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$193+ Cheap flights from Santo Domingo (SDQ) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — TYS
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Santo Domingo to Knoxville

Cheapest flights from Santo Domingo to Knoxville
Explore the most affordable flight options available from Santo Domingo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/232:30 pm
SDQ
-
TYS
1 stop23h 40m
Multiple Airlines
Thu 4/95:10 pm
TYS
-
SDQ
1 stop8h 28m
Multiple Airlines
Deal found 1/26$379
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/122:30 pm
SDQ
-
TYS
1 stop7h 54m
Multiple Airlines
Thu 3/195:24 pm
TYS
-
SDQ
1 stop8h 14m
Multiple Airlines
Deal found 1/26$488
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:00 am
SDQ
-
TYS
2 stops16h 10m
American Airlines
Sun 9/138:39 pm
TYS
-
SDQ
2 stops14h 16m
American Airlines
Deal found 1/27$545
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:00 am
SDQ
-
TYS
1 stop17h 59m
American Airlines
Mon 9/77:00 am
TYS
-
SDQ
1 stop11h 20m
American Airlines
Deal found 1/27$554
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/124:00 pm
SDQ
-
TYS
1 stop7h 59m
American Airlines
Tue 9/86:21 am
TYS
-
SDQ
1 stop15h 37m
American Airlines
Deal found 1/26$562
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/124:03 pm
SDQ
-
TYS
2 stops16h 39m
American Airlines
Thu 3/196:21 pm
TYS
-
SDQ
2 stops14h 39m
American Airlines
Deal found 1/26$573
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:25 pm
SDQ
-
TYS
1 stop6h 06m
American Airlines
Sun 9/135:40 am
TYS
-
SDQ
1 stop14h 15m
American Airlines
Deal found 1/27$670

Find flight deals from Santo Domingo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$379
(Kiwi.com)

One-way from

$193
(Kiwi.com)

Popular in

January

Cheapest in

February

Average price

$780
Provider with most accurate pricing for Santo Domingo Las Americas-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Knoxville McGhee Tyson flights.
Search Deals
From Santo Domingo Las Americas to Knoxville McGhee Tyson
Search Deals
One-way flight from Santo Domingo Las Americas to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($34 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Santo Domingo

Fly to

Knoxville

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 3/23

2:30 pm-2:10 pm

1 stop23h 40m

Knoxville McGhee Tyson

Thu 4/9

5:10 pm-1:38 am

1 stop8h 28m

$379

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 3/12

2:30 pm-10:24 pm

1 stop7h 54m

Knoxville McGhee Tyson

Thu 3/19

5:24 pm-1:38 am

1 stop8h 14m

$488

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 5/15

6:00 am-11:59 pm

1 stop17h 59m

Knoxville McGhee Tyson

Mon 9/7

7:00 am-6:20 pm

1 stop11h 20m

$554

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 5/12

4:00 pm-11:59 pm

1 stop7h 59m

Knoxville McGhee Tyson

Tue 9/8

6:21 am-9:58 pm

1 stop15h 37m

$562

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 3/12

4:03 pm-8:42 am

2 stops16h 39m

Knoxville McGhee Tyson

Thu 3/19

6:21 pm-9:00 am

2 stops14h 39m

$573

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 3/24

2:59 am-10:40 am

1 stop7h 41m

$193

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 5/12

3:37 pm-10:36 am

1 stop18h 59m

$199

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 2/6

3:32 pm-11:09 am

1 stop20h 37m

$207

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 5/12

7:00 am-5:27 pm

2 stops10h 27m

$336

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 5/12

10:20 am-11:59 pm

1 stop13h 39m

$354

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

  • Most accurate provider: When it comes to deals on Santo Domingo-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Knoxville

What is the cheapest month to book a flight from Santo Domingo to Knoxville?

Currently, February is the cheapest month in which you can book a flight from Santo Domingo to Knoxville (average of $489). Flying from Santo Domingo to Knoxville in July is currently the most expensive (average of $696). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 28, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Santo Domingo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,123 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,123 reviews
Delta
7.9
Good
8,123 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,201 reviews
Delta
7.9
Good
8,123 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Knoxville?

    There are many flights that can get you from Santo Domingo to Knoxville in 17h 59m. Fly via American Airlines to get the fastest option. Santo Domingo and Knoxville are separated by a distance of 1484 mi.

  • What are the cheapest airlines flying from Santo Domingo to Knoxville round-trip?

    Our cheapest airline available from Santo Domingo to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $489 on this airline. An additional option worth looking into is American Airlines, starting at $513. You may be able to fly from Santo Domingo to Knoxville for 20% less than the average price by searching for these airlines.

  • Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Knoxville.

  • Can I find deals for business class flights from Santo Domingo to Knoxville?

    Yes. Cheapflights offers flight deals from Santo Domingo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Knoxville?

    Currently, February is the cheapest month in which you can book a flight from Santo Domingo to Knoxville (average of $489). Flying from Santo Domingo to Knoxville in July is currently the most expensive (average of $696). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Santo Domingo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to Nashville flights
Santo Domingo to Chattanooga flights

Top 2 airlines flying from Santo Domingo to Knoxville

Discover the top 2 airlines that operate flights from Santo Domingo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$489Average$579FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$513Average$528FlexibilityNo cancel feeOn-time71%

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