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$257+ Cheap flights from Santo Domingo (SDQ) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/26. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — TYS
nov. 28 — dic. 51
vie. 11/28
vie. 12/5
1 adult, Economy
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Cheap flight deals from Santo Domingo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$441
(Kiwi.com)

One-way from

$257
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$570
Provider with most accurate pricing for Santo Domingo Las Americas-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Knoxville McGhee Tyson flights.
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From Santo Domingo Las Americas to Knoxville McGhee Tyson
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One-way flight from Santo Domingo Las Americas to Knoxville McGhee Tyson
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High demand for flights, 0% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Santo Domingo to Knoxville

Cheapest flights from Santo Domingo to Knoxville
Explore the most affordable flight options available from Santo Domingo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/288:20 amSDQ - TYS
1 stop26h 55mMultiple Airlines
vie. 1/98:30 amTYS - SDQ
1 stop8h 20mMultiple Airlines
Deal found 10/28$441
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/288:20 amSDQ - TYS
1 stop26h 55mMultiple Airlines
sáb. 1/105:59 pmTYS - SDQ
1 stop22h 51mMultiple Airlines
Deal found 10/28$461
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/303:54 pmSDQ - TYS
1 stop6h 25mMultiple Airlines
jue. 11/69:54 amTYS - SDQ
1 stop28h 36mMultiple Airlines
Deal found 10/28$529
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/124:25 pmSDQ - TYS
1 stop17h 39mMultiple Airlines
mié. 11/266:18 pmTYS - SDQ
2 stops34h 07mMultiple Airlines
Deal found 10/29$532
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/123:05 pmSDQ - TYS
1 stop9h 54mAmerican Airlines
mié. 11/265:07 pmTYS - SDQ
1 stop5h 38mAmerican Airlines
Deal found 10/29$543
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/287:13 amSDQ - TYS
1 stop9h 34mAmerican Airlines
sáb. 1/102:19 pmTYS - SDQ
1 stop8h 27mAmerican Airlines
Deal found 10/29$546

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 29, 2025.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Santo Domingo

Fly to

Knoxville

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

dom. 12/28

8:20 am-10:15 am

1 stop26h 55m

Knoxville McGhee Tyson

vie. 1/9

8:30 am-5:50 pm

1 stop8h 20m

$441

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

dom. 12/28

8:20 am-10:15 am

1 stop26h 55m

Knoxville McGhee Tyson

sáb. 1/10

5:59 pm-5:50 pm

1 stop22h 51m

$461

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

mié. 11/12

4:25 pm-9:04 am

1 stop17h 39m

Knoxville McGhee Tyson

mié. 11/26

6:18 pm-5:25 am

2 stops34h 07m

$532

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

mié. 11/12

3:05 pm-11:59 pm

1 stop9h 54m

Knoxville McGhee Tyson

mié. 11/26

5:07 pm-11:45 pm

1 stop5h 38m

$543

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

dom. 12/28

7:13 am-3:47 pm

1 stop9h 34m

Knoxville McGhee Tyson

sáb. 1/10

2:19 pm-11:46 pm

1 stop8h 27m

$546

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

vie. 2/27

8:01 am-4:59 pm

1 stop9h 58m

Knoxville McGhee Tyson

vie. 3/6

11:51 am-1:50 am

2 stops12h 59m

$581

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

vie. 12/26

6:04 pm-6:37 pm

2 stops25h 33m

$257

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

mié. 12/24

3:59 am-7:08 pm

2 stops16h 09m

$264

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

lun. 11/24

4:45 pm-11:59 pm

1 stop8h 14m

$328

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

jue. 12/25

3:45 am-3:51 pm

2 stops13h 06m

$936

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Compare providers for flights from Santo Domingo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Knoxville in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santo Domingo-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated octubre 29, 2025.
Get a feel of what it's like to fly with American Airlines from Santo Domingo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,030 reviews

Comfort

7.2

Overall

7.2

Food

6.4

Crew

8.0

Entertainment

6.9

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.
American Airlines
7.2
Good
11,030 reviews
American Airlines
7.2
Good
11,030 reviews

Comfort

7.2

Overall

7.2

Food

6.4

Crew

8.0

Entertainment

6.9

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What is the cheapest airline to fly from Santo Domingo to Knoxville round-trip?

    Our cheapest airline available from Santo Domingo to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $513 on this airline. You may be able to fly from Santo Domingo to Knoxville for 14% less than the average price by searching for this airline.

  • Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Knoxville.

  • Can I find deals for business class flights from Santo Domingo to Knoxville?

    Yes. Cheapflights offers flight deals from Santo Domingo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Santo Domingo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Santo Domingo to Knoxville

Discover the top airline that operate flights from Santo Domingo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$513Average$517FlexibilityNo cancel feeOn-time71%

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