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$184+ Cheap flights from Myrtle Beach to Louisville (MYR - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/3. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDF
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Louisville

Cheapest flights from Myrtle Beach to Louisville
Explore the most affordable flight options available from Myrtle Beach to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:51 pm
MYR
-
SDF
1 stop18h 47m
Multiple Airlines
Mon 5/47:48 pm
SDF
-
MYR
1 stop13h 54m
Multiple Airlines
Deal found 1/25$229
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/165:18 pm
MYR
-
SDF
1 stop6h 55m
American Airlines
Thu 2/196:00 am
SDF
-
MYR
1 stop3h 57m
American Airlines
Deal found 1/26$279
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:50 pm
MYR
-
SDF
2 stops30h 08m
Multiple Airlines
Mon 5/47:48 pm
SDF
-
MYR
1 stop13h 54m
Multiple Airlines
Deal found 1/25$314
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/1512:05 pm
MYR
-
SDF
1 stop23h 03m
Spirit Airlines
Thu 3/193:33 pm
SDF
-
MYR
1 stop26h 06m
Spirit Airlines
Deal found 1/26$320
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/610:31 am
MYR
-
SDF
1 stop4h 03m
Delta
Sun 3/86:00 am
SDF
-
MYR
1 stop3h 33m
Delta
Deal found 1/25$327
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2210:00 am
MYR
-
SDF
1 stop10h 20m
Multiple Airlines
Mon 5/2512:33 pm
SDF
-
MYR
1 stop23h 15m
Multiple Airlines
Deal found 1/26$328
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/63:17 pm
MYR
-
SDF
2 stops7h 59m
American Airlines
Sun 3/86:33 am
SDF
-
MYR
1 stop5h 13m
American Airlines
Deal found 1/25$332
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/63:35 pm
MYR
-
SDF
2 stops9h 05m
Southwest
Sun 3/85:10 am
SDF
-
MYR
2 stops8h 50m
Southwest
Deal found 1/25$357

Find flight deals from Myrtle Beach to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$229
(Kiwi.com)

One-way from

$184
(Delta)

Popular in

March

Cheapest in

May

Average price

$291
Provider with most accurate pricing for Myrtle Beach Intl-Louisville Intl flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Louisville Intl flights.
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From Myrtle Beach Intl to Louisville Intl
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One-way flight from Myrtle Beach Intl to Louisville Intl
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Highest demand for flights based on searches. 20% potential increase in price ($86 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

Fly from

Myrtle Beach

Fly to

Louisville

Route

Depart

Return

Price

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 4/29

7:51 pm-2:38 pm

1 stop18h 47m

Louisville Intl

Mon 5/4

7:48 pm-9:42 am

1 stop13h 54m

$229

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 4/30

3:45 pm-9:45 pm

1 stop6h 00m

Louisville Intl

Mon 5/4

4:45 pm-8:50 pm

1 stop4h 05m

$279

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Mon 2/16

5:18 pm-12:13 am

1 stop6h 55m

Louisville Intl

Thu 2/19

6:00 am-9:57 am

1 stop3h 57m

$279

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 4/30

12:50 pm-6:58 pm

2 stops30h 08m

Louisville Intl

Mon 5/4

7:48 pm-9:42 am

1 stop13h 54m

$314

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Fri 3/6

10:31 am-2:34 pm

1 stop4h 03m

Louisville Intl

Sun 3/8

6:00 am-9:33 am

1 stop3h 33m

$327

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Sat 5/30

4:30 pm-8:52 pm

1 stop4h 22m

Louisville Intl

Thu 6/4

11:00 am-2:57 pm

1 stop3h 57m

$327

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Fri 3/6

3:17 pm-11:16 pm

2 stops7h 59m

Louisville Intl

Sun 3/8

6:33 am-11:46 am

1 stop5h 13m

$332

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Sun 3/15

6:37 pm-11:08 am

2 stops16h 31m

Louisville Intl

Thu 3/19

3:33 pm-5:39 pm

1 stop26h 06m

$334

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Fri 3/6

3:35 pm-12:40 am

2 stops9h 05m

Louisville Intl

Sun 3/8

5:10 am-2:00 pm

2 stops8h 50m

$357

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Fri 5/22

10:00 am-8:20 pm

1 stop10h 20m

Louisville Intl

Mon 5/25

12:33 pm-9:42 am

2 stops21h 09m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 13 results
1
2

Compare providers for flights from Myrtle Beach to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Louisville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Louisville

What is the cheapest month to book a flight from Myrtle Beach to Louisville?

Currently, May is the cheapest month in which you can book a flight from Myrtle Beach to Louisville (average of $31). Flying from Myrtle Beach to Louisville in January is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated January 27, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Myrtle Beach to Louisville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,118 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,118 reviews
Delta
7.9
Good
8,118 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,197 reviews
Delta
7.9
Good
8,118 reviews

Comfort

7.9

Boarding

8.1

Food

7.2

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Louisville?

    For as low as $279, American Airlines can have you in Louisville from Myrtle Beach in 6h 55m. Airlines will cover a distance of 491 mi.

  • What are the cheapest airlines flying from Myrtle Beach to Louisville round-trip?

    Our cheapest airline available from Myrtle Beach to Louisville is Delta. Our recent data shows that you can find tickets from as low as $127 on this airline. An additional option worth looking into is American Airlines, starting at $256. These flights start at 61% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Louisville one-way?

    One-way options have recently been found by users for as low as $42 on Spirit Airlines. Other airlines that offer cheap prices include Delta from $88 and American Airlines from $108 one-way.

  • Can I find deals for flights from Myrtle Beach to Louisville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Louisville.

  • Can I find deals for business class flights from Myrtle Beach to Louisville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Louisville?

    Currently, May is the cheapest month in which you can book a flight from Myrtle Beach to Louisville (average of $31). Flying from Myrtle Beach to Louisville in January is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Top 2 airlines flying from Myrtle Beach to Louisville

Discover the top 2 airlines that operate flights from Myrtle Beach to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$127Average$321FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$256Average$368FlexibilityNo cancel feeOn-time71%

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