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$214+ Cheap flights from Santo Domingo (SDQ) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/6. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — TYS
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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1. Tell us where you want to go

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Cheap flight deals from Santo Domingo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$500
(Kiwi.com)

One-way from

$214
(eDestinos)

Popular in

December

Cheapest in

September

Average price

$643
Provider with most accurate pricing for Santo Domingo Las Americas-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Knoxville McGhee Tyson flights.
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From Santo Domingo Las Americas to Knoxville McGhee Tyson
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One-way flight from Santo Domingo Las Americas to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 16% potential increase in price ($128 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($53 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Santo Domingo to Knoxville

Cheapest flights from Santo Domingo to Knoxville
Explore the most affordable flight options available from Santo Domingo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/142:50 pmSDQ - TYS
1 stop6h 55mDelta
Sat 8/235:30 amTYS - SDQ
1 stop7h 54mDelta
Deal found 4/30$513
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/296:24 amSDQ - TYS
1 stop15h 56mAmerican Airlines
Thu 6/55:57 pmTYS - SDQ
2 stops15h 16mAmerican Airlines
Deal found 4/30$521
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/64:50 pmSDQ - TYS
1 stop15h 44mMultiple Airlines
Sun 9/712:08 pmTYS - SDQ
2 stops14h 02mMultiple Airlines
Deal found 4/30$529

Cheapflights Fare Finder

Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Santo Domingo

Fly to

Knoxville

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 8/14

2:50 pm-9:45 pm

1 stop6h 55m

Knoxville McGhee Tyson

Sat 8/23

5:30 am-1:24 pm

1 stop7h 54m

$513

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 5/29

6:24 am-10:20 pm

1 stop15h 56m

Knoxville McGhee Tyson

Thu 6/5

5:57 pm-9:13 am

2 stops15h 16m

$521

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 6/6

4:50 pm-8:34 am

1 stop15h 44m

Knoxville McGhee Tyson

Sun 9/7

12:08 pm-2:10 am

2 stops14h 02m

$529

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 6/6

10:19 am-8:34 am

1 stop22h 15m

$214

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 5/21

2:41 pm-11:51 pm

1 stop9h 10m

$316

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Wed 5/21

5:00 am-5:33 pm

2 stops12h 33m

$325

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Compare providers for flights from Santo Domingo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Knoxville in May.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santo Domingo-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Knoxville

What is the cheapest month to book a flight from Santo Domingo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Knoxville (average of $296). Flying from Santo Domingo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 1, 2025.
Delta
8.0
Very good
7,934 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santo Domingo to Knoxville round-trip?

    Our cheapest airline available from Santo Domingo to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $521 on this airline. An additional option worth looking into is Delta, starting at $525. You may be able to fly from Santo Domingo to Knoxville for 17% less than the average price by searching for these airlines.

  • Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Knoxville.

  • Can I find deals for business class flights from Santo Domingo to Knoxville?

    Yes. Cheapflights offers flight deals from Santo Domingo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Knoxville (average of $296). Flying from Santo Domingo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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