosse to Missouri
What is the cheapest month to book a flight from La Crosse to Missouri?
Currently, October is the cheapest month in which you can book a flight from La Crosse to Missouri (average of $196). Flying from La Crosse to Missouri in November is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.