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Knoxville

$140+ Cheap flights from Portland, ME to Knoxville (PWM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — TYS
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Portland to Knoxville

Cheapest flights from Portland to Knoxville
Explore the most affordable flight options available from Portland to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:00 am
PWM
-
TYS
1 stop5h 06m
Delta
Tue 3/105:01 pm
TYS
-
PWM
1 stop6h 11m
Delta
Deal found 1/25$279
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:29 am
PWM
-
TYS
1 stop5h 42m
American Airlines
Fri 4/105:47 am
TYS
-
PWM
1 stop4h 20m
American Airlines
Deal found 1/26$289
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:45 pm
PWM
-
TYS
1 stop8h 10m
Delta
Wed 3/117:40 am
TYS
-
PWM
1 stop4h 29m
Delta
Deal found 1/25$292
This Southwest deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/184:30 pm
PWM
-
TYS
1 stop4h 40m
Southwest
Mon 3/236:30 am
TYS
-
PWM
2 stops17h 35m
Southwest
Deal found 1/24$295
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:20 pm
PWM
-
TYS
1 stop4h 50m
Southwest
Fri 4/106:35 am
TYS
-
PWM
2 stops9h 40m
Southwest
Deal found 1/25$304
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:45 pm
PWM
-
TYS
1 stop8h 10m
Delta
Mon 3/95:10 pm
TYS
-
PWM
1 stop6h 12m
Delta
Deal found 1/25$305
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:29 am
PWM
-
TYS
1 stop5h 42m
American Airlines
Tue 3/36:10 am
TYS
-
PWM
1 stop6h 09m
American Airlines
Deal found 1/25$309
This Southwest deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:40 am
PWM
-
TYS
1 stop7h 40m
Southwest
Sun 5/107:45 am
TYS
-
PWM
1 stop9h 05m
Southwest
Deal found 1/24$310
This Southwest deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:30 pm
PWM
-
TYS
1 stop4h 30m
Southwest
Wed 4/298:15 am
TYS
-
PWM
1 stop4h 05m
Southwest
Deal found 1/24$318

Find flight deals from Portland to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$279
(Delta)

One-way from

$145
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$301
Provider with most accurate pricing for Portland-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Knoxville McGhee Tyson flights.
Search Deals
From Portland to Knoxville McGhee Tyson
Search Deals
One-way flight from Portland to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($59 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Portland

Fly to

Knoxville

Route

Depart

Return

Price

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 3/3

6:00 am-11:06 am

1 stop5h 06m

Knoxville McGhee Tyson

Thu 3/12

6:05 am-11:04 am

1 stop4h 59m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 3/2

5:31 am-11:08 am

1 stop5h 37m

Knoxville McGhee Tyson

Thu 3/12

6:05 am-11:04 am

1 stop4h 59m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 2/26

6:00 am-11:06 am

1 stop5h 06m

Knoxville McGhee Tyson

Fri 3/13

6:38 pm-11:22 pm

1 stop4h 44m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 3/3

6:00 am-11:06 am

1 stop5h 06m

Knoxville McGhee Tyson

Tue 3/10

5:01 pm-11:12 pm

1 stop6h 11m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 3/4

12:43 pm-8:20 pm

1 stop7h 37m

Knoxville McGhee Tyson

Fri 3/13

6:05 am-11:04 am

1 stop4h 59m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 3/3

12:43 pm-8:20 pm

1 stop7h 37m

Knoxville McGhee Tyson

Wed 3/11

7:40 am-12:09 pm

1 stop4h 29m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 3/3

12:43 pm-8:20 pm

1 stop7h 37m

Knoxville McGhee Tyson

Fri 3/13

5:10 pm-11:22 pm

1 stop6h 12m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 2/26

6:00 am-11:06 am

1 stop5h 06m

Knoxville McGhee Tyson

Thu 3/12

6:05 am-11:04 am

1 stop4h 59m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sat 2/28

12:45 pm-8:55 pm

1 stop8h 10m

Knoxville McGhee Tyson

Fri 3/13

6:05 am-11:04 am

1 stop4h 59m

$292

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sat 2/28

12:45 pm-8:55 pm

1 stop8h 10m

Knoxville McGhee Tyson

Tue 3/3

6:01 am-11:18 am

1 stop5h 17m

$292

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Showing 1-10 of 20 results
1
2

Compare providers for flights from Portland to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
Trip.comPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Portland, Maine-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland, Maine-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland, Maine-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Portland, Maine-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Portland to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Knoxville

What is the cheapest month to book a flight from Portland, Maine to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Portland, Maine to Knoxville (average of $54). Flying from Portland, Maine to Knoxville in January is currently the most expensive (average of $166). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Portland, Maine to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 26, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Portland to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,111 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,199 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,189 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Portland to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland, Maine to Knoxville?

    There are many flights that can get you from Portland, Maine to Knoxville in 5h 06m. Fly via Delta to get the fastest option. The distance between Portland, Maine and Knoxville is about 904 mi.

  • What are the cheapest airlines flying from Portland, Maine to Knoxville round-trip?

    Cheapflights users have booked flights from Portland, Maine to Knoxville round-trip from $258. Other airlines that can offer you cheap pricing are Delta, from $258, and United Airlines, from $424. You may be able to fly from Portland, Maine to Knoxville for 38% less than the average price by searching for these airlines.

  • Can I find deals for flights from Portland to Knoxville that include hotel bookings?

    Yes. In addition to deals on Portland to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Knoxville.

  • Can I find deals for business class flights from Portland to Knoxville?

    Yes. Cheapflights offers flight deals from Portland to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Portland, Maine to Knoxville (average of $54). Flying from Portland, Maine to Knoxville in January is currently the most expensive (average of $166). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Portland to Knoxville

Discover the top 3 airlines that operate flights from Portland to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$376FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$343FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$424Average$523FlexibilityNo cancel feeOn-time69%

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