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$212+ Cheap flights from Santa Fe to Knoxville (SAF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — TYS
Apr 24 — May 11
Fri 4/24
Fri 5/1
1 adult, Economy
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Cheap flight deals from Santa Fe to Knoxville

Cheapest flights from Santa Fe to Knoxville
Explore the most affordable flight options available from Santa Fe to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2026.

This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:15 am
SAF
-
TYS
1 stop7h 22m
American Airlines
Wed 4/86:00 am
TYS
-
SAF
1 stop6h 07m
American Airlines
Deal found 3/20$394
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/71:19 pm
SAF
-
TYS
1 stop7h 10m
United Airlines
Sat 4/117:05 am
TYS
-
SAF
2 stops12h 03m
United Airlines
Deal found 3/23$404
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:22 pm
SAF
-
TYS
1 stop7h 16m
United Airlines
Sat 8/297:15 am
TYS
-
SAF
2 stops9h 31m
United Airlines
Deal found 3/23$410
This United Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/41:19 pm
SAF
-
TYS
1 stop7h 10m
United Airlines
Wed 4/87:00 am
TYS
-
SAF
2 stops12h 08m
United Airlines
Deal found 3/20$421
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/710:42 am
SAF
-
TYS
2 stops11h 17m
American Airlines
Sat 4/1111:40 am
TYS
-
SAF
2 stops11h 27m
American Airlines
Deal found 3/23$479
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/121:20 pm
SAF
-
TYS
1 stop7h 00m
United Airlines
Tue 12/158:45 am
TYS
-
SAF
1 stop5h 55m
United Airlines
Deal found 3/24$662

Find flight deals from Santa Fe to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$394
(American Airlines)

One-way from

$212
(American Airlines)

Popular in

August

Cheapest in

December

Average price

$526
Provider with most accurate pricing for Santa Fe-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santa Fe-Knoxville McGhee Tyson flights.
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From Santa Fe to Knoxville McGhee Tyson
Search Deals
One-way flight from Santa Fe to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($64 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in March 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 4/7

1:19 pm-10:29 pm

1 stop7h 10m

Knoxville McGhee Tyson

Sat 4/11

7:05 am-5:08 pm

2 stops12h 03m

$404

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 8/25

1:22 pm-11:57 pm

2 stops8h 35m

Knoxville McGhee Tyson

Sat 8/29

7:15 am-5:11 pm

2 stops11h 56m

$415

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 4/4

1:19 pm-10:29 pm

1 stop7h 10m

Knoxville McGhee Tyson

Wed 4/8

7:00 am-5:08 pm

2 stops12h 08m

$421

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 4/7

10:42 am-11:59 pm

2 stops11h 17m

Knoxville McGhee Tyson

Sat 4/11

11:40 am-9:07 pm

2 stops11h 27m

$479
Cheapest one-way
Quickest one-way

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 4/14

4:09 pm-11:56 pm

1 stop5h 47m

$212

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/20

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Santa Fe-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Fe-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Fe to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Knoxville

What is the cheapest month to book a flight from Santa Fe to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Santa Fe to Knoxville (average of $213). Flying from Santa Fe to Knoxville in December is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 25, 2026.
Read through reviews of airlines operating flights from Santa Fe to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,494 reviews

Entertainment

6.9

Overall

7.1

Boarding

7.5

Comfort

7.2

Crew

7.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,494 reviews
American Airlines
7.1
Good
11,494 reviews

Entertainment

6.9

Overall

7.1

Boarding

7.5

Comfort

7.2

Crew

7.9

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Knoxville?

    Airlines like American Airlines and United Airlines fly from Santa Fe to Knoxville in about 7h 10m. The time it takes to get you to your destination can typically vary by up to 12m. The distance from Santa Fe to Knoxville is about 1236 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Santa Fe to Knoxville round-trip?

    Our cheapest airline available from Santa Fe to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $264 on this airline. Users have found that American Airlines is 39% cheaper than the other options available to this destination.

  • Can I find deals for flights from Santa Fe to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Knoxville.

  • Can I find deals for business class flights from Santa Fe to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Fe to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Santa Fe to Knoxville (average of $213). Flying from Santa Fe to Knoxville in December is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Santa Fe to Knoxville

Discover the top airline that operate flights from Santa Fe to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$344FlexibilityNo cancel feeOn-time71%

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