HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Louisville

$60+ Cheap flights from Myrtle Beach to Louisville (MYR - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/12. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDF
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to Louisville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$166
(Mytrip)

One-way from

$60
(FlightHub)

Popular in

March

Cheapest in

May

Average price

$236
From Myrtle Beach Intl to Louisville Intl
Search Deals
One-way flight from Myrtle Beach Intl to Louisville Intl
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($101 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Myrtle Beach to Louisville

Cheapest flights from Myrtle Beach to Louisville
Explore the most affordable flight options available from Myrtle Beach to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/91:15 pmMYR - SDF
Nonstop1h 35mMultiple Airlines
Mon 8/1112:16 pmSDF - MYR
1 stop8h 48mMultiple Airlines
Deal found 7/27$166
This FlightHub deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:30 pmMYR - SDF
1 stop27h 15mSpirit Airlines
Sat 11/156:00 amSDF - MYR
1 stop6h 24mSpirit Airlines
Deal found 7/28$176
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2610:17 amMYR - SDF
2 stops8h 42mAmerican Airlines
Tue 9/22:58 pmSDF - MYR
1 stop3h 30mAmerican Airlines
Deal found 7/29$202
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2811:31 amMYR - SDF
1 stop6h 45mDelta
Sun 8/316:00 amSDF - MYR
1 stop4h 11mDelta
Deal found 7/29$228
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1412:40 pmMYR - SDF
2 stops10h 10mSouthwest
Sun 8/177:00 amSDF - MYR
2 stops8h 55mSouthwest
Deal found 7/27$395
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1410:53 amMYR - SDF
2 stops8h 48mUnited Airlines
Mon 8/188:40 amSDF - MYR
1 stop5h 55mUnited Airlines
Deal found 7/27$498

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

Fly from

Myrtle Beach

Fly to

Louisville

Route

Depart

Return

Price

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Sat 8/9

1:15 pm-2:50 pm

Nonstop1h 35m

Louisville Intl

Mon 8/11

12:16 pm-9:04 pm

1 stop8h 48m

$166

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 11/13

8:30 pm-11:45 pm

1 stop27h 15m

Louisville Intl

Sat 11/15

6:00 am-12:24 pm

1 stop6h 24m

$176

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 8/26

10:17 am-6:59 pm

2 stops8h 42m

Louisville Intl

Tue 9/2

2:58 pm-6:28 pm

1 stop3h 30m

$202

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 8/28

11:31 am-6:16 pm

1 stop6h 45m

Louisville Intl

Sun 8/31

6:00 am-10:11 am

1 stop4h 11m

$228

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 8/14

12:40 pm-10:50 pm

2 stops10h 10m

Louisville Intl

Sun 8/17

7:00 am-3:55 pm

2 stops8h 55m

$395

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 8/14

10:53 am-7:41 pm

2 stops8h 48m

Louisville Intl

Mon 8/18

8:40 am-2:35 pm

1 stop5h 55m

$498

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 8/12

7:20 am-7:08 pm

1 stop11h 48m

$60

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 8/20

2:20 pm-6:40 pm

1 stop4h 20m

$99

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 8/26

10:17 am-5:43 pm

2 stops7h 26m

$104

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 8/21

12:52 pm-9:34 am

2 stops20h 42m

$131

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 13 results
1
2

Best time to book a flight from Myrtle Beach to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Louisville

What is the cheapest month to book a flight from Myrtle Beach to Louisville?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Louisville (average of $299). Flying from Myrtle Beach to Louisville in April is currently the most expensive (average of $369). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SDF?

Find hourly flight availability from Myrtle Beach to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

One of the essential ways to save on airfare from Myrtle Beach to Louisville is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 57% on airfare.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated July 29, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Myrtle Beach to Louisville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,977 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,899 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Allegiant Air
7.2
Good
703 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Myrtle Beach to Louisville round-trip?

    Our cheapest airline available from Myrtle Beach to Louisville is Spirit Airlines. Our recent data shows that you can find tickets from as low as $176 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $202 and $228 round-trip. These flights start at 46% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Louisville one-way?

    One-way options have recently been found by users for as low as $60 on Spirit Airlines. Other airlines that offer cheap prices include Delta from $99 and American Airlines from $104 one-way.

  • Can I find deals for flights from Myrtle Beach to Louisville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Louisville.

  • Can I find deals for business class flights from Myrtle Beach to Louisville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Louisville?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Louisville (average of $299). Flying from Myrtle Beach to Louisville in April is currently the most expensive (average of $369). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Louisville

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Nashville flights
Savannah to Nashville flights
Charleston to Nashville flights
Charlotte to Cincinnati flights
Greenville to Nashville flights
Charlotte to Louisville flights
Myrtle Beach to Nashville flights
Columbia to Nashville flights
Charlotte to Lexington flights
Charleston to Louisville flights
Charlotte to Knoxville flights
Charleston to Lexington flights
Columbia to Lexington flights
Columbia to Cincinnati flights
Columbia to Louisville flights
Greenville to Cincinnati flights
Charleston to Knoxville flights
Savannah to Knoxville flights
Augusta to Nashville flights
Charleston to Cincinnati flights
Myrtle Beach to Cincinnati flights
Savannah to Louisville flights
Greenville to Louisville flights
Savannah to Cincinnati flights
Augusta to Cincinnati flights
Greenville to Lexington flights
Myrtle Beach to Knoxville flights
Myrtle Beach to Lexington flights
Charlotte to Evansville flights
Savannah to Lexington flights
Greenville to Evansville flights
Augusta to Lexington flights
Florence to Nashville flights
Hilton Head Island to Louisville flights
Hilton Head Island to Cincinnati flights
Florence to Cincinnati flights
Hilton Head Island to Nashville flights
Columbia to Evansville flights
Hilton Head Island to Knoxville flights
Charleston to Evansville flights
Florence to Lexington flights

Top 3 airlines flying from Myrtle Beach to Louisville

Discover the top 3 airlines that operate flights from Myrtle Beach to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$31Average$133FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$226Average$356FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$478FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.