$194+ Cheap flights from Columbia, MO (COU) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
COU — PHX
Sep 16 — Sep 231
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to Mesa with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to Mesa
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Cheapest flights from Columbia to MesaExplore the most affordable flight options available from Columbia to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
Explore the most affordable flight options available from Columbia to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/123:31 pm -
1 stop9h 07m
Fri 9/1812:23 am -
1 stop7h 33m
Deal found 8/12![American Airlines logo]()
$318
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:17 am -
2 stops11h 07m
Sat 9/191:34 pm -
1 stop5h 05m
Deal found 8/13![United Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:15 am -
2 stops11h 34m
Sat 10/171:33 pm -
1 stop5h 00m
Deal found 8/15![United Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:15 am -
1 stop9h 23m
Sun 10/1811:52 pm -
1 stop8h 47m
Deal found 8/14![United Airlines logo]()
$361
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2612:43 pm -
1 stop8h 15m
Sat 8/2910:08 am -
1 stop9h 11m
Deal found 8/12![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:15 am -
2 stops8h 13m
Sat 9/128:04 am -
2 stops10h 35m
Deal found 8/15![United Airlines logo]()
$371
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:00 am -
1 stop5h 28m
Sat 8/296:00 am -
2 stops12h 59m
Deal found 8/12![United Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:15 am -
2 stops11h 34m
Sat 10/171:33 pm -
1 stop5h 00m
Deal found 8/15![United Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:11 pm -
1 stop5h 44m
Sat 12/512:20 am -
1 stop8h 28m
Deal found 8/16![American Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2810:55 am -
1 stop6h 25m
Mon 8/3111:32 am -
2 stops9h 23m
Deal found 8/14![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:12 pm -
1 stop8h 25m
Tue 10/611:54 am -
1 stop6h 39m
Deal found 8/13![United Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2812:43 pm -
1 stop6h 16m
Mon 8/3112:20 pm -
1 stop8h 08m
Deal found 8/15![American Airlines logo]()
$413
Best flights from Columbia to MesaDiscover carefully curated flight deals from Columbia to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
Discover carefully curated flight deals from Columbia to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:20 am -
1 stop9h 13m
Sun 9/2711:52 pm -
1 stop8h 47m
Deal found 8/12![United Airlines logo]()
$318
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:15 am -
1 stop9h 23m
Sun 10/1811:52 pm -
1 stop8h 47m
Deal found 8/14![United Airlines logo]()
$361
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:20 am -
1 stop8h 56m
Wed 11/182:50 pm -
1 stop4h 51m
Deal found 8/16![United Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am -
2 stops10h 45m
Wed 9/3011:52 pm -
1 stop8h 47m
Deal found 8/13![United Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:00 am -
3 stops14h 59m
Sat 11/141:53 pm -
1 stop6h 45m
Deal found 8/13![United Airlines logo]()
$419
Last-minute flights from Columbia to MesaDiscover last-minute flight deals from Columbia to Mesa. Data last updated August 17, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to Mesa. Data last updated August 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2612:43 pm -
1 stop8h 15m
Sat 8/2910:08 am -
1 stop9h 11m
Deal found 8/12![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:00 am -
1 stop5h 28m
Sat 8/296:00 am -
2 stops12h 59m
Deal found 8/12![United Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2810:55 am -
1 stop6h 25m
Mon 8/3111:32 am -
2 stops9h 23m
Deal found 8/14![United Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2812:43 pm -
1 stop6h 16m
Mon 8/3112:20 pm -
1 stop8h 08m
Deal found 8/15![American Airlines logo]()
$413
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:15 am -
1 stop6h 53m
Thu 9/1011:32 am -
1 stop7h 07m
Deal found 8/13![United Airlines logo]()
$433
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:00 am -
2 stops8h 59m
Tue 9/811:34 pm -
1 stop8h 22m
Deal found 8/13![American Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/510:55 am -
2 stops11h 29m
Wed 9/99:23 am -
2 stops11h 32m
Deal found 8/13![United Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:15 am -
2 stops8h 13m
Sat 9/128:04 am -
2 stops10h 35m
Deal found 8/15![United Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/123:31 pm -
1 stop9h 07m
Fri 9/1812:23 am -
1 stop7h 33m
Deal found 8/12![American Airlines logo]()
$318
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:17 am -
2 stops11h 07m
Sat 9/191:34 pm -
1 stop5h 05m
Deal found 8/13![United Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:20 am -
1 stop9h 13m
Mon 10/511:52 pm -
1 stop8h 47m
Deal found 8/13![United Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:20 am -
2 stops13h 28m
Sun 10/411:52 pm -
1 stop8h 47m
Deal found 8/13![United Airlines logo]()
$414
One-way flights from Columbia to MesaSearch for one-way flight options from Columbia to Mesa. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
Search for one-way flight options from Columbia to Mesa. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:28 pm -
3 stops32h 15m
Deal found 8/15![Multiple Airlines logo]()
$194
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:59 am -
1 stop5h 16m
Deal found 8/15![American Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:32 pm -
1 stop7h 50m
Deal found 8/14![American Airlines logo]()
$508
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/269:00 am -
2 stops11h 35m
Deal found 8/16![United Airlines logo]()
$650
Find flight deals from Columbia to Mesa
Keep the following information in mind while searching for Columbia to Mesa flight deals. Data was last updated August 17, 2026.
Round-trip from | $318 (American Airlines) |
|---|---|
One-way from | $194 (Kiwi.com) |
Popular in | October |
Cheapest in | January |
Average price | $398 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Columbia to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaPhoenix
COU Columbia Regional - PHX Phoenix Sky Harbor Intl
COUPHX
Columbia Regional
Wed 9/23
11:20 am-6:33 pm
1 stop9h 13m
Phoenix Sky Harbor Intl
Sun 9/27
11:52 pm-10:39 am
1 stop8h 47m
$318
ColumbiaPhoenix
COU Columbia Regional - PHX Phoenix Sky Harbor Intl
COUPHX
Columbia Regional
Wed 10/14
11:15 am-6:38 pm
1 stop9h 23m
Phoenix Sky Harbor Intl
Sun 10/18
11:52 pm-10:39 am
1 stop8h 47m
$361
Quickest round-trip
ColumbiaPhoenix
COU Columbia Regional - PHX Phoenix Sky Harbor Intl
COUPHX
Columbia Regional
Sat 11/14
11:20 am-7:16 pm
1 stop8h 56m
Phoenix Sky Harbor Intl
Wed 11/18
2:50 pm-8:41 pm
1 stop4h 51m
$408
ColumbiaPhoenix
COU Columbia Regional - PHX Phoenix Sky Harbor Intl
COUPHX
Columbia Regional
Sat 9/26
6:15 am-3:00 pm
2 stops10h 45m
Phoenix Sky Harbor Intl
Wed 9/30
11:52 pm-10:39 am
1 stop8h 47m
$414
ColumbiaPhoenix
COU Columbia Regional - PHX Phoenix Sky Harbor Intl
COUPHX
Columbia Regional
Wed 11/11
8:00 am-9:59 pm
3 stops14h 59m
Phoenix Sky Harbor Intl
Sat 11/14
1:53 pm-9:38 pm
1 stop6h 45m
$419
Cheapest one-way
ColumbiaPhoenix
COU Columbia Regional - PHX Phoenix Sky Harbor Intl
COUPHX
Columbia Regional
Fri 9/11
5:28 pm-11:43 pm
3 stops32h 15m
$194
Quickest one-way
ColumbiaPhoenix
COU Columbia Regional - PHX Phoenix Sky Harbor Intl
COUPHX
Columbia Regional
Sat 9/26
11:59 am-3:15 pm
1 stop5h 16m
$508
ColumbiaPhoenix
COU Columbia Regional - PHX Phoenix Sky Harbor Intl
COUPHX
Columbia Regional
Sat 9/26
9:00 am-6:35 pm
2 stops11h 35m
$650
Sorted by cheapest first
Best time to book a flight from Columbia to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Columbia with our price prediction graph.
COU-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbia to Mesa
COU-MS9
COU-PHX
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated August 17, 2026.
Get a feel of what it's like to fly with United Airlines and American Airlines from Columbia to Mesa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.1
Food
6.7
Comfort
7.3
Crew
8.1
Overall
7.4
Boarding
7.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Entertainment
7.1
Food
6.7
Comfort
7.3
Crew
8.1
Overall
7.4
Boarding
7.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Entertainment
7.1
Food
6.7
Comfort
7.3
Crew
8.1
Overall
7.4
Boarding
7.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Columbia to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Columbia to Mesa
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Columbia to Mesa by cabin class
Find flights from Columbia to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Columbia and Mesa flights
Browse other Columbia and Mesa flight options. Last updated on August 17, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on August 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Columbia to Mesa flights
Consider these flights traveling from Columbia to Mesa.
Top 2 airlines flying from Columbia to Mesa
Discover the top 2 airlines that operate flights from Columbia to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$358 | Average$493 | FlexibilityNo cancel fee | On-time71% |