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Lyon

$530+ Cheap flights from Knoxville (TYS) to Lyon (LYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — LYS
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
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Cheap flight deals from Knoxville to Lyon

Cheapest flights from Knoxville to Lyon
Explore the most affordable flight options available from Knoxville to Lyon. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:55 pm
TYS
-
LYS
2 stops37h 30m
United Airlines
Sun 3/11:40 pm
LYS
-
TYS
2 stops36h 57m
United Airlines
Deal found 1/19$530
This Cheapflightsfares deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/182:21 pm
TYS
-
LYS
2 stops17h 49m
Lufthansa
Wed 2/256:25 am
LYS
-
TYS
2 stops20h 12m
Lufthansa
Deal found 1/20$540
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/169:40 am
TYS
-
LYS
2 stops19h 30m
United Airlines
Mon 2/236:25 am
LYS
-
TYS
2 stops38h 50m
United Airlines
Deal found 1/19$554
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/19:40 am
TYS
-
LYS
2 stops20h 45m
United Airlines
Sat 3/71:05 pm
LYS
-
TYS
2 stops59h 50m
United Airlines
Deal found 1/19$565
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/45:36 pm
TYS
-
LYS
2 stops18h 29m
American Airlines
Sun 2/86:10 am
LYS
-
TYS
2 stops21h 59m
American Airlines
Deal found 1/19$605
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/182:21 pm
TYS
-
LYS
2 stops13h 44m
United Airlines
Wed 2/257:00 am
LYS
-
TYS
3 stops18h 29m
United Airlines
Deal found 1/20$669
This Booking.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1210:16 am
TYS
-
LYS
2 stops43h 24m
Air Canada
Sun 6/281:55 pm
LYS
-
TYS
2 stops50h 05m
Air Canada
Deal found 1/19$1,135
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:35 pm
TYS
-
LYS
2 stops34h 05m
United Airlines
Sun 6/281:55 pm
LYS
-
TYS
2 stops50h 05m
United Airlines
Deal found 1/19$1,313
This Air Canada deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/49:30 am
TYS
-
LYS
3 stops19h 35m
Multiple Airlines
Sun 2/81:40 pm
LYS
-
TYS
2 stops31h 09m
Multiple Airlines
Deal found 1/19$1,671
This Air Canada deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/49:30 am
TYS
-
LYS
3 stops19h 35m
Air Canada
Sun 2/81:40 pm
LYS
-
TYS
3 stops27h 17m
Air Canada
Deal found 1/19$1,679
This Air Canada deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:25 pm
TYS
-
LYS
2 stops33h 40m
Multiple Airlines
Sat 3/71:40 pm
LYS
-
TYS
3 stops30h 10m
Multiple Airlines
Deal found 1/19$2,049

Find flight deals from Knoxville to Lyon

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Lyon (LYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$530
(United Airlines)
Provider with most accurate pricing for Knoxville McGhee Tyson-Lyon-Saint Exupéry flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Lyon-Saint Exupéry flights.
Search Deals
From Knoxville McGhee Tyson to Lyon-Saint Exupéry
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Lyon that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from Knoxville to Lyon that are best for you.

Fly from

Knoxville

Fly to

Lyon

Route

Depart

Return

Price

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/25

7:25 pm-12:25 pm

2 stops35h 00m

Lyon-Saint Exupéry

Sun 3/1

1:40 pm-8:37 pm

2 stops36h 57m

$530

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/18

2:21 pm-2:10 pm

2 stops17h 49m

Lyon-Saint Exupéry

Wed 2/25

6:25 am-8:37 pm

2 stops20h 12m

$540

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Mon 2/16

9:40 am-11:10 am

2 stops19h 30m

Lyon-Saint Exupéry

Mon 2/23

6:25 am-3:15 pm

2 stops38h 50m

$554

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Sun 3/1

9:40 am-12:25 pm

2 stops20h 45m

Lyon-Saint Exupéry

Sat 3/7

1:05 pm-6:55 pm

2 stops59h 50m

$565

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/4

5:36 pm-6:05 pm

2 stops18h 29m

Lyon-Saint Exupéry

Sun 2/8

6:10 am-10:09 pm

2 stops21h 59m

$605

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/18

2:21 pm-10:05 am

2 stops13h 44m

Lyon-Saint Exupéry

Wed 2/25

7:00 am-7:29 pm

3 stops18h 29m

$669

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Fri 6/12

10:16 am-11:40 am

2 stops43h 24m

Lyon-Saint Exupéry

Sun 6/28

1:55 pm-10:00 am

2 stops50h 05m

$1,135

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Fri 6/12

7:35 pm-11:40 am

2 stops34h 05m

Lyon-Saint Exupéry

Sun 6/28

1:55 pm-10:00 am

2 stops50h 05m

$1,313

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/4

9:30 am-11:05 am

3 stops19h 35m

Lyon-Saint Exupéry

Sun 2/8

1:40 pm-2:49 pm

2 stops31h 09m

$1,671

KnoxvilleLyon

TYS - LYS

TYSLYS

Knoxville McGhee Tyson

Wed 2/4

9:30 am-11:05 am

3 stops19h 35m

Lyon-Saint Exupéry

Sun 2/8

1:40 pm-10:57 am

3 stops27h 17m

$1,679

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/18

  • Most accurate provider: When it comes to deals on Knoxville-Lyon flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Lyon flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Lyon flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Lyon flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Lyon flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Lyon

Have a flexible travel schedule? Discover the best time to fly to Lyon from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Lyon. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Lyon?

    For as low as $540, United Airlines can have you in Lyon from Knoxville in 17h 49m. There are 4465 mi between Knoxville and Lyon. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Lyon that include hotel bookings?

    Yes. In addition to deals on Knoxville to Lyon flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Lyon?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Lyon.

  • Can I find deals for business class flights from Knoxville to Lyon?

    Yes. Cheapflights offers flight deals from Knoxville to Lyon by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Lyon?

Book flights to Lyon if you plan to visit one of these locations
Annemasse
Huez

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