$298+ Cheap flights from Columbia, MO (COU) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/23. Fares are subject to change and may not be available on all flights or dates of travel.
COU — PHX
Jun 18 — Jun 251
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to Mesa
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Best
Last-minute
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Cheapest flights from Columbia to MesaExplore the most affordable flight options available from Columbia to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 19, 2026.
Explore the most affordable flight options available from Columbia to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 19, 2026.
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:47 pm
COU
- PHX
1 stop7h 33m
American Airlines
Sun 6/2112:50 am
PHX
- COU
1 stop7h 16m
American Airlines
Deal found 5/17![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:19 pm
COU
- PHX
1 stop7h 54m
American Airlines
Sat 6/63:15 pm
PHX
- COU
1 stop5h 05m
American Airlines
Deal found 5/18![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:25 pm
COU
- PHX
1 stop9h 02m
United Airlines
Sat 6/272:45 pm
PHX
- COU
1 stop6h 48m
United Airlines
Deal found 5/17![United Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:25 am
COU
- PHX
1 stop7h 45m
American Airlines
Sat 6/2010:14 am
PHX
- COU
1 stop9h 10m
American Airlines
Deal found 5/18![American Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:00 am
COU
- PHX
1 stop9h 19m
United Airlines
Fri 8/142:26 pm
PHX
- COU
1 stop6h 09m
United Airlines
Deal found 5/14![United Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:25 pm
COU
- PHX
1 stop8h 50m
United Airlines
Sat 6/272:45 pm
PHX
- COU
1 stop6h 48m
United Airlines
Deal found 5/17![United Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1911:44 am
COU
- PHX
1 stop5h 56m
American Airlines
Sun 6/2112:50 am
PHX
- COU
1 stop7h 16m
American Airlines
Deal found 5/17![American Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:39 pm
COU
- PHX
1 stop5h 54m
American Airlines
Sat 6/2012:50 am
PHX
- COU
1 stop7h 16m
American Airlines
Deal found 5/18![American Airlines logo]()
$426
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1710:48 am
COU
- PHX
1 stop6h 27m
United Airlines
Mon 6/226:54 pm
PHX
- COU
2 stops13h 19m
United Airlines
Deal found 5/17![United Airlines logo]()
$446
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/183:25 pm
COU
- PHX
1 stop9h 02m
United Airlines
Sun 6/2111:50 pm
PHX
- COU
1 stop8h 23m
United Airlines
Deal found 5/17![United Airlines logo]()
$459
Best flights from Columbia to MesaDiscover carefully curated flight deals from Columbia to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 19, 2026.
Discover carefully curated flight deals from Columbia to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 19, 2026.
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:25 pm
COU
- PHX
1 stop9h 02m
United Airlines
Sat 6/272:45 pm
PHX
- COU
1 stop6h 48m
United Airlines
Deal found 5/17![United Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:47 pm
COU
- PHX
1 stop7h 33m
American Airlines
Sat 6/2012:50 am
PHX
- COU
1 stop7h 16m
American Airlines
Deal found 5/16![American Airlines logo]()
$426
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:48 am
COU
- PHX
1 stop6h 27m
United Airlines
Sun 6/2111:50 pm
PHX
- COU
1 stop8h 23m
United Airlines
Deal found 5/17![United Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/183:25 pm
COU
- PHX
1 stop9h 02m
United Airlines
Sun 6/2111:50 pm
PHX
- COU
1 stop8h 23m
United Airlines
Deal found 5/17![United Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/73:25 pm
COU
- PHX
2 stops9h 34m
United Airlines
Fri 8/142:26 pm
PHX
- COU
1 stop6h 09m
United Airlines
Deal found 5/15![United Airlines logo]()
$526
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:48 am
COU
- PHX
2 stops11h 34m
United Airlines
Mon 6/226:54 pm
PHX
- COU
2 stops13h 19m
United Airlines
Deal found 5/17![United Airlines logo]()
$530
Last-minute flights from Columbia to MesaDiscover last-minute flight deals from Columbia to Mesa. Data last updated May 19, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to Mesa. Data last updated May 19, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:25 pm
COU
- PHX
1 stop8h 50m
United Airlines
Sat 6/272:45 pm
PHX
- COU
1 stop6h 48m
United Airlines
Deal found 5/17![United Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:19 pm
COU
- PHX
1 stop7h 54m
American Airlines
Sat 6/63:15 pm
PHX
- COU
1 stop5h 05m
American Airlines
Deal found 5/18![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:25 am
COU
- PHX
1 stop7h 45m
American Airlines
Sat 6/2010:14 am
PHX
- COU
1 stop9h 10m
American Airlines
Deal found 5/18![American Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:25 pm
COU
- PHX
1 stop9h 02m
United Airlines
Sat 6/272:45 pm
PHX
- COU
1 stop6h 48m
United Airlines
Deal found 5/17![United Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:47 pm
COU
- PHX
1 stop7h 33m
American Airlines
Sun 6/2112:50 am
PHX
- COU
1 stop7h 16m
American Airlines
Deal found 5/17![American Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:47 pm
COU
- PHX
1 stop7h 33m
American Airlines
Sun 6/2112:50 am
PHX
- COU
1 stop7h 16m
American Airlines
Deal found 5/17![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1710:48 am
COU
- PHX
1 stop6h 27m
United Airlines
Mon 6/226:54 pm
PHX
- COU
2 stops13h 19m
United Airlines
Deal found 5/17![United Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:39 pm
COU
- PHX
1 stop5h 54m
American Airlines
Sat 6/2012:50 am
PHX
- COU
1 stop7h 16m
American Airlines
Deal found 5/18![American Airlines logo]()
$426
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/183:25 pm
COU
- PHX
1 stop9h 02m
United Airlines
Sun 6/2111:50 pm
PHX
- COU
1 stop8h 23m
United Airlines
Deal found 5/17![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1911:44 am
COU
- PHX
1 stop5h 56m
American Airlines
Sun 6/2112:50 am
PHX
- COU
1 stop7h 16m
American Airlines
Deal found 5/17![American Airlines logo]()
$423
One-way flights from Columbia to MesaSearch for one-way flight options from Columbia to Mesa. Find affordable one-way fares based on user searches. Data last updated May 19, 2026.
Search for one-way flight options from Columbia to Mesa. Find affordable one-way fares based on user searches. Data last updated May 19, 2026.
This American Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:47 pm
COU
- PHX
1 stop7h 33m
American Airlines
Deal found 5/17![American Airlines logo]()
$298
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:00 am
COU
- PHX
2 stops15h 39m
United Airlines
Deal found 5/17![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:19 pm
COU
- PHX
1 stop8h 14m
American Airlines
Deal found 5/14![American Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:00 am
COU
- PHX
2 stops12h 24m
United Airlines
Deal found 5/14![United Airlines logo]()
$379
Find flight deals from Columbia to Mesa
Keep the following information in mind while searching for Columbia to Mesa flight deals. Data was last updated May 19, 2026.
Round-trip from | $308 (American Airlines) |
|---|---|
One-way from | $298 (American Airlines) |
Popular in | October |
Cheapest in | January |
Average price | $429 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 19, 2026.
Use the filters below to find and compare flights from Columbia to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Wed 6/3
3:25 pm-10:27 pm
1 stop9h 02m
Phoenix Sky Harbor Intl
Sat 6/27
2:45 pm-11:33 pm
1 stop6h 48m
$362
Quickest round-trip
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Thu 6/18
6:47 pm-12:20 am
1 stop7h 33m
Phoenix Sky Harbor Intl
Sat 6/20
12:50 am-10:06 am
1 stop7h 16m
$426
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Tue 6/16
10:48 am-3:15 pm
1 stop6h 27m
Phoenix Sky Harbor Intl
Sun 6/21
11:50 pm-10:13 am
1 stop8h 23m
$459
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Thu 6/18
3:25 pm-10:27 pm
1 stop9h 02m
Phoenix Sky Harbor Intl
Sun 6/21
11:50 pm-10:13 am
1 stop8h 23m
$459
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Fri 8/7
3:25 pm-10:59 pm
2 stops9h 34m
Phoenix Sky Harbor Intl
Fri 8/14
2:26 pm-10:35 pm
1 stop6h 09m
$526
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Tue 6/16
10:48 am-8:22 pm
2 stops11h 34m
Phoenix Sky Harbor Intl
Mon 6/22
6:54 pm-10:13 am
2 stops13h 19m
$530
Cheapest one-way
Quickest one-way
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Tue 6/23
6:47 pm-12:20 am
1 stop7h 33m
$298
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Tue 6/23
8:00 am-9:39 pm
2 stops15h 39m
$349
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Wed 6/3
10:25 am-10:41 pm
1 stop14h 16m
$373
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Sat 5/30
5:19 pm-11:33 pm
1 stop8h 14m
$373
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from Columbia to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Columbia with our price prediction graph.
COU-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbia to Mesa
COU-MS9
COU-PHX
How much does it cost to fly round-trip from Columbia, Missouri to Mesa?
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated May 19, 2026.
Get a feel of what it's like to fly with United Airlines and American Airlines from Columbia to Mesa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Comfort
7.3
Overall
7.4
Food
6.6
Crew
8.1
Entertainment
7.1
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Boarding
7.7
Comfort
7.3
Overall
7.4
Food
6.6
Crew
8.1
Entertainment
7.1
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Boarding
7.7
Comfort
7.3
Overall
7.4
Food
6.6
Crew
8.1
Entertainment
7.1
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Related info for your journey
Find useful and relevant information for your journey from Columbia to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Columbia to Mesa
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Complete your trip
Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Columbia to Mesa by cabin class
Find flights from Columbia to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Columbia and Mesa flights
Browse other Columbia and Mesa flight options. Last updated on May 19, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on May 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Columbia to Mesa flights
Consider these flights traveling from Columbia to Mesa.
Top 2 airlines flying from Columbia to Mesa
Discover the top 2 airlines that operate flights from Columbia to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$348 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$409 | Average$628 | FlexibilityNo cancel fee | On-time71% |