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$264+ Cheap flights from Santa Fe to Knoxville (SAF - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — TYS
Aug 16 — Aug 231
Sat 8/16
Sat 8/23
1 adult, Economy
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Cheap flight deals from Santa Fe to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 11, 2025.

Round-trip from

$264
(American Airlines)
From Santa Fe to Knoxville McGhee Tyson
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Find flight deals from Santa Fe to Knoxville

Cheapest flights from Santa Fe to Knoxville
Explore the most affordable flight options available from Santa Fe to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2025.

This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/114:58 pmSAF - TYS
1 stop4h 53mAmerican Airlines
Sat 9/206:00 amTYS - SAF
1 stop5h 33mAmerican Airlines
Deal found 8/11$264
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/266:15 amSAF - TYS
1 stop5h 21mAmerican Airlines
Sat 8/3012:20 pmTYS - SAF
1 stop6h 01mAmerican Airlines
Deal found 8/11$314
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2610:45 amSAF - TYS
2 stops11h 12mUnited Airlines
Sat 8/3012:00 pmTYS - SAF
2 stops12h 00mUnited Airlines
Deal found 8/11$372
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1211:47 amSAF - TYS
2 stops9h 16mAmerican Airlines
Sat 9/206:00 amTYS - SAF
2 stops10h 51mAmerican Airlines
Deal found 8/11$416
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/237:00 amSAF - TYS
2 stops11h 56mUnited Airlines
Fri 9/264:40 pmTYS - SAF
1 stop18h 44mUnited Airlines
Deal found 8/11$438
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/77:15 amSAF - TYS
1 stop6h 26mAmerican Airlines
Fri 9/124:37 pmTYS - SAF
1 stop6h 29mAmerican Airlines
Deal found 8/11$584

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2025.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Santa Fe

Fly to

Knoxville

Route

Depart

Return

Price

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Thu 9/11

4:58 pm-11:51 pm

1 stop4h 53m

Knoxville McGhee Tyson

Sat 9/20

6:00 am-9:33 am

1 stop5h 33m

$264

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 8/26

6:15 am-1:36 pm

1 stop5h 21m

Knoxville McGhee Tyson

Sat 8/30

12:20 pm-4:21 pm

1 stop6h 01m

$314

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 8/26

10:45 am-11:57 pm

2 stops11h 12m

Knoxville McGhee Tyson

Sat 8/30

12:00 pm-10:00 pm

2 stops12h 00m

$372

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 9/12

11:47 am-11:03 pm

2 stops9h 16m

Knoxville McGhee Tyson

Sat 9/20

6:00 am-2:51 pm

2 stops10h 51m

$416

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 9/23

7:00 am-8:56 pm

2 stops11h 56m

Knoxville McGhee Tyson

Fri 9/26

4:40 pm-9:24 am

1 stop18h 44m

$438

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sun 9/7

7:15 am-3:41 pm

1 stop6h 26m

Knoxville McGhee Tyson

Fri 9/12

4:37 pm-9:06 pm

1 stop6h 29m

$584

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/11

Best time to book a flight from Santa Fe to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Knoxville

What is the cheapest month to book a flight from Santa Fe to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santa Fe to Knoxville (average of $294). Flying from Santa Fe to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 11, 2025.
Read through reviews of airlines operating flights from Santa Fe to Knoxville, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,922 reviews

Comfort

7.3

Crew

8.1

Boarding

7.7

Entertainment

7.1

Overall

7.4

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,922 reviews
United Airlines
7.4
Good
8,922 reviews

Comfort

7.3

Crew

8.1

Boarding

7.7

Entertainment

7.1

Overall

7.4

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,922 reviews

Comfort

7.3

Crew

8.1

Boarding

7.7

Entertainment

7.1

Overall

7.4

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Santa Fe to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Knoxville.

  • Can I find deals for business class flights from Santa Fe to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Fe to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santa Fe to Knoxville (average of $294). Flying from Santa Fe to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top airline flying from Santa Fe to Knoxville

Discover the top airline that operate flights from Santa Fe to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$298Average$407FlexibilityNo cancel feeOn-time71%

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