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$464+ Cheap flights from Knoxville (TYS) to Lyon (LYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — LYS
Mar 16 — Mar 231
Mon 3/16
Mon 3/23
1 adult, Economy
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Cheap flight deals from Knoxville to Lyon

Cheapest flights from Knoxville to Lyon
Explore the most affordable flight options available from Knoxville to Lyon. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.

This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/251:50 pm
TYS
-
LYS
2 stops15h 20m
United Airlines
Sun 3/16:10 am
LYS
-
TYS
2 stops20h 27m
United Airlines
Deal found 2/10$756

Find flight deals from Knoxville to Lyon

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Lyon (LYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$750
(Delta)

One-way from

$464
(Kiwi.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Lyon-Saint Exupéry flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lyon-Saint Exupéry flights.
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From Knoxville McGhee Tyson to Lyon-Saint Exupéry
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One-way flight from Knoxville McGhee Tyson to Lyon-Saint Exupéry
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Lyon that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Knoxville to Lyon that are best for you.

Fly from

Knoxville

Fly to

Lyon

Route

Depart

Return

Price

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/25

1:50 pm-11:10 am

2 stops15h 20m

Lyon-Saint Exupéry

Sun 3/1

6:10 am-8:37 pm

2 stops20h 27m

$756

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Fri 3/6

2:06 pm-8:55 am

2 stops36h 49m

$464

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

  • Most accurate provider: When it comes to deals on Knoxville-Lyon flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Lyon flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Lyon flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Lyon flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Lyon flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Lyon

Have a flexible travel schedule? Discover the best time to fly to Lyon from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Lyon. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Lyon?

    For as low as $756, United Airlines can have you in Lyon from Knoxville in 15h 20m. There are 4465 mi between Knoxville and Lyon.

  • Can I find deals for flights from Knoxville to Lyon that include hotel bookings?

    Yes. In addition to deals on Knoxville to Lyon flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Lyon?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Lyon.

  • Can I find deals for business class flights from Knoxville to Lyon?

    Yes. Cheapflights offers flight deals from Knoxville to Lyon by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Lyon?

Book flights to Lyon if you plan to visit one of these locations
Annemasse
Huez

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