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$246+ Cheap flights from Santo Domingo (SDQ) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — TYS
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Santo Domingo to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 11, 2025.

Round-trip from

$549
(Delta)

One-way from

$246
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$515
From Santo Domingo Las Americas to Knoxville McGhee Tyson
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One-way flight from Santo Domingo Las Americas to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 1% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Santo Domingo to Knoxville

Cheapest flights from Santo Domingo to Knoxville
Explore the most affordable flight options available from Santo Domingo to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/232:50 pmSDQ - TYS
1 stop8h 54mDelta
mar. 9/305:45 amTYS - SDQ
1 stop7h 39mDelta
Deal found 9/10$549

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Santo Domingo to Knoxville that are best for you.

Fly from

Santo Domingo

Fly to

Knoxville

Route

Depart

Return

Price

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

mar. 9/23

2:50 pm-11:44 pm

1 stop8h 54m

Knoxville McGhee Tyson

mar. 9/30

5:45 am-1:24 pm

1 stop7h 39m

$549

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

jue. 2/19

6:45 am-5:35 pm

1 stop11h 50m

Knoxville McGhee Tyson

dom. 2/22

7:55 pm-1:20 pm

1 stop16h 25m

$635

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

mar. 10/14

6:18 am-11:55 am

1 stop29h 37m

$246

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

jue. 12/25

8:01 am-10:15 am

1 stop27h 14m

$261

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

jue. 10/16

6:24 pm-10:18 am

2 stops39h 54m

$263

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

mié. 10/15

12:56 pm-7:53 am

3 stops42h 57m

$280

Santo DomingoKnoxville

SDQ - TYS

SDQTYS

Santo Domingo Las Americas

mié. 10/15

7:49 pm-10:45 am

2 stops14h 56m

$322

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Best time to book a flight from Santo Domingo to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Knoxville

What is the cheapest month to book a flight from Santo Domingo to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Knoxville (average of $294). Flying from Santo Domingo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated septiembre 11, 2025.
Get a feel of what it's like to fly with American Airlines from Santo Domingo to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Crew

8.0

Overall

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Crew

8.0

Overall

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to Knoxville?

    There are many flights that can get you from Santo Domingo to Knoxville in 8h 54m. Fly via Delta or American Airlines to get the fastest option. Santo Domingo and Knoxville are separated by a distance of 1484 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Santo Domingo to Knoxville round-trip?

    Our cheapest airline available from Santo Domingo to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $513 on this airline. You may be able to fly from Santo Domingo to Knoxville for 12% less than the average price by searching for this airline.

  • Can I find deals for flights from Santo Domingo to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Knoxville.

  • Can I find deals for business class flights from Santo Domingo to Knoxville?

    Yes. Cheapflights offers flight deals from Santo Domingo to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santo Domingo to Knoxville (average of $294). Flying from Santo Domingo to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Santo Domingo to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Santo Domingo to Nashville flights
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Top airline flying from Santo Domingo to Knoxville

Discover the top airline that operate flights from Santo Domingo to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$513Average$517FlexibilityNo cancel feeOn-time71%

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