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$116+ Cheap flights from Fort Myers (RSW) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — STL
Apr 22 — Apr 291
Wed 4/22
Wed 4/29
1 adult, Economy
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Cheap flight deals from Fort Myers to Missouri

Cheapest flights from Fort Myers to Missouri
Explore the most affordable flight options available from Fort Myers to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This Expedia deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/35:24 pm
RSW
-
STL
1 stop17h 24m
Frontier
Sun 4/511:21 am
STL
-
RSW
1 stop6h 25m
Frontier
Deal found 3/22$205
This Expedia deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:24 pm
RSW
-
STL
1 stop17h 24m
Frontier
Sun 4/511:21 am
STL
-
RSW
1 stop6h 25m
Frontier
Deal found 3/18$250
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:40 pm
RSW
-
MCI
1 stop5h 00m
Southwest
Tue 4/285:25 am
MCI
-
RSW
1 stop6h 20m
Southwest
Deal found 3/22$291
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:10 am
RSW
-
STL
Nonstop2h 40m
Southwest
Tue 4/2110:15 am
STL
-
RSW
Nonstop2h 25m
Southwest
Deal found 3/20$303
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:00 am
RSW
-
STL
Nonstop2h 45m
Southwest
Mon 4/207:40 pm
STL
-
RSW
Nonstop2h 25m
Southwest
Deal found 3/18$309
This United Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:01 am
RSW
-
STL
1 stop6h 21m
United Airlines
Tue 4/216:30 am
STL
-
RSW
1 stop5h 46m
United Airlines
Deal found 3/20$318
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:05 pm
RSW
-
STL
Nonstop2h 45m
Southwest
Mon 4/205:00 am
STL
-
RSW
1 stop5h 10m
Southwest
Deal found 3/20$319
This Delta deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:30 pm
RSW
-
SGF
1 stop4h 37m
Delta
Tue 5/56:05 am
SGF
-
RSW
1 stop6h 49m
Delta
Deal found 3/22$319
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:20 am
RSW
-
STL
1 stop5h 30m
Southwest
Tue 4/216:45 pm
STL
-
RSW
Nonstop2h 25m
Southwest
Deal found 3/19$320
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:34 am
RSW
-
STL
1 stop5h 00m
Delta
Sat 4/186:00 am
STL
-
RSW
1 stop6h 54m
Delta
Deal found 3/18$329
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:00 am
RSW
-
JLN
1 stop7h 22m
United Airlines
Fri 6/261:57 pm
JLN
-
RSW
1 stop6h 53m
United Airlines
Deal found 3/22$334
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:28 pm
RSW
-
MCI
1 stop27h 27m
Frontier
Sun 3/298:40 pm
MCI
-
RSW
1 stop18h 51m
Frontier
Deal found 3/23$336

Find flight deals from Fort Myers to Missouri

Keep the following information in mind while searching for Fort Myers to Missouri flight deals. Data was last updated March 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$205
(Expedia)

One-way from

$116
(Southwest)

Popular in

March

Cheapest in

August

Average price

$547
Provider with most accurate pricing for Fort Myers SW Florida Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Lambert-St Louis flights.
Search Deals
From Fort Myers SW Florida Intl to Missouri
Search Deals
One-way flight from Fort Myers SW Florida Intl to Missouri
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($111 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Fort Myers to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Fort MyersKansas City

RSW - MCI

RSWMCI

Fort Myers SW Florida Intl

Tue 4/21

6:40 pm-10:40 pm

1 stop5h 00m

Kansas City

Tue 4/28

5:25 am-12:45 pm

1 stop6h 20m

$291

Fort MyersSpringfield

RSW - SGF

RSWSGF

Fort Myers SW Florida Intl

Thu 4/30

5:30 pm-9:07 pm

1 stop4h 37m

Springfield-Branson

Tue 5/5

6:05 am-1:54 pm

1 stop6h 49m

$319

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Fri 4/17

6:20 am-10:50 am

1 stop5h 30m

Lambert-St Louis

Tue 4/21

6:45 pm-10:10 pm

Nonstop2h 25m

$320

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Sat 4/11

6:15 pm-11:25 pm

1 stop6h 10m

Lambert-St Louis

Mon 4/13

4:41 pm-9:40 pm

1 stop3h 59m

$329

Fort MyersJoplin

RSW - JLN

RSWJLN

Fort Myers SW Florida Intl

Fri 4/24

7:01 am-1:12 pm

1 stop7h 11m

Joplin

Tue 4/28

8:56 am-4:51 pm

1 stop6h 55m

$334

Fort MyersJoplin

RSW - JLN

RSWJLN

Fort Myers SW Florida Intl

Thu 4/30

7:03 am-1:37 pm

1 stop7h 34m

Joplin

Tue 5/5

9:06 am-10:41 pm

2 stops12h 35m

$340

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Sat 4/18

6:25 am-9:50 am

1 stop4h 25m

Lambert-St Louis

Tue 4/21

10:15 am-4:00 pm

1 stop4h 45m

$346

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Sat 4/18

7:01 am-12:22 pm

1 stop6h 21m

Lambert-St Louis

Mon 4/20

6:30 am-1:16 pm

1 stop5h 46m

$351

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Thu 8/20

6:50 am-3:15 pm

2 stops9h 25m

Lambert-St Louis

Sun 8/23

3:30 pm-9:45 pm

1 stop5h 15m

$356

Fort MyersSpringfield

RSW - SGF

RSWSGF

Fort Myers SW Florida Intl

Sat 4/18

5:02 pm-10:00 pm

1 stop5h 58m

Springfield-Branson

Wed 4/22

11:23 am-8:16 pm

1 stop7h 53m

$360

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/18

Showing 1-10 of 55 resultsSorted by cheapest first
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Best time to book a flight from Fort Myers to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Missouri

What is the cheapest month to book a flight from Fort Myers to Missouri?

Currently, October is the cheapest month in which you can book a flight from Fort Myers to Missouri (average of $133). Flying from Fort Myers to Missouri in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to MO?

Find hourly flight availability from Fort Myers to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 23, 2026.

One of the essential ways to save on airfare from Fort Myers to Missouri is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight at noon could potentially save you up to 22% on airfare.

What is the cheapest day to fly from Fort Myers to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Fort Myers to Missouri. Price data was last updated on March 23, 2026.

Travelers seeking maximum savings on their Fort Myers to Missouri flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated March 23, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from Fort Myers to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,324 reviews

Entertainment

7.5

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,324 reviews
Southwest
8.0
Very good
4,324 reviews

Entertainment

7.5

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,319 reviews
Southwest
8.0
Very good
4,324 reviews

Entertainment

7.5

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,489 reviews
Southwest
8.0
Very good
4,324 reviews

Entertainment

7.5

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Fort Myers to Missouri?

    Fort Myers SW Florida Intl (RSW) is the airport you will fly out of if you book a flight from Fort Myers to Missouri. It is only a 10.0 mi journey to SW Florida Intl (RSW) from Fort Myers’s city center.

  • How popular is this Fort Myers to Missouri flight route?

    The Fort Myers SW Florida Intl to Missouri flight path was viewed by 15 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Fort Myers to Missouri?

    Departing from Fort Myers to Missouri will take you 4h 37m. There are 1004 mi between Fort Myers and Missouri. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Fort Myers to Missouri one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $99. However, be on the lookout for offers from Delta and Southwest, as they are both options that can get you from Fort Myers to Missouri for a low price.

  • What are the most popular routes from Fort Myers to Missouri?

    While some choose either Fort Myers SW Florida Intl - Kansas City or Fort Myers SW Florida Intl - Springfield-Branson, Fort Myers SW Florida Intl - Lambert-St Louis is the most popular route from Fort Myers to Missouri.

  • What are the cheapest flights from Fort Myers to Missouri?

    On average you can expect to pay $360 for a flight from Fort Myers to Missouri. The cheapest flight overall is $155 while the most popular route, (Fort Myers SW Florida Intl - Lambert-St Louis) is currently priced at $266.

  • Can I find deals for flights from Fort Myers to Missouri that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Missouri.

  • Can I find deals for business class flights from Fort Myers to Missouri?

    Yes. Cheapflights offers flight deals from Fort Myers to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Missouri?

    Currently, October is the cheapest month in which you can book a flight from Fort Myers to Missouri (average of $133). Flying from Fort Myers to Missouri in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Fort Myers to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Fort Myers to Missouri

Discover the top 3 airlines that operate flights from Fort Myers to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$177Average$416FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$186Average$488FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$415FlexibilityNo cancel feeOn-timeN/A

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