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$249+ Cheap flights from Sioux Falls to Knoxville (FSD - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Sioux Falls to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$249
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$293
From Sioux Falls Joe Foss Field to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($109 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Sioux Falls to Knoxville

Cheapest flights from Sioux Falls to Knoxville
Explore the most affordable flight options available from Sioux Falls to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/255:05 pmFSD - TYS
1 stop6h 18mAmerican Airlines
Tue 10/285:37 pmTYS - FSD
1 stop6h 05mAmerican Airlines
Deal found 9/10$249
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/125:30 amFSD - TYS
1 stop6h 13mAmerican Airlines
Sun 11/237:54 amTYS - FSD
1 stop6h 19mAmerican Airlines
Deal found 9/10$260
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/241:19 pmFSD - TYS
2 stops9h 31mAmerican Airlines
Sat 9/274:37 pmTYS - FSD
1 stop5h 46mAmerican Airlines
Deal found 9/10$264
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/81:43 pmFSD - TYS
2 stops9h 08mAmerican Airlines
Wed 11/127:54 amTYS - FSD
1 stop7h 51mAmerican Airlines
Deal found 9/10$301
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/156:00 amFSD - TYS
1 stop5h 21mAmerican Airlines
Mon 9/224:37 pmTYS - FSD
1 stop5h 46mAmerican Airlines
Deal found 9/10$324
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:00 amFSD - TYS
2 stops10h 00mUnited Airlines
Sat 9/2710:51 amTYS - FSD
2 stops10h 30mUnited Airlines
Deal found 9/11$364
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1710:08 amFSD - TYS
1 stop6h 09mAllegiant Air
Sat 10/254:32 pmTYS - FSD
1 stop16h 55mAllegiant Air
Deal found 9/10$369

Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Sioux Falls

Fly to

Knoxville

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 11/8

5:27 pm-12:08 am

1 stop5h 41m

Knoxville McGhee Tyson

Wed 11/12

7:54 am-2:45 pm

1 stop7h 51m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 11/12

3:15 pm-10:55 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sun 11/23

8:26 am-2:40 pm

1 stop7h 14m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

5:05 pm-12:23 am

1 stop6h 18m

Knoxville McGhee Tyson

Tue 10/28

5:37 pm-10:42 pm

1 stop6h 05m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 11/12

1:03 pm-11:59 pm

2 stops9h 56m

Knoxville McGhee Tyson

Sun 11/23

7:54 am-1:13 pm

1 stop6h 19m

$254

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 9/24

7:00 am-1:13 pm

1 stop5h 13m

Knoxville McGhee Tyson

Sat 9/27

4:37 pm-9:23 pm

1 stop5h 46m

$259

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 10/7

5:05 pm-12:23 am

1 stop6h 18m

$322

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 10/7

5:20 am-1:50 pm

2 stops7h 30m

$335

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 10/7

1:29 pm-4:44 pm

3 stops50h 15m

$424

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Sioux Falls to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Sioux Falls to Knoxville

What is the cheapest month to book a flight from Sioux Falls to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Sioux Falls to Knoxville (average of $294). Flying from Sioux Falls to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from FSD to TYS?

Find hourly flight availability from Sioux Falls to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s optimal to fly from Sioux Falls to Knoxville at noon. By choosing this option you can save up to 39% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Sioux Falls to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Sioux Falls to Knoxville?

    Departing from Sioux Falls to Knoxville will take you 5h 41m. The distance from Sioux Falls to Knoxville is about 863 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Sioux Falls to Knoxville round-trip?

    Cheapflights users have booked flights from Sioux Falls to Knoxville round-trip from $248. Other airlines that can offer you cheap pricing are American Airlines, from $248, and United Airlines, from $268. Delta is priced at 38% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Sioux Falls to Knoxville one-way?

    One-way options have recently been found by users for as low as $322 on American Airlines. Other airlines that offer cheap prices include Delta from $335 and Allegiant Air from $424 one-way.

  • Can I find deals for flights from Sioux Falls to Knoxville that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Knoxville.

  • Can I find deals for business class flights from Sioux Falls to Knoxville?

    Yes. Cheapflights offers flight deals from Sioux Falls to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Sioux Falls to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Sioux Falls to Knoxville (average of $294). Flying from Sioux Falls to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Sioux Falls to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Sioux Falls to Knoxville

Discover the top 3 airlines that operate flights from Sioux Falls to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$323FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$389FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$440FlexibilityNo cancel feeOn-time69%

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