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Mesa

$308+ Cheap flights from Columbia, MO (COU) to Mesa, AZ

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
COU — PHX
Apr 19 — Apr 261
Sun 4/19
Sun 4/26
1 adult, Economy
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Cheap flight deals from Columbia to Mesa

Cheapest flights from Columbia to Mesa
Explore the most affordable flight options available from Columbia to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 20, 2026.

This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:21 pm
COU
-
PHX
1 stop6h 25m
American Airlines
Mon 4/1311:59 pm
PHX
-
COU
1 stop7h 47m
American Airlines
Deal found 3/15$308
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/179:02 am
COU
-
PHX
2 stops11h 01m
United Airlines
Tue 4/2112:00 pm
PHX
-
COU
1 stop7h 03m
United Airlines
Deal found 3/18$334
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:25 pm
COU
-
PHX
1 stop7h 45m
American Airlines
Wed 7/151:15 am
PHX
-
COU
1 stop6h 37m
American Airlines
Deal found 3/15$338
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:30 am
COU
-
PHX
2 stops10h 59m
United Airlines
Mon 8/2410:26 am
PHX
-
COU
2 stops9h 23m
United Airlines
Deal found 3/17$339
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:28 pm
COU
-
PHX
1 stop9h 31m
American Airlines
Mon 5/1811:59 pm
PHX
-
COU
1 stop7h 47m
American Airlines
Deal found 3/15$349
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:05 pm
COU
-
PHX
1 stop9h 05m
United Airlines
Fri 7/1711:50 pm
PHX
-
COU
1 stop8h 58m
United Airlines
Deal found 3/18$350
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:23 pm
COU
-
PHX
1 stop8h 57m
United Airlines
Sat 4/189:50 am
PHX
-
COU
2 stops10h 11m
United Airlines
Deal found 3/17$357
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:10 am
COU
-
PHX
1 stop8h 00m
American Airlines
Sat 4/43:30 pm
PHX
-
COU
1 stop5h 06m
American Airlines
Deal found 3/19$403
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:00 am
COU
-
PHX
1 stop8h 58m
United Airlines
Sat 5/27:05 pm
PHX
-
COU
2 stops13h 52m
United Airlines
Deal found 3/15$414
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1511:30 am
COU
-
PHX
1 stop8h 35m
United Airlines
Wed 8/197:07 am
PHX
-
COU
1 stop8h 38m
United Airlines
Deal found 3/18$418

Find flight deals from Columbia to Mesa

Keep the following information in mind while searching for Columbia to Mesa flight deals. Data was last updated March 20, 2026.

Round-trip from

$308
(American Airlines)

Popular in

October

Cheapest in

January

Average price

$499
From Columbia Regional to Mesa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($128 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($33 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 20, 2026.
Use the filters below to find and compare flights from Columbia to Mesa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Fri 4/10

5:21 pm-8:38 pm

1 stop5h 17m

Phoenix Sky Harbor Intl

Mon 4/13

11:59 pm-9:46 am

1 stop7h 47m

$328

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Fri 8/21

3:05 pm-9:58 pm

1 stop8h 53m

Phoenix Sky Harbor Intl

Mon 8/24

11:28 am-9:49 pm

1 stop8h 21m

$328

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Thu 4/30

4:28 pm-11:59 pm

1 stop9h 31m

Phoenix Sky Harbor Intl

Mon 5/4

11:59 pm-9:46 am

1 stop7h 47m

$328

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Tue 4/28

8:00 am-2:58 pm

1 stop8h 58m

Phoenix Sky Harbor Intl

Sat 5/2

7:05 pm-10:57 am

2 stops13h 52m

$414

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Thu 7/9

3:05 pm-10:59 pm

2 stops9h 54m

Phoenix Sky Harbor Intl

Thu 7/16

11:50 pm-10:48 am

1 stop8h 58m

$419

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Sat 8/15

8:00 am-12:26 pm

1 stop6h 26m

Phoenix Sky Harbor Intl

Wed 8/19

6:40 pm-10:55 am

2 stops14h 15m

$424
Cheapest one-way
Quickest one-way

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Sat 4/4

12:27 pm-5:22 pm

1 stop6h 55m

$373

ColumbiaPhoenix

COU - PHX

COUPHX

Columbia Regional

Sat 4/4

11:30 am-8:19 pm

2 stops10h 49m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/19

Sorted by cheapest first

Best time to book a flight from Columbia to Mesa

Have a flexible travel schedule? Discover the best time to fly to Mesa from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to Mesa

What is the cheapest month to book a flight from Columbia, Missouri to Mesa?

Currently, January is the cheapest month in which you can book a flight from Columbia, Missouri to Mesa (average of $248). Flying from Columbia, Missouri to Mesa in October is currently the most expensive (average of $879). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Columbia, Missouri to Mesa?

Reviews of airlines servicing Mesa

Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated March 20, 2026.
Get a feel of what it's like to fly with United Airlines and American Airlines from Columbia to Mesa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,451 reviews

Food

6.6

Entertainment

7.1

Crew

8.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,451 reviews
United Airlines
7.4
Good
9,451 reviews

Food

6.6

Entertainment

7.1

Crew

8.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
American Airlines
7.1
Good
11,480 reviews
United Airlines
7.4
Good
9,451 reviews

Food

6.6

Entertainment

7.1

Crew

8.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Columbia to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to Mesa?

    For a flight from Columbia to Mesa, you will be flying from Columbia Regional. Columbia Regional (COU) is just 11.1 mi from the center of the city. Columbia Regional is the only Columbia airport and it handles 0 outbound flights to Mesa per day. 2 airlines have flights to Mesa from Columbia Regional on a regular basis.

  • How long is the flight from Columbia, Missouri to Mesa?

    For as low as $328, American Airlines can have you in Mesa from Columbia, Missouri in 5h 17m. There are 1161 mi between Columbia, Missouri and Mesa. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Columbia to Mesa that include hotel bookings?

    Yes. In addition to deals on Columbia to Mesa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Mesa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Mesa.

  • Can I find deals for business class flights from Columbia to Mesa?

    Yes. Cheapflights offers flight deals from Columbia to Mesa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbia, Missouri to Mesa?

    Currently, January is the cheapest month in which you can book a flight from Columbia, Missouri to Mesa (average of $248). Flying from Columbia, Missouri to Mesa in October is currently the most expensive (average of $879). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Columbia to Mesa

Discover the top 2 airlines that operate flights from Columbia to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$348FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$420Average$610FlexibilityNo cancel feeOn-time71%

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