$298+ Cheap flights from Columbia, MO (COU) to Mesa, AZ
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.
COU — PHX
Aug 15 — Aug 221
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Columbia to Mesa with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to Mesa
Cheapest
Best
Last-minute
One-way
Cheapest flights from Columbia to MesaExplore the most affordable flight options available from Columbia to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 16, 2026.
Explore the most affordable flight options available from Columbia to Mesa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 16, 2026.
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:00 am
COU
- PHX
1 stop6h 25m
American Airlines
Sat 9/510:08 am
PHX
- COU
1 stop9h 11m
American Airlines
Deal found 7/13![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:15 am
COU
- PHX
1 stop6h 53m
United Airlines
Sat 9/59:23 am
PHX
- COU
2 stops11h 32m
United Airlines
Deal found 7/13![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:14 pm
COU
- PHX
1 stop5h 37m
American Airlines
Mon 10/1911:33 pm
PHX
- COU
1 stop8h 25m
American Airlines
Deal found 7/13![American Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:26 pm
COU
- PHX
1 stop6h 02m
American Airlines
Sat 8/112:50 am
PHX
- COU
1 stop7h 11m
American Airlines
Deal found 7/16![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:15 am
COU
- PHX
2 stops10h 40m
United Airlines
Mon 9/142:26 pm
PHX
- COU
1 stop6h 29m
United Airlines
Deal found 7/14![United Airlines logo]()
$362
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:19 pm
COU
- PHX
2 stops8h 40m
United Airlines
Sat 10/1011:52 pm
PHX
- COU
1 stop8h 45m
United Airlines
Deal found 7/15![United Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:55 am
COU
- PHX
2 stops8h 15m
United Airlines
Wed 9/2311:32 am
PHX
- COU
2 stops9h 23m
United Airlines
Deal found 7/16![United Airlines logo]()
$365
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/710:49 am
COU
- PHX
1 stop6h 30m
United Airlines
Thu 8/132:19 pm
PHX
- COU
1 stop6h 36m
United Airlines
Deal found 7/14![United Airlines logo]()
$369
Best flights from Columbia to MesaDiscover carefully curated flight deals from Columbia to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 16, 2026.
Discover carefully curated flight deals from Columbia to Mesa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 16, 2026.
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:14 pm
COU
- PHX
1 stop5h 37m
American Airlines
Mon 10/1912:31 am
PHX
- COU
1 stop7h 27m
American Airlines
Deal found 7/13![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:19 pm
COU
- PHX
2 stops8h 40m
United Airlines
Tue 10/2011:54 am
PHX
- COU
2 stops9h 01m
United Airlines
Deal found 7/13![United Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/223:12 pm
COU
- PHX
1 stop8h 17m
United Airlines
Sat 9/2611:52 pm
PHX
- COU
1 stop8h 45m
United Airlines
Deal found 7/16![United Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/711:46 am
COU
- PHX
1 stop5h 01m
American Airlines
Fri 8/1412:09 pm
PHX
- COU
1 stop7h 10m
American Airlines
Deal found 7/12![American Airlines logo]()
$426
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:12 pm
COU
- PHX
2 stops9h 45m
United Airlines
Fri 9/42:19 pm
PHX
- COU
1 stop6h 36m
United Airlines
Deal found 7/14![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:00 am
COU
- PHX
1 stop6h 26m
United Airlines
Thu 8/1310:26 am
PHX
- COU
2 stops10h 29m
United Airlines
Deal found 7/12![United Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/710:49 am
COU
- PHX
1 stop6h 30m
United Airlines
Fri 8/146:41 pm
PHX
- COU
2 stops13h 33m
United Airlines
Deal found 7/14![United Airlines logo]()
$464
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/123:11 pm
COU
- PHX
1 stop9h 10m
United Airlines
Sat 8/159:23 am
PHX
- COU
2 stops11h 32m
United Airlines
Deal found 7/15![United Airlines logo]()
$484
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/911:15 am
COU
- PHX
2 stops11h 34m
United Airlines
Mon 10/1211:52 pm
PHX
- COU
1 stop8h 45m
United Airlines
Deal found 7/15![United Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/911:15 am
COU
- PHX
2 stops11h 34m
United Airlines
Sat 10/1011:52 pm
PHX
- COU
1 stop8h 45m
United Airlines
Deal found 7/15![United Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/153:16 pm
COU
- PHX
2 stops8h 35m
United Airlines
Sun 12/208:00 am
PHX
- COU
1 stop8h 23m
United Airlines
Deal found 7/14![United Airlines logo]()
$489
Last-minute flights from Columbia to MesaDiscover last-minute flight deals from Columbia to Mesa. Data last updated July 16, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to Mesa. Data last updated July 16, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:19 pm
COU
- PHX
1 stop8h 09m
American Airlines
Wed 7/298:30 am
PHX
- COU
1 stop6h 19m
American Airlines
Deal found 7/15![American Airlines logo]()
$403
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:26 pm
COU
- PHX
1 stop6h 02m
American Airlines
Sat 8/112:50 am
PHX
- COU
1 stop7h 11m
American Airlines
Deal found 7/16![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/710:49 am
COU
- PHX
1 stop6h 30m
United Airlines
Thu 8/132:19 pm
PHX
- COU
1 stop6h 36m
United Airlines
Deal found 7/14![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:00 am
COU
- PHX
1 stop5h 28m
United Airlines
Fri 9/42:19 pm
PHX
- COU
1 stop6h 36m
United Airlines
Deal found 7/14![United Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:55 am
COU
- PHX
2 stops8h 15m
United Airlines
Thu 9/38:00 am
PHX
- COU
2 stops10h 59m
United Airlines
Deal found 7/14![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:00 am
COU
- PHX
1 stop6h 25m
American Airlines
Sat 9/510:08 am
PHX
- COU
1 stop9h 11m
American Airlines
Deal found 7/13![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:15 am
COU
- PHX
1 stop6h 53m
United Airlines
Sat 9/59:23 am
PHX
- COU
2 stops11h 32m
United Airlines
Deal found 7/13![United Airlines logo]()
$314
One-way flights from Columbia to MesaSearch for one-way flight options from Columbia to Mesa. Find affordable one-way fares based on user searches. Data last updated July 16, 2026.
Search for one-way flight options from Columbia to Mesa. Find affordable one-way fares based on user searches. Data last updated July 16, 2026.
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:15 am
COU
- PHX
1 stop7h 48m
United Airlines
Deal found 7/16![United Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:45 am
COU
- PHX
1 stop7h 24m
American Airlines
Deal found 7/13![American Airlines logo]()
$503
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:14 am
COU
- PHX
2 stops10h 45m
United Airlines
Deal found 7/13![United Airlines logo]()
$669
Find flight deals from Columbia to Mesa
Keep the following information in mind while searching for Columbia to Mesa flight deals. Data was last updated July 16, 2026.
Round-trip from | $308 (American Airlines) |
|---|---|
One-way from | $298 (United Airlines) |
Popular in | October |
Cheapest in | January |
Average price | $409 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to Mesa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2026.
Use the filters below to find and compare flights from Columbia to Mesa that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Tue 10/6
5:14 pm-8:51 pm
1 stop5h 37m
Phoenix Sky Harbor Intl
Mon 10/19
12:31 am-9:58 am
1 stop7h 27m
$308
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Tue 10/6
3:19 pm-9:59 pm
2 stops8h 40m
Phoenix Sky Harbor Intl
Tue 10/20
11:54 am-10:55 pm
2 stops9h 01m
$367
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Tue 9/22
3:12 pm-9:29 pm
1 stop8h 17m
Phoenix Sky Harbor Intl
Sat 9/26
11:52 pm-10:37 am
1 stop8h 45m
$398
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Sat 8/29
3:12 pm-10:57 pm
2 stops9h 45m
Phoenix Sky Harbor Intl
Fri 9/4
2:19 pm-10:55 pm
1 stop6h 36m
$404
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Fri 8/7
8:00 am-12:26 pm
1 stop6h 26m
Phoenix Sky Harbor Intl
Thu 8/13
10:26 am-10:55 pm
2 stops10h 29m
$422
Quickest round-trip
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Fri 8/7
11:46 am-2:47 pm
1 stop5h 01m
Phoenix Sky Harbor Intl
Fri 8/14
12:09 pm-9:19 pm
1 stop7h 10m
$426
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Fri 8/7
10:49 am-3:19 pm
1 stop6h 30m
Phoenix Sky Harbor Intl
Fri 8/14
6:41 pm-10:14 am
2 stops13h 33m
$464
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Wed 8/12
3:11 pm-10:21 pm
1 stop9h 10m
Phoenix Sky Harbor Intl
Sat 8/15
9:23 am-10:55 pm
2 stops11h 32m
$484
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Fri 10/9
11:15 am-8:49 pm
2 stops11h 34m
Phoenix Sky Harbor Intl
Mon 10/12
11:52 pm-10:37 am
1 stop8h 45m
$489
ColumbiaPhoenix
COU - PHX
COUPHX
Columbia Regional
Fri 10/9
11:15 am-8:49 pm
2 stops11h 34m
Phoenix Sky Harbor Intl
Sat 10/10
11:52 pm-10:37 am
1 stop8h 45m
$489
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Columbia to Mesa
Have a flexible travel schedule? Discover the best time to fly to Mesa from Columbia with our price prediction graph.
COU-PHX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbia to Mesa
COU-MS9
COU-PHX
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mesa
Get insights into the airlines that provide service to Mesa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mesa. Reviews last updated July 16, 2026.
Get a feel of what it's like to fly with United Airlines and American Airlines from Columbia to Mesa by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Boarding
7.7
Crew
8.1
Food
6.6
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
6.0
GoodROHIT,Jun 2026
IND - EWR
Overall
7.4
Boarding
7.7
Crew
8.1
Food
6.6
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
6.0
GoodROHIT,Jun 2026
IND - EWR
Overall
7.4
Boarding
7.7
Crew
8.1
Food
6.6
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
6.0
GoodROHIT,Jun 2026
IND - EWR
Related info for your journey
Find useful and relevant information for your journey from Columbia to Mesa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Columbia
Popular flights
Top destinations
Alternative routes for Columbia to Mesa
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Mesa by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Columbia to Mesa by cabin class
Find flights from Columbia to Mesa, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Columbia and Mesa flights
Browse other Columbia and Mesa flight options. Last updated on July 16, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on July 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Columbia to Mesa flights
Consider these flights traveling from Columbia to Mesa.
Top 2 airlines flying from Columbia to Mesa
Discover the top 2 airlines that operate flights from Columbia to Mesa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$368 | Average$519 | FlexibilityNo cancel fee | On-time71% |