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Mayagüez

$461+ Cheap flights from South Carolina to Mayagüez (MAZ)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — MAZ
Mar 8 — Mar 151
Sun 3/8
Sun 3/15
1 adult, Economy
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Cheap flight deals from South Carolina to Mayagüez

Cheapest flights from South Carolina to Mayagüez
Explore the most affordable flight options available from South Carolina to Mayagüez. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 6, 2026.

This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:49 pm
CLT
-
MAZ
2 stops23h 54m
Multiple Airlines
Sat 2/214:36 pm
MAZ
-
CLT
2 stops18h 41m
Multiple Airlines
Deal found 2/3$461
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/97:35 pm
CAE
-
MAZ
2 stops44h 14m
United Airlines
Thu 8/131:25 pm
MAZ
-
CAE
2 stops20h 45m
United Airlines
Deal found 2/5$1,597
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:38 pm
CAE
-
MAZ
2 stops20h 33m
United Airlines
Sat 5/161:19 pm
MAZ
-
CAE
2 stops10h 40m
United Airlines
Deal found 2/4$1,708
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:33 am
CLT
-
MAZ
2 stops32h 38m
United Airlines
Sun 2/221:19 pm
MAZ
-
CLT
2 stops33h 38m
United Airlines
Deal found 2/5$1,884
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/197:44 pm
CLT
-
MAZ
2 stops19h 27m
United Airlines
Fri 2/271:19 pm
MAZ
-
CLT
2 stops21h 42m
United Airlines
Deal found 2/5$1,944
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/197:44 pm
CLT
-
MAZ
2 stops19h 27m
United Airlines
Wed 2/251:19 pm
MAZ
-
CLT
2 stops25h 52m
United Airlines
Deal found 2/5$1,957
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:44 pm
CLT
-
MAZ
2 stops43h 27m
United Airlines
Sun 2/221:19 pm
MAZ
-
CLT
2 stops33h 38m
United Airlines
Deal found 2/5$2,052
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:00 am
CLT
-
MAZ
2 stops33h 11m
United Airlines
Sun 2/221:19 pm
MAZ
-
CLT
2 stops33h 38m
United Airlines
Deal found 2/5$2,053
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:44 pm
CLT
-
MAZ
2 stops43h 27m
United Airlines
Fri 2/271:19 pm
MAZ
-
CLT
2 stops21h 42m
United Airlines
Deal found 2/5$2,138
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:44 pm
CLT
-
MAZ
2 stops43h 27m
United Airlines
Wed 2/251:19 pm
MAZ
-
CLT
2 stops25h 52m
United Airlines
Deal found 2/5$2,151
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/1610:42 am
CLT
-
MAZ
2 stops28h 29m
United Airlines
Fri 2/271:19 pm
MAZ
-
CLT
2 stops22h 07m
United Airlines
Deal found 2/5$2,166
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:44 pm
CLT
-
MAZ
2 stops43h 27m
United Airlines
Wed 2/251:19 pm
MAZ
-
CLT
2 stops20h 42m
United Airlines
Deal found 2/5$2,195

Find flight deals from South Carolina to Mayagüez

Keep the following information in mind while searching for South Carolina to Mayagüez flight deals. Data was last updated February 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$461
(Mytrip)
Provider with most accurate pricing for Myrtle Beach Intl-Mayagüez Eugenio M De Hostos flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Mayagüez Eugenio M De Hostos flights.
Search Deals
From South Carolina to Mayagüez Eugenio M De Hostos
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Mayagüez that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from South Carolina to Mayagüez that are best for you.

Fly from

South Carolina

Fly to

Mayagüez

Route

Depart

Return

Price

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Wed 2/18

5:49 pm-6:43 pm

2 stops23h 54m

Mayagüez Eugenio M De Hostos

Sat 2/21

4:36 pm-10:17 am

2 stops18h 41m

$461

ColumbiaMayagüez

CAE - MAZ

CAEMAZ

Columbia Metropolitan

Fri 5/1

7:38 pm-4:11 pm

2 stops20h 33m

Mayagüez Eugenio M De Hostos

Sat 5/16

1:19 pm-11:59 pm

2 stops10h 40m

$1,708

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Thu 2/19

7:44 pm-4:11 pm

2 stops19h 27m

Mayagüez Eugenio M De Hostos

Fri 2/27

1:19 pm-10:01 am

2 stops21h 42m

$1,944

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Thu 2/19

7:44 pm-4:11 pm

2 stops19h 27m

Mayagüez Eugenio M De Hostos

Thu 2/26

1:19 pm-10:01 am

2 stops21h 42m

$1,944

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Mon 2/16

6:00 am-4:11 pm

2 stops33h 11m

Mayagüez Eugenio M De Hostos

Sun 2/22

1:19 pm-9:57 pm

2 stops33h 38m

$2,053

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Wed 2/18

7:44 pm-4:11 pm

2 stops43h 27m

Mayagüez Eugenio M De Hostos

Fri 2/27

1:19 pm-10:01 am

2 stops21h 42m

$2,138

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Wed 2/18

7:44 pm-4:11 pm

2 stops43h 27m

Mayagüez Eugenio M De Hostos

Wed 2/25

1:19 pm-2:11 pm

2 stops25h 52m

$2,151

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Mon 2/16

10:42 am-4:11 pm

2 stops28h 29m

Mayagüez Eugenio M De Hostos

Thu 2/26

1:19 pm-10:26 am

2 stops22h 07m

$2,166

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Mon 2/16

10:42 am-4:11 pm

2 stops28h 29m

Mayagüez Eugenio M De Hostos

Fri 2/27

1:19 pm-10:26 am

2 stops22h 07m

$2,166

CharlotteMayagüez

CLT - MAZ

CLTMAZ

Charlotte Douglas

Mon 2/16

6:00 am-4:11 pm

2 stops33h 11m

Mayagüez Eugenio M De Hostos

Wed 2/25

1:19 pm-10:26 am

2 stops22h 07m

$2,166

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Showing 1-10 of 13 results
1
2

Best time to book a flight from South Carolina to Mayagüez

Have a flexible travel schedule? Discover the best time to fly to Mayagüez from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Mayagüez

What is the cheapest month to book a flight from South Carolina to Mayagüez?

Currently, June is the cheapest month in which you can book a flight from South Carolina to Mayagüez (average of $149). Flying from South Carolina to Mayagüez in December is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Mayagüez. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Mayagüez from South Carolina?

    Mayagüez Eugenio M De Hostos (MAZ), located 3.7 mi from the city center, is the airport you fly into when you book flights from South Carolina to Mayagüez.

  • How long is the flight from South Carolina to Mayagüez?

    United Airlines can get you from South Carolina to Mayagüez in just under 20h 33m. Your travel time can differ by up to . South Carolina and Mayagüez are separated by a distance of 1384 mi.

  • What are the most popular routes from South Carolina to Mayagüez?

    When deciding which route to take from South Carolina to Mayagüez consider Columbia Metropolitan - Mayagüez Eugenio M De Hostos, Charlotte Douglas - Mayagüez Eugenio M De Hostos or Myrtle Beach Intl - Mayagüez Eugenio M De Hostos as they are the most popular.

  • Can I find deals for flights from South Carolina to Mayagüez that include hotel bookings?

    Yes. In addition to deals on South Carolina to Mayagüez flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Mayagüez?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Mayagüez.

  • Can I find deals for business class flights from South Carolina to Mayagüez?

    Yes. Cheapflights offers flight deals from South Carolina to Mayagüez by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Mayagüez?

    Currently, June is the cheapest month in which you can book a flight from South Carolina to Mayagüez (average of $149). Flying from South Carolina to Mayagüez in December is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mayagüez?

Book flights to Mayagüez if you plan to visit one of these locations
Cabo Rojo
Boqueron
Rincon

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Mayagüez

See prices for flight routes from nearby airports that may be better suited for you.
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