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$136+ Cheap flights from Sioux Falls to Knoxville (FSD - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — TYS
Aug 2 — Aug 91
Sat 8/2
Sat 8/9
1 adult, Economy
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Cheap flight deals from Sioux Falls to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 28, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$136
(American Airlines)

Popular in

January

Cheapest in

September

Average price

$343
From Sioux Falls Joe Foss Field to Knoxville McGhee Tyson
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One-way flight from Sioux Falls Joe Foss Field to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 21% potential increase in price ($108 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Sioux Falls to Knoxville

Cheapest flights from Sioux Falls to Knoxville
Explore the most affordable flight options available from Sioux Falls to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2025.

This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/255:05 pmFSD - TYS
1 stop6h 18mAmerican Airlines
Tue 10/286:00 amTYS - FSD
1 stop7h 45mAmerican Airlines
Deal found 7/27$249
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/242:32 pmFSD - TYS
2 stops8h 12mDelta
Sat 9/275:45 amTYS - FSD
2 stops10h 41mDelta
Deal found 7/26$270
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/56:06 amFSD - TYS
1 stop7h 58mUnited Airlines
Tue 8/125:46 pmTYS - FSD
1 stop5h 14mUnited Airlines
Deal found 7/28$344
This Mytrip deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/36:38 pmFSD - TYS
1 stop16h 20mMultiple Airlines
Fri 8/86:00 amTYS - FSD
2 stops14h 16mMultiple Airlines
Deal found 7/26$403

Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Sioux Falls

Fly to

Knoxville

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

5:05 pm-12:23 am

1 stop6h 18m

Knoxville McGhee Tyson

Tue 10/28

6:00 am-12:45 pm

1 stop7h 45m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 9/24

2:32 pm-11:44 pm

2 stops8h 12m

Knoxville McGhee Tyson

Sat 9/27

5:45 am-3:26 pm

2 stops10h 41m

$270

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 8/9

7:30 pm-11:11 am

1 stop14h 41m

Knoxville McGhee Tyson

Fri 8/15

7:15 am-7:21 pm

3 stops13h 06m

$410

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

9:30 am-10:50 pm

2 stops12h 20m

Knoxville McGhee Tyson

Tue 10/28

5:45 am-9:46 pm

3 stops17h 01m

$459

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 11/12

5:30 am-12:43 pm

1 stop6h 13m

$136

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Sioux Falls to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Sioux Falls to Knoxville

What is the cheapest month to book a flight from Sioux Falls to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Sioux Falls to Knoxville (average of $295). Flying from Sioux Falls to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from FSD to TYS?

Find hourly flight availability from Sioux Falls to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 28, 2025.

It’s optimal to fly from Sioux Falls to Knoxville at noon. By choosing this option you can save up to 39% on the cost of your flight, compared to a flight in the morning.

How much does it cost to fly round-trip from Sioux Falls to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 28, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Sioux Falls to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,971 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,971 reviews
Delta
8.0
Very good
7,971 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,893 reviews
Delta
8.0
Very good
7,971 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,971 reviews

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Sioux Falls to Knoxville round-trip?

    Cheapflights users have booked flights from Sioux Falls to Knoxville round-trip from $249. Other airlines that can offer you cheap pricing are Delta, from $270, and United Airlines, from $459. American Airlines is priced at 38% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Sioux Falls to Knoxville that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Knoxville.

  • Can I find deals for business class flights from Sioux Falls to Knoxville?

    Yes. Cheapflights offers flight deals from Sioux Falls to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Sioux Falls to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Sioux Falls to Knoxville (average of $295). Flying from Sioux Falls to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Alcoa
Oak Ridge
Murphy

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Alternative routes for Sioux Falls to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Sioux Falls to Knoxville

Discover the top 3 airlines that operate flights from Sioux Falls to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$221Average$293FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$382FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$395FlexibilityNo cancel feeOn-time69%

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