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$71+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — STL
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Detroit to Missouri

Keep the following information in mind while searching for Detroit to Missouri flight deals. Data was last updated September 15, 2025.

Round-trip from

$146
(Priceline)

One-way from

$71
(Kiwi.com)

Popular in

November

Cheapest in

July

Average price

$330

Good round-trip deal

$218 or less

Good one-way deal

$120 or less
From Detroit Metropolitan Wayne County to Missouri
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One-way flight from Detroit Metropolitan Wayne County to Missouri
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Highest demand for flights based on searches. 13% potential increase in price ($56 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to Missouri.
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Price to beat on a one-way flight from Detroit Metropolitan Wayne County to Missouri.
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Find flight deals from Detroit to Missouri

Cheapest flights from Detroit to Missouri
Explore the most affordable flight options available from Detroit to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:10 amDTW - MCI
1 stop8h 38mFrontier
Mon 10/63:01 pmMCI - DTW
1 stop8h 45mFrontier
Deal found 9/13$146
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/27:20 amDTW - STL
1 stop8h 44mMultiple Airlines
Mon 10/64:00 pmSTL - DTW
1 stop15h 16mMultiple Airlines
Deal found 9/12$152
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/287:20 amDTW - STL
1 stop8h 44mMultiple Airlines
Thu 10/24:00 pmSTL - DTW
1 stop21h 46mMultiple Airlines
Deal found 9/13$164
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/279:19 pmDTW - STL
1 stop18h 45mMultiple Airlines
Mon 9/294:00 pmSTL - DTW
1 stop15h 14mMultiple Airlines
Deal found 9/12$167
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:15 pmDTW - MCI
1 stop18h 02mMultiple Airlines
Mon 11/1011:12 amMCI - DTW
1 stop7h 57mMultiple Airlines
Deal found 9/14$168
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:20 pmDTW - MCI
1 stop14h 23mMultiple Airlines
Mon 12/811:51 amMCI - DTW
1 stop19h 09mMultiple Airlines
Deal found 9/13$180
This Trip.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/278:00 amDTW - STL
1 stop26h 06mFrontier
Tue 9/307:55 pmSTL - DTW
1 stop27h 51mFrontier
Deal found 9/13$181
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/87:00 amDTW - STL
1 stop7h 44mAmerican Airlines
Wed 10/156:00 amSTL - DTW
1 stop10h 34mAmerican Airlines
Deal found 9/14$183
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/226:10 amDTW - STL
1 stop27h 56mFrontier
Tue 9/237:55 pmSTL - DTW
1 stop27h 51mFrontier
Deal found 9/12$185
This Frontier deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/31:36 pmDTW - STL
1 stop8h 01mFrontier
Sun 10/510:39 amSTL - DTW
2 stops21h 05mFrontier
Deal found 9/13$189
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:05 pmDTW - MCI
1 stop14h 12mMultiple Airlines
Sun 11/28:28 pmMCI - DTW
1 stop18h 51mMultiple Airlines
Deal found 9/14$189
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/13:18 pmDTW - STL
1 stop7h 35mAmerican Airlines
Sat 10/47:23 amSTL - DTW
1 stop13h 28mAmerican Airlines
Deal found 9/12$191

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Missouri that are best for you.

Fly from

Detroit

Fly to

Missouri

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 10/11

8:18 pm-9:22 am

1 stop14h 04m

Lambert-St Louis

Mon 10/13

7:52 pm-5:50 pm

2 stops20h 58m

$220

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/23

8:25 am-9:05 am

Nonstop1h 40m

Lambert-St Louis

Mon 10/27

8:10 pm-10:40 pm

Nonstop1h 30m

$233

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/15

8:00 am-8:40 am

Nonstop1h 40m

Lambert-St Louis

Sun 10/19

8:10 pm-10:40 pm

Nonstop1h 30m

$233

DetroitKansas City

DTW - MCI

DTWMCI

Detroit Metropolitan Wayne County

Fri 10/10

6:00 am-7:53 pm

1 stop14h 53m

Kansas City

Fri 10/17

8:38 pm-12:59 am

1 stop27h 21m

$238

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 9/30

7:10 am-1:10 pm

2 stops7h 00m

Lambert-St Louis

Tue 9/30

2:25 pm-10:30 pm

2 stops7h 05m

$248

DetroitJoplin

DTW - JLN

DTWJLN

Detroit Metropolitan Wayne County

Sat 9/27

6:05 pm-11:28 pm

1 stop6h 23m

Joplin

Wed 10/1

8:55 am-3:33 pm

1 stop5h 38m

$254

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/8

12:45 pm-1:22 pm

Nonstop1h 37m

Lambert-St Louis

Wed 10/15

6:40 am-9:12 am

Nonstop1h 32m

$255

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 11/3

6:45 pm-7:25 pm

Nonstop1h 40m

Lambert-St Louis

Tue 11/4

6:10 pm-8:40 pm

Nonstop1h 30m

$255

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 11/19

7:00 am-9:40 am

1 stop3h 40m

Lambert-St Louis

Sun 11/23

8:00 am-10:30 am

Nonstop1h 30m

$257

DetroitSpringfield

DTW - SGF

DTWSGF

Detroit Metropolitan Wayne County

Fri 9/26

4:05 pm-8:43 pm

1 stop5h 38m

Springfield-Branson

Mon 9/29

6:12 pm-11:21 pm

1 stop4h 09m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 60 results
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Best time to book a flight from Detroit to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Missouri

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Missouri (average of $311). Flying from Detroit Metropolitan Wayne County Airport to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to MO?

Find hourly flight availability from Detroit to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Detroit Metropolitan Wayne County Airport to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to Missouri

Explore weekly flight availability from Detroit to Missouri. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 15, 2025.

The most flights from DTW to USMO are scheduled on a Monday (16 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (11 on average).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 15, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Detroit Metropolitan Wayne County Airport to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,245 reviews

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,245 reviews
Southwest
8.0
Very good
4,245 reviews

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,956 reviews
Southwest
8.0
Very good
4,245 reviews

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,931 reviews
Southwest
8.0
Very good
4,245 reviews

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,245 reviews

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,016 reviews
Southwest
8.0
Very good
4,245 reviews

Overall

8.0

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Detroit to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to Missouri?

    For a flight from Detroit to Missouri, you will be flying from Detroit Metropolitan Wayne County. Detroit Metropolitan Wayne County (DTW) is just 17.3 mi from the center of the city.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to Missouri?

    Airlines like Southwest, Frontier, and United Airlines fly from Detroit Metropolitan Wayne County Airport to Missouri in about 1h 40m. The time it takes to get you to your destination can typically vary by up to 13h 13m. Airlines will cover a distance of 439 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Detroit Metropolitan Wayne County Airport to Missouri?

    When deciding which route to take from Detroit Metropolitan Wayne County Airport to Missouri consider Detroit Metropolitan Wayne County - Kansas City, Detroit Metropolitan Wayne County - Lambert-St Louis or Detroit Metropolitan Wayne County - Springfield-Branson as they are the most popular.

  • What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to Missouri?

    Before booking your flight to Missouri from Detroit Metropolitan Wayne County Airport, check out the most reliable airlines to get you to your destination on time: SkyWest Airlines (100%), Aeromexico (89%), Spirit Airlines( 88%).

  • What are the cheapest flights from Detroit Metropolitan Wayne County Airport to Missouri?

    Looking for the cheapest flight from Detroit Metropolitan Wayne County Airport to Missouri? While on average our users pay $222, our data indicates the cheapest price to be $42. The most popular route (Detroit Metropolitan Wayne County - Kansas City), is priced around $168.

  • Can I find deals for flights from Detroit to Missouri that include hotel bookings?

    Yes. In addition to deals on Detroit to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Missouri.

  • Can I find deals for business class flights from Detroit to Missouri?

    Yes. Cheapflights offers flight deals from Detroit to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Missouri (average of $311). Flying from Detroit Metropolitan Wayne County Airport to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Detroit to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Detroit to Missouri

Discover the top 5 airlines that operate flights from Detroit to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$36Average$152FlexibilityNo cancel feeOn-time65%
DeltaCheapest$141Average$365FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$148Average$350FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$158Average$493FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$313Average$529FlexibilityNo cancel feeOn-time69%

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