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Lyon

$551+ Cheap flights from Knoxville (TYS) to Lyon (LYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — LYS
Mar 11 — Mar 181
Wed 3/11
Wed 3/18
1 adult, Economy
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Cheap flight deals from Knoxville to Lyon

Cheapest flights from Knoxville to Lyon
Explore the most affordable flight options available from Knoxville to Lyon. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 9, 2026.

This United Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:00 am
TYS
-
LYS
2 stops22h 40m
United Airlines
Wed 4/222:35 pm
LYS
-
TYS
2 stops26h 15m
United Airlines
Deal found 2/6$551
This United Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:40 am
TYS
-
LYS
2 stops20h 30m
United Airlines
Sun 3/152:55 pm
LYS
-
TYS
2 stops54h 50m
United Airlines
Deal found 2/6$577
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:21 pm
TYS
-
LYS
2 stops14h 49m
United Airlines
Sun 3/11:40 pm
LYS
-
TYS
2 stops36h 57m
United Airlines
Deal found 2/7$732
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:38 pm
TYS
-
LYS
2 stops20h 57m
Delta
Sun 3/16:40 am
LYS
-
TYS
2 stops23h 12m
Delta
Deal found 2/8$753
This Air Canada deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2510:53 am
TYS
-
LYS
2 stops18h 12m
Multiple Airlines
Sun 3/11:40 pm
LYS
-
TYS
3 stops31h 35m
Multiple Airlines
Deal found 2/8$1,101
This Air Canada deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2510:53 am
TYS
-
LYS
3 stops18h 12m
Air Canada
Sun 3/11:40 pm
LYS
-
TYS
3 stops31h 35m
Air Canada
Deal found 2/8$1,109
This Air Canada deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/129:40 am
TYS
-
LYS
3 stops20h 00m
Air Canada
Wed 4/226:25 am
LYS
-
TYS
3 stops19h 17m
Air Canada
Deal found 2/6$1,647
This Air Canada deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:25 pm
TYS
-
LYS
2 stops33h 40m
Multiple Airlines
Sun 3/1512:55 pm
LYS
-
TYS
3 stops26h 54m
Multiple Airlines
Deal found 2/6$2,058
This BusinessClass deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/125:06 pm
TYS
-
LYS
2 stops40h 59m
Aer Lingus
Wed 4/224:45 pm
LYS
-
TYS
2 stops34h 50m
Aer Lingus
Deal found 2/6$3,505

Find flight deals from Knoxville to Lyon

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Lyon (LYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$551
(United Airlines)
Provider with most accurate pricing for Knoxville McGhee Tyson-Lyon-Saint Exupéry flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lyon-Saint Exupéry flights.
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From Knoxville McGhee Tyson to Lyon-Saint Exupéry
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Lyon that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Knoxville to Lyon that are best for you.

Fly from

Knoxville

Fly to

Lyon

Route

Depart

Return

Price

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Sun 4/12

7:00 am-11:40 am

2 stops22h 40m

Lyon-Saint Exupéry

Wed 4/22

2:35 pm-10:50 am

2 stops26h 15m

$551

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Sun 3/8

9:40 am-11:10 am

2 stops20h 30m

Lyon-Saint Exupéry

Sun 3/15

2:55 pm-4:45 pm

2 stops54h 50m

$577

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/25

2:21 pm-11:10 am

2 stops14h 49m

Lyon-Saint Exupéry

Sun 3/1

1:40 pm-8:37 pm

2 stops36h 57m

$732

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/25

2:38 pm-5:35 pm

2 stops20h 57m

Lyon-Saint Exupéry

Sun 3/1

6:40 am-11:52 pm

2 stops23h 12m

$753

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/25

10:53 am-11:05 am

2 stops18h 12m

Lyon-Saint Exupéry

Sun 3/1

1:40 pm-3:15 pm

3 stops31h 35m

$1,101

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/25

10:53 am-11:05 am

3 stops18h 12m

Lyon-Saint Exupéry

Sun 3/1

1:40 pm-3:15 pm

3 stops31h 35m

$1,109

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Sun 4/12

9:40 am-11:40 am

3 stops20h 00m

Lyon-Saint Exupéry

Wed 4/22

6:25 am-7:42 pm

3 stops19h 17m

$1,647

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Sun 3/8

7:25 pm-10:05 am

2 stops33h 40m

Lyon-Saint Exupéry

Sun 3/15

12:55 pm-10:49 am

3 stops26h 54m

$2,058

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Sun 4/12

5:06 pm-4:05 pm

2 stops40h 59m

Lyon-Saint Exupéry

Wed 4/22

4:45 pm-9:35 pm

2 stops34h 50m

$3,505

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/6

  • Most accurate provider: When it comes to deals on Knoxville-Lyon flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Lyon flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Lyon flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Lyon flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Lyon flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Lyon

Have a flexible travel schedule? Discover the best time to fly to Lyon from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Lyon. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Lyon?

    For as low as $753, United Airlines can have you in Lyon from Knoxville in 20h 57m. There are 4465 mi between Knoxville and Lyon. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Lyon that include hotel bookings?

    Yes. In addition to deals on Knoxville to Lyon flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Lyon?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Lyon.

  • Can I find deals for business class flights from Knoxville to Lyon?

    Yes. Cheapflights offers flight deals from Knoxville to Lyon by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Lyon?

Book flights to Lyon if you plan to visit one of these locations
Annemasse
Huez

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