What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to Missouri one-way?

$36 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Frontier and Delta, with prices starting from $48 and $60, respectively.

In terms of precipitation, rainfall in Missouri ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit Missouri when rainfall is around 2.2 in.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular routes from Detroit Metropolitan Wayne County Airport to Missouri?

When deciding which route to take from Detroit Metropolitan Wayne County Airport to Missouri consider Detroit Metropolitan Wayne County - Kansas City, Detroit Metropolitan Wayne County - Lambert-St Louis or Detroit Metropolitan Wayne County - Springfield-Branson as they are the most popular.

What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to Missouri?

Before booking your flight to Missouri from Detroit Metropolitan Wayne County Airport, check out the most reliable airlines to get you to your destination on time: Korean Air (87%), WestJet (82%), Delta( 78%).

What are the most popular airlines that fly from Detroit Metropolitan Wayne County Airport to Missouri?

Before booking your flight from Detroit Metropolitan Wayne County Airport to Missouri check out the most popular airlines for this route: Delta, Southwest or Spirit Airlines.

What airport do you fly from for flights from Detroit to Missouri?

For a flight from Detroit to Missouri, you will be flying from Detroit Metropolitan Wayne County. Detroit Metropolitan Wayne County (DTW) is just 17.3 mi from the center of the city.

Can I find deals for flights from Detroit to Missouri that include hotel bookings?

Yes. In addition to deals on Detroit to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Detroit to Missouri?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Missouri.

Can I find deals for business class flights from Detroit to Missouri?

Yes. Cheapflights offers flight deals from Detroit to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$64+ Flights from Detroit Metropolitan Wayne County Airport to Missouri

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Find cheap flights from Detroit to Missouri with Cheapflights

1. Tell us where you want to go

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Cheap flight deals from Detroit to Missouri

Cheapest flights from Detroit to Missouri
Explore the most affordable flight options available from Detroit to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Wed 12/314:56 pmDTW - SGF

1 stop5h 23mDelta

Wed 1/75:00 pmSGF - DTW

1 stop5h 42mDelta

Deal found 12/16

$274

Thu 12/1810:01 pmDTW - STL

1 stop13h 01mFrontier

Sun 12/2110:57 amSTL - DTW

1 stop6h 12mFrontier

Deal found 12/15

$298

Tue 12/3012:15 pmDTW - MCI

2 stops35h 44mMultiple Airlines

Mon 1/511:38 amMCI - DTW

1 stop19h 29mMultiple Airlines

Deal found 12/16

$308

Fri 12/263:35 pmDTW - SGF

1 stop6h 29mAmerican Airlines

Thu 1/14:27 pmSGF - DTW

1 stop5h 07mAmerican Airlines

Deal found 12/15

$309

Wed 12/312:43 pmDTW - STL

2 stops19h 57mFrontier

Sun 1/410:57 amSTL - DTW

1 stop22h 56mFrontier

Deal found 12/16

$337

Wed 12/316:40 pmDTW - STL

1 stop17h 16mMultiple Airlines

Sun 1/410:57 amSTL - DTW

1 stop22h 56mMultiple Airlines

Deal found 12/16

$349

Wed 12/174:47 pmDTW - SGF

1 stop5h 07mAmerican Airlines

Fri 12/264:27 pmSGF - DTW

1 stop7h 17mAmerican Airlines

Deal found 12/17

$354

Sat 12/275:11 pmDTW - SGF

1 stop5h 53mAmerican Airlines

Thu 1/14:27 pmSGF - DTW

1 stop7h 17mAmerican Airlines

Deal found 12/15

$357

Tue 12/3010:01 pmDTW - STL

1 stop13h 01mFrontier

Thu 1/110:42 amSTL - DTW

1 stop6h 27mFrontier

Deal found 12/17

$362

Fri 12/269:12 amDTW - SGF

1 stop6h 26mUnited Airlines

Tue 12/303:14 pmSGF - DTW

1 stop6h 16mUnited Airlines

Deal found 12/15

$374

Wed 12/316:00 amDTW - SGF

2 stops9h 38mUnited Airlines

Wed 1/73:14 pmSGF - DTW

1 stop4h 12mUnited Airlines

Deal found 12/16

$381

Fri 12/263:35 pmDTW - SGF

1 stop6h 29mAmerican Airlines

Tue 12/304:00 pmSGF - DTW

1 stop5h 57mAmerican Airlines

Deal found 12/15

$387

Best flights from Detroit to Missouri
Discover carefully curated flight deals from Detroit to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

Thu 1/2910:08 pmDTW - STL

2 stops26h 25mMultiple Airlines

Mon 2/25:42 pmSTL - DTW

1 stop16h 12mMultiple Airlines

Deal found 12/16

$165

Sat 1/2411:05 amDTW - STL

1 stop4h 23mUnited Airlines

Tue 1/279:57 amSTL - DTW

1 stop6h 06mUnited Airlines

Deal found 12/17

$182

Thu 1/293:16 pmDTW - STL

1 stop9h 17mFrontier

Fri 1/301:03 pmSTL - DTW

1 stop9h 56mFrontier

Deal found 12/16

$198

Thu 1/295:50 amDTW - STL

Nonstop2h 00mSouthwest

Sat 1/315:45 pmSTL - DTW

Nonstop1h 30mSouthwest

Deal found 12/16

$231

Tue 1/62:46 pmDTW - SGF

1 stop7h 14mAmerican Airlines

Sat 1/105:39 pmSGF - DTW

1 stop5h 17mAmerican Airlines

Deal found 12/17

$274

Wed 12/314:56 pmDTW - SGF

1 stop5h 23mDelta

Wed 1/75:00 pmSGF - DTW

1 stop5h 42mDelta

Deal found 12/16

$274

Mon 1/265:15 pmDTW - MCI

1 stop21h 35mAlaska Airlines

Fri 1/302:45 pmMCI - DTW

1 stop24h 34mAlaska Airlines

Deal found 12/16

$384

Fri 1/305:15 amDTW - MCI

1 stop11h 54mMultiple Airlines

Mon 2/212:45 pmMCI - DTW

1 stop8h 23mMultiple Airlines

Deal found 12/17

$228

Sat 1/178:50 amDTW - STL

Nonstop1h 55mSouthwest

Wed 1/218:20 amSTL - DTW

1 stop6h 10mSouthwest

Deal found 12/16

$232

Wed 1/75:30 amDTW - STL

1 stop6h 32mUnited Airlines

Thu 1/86:40 pmSTL - DTW

1 stop4h 04mUnited Airlines

Deal found 12/16

$242

Wed 1/145:50 amDTW - STL

Nonstop2h 00mSouthwest

Wed 1/212:35 pmSTL - DTW

1 stop5h 50mSouthwest

Deal found 12/17

$232

Tue 1/135:30 amDTW - SGF

2 stops8h 16mUnited Airlines

Tue 1/203:14 pmSGF - DTW

1 stop5h 56mUnited Airlines

Deal found 12/16

$244

Wed 1/76:15 amDTW - SGF

1 stop27h 26mMultiple Airlines

Mon 1/128:55 amSGF - DTW

1 stop27h 57mMultiple Airlines

Deal found 12/17

$248

Thu 1/296:25 amDTW - STL

1 stop4h 50mSouthwest

Mon 2/25:55 pmSTL - DTW

Nonstop1h 30mSouthwest

Deal found 12/16

$241

Fri 12/263:35 pmDTW - SGF

1 stop6h 29mAmerican Airlines

Thu 1/14:27 pmSGF - DTW

1 stop5h 07mAmerican Airlines

Deal found 12/15

$309

Wed 1/215:50 amDTW - STL

Nonstop2h 00mSouthwest

Sat 1/245:30 amSTL - DTW

1 stop9h 20mSouthwest

Deal found 12/17

$241

Thu 1/11:56 pmDTW - COU

1 stop4h 29mUnited Airlines

Mon 1/53:10 pmCOU - DTW

1 stop6h 20mUnited Airlines

Deal found 12/17

$268

Sun 1/47:20 pmDTW - MCI

1 stop15h 48mMultiple Airlines

Tue 1/66:15 pmMCI - DTW

2 stops30h 04mMultiple Airlines

Deal found 12/15

$275

Tue 1/135:25 amDTW - STL

2 stops8h 20mSouthwest

Tue 1/201:10 pmSTL - DTW

2 stops8h 20mSouthwest

Deal found 12/16

$243

Tue 1/611:05 amDTW - SGF

1 stop4h 33mUnited Airlines

Sat 1/103:14 pmSGF - DTW

1 stop5h 56mUnited Airlines

Deal found 12/16

$269

Thu 1/295:15 pmDTW - MCI

1 stop21h 35mAlaska Airlines

Mon 2/22:45 pmMCI - DTW

1 stop24h 34mAlaska Airlines

Deal found 12/15

$385

Mon 2/169:01 amDTW - MCI

1 stop15h 32mMultiple Airlines

Fri 2/206:13 pmMCI - DTW

1 stop28h 42mMultiple Airlines

Deal found 12/17

$296

Fri 2/278:35 amDTW - MCI

Nonstop2h 19mDelta

Wed 3/45:47 pmMCI - DTW

Nonstop1h 58mDelta

Deal found 12/16

$399

Fri 1/911:05 amDTW - SGF

1 stop4h 33mUnited Airlines

Mon 1/127:45 amSGF - DTW

2 stops10h 51mUnited Airlines

Deal found 12/15

$274

Sat 1/39:12 amDTW - SGF

1 stop6h 26mUnited Airlines

Mon 1/56:20 pmSGF - DTW

1 stop4h 18mUnited Airlines

Deal found 12/17

$279

Thu 3/55:15 amDTW - MCI

1 stop11h 14mMultiple Airlines

Sun 3/88:40 pmMCI - DTW

1 stop24h 02mMultiple Airlines

Deal found 12/17

$368

Thu 3/1210:28 amDTW - COU

1 stop4h 43mUnited Airlines

Tue 3/178:00 amCOU - DTW

1 stop4h 28mUnited Airlines

Deal found 12/15

$328

Thu 1/226:50 amDTW - MCI

2 stops8h 30mSouthwest

Mon 1/263:55 pmMCI - DTW

1 stop3h 30mSouthwest

Deal found 12/16

$378

Thu 1/89:00 amDTW - COU

1 stop6h 35mUnited Airlines

Mon 1/123:10 pmCOU - DTW

1 stop6h 00mUnited Airlines

Deal found 12/15

$328

Wed 2/186:50 amDTW - MCI

1 stop4h 15mSouthwest

Fri 2/201:25 pmMCI - DTW

2 stops7h 35mSouthwest

Deal found 12/16

$380

Last-minute flights from Detroit to Missouri
Discover last-minute flight deals from Detroit to Missouri. Data last updated December 18, 2025 and is based on user searches.

Mon 1/55:49 pmDTW - STL

1 stop29h 44mMultiple Airlines

Mon 1/125:11 pmSTL - DTW

1 stop19h 41mMultiple Airlines

Deal found 12/16

$165

Sat 1/105:15 amDTW - STL

1 stop18h 18mMultiple Airlines

Mon 1/125:11 pmSTL - DTW

1 stop19h 41mMultiple Airlines

Deal found 12/17

$171

Mon 1/125:15 pmDTW - MCI

1 stop23h 54mMultiple Airlines

Fri 1/168:27 pmMCI - DTW

2 stops24h 29mMultiple Airlines

Deal found 12/16

$196

Tue 1/132:36 pmDTW - STL

1 stop17h 15mMultiple Airlines

Tue 1/205:42 pmSTL - DTW

1 stop19h 10mMultiple Airlines

Deal found 12/16

$158

Wed 1/145:15 amDTW - STL

1 stop18h 19mMultiple Airlines

Wed 1/218:22 pmSTL - DTW

1 stop20h 57mMultiple Airlines

Deal found 12/17

$153

Thu 1/153:12 pmDTW - MCI

1 stop20h 19mMultiple Airlines

Sun 1/188:27 pmMCI - DTW

1 stop13h 57mMultiple Airlines

Deal found 12/16

$167

Wed 1/215:15 pmDTW - STL

1 stop7h 18mMultiple Airlines

Sat 1/248:22 pmSTL - DTW

1 stop14h 49mMultiple Airlines

Deal found 12/17

$150

Thu 1/2210:54 amDTW - MCI

1 stop24h 37mMultiple Airlines

Mon 1/2612:45 pmMCI - DTW

1 stop8h 23mMultiple Airlines

Deal found 12/16

$181

Fri 1/237:14 pmDTW - STL

1 stop12h 37mMultiple Airlines

Mon 1/268:22 pmSTL - DTW

1 stop16h 08mMultiple Airlines

Deal found 12/17

$136

Thu 1/293:16 pmDTW - STL

1 stop20h 07mFrontier

Mon 2/25:42 pmSTL - DTW

1 stop16h 12mFrontier

Deal found 12/16

$148

Thu 1/297:14 pmDTW - STL

2 stops16h 09mFrontier

Sat 1/318:22 pmSTL - DTW

1 stop14h 49mFrontier

Deal found 12/16

$167

Fri 1/307:14 pmDTW - STL

1 stop12h 37mMultiple Airlines

Fri 2/68:22 pmSTL - DTW

1 stop12h 58mMultiple Airlines

Deal found 12/16

$156

One-way flights from Detroit to Missouri
Search for one-way flight options from Detroit to Missouri. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

Wed 2/119:35 amDTW - STL

1 stop7h 18mFrontier

Deal found 12/17

$64

Wed 2/119:35 amDTW - MCI

1 stop7h 09mFrontier

Deal found 12/16

$64

Fri 1/237:14 pmDTW - STL

1 stop12h 37mFrontier

Deal found 12/17

$67

Fri 1/165:50 pmDTW - STL

1 stop14h 01mFrontier

Deal found 12/17

$68

Tue 2/108:48 pmDTW - STL

1 stop26h 39mFrontier

Deal found 12/17

$70

Tue 1/132:36 pmDTW - STL

1 stop17h 15mMultiple Airlines

Deal found 12/17

$76

Sun 2/81:43 pmDTW - MCI

1 stop21h 48mMultiple Airlines

Deal found 12/15

$77

Mon 2/236:00 amDTW - MCI

1 stop13h 31mFrontier

Deal found 12/16

$78

Sun 1/185:59 pmDTW - STL

1 stop13h 52mFrontier

Deal found 12/17

$79

Thu 1/1512:19 pmDTW - MCI

1 stop8h 29mFrontier

Deal found 12/16

$79

Mon 2/2310:29 pmDTW - STL

1 stop24h 58mFrontier

Deal found 12/17

$80

Wed 2/189:35 amDTW - MCI

1 stop7h 09mFrontier

Deal found 12/16

$80

Find flight deals from Detroit to Missouri

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$136 (Kiwi.com)
One-way from	$64 (Expedia)
Popular in	December
Cheapest in	August
Average price	$383
Good round-trip deal	$298 or less
Good one-way deal	$254 or less

Provider with most accurate pricing for Detroit (DTT)-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Detroit (DTT)-Lambert-St Louis flights.

Search Deals

From Detroit Metropolitan Wayne County to Missouri

Search Deals

One-way flight from Detroit Metropolitan Wayne County to Missouri

Search Deals

Highest demand for flights based on searches. 22% potential increase in price ($77 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to Missouri.

Search Deals

Price to beat on a one-way flight from Detroit Metropolitan Wayne County to Missouri.

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/29

10:08 pm-11:33 pm

2 stops26h 25m

Lambert-St Louis

Mon 2/2

5:42 pm-10:54 am

1 stop16h 12m

$165

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 1/24

11:05 am-2:28 pm

1 stop4h 23m

Lambert-St Louis

Tue 1/27

9:57 am-5:03 pm

1 stop6h 06m

$182

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/29

3:16 pm-11:33 pm

1 stop9h 17m

Lambert-St Louis

Fri 1/30

1:03 pm-11:59 pm

1 stop9h 56m

$198

DetroitKansas City

DTW - MCI

DTWMCI

Detroit Metropolitan Wayne County

Fri 1/30

5:15 am-4:09 pm

1 stop11h 54m

Kansas City

Mon 2/2

12:45 pm-10:08 pm

1 stop8h 23m

$228

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/29

5:50 am-6:50 am

Nonstop2h 00m

Lambert-St Louis

Sat 1/31

5:45 pm-8:15 pm

Nonstop1h 30m

$231

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 1/17

8:50 am-9:45 am

Nonstop1h 55m

Lambert-St Louis

Wed 1/21

8:20 am-3:30 pm

1 stop6h 10m

$232

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 1/14

5:50 am-6:50 am

Nonstop2h 00m

Lambert-St Louis

Wed 1/21

2:35 pm-9:25 pm

1 stop5h 50m

$232

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/29

6:25 am-10:15 am

1 stop4h 50m

Lambert-St Louis

Mon 2/2

5:55 pm-8:25 pm

Nonstop1h 30m

$241

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 1/21

5:50 am-6:50 am

Nonstop2h 00m

Lambert-St Louis

Sat 1/24

5:30 am-3:50 pm

1 stop9h 20m

$241

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 1/7

5:30 am-11:02 am

1 stop6h 32m

Lambert-St Louis

Thu 1/8

6:40 pm-11:44 pm

1 stop4h 04m

$242

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 49 results

...

Best time to book a flight from Detroit to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Detroit with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Missouri

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Missouri (average of $39). Flying from Detroit Metropolitan Wayne County Airport to Missouri in December is currently the most expensive (average of $255). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to MO?

One of the essential ways to save on airfare from Detroit Metropolitan Wayne County Airport to Missouri is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 18% on airfare.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to Missouri?

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to Missouri flight should consider departing on Friday at noon when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Detroit Metropolitan Wayne County Airport to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

7.9

Good

4,250 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,005 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

United Airlines

7.4

Good

9,091 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,054 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Spirit Airlines

6.3

Okay

8,190 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

What airport do you fly from for flights from Detroit to Missouri?
For a flight from Detroit to Missouri, you will be flying from Detroit Metropolitan Wayne County. Detroit Metropolitan Wayne County (DTW) is just 17.3 mi from the center of the city.
How long is the flight from Detroit Metropolitan Wayne County Airport to Missouri?
Airlines like United Airlines, Frontier, and Southwest fly from Detroit Metropolitan Wayne County Airport to Missouri in about 2h. The time it takes to get you to your destination can typically vary by up to 7h 17m. Airlines will cover a distance of 439 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to Missouri one-way?
$36 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Frontier and Delta, with prices starting from $48 and $60, respectively.
What are the most popular routes from Detroit Metropolitan Wayne County Airport to Missouri?
When deciding which route to take from Detroit Metropolitan Wayne County Airport to Missouri consider Detroit Metropolitan Wayne County - Kansas City, Detroit Metropolitan Wayne County - Lambert-St Louis or Detroit Metropolitan Wayne County - Springfield-Branson as they are the most popular.
What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to Missouri?
Before booking your flight to Missouri from Detroit Metropolitan Wayne County Airport, check out the most reliable airlines to get you to your destination on time: Korean Air (87%), WestJet (82%), Delta( 78%).
What are the cheapest flights from Detroit Metropolitan Wayne County Airport to Missouri?
Looking for the cheapest flight from Detroit Metropolitan Wayne County Airport to Missouri? While on average our users pay $509, our data indicates the cheapest price to be $278. The most popular route (Detroit Metropolitan Wayne County - Kansas City), is priced around $167.
Can I find deals for flights from Detroit to Missouri that include hotel bookings?
Yes. In addition to deals on Detroit to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Detroit to Missouri?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Missouri.
Can I find deals for business class flights from Detroit to Missouri?
Yes. Cheapflights offers flight deals from Detroit to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?
Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Missouri (average of $39). Flying from Detroit Metropolitan Wayne County Airport to Missouri in December is currently the most expensive (average of $255). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Missouri car rentals

Kansas City Airport car rentals

Lambert-St Louis Airport car rentals

Springfield-Branson Airport car rentals

Columbia Regional Airport car rentals

Joplin Airport car rentals

Cape Girardeau Airport car rentals

Fort Leonard Wood Waynesville Regional Airport car rentals

Kirksville Cannon Memorial Airport car rentals

St. Louis car rentals

Kansas City car rentals

Springfield car rentals

Top 6 airlines flying from Detroit to Missouri

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$36	Average$150	FlexibilityNo cancel fee	On-time65%
Frontier	Cheapest$111	Average$229	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$136	Average$369	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$137	Average$387	FlexibilityNo cancel fee	On-time63%
American Airlines	Cheapest$203	Average$429	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$253	Average$498	FlexibilityNo cancel fee	On-time69%

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$64+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/11. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Detroit to Missouri

Cheapest flights from Detroit to MissouriExplore the most affordable flight options available from Detroit to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Explore the most affordable flight options available from Detroit to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Find flight deals from Detroit to Missouri

Keep the following information in mind while searching for Detroit to Missouri flight deals. Data was last updated December 18, 2025.

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Best time to book a flight from Detroit to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Detroit with our price prediction graph.

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Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Missouri

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

What is the cheapest time of day to fly from DTW to MO?

Find hourly flight availability from Detroit to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Detroit to Missouri. Price data was last updated on December 16, 2024.

Reviews of airlines servicing Missouri

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Detroit Metropolitan Wayne County Airport to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Detroit to Missouri?

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What are the cheapest flights from Detroit Metropolitan Wayne County Airport to Missouri?

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What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

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Alternative routes for Detroit to Missouri

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Top 6 airlines flying from Detroit to Missouri

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Cheapest flights from Detroit to Missouri
Explore the most affordable flight options available from Detroit to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.