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$55+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — STL
Dec 4 — Dec 111
Thu 12/4
Thu 12/11
1 adult, Economy
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Find flight deals from Detroit to Missouri

Cheapest flights from Detroit to Missouri
Explore the most affordable flight options available from Detroit to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2025.

This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:29 pmDTW - STL
1 stop5h 32mFrontier
Sun 11/237:57 pmSTL - DTW
1 stop14h 46mFrontier
Deal found 11/3$136
This Booking.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:45 amDTW - MCI
1 stop14h 48mFrontier
Fri 11/288:28 pmMCI - DTW
1 stop14h 15mFrontier
Deal found 11/4$153
This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:18 amDTW - STL
1 stop14h 15mFrontier
Thu 12/113:30 pmSTL - DTW
1 stop15h 50mFrontier
Deal found 11/3$159
This Flightnetwork deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:12 pmDTW - STL
1 stop15h 47mFrontier
Sat 12/67:43 pmSTL - DTW
1 stop19h 36mFrontier
Deal found 11/3$164
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:20 pmDTW - STL
1 stop17h 54mMultiple Airlines
Mon 12/810:47 amSTL - DTW
1 stop8h 05mMultiple Airlines
Deal found 11/2$170
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:59 pmDTW - STL
1 stop17h 08mMultiple Airlines
Sat 12/67:43 pmSTL - DTW
1 stop19h 36mMultiple Airlines
Deal found 11/3$173
This Orbitz deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:20 amDTW - MCI
1 stop7h 43mSpirit Airlines
Thu 11/276:00 amMCI - DTW
1 stop13h 06mSpirit Airlines
Deal found 11/2$179
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:20 pmDTW - STL
1 stop17h 54mFrontier
Sat 12/67:43 pmSTL - DTW
2 stops15h 09mFrontier
Deal found 11/3$182
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:59 pmDTW - STL
1 stop17h 08mMultiple Airlines
Mon 12/810:47 amSTL - DTW
1 stop20h 20mMultiple Airlines
Deal found 11/3$183
This Trip.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/175:14 pmDTW - STL
1 stop16h 53mFrontier
Thu 11/204:13 pmSTL - DTW
1 stop24h 02mFrontier
Deal found 11/4$188
This Booking.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:01 amDTW - STL
1 stop6h 28mFrontier
Thu 11/277:57 pmSTL - DTW
1 stop21h 10mFrontier
Deal found 11/3$192
This Mytrip deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:20 pmDTW - STL
1 stop17h 54mFrontier
Sun 12/79:54 amSTL - DTW
1 stop21h 26mFrontier
Deal found 11/2$193

Cheap flight deals from Detroit to Missouri

Keep the following information in mind while searching for Detroit to Missouri flight deals. Data was last updated November 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$124
(Priceline)

One-way from

$55
(Priceline)

Popular in

October

Cheapest in

August

Average price

$353

Good round-trip deal

$291 or less

Good one-way deal

$202 or less
Provider with most accurate pricing for Detroit (DTT)-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Lambert-St Louis flights.
Search Deals
From Detroit Metropolitan Wayne County to Missouri
Search Deals
One-way flight from Detroit Metropolitan Wayne County to Missouri
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($45 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to Missouri.
Search Deals
Price to beat on a one-way flight from Detroit Metropolitan Wayne County to Missouri.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Missouri that are best for you.

Fly from

Detroit

Fly to

Missouri

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 12/5

5:20 pm-10:14 am

1 stop17h 54m

Lambert-St Louis

Mon 12/8

10:47 am-7:52 pm

1 stop8h 05m

$170

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 11/17

5:14 pm-9:07 am

1 stop16h 53m

Lambert-St Louis

Thu 11/20

4:13 pm-5:15 pm

1 stop24h 02m

$188

DetroitSpringfield

DTW - SGF

DTWSGF

Detroit Metropolitan Wayne County

Fri 12/5

6:00 am-10:56 am

1 stop5h 56m

Springfield-Branson

Sun 12/7

11:31 am-5:07 pm

1 stop4h 36m

$249

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 12/6

5:45 am-12:15 pm

2 stops7h 30m

Lambert-St Louis

Sat 12/6

5:27 pm-10:11 pm

1 stop3h 44m

$256

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 1/16

7:15 am-10:52 am

1 stop4h 37m

Lambert-St Louis

Mon 1/19

3:11 pm-8:26 pm

1 stop4h 15m

$258

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Mon 11/17

5:14 pm-9:07 am

1 stop16h 53m

Lambert-St Louis

Fri 11/21

12:01 pm-6:05 am

1 stop17h 04m

$263

DetroitSpringfield

DTW - SGF

DTWSGF

Detroit Metropolitan Wayne County

Fri 11/21

10:20 am-3:17 pm

1 stop5h 57m

Springfield-Branson

Mon 11/24

6:58 pm-12:42 am

1 stop4h 44m

$264

DetroitSpringfield

DTW - SGF

DTWSGF

Detroit Metropolitan Wayne County

Thu 11/20

5:45 am-10:53 am

1 stop6h 08m

Springfield-Branson

Mon 11/24

6:58 pm-12:42 am

1 stop4h 44m

$264

DetroitSpringfield

DTW - SGF

DTWSGF

Detroit Metropolitan Wayne County

Fri 11/21

5:51 pm-10:13 pm

1 stop5h 22m

Springfield-Branson

Sun 11/23

8:00 am-3:27 pm

1 stop6h 27m

$264

DetroitKansas City

DTW - MCI

DTWMCI

Detroit Metropolitan Wayne County

Sun 11/16

7:00 am-10:17 am

1 stop28h 17m

Kansas City

Fri 11/21

11:20 am-8:06 am

1 stop19h 46m

$267

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 58 results
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Best time to book a flight from Detroit to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Missouri

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Missouri (average of $40). Flying from Detroit Metropolitan Wayne County Airport to Missouri in December is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to MO?

Find hourly flight availability from Detroit to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2025.

One of the essential ways to save on airfare from Detroit Metropolitan Wayne County Airport to Missouri is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 18% on airfare.

What is the cheapest day to fly from Detroit Metropolitan Wayne County Airport to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Detroit to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Detroit Metropolitan Wayne County Airport to Missouri flight should consider departing on Friday at noon when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 4, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Detroit Metropolitan Wayne County Airport to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,239 reviews

Boarding

8.1

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,239 reviews
Southwest
8.0
Very good
4,239 reviews

Boarding

8.1

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,003 reviews
Southwest
8.0
Very good
4,239 reviews

Boarding

8.1

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,002 reviews
Southwest
8.0
Very good
4,239 reviews

Boarding

8.1

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,239 reviews

Boarding

8.1

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,113 reviews
Southwest
8.0
Very good
4,239 reviews

Boarding

8.1

Overall

8.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Detroit to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to Missouri?

    For a flight from Detroit to Missouri, you will be flying from Detroit Metropolitan Wayne County. Detroit Metropolitan Wayne County (DTW) is just 17.3 mi from the center of the city.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to Missouri?

    Airlines like Frontier, United Airlines, and Delta fly from Detroit Metropolitan Wayne County Airport to Missouri in about 5h 56m. The time it takes to get you to your destination can typically vary by up to 10h 57m. Airlines will cover a distance of 633 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to Missouri one-way?

    $68 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on United Airlines and Southwest, with prices starting from $89 and $177, respectively.

  • What are the most popular routes from Detroit Metropolitan Wayne County Airport to Missouri?

    When deciding which route to take from Detroit Metropolitan Wayne County Airport to Missouri consider Detroit Metropolitan Wayne County - Lambert-St Louis, Detroit Metropolitan Wayne County - Kansas City or Detroit Metropolitan Wayne County - Springfield-Branson as they are the most popular.

  • What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to Missouri?

    Before booking your flight to Missouri from Detroit Metropolitan Wayne County Airport, check out the most reliable airlines to get you to your destination on time: SkyWest Airlines (100%), Endeavor Airlines (100%), Delta( 95%).

  • What are the cheapest flights from Detroit Metropolitan Wayne County Airport to Missouri?

    Looking for the cheapest flight from Detroit Metropolitan Wayne County Airport to Missouri? While on average our users pay $300, our data indicates the cheapest price to be $127. The most popular route (Detroit Metropolitan Wayne County - Lambert-St Louis), is priced around $173.

  • Can I find deals for flights from Detroit to Missouri that include hotel bookings?

    Yes. In addition to deals on Detroit to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Missouri.

  • Can I find deals for business class flights from Detroit to Missouri?

    Yes. Cheapflights offers flight deals from Detroit to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Missouri (average of $40). Flying from Detroit Metropolitan Wayne County Airport to Missouri in December is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Detroit to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Detroit to Missouri

Discover the top 6 airlines that operate flights from Detroit to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$36Average$150FlexibilityNo cancel feeOn-time65%
FrontierCheapest$111Average$262FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$137Average$358FlexibilityNo cancel feeOn-time63%
DeltaCheapest$137Average$368FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$203Average$491FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$253Average$581FlexibilityNo cancel feeOn-time69%

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