HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$195+ Cheap flights from Santo Domingo (SDQ) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/23. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santo Domingo to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santo Domingo to Knoxville

Cheapest flights from Santo Domingo to Knoxville
Explore the most affordable flight options available from Santo Domingo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:57 pmSDQ - TYS
1 stop6h 41mAmerican Airlines
Mon 1/55:42 amTYS - SDQ
1 stop15h 18mAmerican Airlines
Deal found 12/10$667
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/292:53 pmSDQ - TYS
2 stops21h 03mUnited Airlines
Wed 12/317:23 pmTYS - SDQ
2 stops17h 18mUnited Airlines
Deal found 12/9$5,187

Find flight deals from Santo Domingo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$439
(Kiwi.com)

One-way from

$195
(Kiwi.com)

Popular in

May

Cheapest in

February

Average price

$669
Provider with most accurate pricing for Santo Domingo Las Americas-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Knoxville McGhee Tyson flights.
Search Deals
From Santo Domingo Las Americas to Knoxville McGhee Tyson
Search Deals
One-way flight from Santo Domingo Las Americas to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Santo Domingo

Fly to

Knoxville

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 2/6

3:32 pm-11:09 am

1 stop20h 37m

Knoxville McGhee Tyson

Sun 2/15

6:30 am-12:45 am

1 stop17h 15m

$439

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Tue 12/23

6:57 pm-12:38 am

1 stop6h 41m

Knoxville McGhee Tyson

Mon 1/5

5:42 am-10:00 pm

1 stop15h 18m

$667

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 12/29

2:53 pm-10:56 am

2 stops21h 03m

Knoxville McGhee Tyson

Wed 12/31

7:23 pm-1:41 pm

2 stops17h 18m

$5,187

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Fri 1/23

3:32 pm-11:09 am

1 stop20h 37m

$195

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 5/7

6:10 am-11:55 am

1 stop29h 45m

$273

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Thu 5/7

7:55 am-11:43 pm

2 stops15h 48m

$333

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 5/25

8:00 am-11:59 pm

2 stops15h 59m

$392

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

Mon 5/25

6:10 am-4:14 pm

3 stops34h 04m

$565

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Compare providers for flights from Santo Domingo to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Knoxville in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santo Domingo-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santo Domingo-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santo Domingo-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
Get a feel of what it's like to fly with American Airlines from Santo Domingo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,050 reviews

Entertainment

6.9

Overall

7.2

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.5

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,050 reviews
American Airlines
7.2
Good
11,050 reviews

Entertainment

6.9

Overall

7.2

Comfort

7.2

Boarding

7.5

Crew

8.0

Food

6.5

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Knoxville?

    There are many flights that can get you from Santo Domingo to Knoxville in 6h 41m. Fly via American Airlines to get the fastest option. Santo Domingo and Knoxville are separated by a distance of 1484 mi.

  • What is the cheapest airline to fly from Santo Domingo to Knoxville round-trip?

    Our cheapest airline available from Santo Domingo to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $513 on this airline. You may be able to fly from Santo Domingo to Knoxville for 14% less than the average price by searching for this airline.

  • Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Knoxville.

  • Can I find deals for business class flights from Santo Domingo to Knoxville?

    Yes. Cheapflights offers flight deals from Santo Domingo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to Nashville flights
Santo Domingo to Chattanooga flights

Top airline flying from Santo Domingo to Knoxville

Discover the top airline that operate flights from Santo Domingo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$513Average$528FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.