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$62+ Cheap flights from Myrtle Beach to Louisville (MYR - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDF
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$169
(Booking.com)

One-way from

$62
(Cheapflightsfares)

Popular in

March

Cheapest in

May

Average price

$321
From Myrtle Beach Intl to Louisville Intl
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One-way flight from Myrtle Beach Intl to Louisville Intl
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Highest demand for flights based on searches. 21% potential increase in price ($90 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($33 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Myrtle Beach to Louisville

Cheapest flights from Myrtle Beach to Louisville
Explore the most affordable flight options available from Myrtle Beach to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/87:00 amMYR - SDF
1 stop10h 55mSpirit Airlines
Sat 10/117:15 amSDF - MYR
1 stop10h 34mSpirit Airlines
Deal found 9/11$146
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:07 pmMYR - SDF
1 stop4h 15mAmerican Airlines
Sat 11/156:24 amSDF - MYR
1 stop4h 09mAmerican Airlines
Deal found 9/11$204
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/217:35 pmMYR - SDF
1 stop3h 49mAmerican Airlines
Thu 10/233:46 pmSDF - MYR
1 stop3h 44mAmerican Airlines
Deal found 9/9$212
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/71:20 pmMYR - SDF
1 stop4h 45mSouthwest
Fri 10/101:20 pmSDF - MYR
1 stop9h 00mSouthwest
Deal found 9/11$281
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/78:14 amMYR - SDF
2 stops32h 22mSpirit Airlines
Fri 10/1011:47 amSDF - MYR
1 stop8h 17mSpirit Airlines
Deal found 9/10$285
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/257:36 pmMYR - SDF
1 stop26h 28mSpirit Airlines
Mon 9/298:23 amSDF - MYR
1 stop11h 43mSpirit Airlines
Deal found 9/10$288
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:00 amMYR - SDF
2 stops26h 57mMultiple Airlines
Mon 9/298:23 amSDF - MYR
1 stop11h 43mMultiple Airlines
Deal found 9/10$313

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

Fly from

Myrtle Beach

Fly to

Louisville

Route

Depart

Return

Price

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 10/8

7:00 am-5:55 pm

1 stop10h 55m

Louisville Intl

Sat 10/11

7:15 am-5:49 pm

1 stop10h 34m

$169

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 11/13

8:07 pm-12:22 am

1 stop4h 15m

Louisville Intl

Sat 11/15

6:24 am-10:33 am

1 stop4h 09m

$204

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 10/21

7:35 pm-11:24 pm

1 stop3h 49m

Louisville Intl

Thu 10/23

3:46 pm-7:30 pm

1 stop3h 44m

$212

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 10/8

7:00 am-1:43 pm

2 stops6h 43m

Louisville Intl

Sat 10/11

8:08 pm-11:59 pm

1 stop3h 51m

$262

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 10/7

8:14 am-4:36 pm

2 stops32h 22m

Louisville Intl

Fri 10/10

11:47 am-8:04 pm

1 stop8h 17m

$285

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 10/7

8:25 am-6:05 pm

1 stop9h 40m

Louisville Intl

Fri 10/10

1:20 pm-10:20 pm

1 stop9h 00m

$286

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 9/25

6:00 am-8:57 am

2 stops26h 57m

Louisville Intl

Mon 9/29

8:23 am-8:06 pm

1 stop11h 43m

$313

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 11/13

12:40 pm-9:40 pm

2 stops9h 00m

Louisville Intl

Sat 11/15

10:45 am-7:35 pm

2 stops8h 50m

$367

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Sat 9/27

4:23 pm-10:04 pm

1 stop5h 41m

$62

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 10/14

7:35 pm-11:24 pm

1 stop3h 49m

$95

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 16 results
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Best time to book a flight from Myrtle Beach to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Louisville

What is the cheapest month to book a flight from Myrtle Beach to Louisville?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Louisville (average of $299). Flying from Myrtle Beach to Louisville in April is currently the most expensive (average of $369). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SDF?

Find hourly flight availability from Myrtle Beach to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from Myrtle Beach to Louisville is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 57% on airfare.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Delta, American Airlines, and Spirit Airlines from Myrtle Beach to Louisville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Spirit Airlines
6.3
Okay
8,023 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Louisville?

    For as low as $204, Spirit Airlines can have you in Louisville from Myrtle Beach in 4h 15m. Airlines will cover a distance of 491 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Myrtle Beach to Louisville round-trip?

    Our cheapest airline available from Myrtle Beach to Louisville is Spirit Airlines. Our recent data shows that you can find tickets from as low as $31 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $196 and $246 round-trip. These flights start at 90% lower than the current average price 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Louisville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Louisville.

  • Can I find deals for business class flights from Myrtle Beach to Louisville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Louisville?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Louisville (average of $299). Flying from Myrtle Beach to Louisville in April is currently the most expensive (average of $369). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Top 3 airlines flying from Myrtle Beach to Louisville

Discover the top 3 airlines that operate flights from Myrtle Beach to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$31Average$133FlexibilityNo cancel feeOn-time65%
DeltaCheapest$196Average$477FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$246Average$366FlexibilityNo cancel feeOn-time71%

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