$169+ Cheap flights from Knoxville to Missoula (TYS - MSO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSO
May 22 — May 291
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Missoula with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to MissoulaExplore the most affordable flight options available from Knoxville to Missoula. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
Explore the most affordable flight options available from Knoxville to Missoula. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:33 pm
TYS
- MSO
1 stop7h 05m
American Airlines
Tue 6/92:12 pm
MSO
- TYS
1 stop7h 44m
American Airlines
Deal found 4/19![American Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:20 pm
TYS
- MSO
2 stops9h 02m
Delta
Thu 6/116:29 pm
MSO
- TYS
2 stops13h 09m
Delta
Deal found 4/22![Delta logo]()
$445
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:33 pm
TYS
- MSO
1 stop7h 05m
American Airlines
Wed 6/102:12 pm
MSO
- TYS
1 stop7h 44m
American Airlines
Deal found 4/20![American Airlines logo]()
$450
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:36 am
TYS
- MSO
1 stop9h 52m
American Airlines
Thu 6/112:12 pm
MSO
- TYS
1 stop7h 44m
American Airlines
Deal found 4/20![American Airlines logo]()
$451
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:10 am
TYS
- MSO
1 stop7h 39m
American Airlines
Thu 6/42:12 pm
MSO
- TYS
1 stop7h 44m
American Airlines
Deal found 4/20![American Airlines logo]()
$475
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:33 pm
TYS
- MSO
1 stop7h 05m
American Airlines
Thu 6/112:12 pm
MSO
- TYS
1 stop7h 44m
American Airlines
Deal found 4/19![American Airlines logo]()
$476
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:45 pm
TYS
- MSO
2 stops42h 49m
Multiple Airlines
Sun 7/1210:24 am
MSO
- TYS
1 stop25h 33m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$496
Best flights from Knoxville to MissoulaDiscover carefully curated flight deals from Knoxville to Missoula that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
Discover carefully curated flight deals from Knoxville to Missoula that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2026.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:30 am
TYS
- MSO
2 stops11h 07m
Delta
Sun 8/165:45 am
MSO
- TYS
2 stops10h 32m
Delta
Deal found 4/21![Delta logo]()
$580
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:33 pm
TYS
- MSO
1 stop7h 07m
American Airlines
Wed 7/82:24 pm
MSO
- TYS
1 stop7h 28m
American Airlines
Deal found 4/20![American Airlines logo]()
$592
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:18 pm
TYS
- MSO
2 stops28h 12m
United Airlines
Tue 6/212:34 pm
MSO
- TYS
1 stop6h 22m
United Airlines
Deal found 4/17![United Airlines logo]()
$595
This Alaska Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:20 pm
TYS
- MSO
2 stops26h 03m
Alaska Airlines
Tue 6/22:03 pm
MSO
- TYS
2 stops21h 07m
Alaska Airlines
Deal found 4/18![Alaska Airlines logo]()
$749
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:40 am
TYS
- MSO
2 stops11h 00m
Delta
Thu 6/116:29 pm
MSO
- TYS
2 stops13h 09m
Delta
Deal found 4/22![Delta logo]()
$591
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/194:09 pm
TYS
- MSO
1 stop7h 36m
American Airlines
Tue 6/22:18 pm
MSO
- TYS
1 stop7h 38m
American Airlines
Deal found 4/17![American Airlines logo]()
$650
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:59 pm
TYS
- MSO
2 stops9h 45m
Delta
Wed 7/85:55 am
MSO
- TYS
2 stops10h 00m
Delta
Deal found 4/20![Delta logo]()
$652
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:37 pm
TYS
- MSO
1 stop7h 07m
Delta
Tue 7/75:55 am
MSO
- TYS
1 stop15h 06m
Delta
Deal found 4/20![Delta logo]()
$743
Last-minute flights from Knoxville to MissoulaDiscover last-minute flight deals from Knoxville to Missoula. Data last updated April 22, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Missoula. Data last updated April 22, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:20 pm
TYS
- MSO
1 stop7h 10m
United Airlines
Sun 5/106:15 am
MSO
- TYS
1 stop6h 52m
United Airlines
Deal found 4/21![United Airlines logo]()
$610
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:18 pm
TYS
- MSO
2 stops28h 12m
United Airlines
Tue 6/212:34 pm
MSO
- TYS
1 stop6h 22m
United Airlines
Deal found 4/17![United Airlines logo]()
$595
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:30 am
TYS
- MSO
1 stop7h 02m
United Airlines
Thu 5/2812:33 pm
MSO
- TYS
1 stop6h 23m
United Airlines
Deal found 4/21![United Airlines logo]()
$643
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:10 am
TYS
- MSO
1 stop7h 39m
American Airlines
Thu 6/42:12 pm
MSO
- TYS
1 stop7h 44m
American Airlines
Deal found 4/20![American Airlines logo]()
$475
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:30 am
TYS
- MSO
1 stop7h 02m
United Airlines
Wed 6/312:33 pm
MSO
- TYS
1 stop6h 23m
United Airlines
Deal found 4/20![United Airlines logo]()
$583
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:10 am
TYS
- MSO
1 stop7h 39m
American Airlines
Wed 6/32:18 pm
MSO
- TYS
1 stop7h 38m
American Airlines
Deal found 4/20![American Airlines logo]()
$620
One-way flights from Knoxville to MissoulaSearch for one-way flight options from Knoxville to Missoula. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
Search for one-way flight options from Knoxville to Missoula. Find affordable one-way fares based on user searches. Data last updated April 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
TYS
- MSO
2 stops29h 23m
Allegiant Air
Deal found 4/22![Allegiant Air logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
TYS
- MSO
3 stops58h 01m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$250
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:33 pm
TYS
- MSO
1 stop7h 05m
American Airlines
Deal found 4/22![American Airlines logo]()
$266
Find flight deals from Knoxville to Missoula
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Missoula (MSO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $394 (American Airlines) |
Popular in | June |
Cheapest in | January |
Average price | $501 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Missoula that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Knoxville to Missoula that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Fri 8/14
5:30 am-2:37 pm
2 stops11h 07m
Missoula Johnson-Bell Field
Sun 8/16
5:45 am-6:17 pm
2 stops10h 32m
$580
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Wed 6/3
5:40 am-2:40 pm
2 stops11h 00m
Missoula Johnson-Bell Field
Thu 6/11
6:29 pm-9:38 am
2 stops13h 09m
$591
Quickest round-trip
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Sat 7/4
5:33 pm-10:40 pm
1 stop7h 07m
Missoula Johnson-Bell Field
Wed 7/8
2:24 pm-11:52 pm
1 stop7h 28m
$592
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Tue 5/19
7:18 pm-9:30 pm
2 stops28h 12m
Missoula Johnson-Bell Field
Tue 6/2
12:34 pm-8:56 pm
1 stop6h 22m
$595
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Tue 5/19
4:09 pm-9:45 pm
1 stop7h 36m
Missoula Johnson-Bell Field
Tue 6/2
2:18 pm-11:56 pm
1 stop7h 38m
$650
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Sat 7/4
3:59 pm-11:44 pm
2 stops9h 45m
Missoula Johnson-Bell Field
Wed 7/8
5:55 am-5:55 pm
2 stops10h 00m
$652
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Mon 6/29
6:37 pm-11:44 pm
1 stop7h 07m
Missoula Johnson-Bell Field
Tue 7/7
5:55 am-11:01 pm
1 stop15h 06m
$743
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Tue 5/19
1:20 pm-1:23 pm
2 stops26h 03m
Missoula Johnson-Bell Field
Tue 6/2
2:03 pm-1:10 pm
2 stops21h 07m
$749
Cheapest one-way
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Sat 5/30
6:00 am-9:23 am
2 stops29h 23m
$169
KnoxvilleMissoula
TYS - MSO
TYSMSO
Knoxville McGhee Tyson
Sat 5/30
6:00 am-2:01 pm
3 stops58h 01m
$250
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Missoula
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Missoula in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Missoula flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Missoula flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Missoula flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Missoula flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Missoula flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Missoula
Have a flexible travel schedule? Discover the best time to fly to Missoula from Knoxville with our price prediction graph.
TYS-MSO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Missoula
Prices
More
What’s the top layover airport for flights from Knoxville to Missoula?
Share of 1-stop round-trip flights from Knoxville to Missoula chosen by Cheapflights users in the past 12 months, using the same layover each way.
Chicago (ORD) – chosen by Cheapflights users on 86% of 1-stop itineraries from Knoxville to Missoula on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to Missoula?
Average round-trip fare for 1-stop flights from Knoxville to Missoula, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Chicago (ORD) is the most affordable 1-stop option, with an average round-trip price of $425.
What’s the fastest layover option from Knoxville to Missoula?
Shortest average travel time for 1-stop one-way flights from Knoxville to Missoula, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 6h 30m.
Which airport typically offers the quickest layover for flights from Knoxville to Missoula?
Average layover duration for 1-stop one-way flights from Knoxville to Missoula, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 1h 50m.
Reviews of airlines servicing Missoula
Get insights into the airlines that provide service to Missoula. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missoula. Reviews last updated April 22, 2026.
Read reviews from past customers who have flown United Airlines and American Airlines from Knoxville to Missoula. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Food
6.6
Crew
8.1
Overall
7.4
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Boarding
7.7
Food
6.6
Crew
8.1
Overall
7.4
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Boarding
7.7
Food
6.6
Crew
8.1
Overall
7.4
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Missoula. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Other flights to Missoula
Explore flights to Missoula departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 22, 2026.
Knoxville and Missoula flights
Browse other Knoxville and Missoula flight options. Last updated on April 22, 2026.
Other flights from Knoxville
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Top 2 airlines flying from Knoxville to Missoula
Discover the top 2 airlines that operate flights from Knoxville to Missoula. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$288 | Average$418 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$356 | Average$538 | FlexibilityNo cancel fee | On-time69% |