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$28+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — STL
ago. 4 — ago. 111
lun. 8/4
lun. 8/11
1 adult, Economy
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Cheap flight deals from Detroit to Missouri

Keep the following information in mind while searching for Detroit to Missouri flight deals. Data was last updated julio 30, 2025.

Round-trip from

$60
(Priceline)

One-way from

$28
(Booking.com)

Popular in

November

Cheapest in

February

Average price

$269

Good round-trip deal

$111 or less

Good one-way deal

$88 or less
From Detroit Metropolitan Wayne County to Missouri
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One-way flight from Detroit Metropolitan Wayne County to Missouri
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Highest demand for flights based on searches. 13% potential increase in price ($61 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Detroit Metropolitan Wayne County to Missouri.
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Price to beat on a one-way flight from Detroit Metropolitan Wayne County to Missouri.
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Find flight deals from Detroit to Missouri

Cheapest flights from Detroit to Missouri
Explore the most affordable flight options available from Detroit to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

This Priceline deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/181:00 pmDTW - STL
Nonstop1h 32mSpirit Airlines
jue. 8/212:30 pmSTL - DTW
Nonstop1h 30mSpirit Airlines
Deal found 7/28$60
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/288:55 amDTW - STL
Nonstop1h 37mDelta
jue. 8/286:00 pmSTL - DTW
Nonstop1h 30mDelta
Deal found 7/29$119
This Trip.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/281:00 pmDTW - STL
Nonstop1h 32mMultiple Airlines
dom. 8/3110:17 amSTL - DTW
1 stop6h 43mMultiple Airlines
Deal found 7/28$142
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/285:40 amDTW - STL
1 stop6h 50mSouthwest
dom. 8/319:55 amSTL - DTW
Nonstop1h 30mSouthwest
Deal found 7/29$167
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/281:07 pmDTW - STL
1 stop8h 19mAmerican Airlines
mié. 10/297:16 amSTL - DTW
1 stop9h 19mAmerican Airlines
Deal found 7/30$171
This CheapOair deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/152:53 pmDTW - MCI
1 stop9h 14mSpirit Airlines
jue. 9/185:15 amMCI - DTW
1 stop7h 42mSpirit Airlines
Deal found 7/28$176
This CheapOair deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/112:53 pmDTW - MCI
1 stop9h 14mMultiple Airlines
dom. 9/143:01 pmMCI - DTW
1 stop8h 45mMultiple Airlines
Deal found 7/28$202
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/1811:44 amDTW - MCI
1 stop8h 20mFrontier
vie. 8/226:02 pmMCI - DTW
1 stop5h 42mFrontier
Deal found 7/30$218
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/277:10 amDTW - MCI
2 stops7h 15mSouthwest
mié. 9/34:30 pmMCI - DTW
1 stop3h 55mSouthwest
Deal found 7/30$242
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/213:16 pmDTW - SGF
1 stop7h 27mAmerican Airlines
mié. 8/2711:33 amSGF - DTW
1 stop5h 01mAmerican Airlines
Deal found 7/29$248
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/1410:32 amDTW - SGF
1 stop4h 59mUnited Airlines
lun. 8/186:25 pmSGF - DTW
1 stop4h 32mUnited Airlines
Deal found 7/30$259
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/46:05 pmDTW - JLN
1 stop6h 23mUnited Airlines
mar. 10/78:55 amJLN - DTW
1 stop5h 38mUnited Airlines
Deal found 7/29$314

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Missouri that are best for you.

Fly from

Detroit

Fly to

Missouri

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

lun. 8/18

1:00 pm-1:32 pm

Nonstop1h 32m

Lambert-St Louis

jue. 8/21

2:30 pm-5:00 pm

Nonstop1h 30m

$60

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

jue. 8/28

8:55 am-9:32 am

Nonstop1h 37m

Lambert-St Louis

jue. 8/28

6:00 pm-8:30 pm

Nonstop1h 30m

$119

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

jue. 8/28

1:00 pm-1:32 pm

Nonstop1h 32m

Lambert-St Louis

dom. 8/31

10:17 am-6:00 pm

1 stop6h 43m

$142

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

jue. 8/28

5:40 am-11:30 am

1 stop6h 50m

Lambert-St Louis

dom. 8/31

9:55 am-12:25 pm

Nonstop1h 30m

$167

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

mar. 10/28

1:07 pm-8:26 pm

1 stop8h 19m

Lambert-St Louis

mié. 10/29

7:16 am-5:35 pm

1 stop9h 19m

$171

DetroitKansas City

DTW - MCI

DTWMCI

Detroit Metropolitan Wayne County

lun. 9/15

2:53 pm-11:07 pm

1 stop9h 14m

Kansas City

jue. 9/18

5:15 am-1:57 pm

1 stop7h 42m

$176

DetroitKansas City

DTW - MCI

DTWMCI

Detroit Metropolitan Wayne County

jue. 9/11

2:53 pm-11:07 pm

1 stop9h 14m

Kansas City

dom. 9/14

3:01 pm-12:46 am

1 stop8h 45m

$202

DetroitKansas City

DTW - MCI

DTWMCI

Detroit Metropolitan Wayne County

lun. 8/18

11:44 am-7:04 pm

1 stop8h 20m

Kansas City

vie. 8/22

6:02 pm-12:44 am

1 stop5h 42m

$218

DetroitKansas City

DTW - MCI

DTWMCI

Detroit Metropolitan Wayne County

mié. 8/27

7:10 am-1:25 pm

2 stops7h 15m

Kansas City

mié. 9/3

4:30 pm-9:25 pm

1 stop3h 55m

$242

DetroitSpringfield

DTW - SGF

DTWSGF

Detroit Metropolitan Wayne County

jue. 8/21

3:16 pm-9:43 pm

1 stop7h 27m

Springfield-Branson

mié. 8/27

11:33 am-5:34 pm

1 stop5h 01m

$248

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 29 results
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Best time to book a flight from Detroit to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit Metropolitan Wayne County Airport to Missouri

What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Missouri (average of $311). Flying from Detroit Metropolitan Wayne County Airport to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTW to MO?

Find hourly flight availability from Detroit to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 30, 2025.

When flying from Detroit Metropolitan Wayne County Airport to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Detroit Metropolitan Wayne County Airport to Missouri

Explore weekly flight availability from Detroit to Missouri. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated julio 30, 2025.

The most flights from DTW to USMO are scheduled on a Monday (17 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (1 on average).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated julio 30, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Detroit Metropolitan Wayne County Airport to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,896 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Spirit Airlines
6.3
Okay
8,048 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to Missouri?

    For a flight from Detroit to Missouri, you will be flying from Detroit Metropolitan Wayne County. Detroit Metropolitan Wayne County (DTW) is just 17.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Detroit Metropolitan Wayne County Airport to Missouri one-way?

    $28 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $60 and $91, respectively.

  • What are the most popular routes from Detroit Metropolitan Wayne County Airport to Missouri?

    When deciding which route to take from Detroit Metropolitan Wayne County Airport to Missouri consider Detroit Metropolitan Wayne County - Kansas City, Detroit Metropolitan Wayne County - Lambert-St Louis or Detroit Metropolitan Wayne County - Springfield-Branson as they are the most popular.

  • What are the most reliable airlines from Detroit Metropolitan Wayne County Airport to Missouri?

    Before booking your flight to Missouri from Detroit Metropolitan Wayne County Airport, check out the most reliable airlines to get you to your destination on time: Aeromexico (91%), Spirit Airlines (84%), Endeavor Airlines( 83%).

  • What are the cheapest flights from Detroit Metropolitan Wayne County Airport to Missouri?

    Looking for the cheapest flight from Detroit Metropolitan Wayne County Airport to Missouri? While on average our users pay $157, our data indicates the cheapest price to be $38. The most popular route (Detroit Metropolitan Wayne County - Kansas City), is priced around $176.

  • Can I find deals for flights from Detroit to Missouri that include hotel bookings?

    Yes. In addition to deals on Detroit to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Missouri.

  • Can I find deals for business class flights from Detroit to Missouri?

    Yes. Cheapflights offers flight deals from Detroit to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Missouri (average of $311). Flying from Detroit Metropolitan Wayne County Airport to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Detroit to Missouri

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Top 5 airlines flying from Detroit to Missouri

Discover the top 5 airlines that operate flights from Detroit to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$29Average$145FlexibilityNo cancel feeOn-time65%
DeltaCheapest$149Average$420FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$149Average$358FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$158Average$431FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$318Average$555FlexibilityNo cancel feeOn-time69%

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