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$277+ Cheap flights from Santa Fe to Knoxville (SAF - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — TYS
Jan 25 — Feb 11
Sun 1/25
Sun 2/1
1 adult, Economy
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Cheap flight deals from Santa Fe to Knoxville

Best flights from Santa Fe to Knoxville
Discover carefully curated flight deals from Santa Fe to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 26, 2025.

This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2210:28 amSAF - TYS
1 stop5h 14mAmerican Airlines
Tue 3/177:40 amTYS - SAF
1 stop8h 23mAmerican Airlines
Deal found 12/24$277
This United Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/37:00 amSAF - TYS
1 stop6h 14mUnited Airlines
Sat 2/79:30 amTYS - SAF
2 stops9h 26mUnited Airlines
Deal found 12/24$392
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3112:59 pmSAF - TYS
1 stop7h 48mAmerican Airlines
Sun 2/155:35 amTYS - SAF
1 stop6h 04mAmerican Airlines
Deal found 12/24$357
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/26:25 amSAF - TYS
1 stop7h 21mAmerican Airlines
Sun 2/155:35 amTYS - SAF
1 stop6h 04mAmerican Airlines
Deal found 12/24$364
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3112:59 pmSAF - TYS
1 stop7h 48mAmerican Airlines
Mon 2/165:35 amTYS - SAF
1 stop6h 04mAmerican Airlines
Deal found 12/24$382
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/26:25 amSAF - TYS
1 stop7h 21mAmerican Airlines
Mon 2/165:35 amTYS - SAF
1 stop6h 04mAmerican Airlines
Deal found 12/24$389
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/112:59 pmSAF - TYS
1 stop7h 48mAmerican Airlines
Sun 2/155:35 amTYS - SAF
1 stop6h 04mAmerican Airlines
Deal found 12/24$415

Find flight deals from Santa Fe to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 26, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$277
(American Airlines)
Provider with most accurate pricing for Santa Fe-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santa Fe-Knoxville McGhee Tyson flights.
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From Santa Fe to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Santa Fe

Fly to

Knoxville

Route

Depart

Return

Price

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Thu 1/22

10:28 am-5:42 pm

1 stop5h 14m

Knoxville McGhee Tyson

Tue 3/17

7:40 am-2:03 pm

1 stop8h 23m

$277

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/31

12:59 pm-10:47 pm

1 stop7h 48m

Knoxville McGhee Tyson

Sun 2/15

5:35 am-9:39 am

1 stop6h 04m

$357

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Mon 2/2

6:25 am-3:46 pm

1 stop7h 21m

Knoxville McGhee Tyson

Sun 2/15

5:35 am-9:39 am

1 stop6h 04m

$364

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 1/31

12:59 pm-10:47 pm

1 stop7h 48m

Knoxville McGhee Tyson

Mon 2/16

5:35 am-9:39 am

1 stop6h 04m

$382

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Mon 2/2

6:25 am-3:46 pm

1 stop7h 21m

Knoxville McGhee Tyson

Mon 2/16

5:35 am-9:39 am

1 stop6h 04m

$389

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 2/3

7:00 am-3:14 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sat 2/7

9:30 am-4:56 pm

2 stops9h 26m

$392

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sun 2/1

12:59 pm-10:47 pm

1 stop7h 48m

Knoxville McGhee Tyson

Sun 2/15

5:35 am-9:39 am

1 stop6h 04m

$415

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

  • Most accurate provider: When it comes to deals on Santa Fe-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Fe-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Fe to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Knoxville

What is the cheapest month to book a flight from Santa Fe to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Santa Fe to Knoxville (average of $210). Flying from Santa Fe to Knoxville in December is currently the most expensive (average of $326). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 26, 2025.
Read through reviews of airlines operating flights from Santa Fe to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,062 reviews

Comfort

7.2

Food

6.5

Entertainment

6.9

Overall

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,062 reviews
American Airlines
7.2
Good
11,062 reviews

Comfort

7.2

Food

6.5

Entertainment

6.9

Overall

7.2

Boarding

7.5

Crew

8.0

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Knoxville?

    Airlines like American Airlines fly from Santa Fe to Knoxville in about 5h 14m. The time it takes to get you to your destination can typically vary by up to . The distance from Santa Fe to Knoxville is about 1236 mi.

  • What is the cheapest airline to fly from Santa Fe to Knoxville round-trip?

    Our cheapest airline available from Santa Fe to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $264 on this airline.

  • Can I find deals for flights from Santa Fe to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Knoxville.

  • Can I find deals for business class flights from Santa Fe to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Fe to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Santa Fe to Knoxville (average of $210). Flying from Santa Fe to Knoxville in December is currently the most expensive (average of $326). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Santa Fe to Knoxville

Discover the top airline that operate flights from Santa Fe to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$347FlexibilityNo cancel feeOn-time71%

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