HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$440+ Cheap flights from Santo Domingo (SDQ) to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/6. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — TYS
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santo Domingo to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santo Domingo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2025.

Round-trip from

$363
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$696
From Santo Domingo Las Americas to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Santo Domingo to Knoxville

Cheapest flights from Santo Domingo to Knoxville
Explore the most affordable flight options available from Santo Domingo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/64:52 pmSDQ - TYS
1 stop21h 29mMultiple Airlines
Wed 8/134:15 pmTYS - SDQ
1 stop23h 45mMultiple Airlines
Deal found 7/28$440
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/203:06 pmSDQ - TYS
1 stop8h 38mDelta
Sun 9/285:45 amTYS - SDQ
2 stops12h 14mDelta
Deal found 7/29$510
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/117:00 amSDQ - TYS
2 stops12h 46mAmerican Airlines
Thu 9/185:05 amTYS - SDQ
2 stops10h 15mAmerican Airlines
Deal found 7/28$530

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Santo Domingo

Fly to

Knoxville

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Sat 9/20

3:06 pm-11:44 pm

1 stop8h 38m

Knoxville McGhee Tyson

Sun 9/28

5:45 am-5:59 pm

2 stops12h 14m

$510

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 9/11

7:00 am-7:46 pm

2 stops12h 46m

Knoxville McGhee Tyson

Thu 9/18

5:05 am-3:20 pm

2 stops10h 15m

$530

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 9/11

5:05 pm-5:34 pm

2 stops24h 29m

Knoxville McGhee Tyson

Thu 9/18

2:33 pm-4:00 pm

3 stops25h 27m

$547

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Santo Domingo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Knoxville

What is the cheapest month to book a flight from Santo Domingo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Knoxville (average of $294). Flying from Santo Domingo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 30, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Santo Domingo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santo Domingo to Knoxville round-trip?

    Our cheapest airline available from Santo Domingo to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $510 on this airline. An additional option worth looking into is American Airlines, starting at $530. You may be able to fly from Santo Domingo to Knoxville for 13% less than the average price by searching for these airlines.

  • Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Knoxville.

  • Can I find deals for business class flights from Santo Domingo to Knoxville?

    Yes. Cheapflights offers flight deals from Santo Domingo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Knoxville (average of $294). Flying from Santo Domingo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to Nashville flights
Santo Domingo to Chattanooga flights

Top airline flying from Santo Domingo to Knoxville

Discover the top airline that operate flights from Santo Domingo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$513Average$517FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.