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$140+ Cheap flights from Portland, ME to Knoxville (PWM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — TYS
nov. 27 — dic. 41
jue. 11/27
jue. 12/4
1 adult, Economy
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Find flight deals from Portland to Knoxville

Cheapest flights from Portland to Knoxville
Explore the most affordable flight options available from Portland to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 28, 2025.

This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/55:17 pmPWM - TYS
1 stop4h 19mAmerican Airlines
mar. 12/94:32 pmTYS - PWM
1 stop7h 05mAmerican Airlines
Deal found 10/26$279
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/55:34 amPWM - TYS
2 stops8h 53mAmerican Airlines
lun. 12/86:00 amTYS - PWM
1 stop5h 37mAmerican Airlines
Deal found 10/26$284
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/174:40 pmPWM - TYS
2 stops7h 01mDelta
jue. 11/205:35 amTYS - PWM
2 stops10h 32mDelta
Deal found 10/26$289
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/45:17 pmPWM - TYS
1 stop4h 19mAmerican Airlines
lun. 12/86:00 amTYS - PWM
1 stop5h 37mAmerican Airlines
Deal found 10/26$309
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/104:53 pmPWM - TYS
2 stops6h 48mDelta
vie. 11/145:26 pmTYS - PWM
1 stop5h 53mDelta
Deal found 10/26$314
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/95:43 amPWM - TYS
2 stops7h 16mAmerican Airlines
mié. 11/126:06 amTYS - PWM
1 stop5h 40mAmerican Airlines
Deal found 10/26$349
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/96:00 amPWM - TYS
1 stop6h 09mDelta
mié. 11/125:35 amTYS - PWM
1 stop6h 55mDelta
Deal found 10/28$364
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/115:17 pmPWM - TYS
1 stop17h 33mAmerican Airlines
sáb. 12/134:31 pmTYS - PWM
1 stop6h 01mAmerican Airlines
Deal found 10/26$397

Cheap flight deals from Portland to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$279
(American Airlines)

One-way from

$140
(American Airlines)

Popular in

May

Cheapest in

December

Average price

$408
Provider with most accurate pricing for Portland-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Knoxville McGhee Tyson flights.
Search Deals
From Portland to Knoxville McGhee Tyson
Search Deals
One-way flight from Portland to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($52 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 28, 2025.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Portland

Fly to

Knoxville

Route

Depart

Return

Price

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

dom. 1/18

5:20 am-11:03 am

1 stop5h 43m

Knoxville McGhee Tyson

vie. 1/23

5:14 pm-10:07 pm

1 stop4h 53m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

vie. 12/5

5:17 pm-9:36 pm

1 stop4h 19m

Knoxville McGhee Tyson

lun. 12/8

6:00 am-11:37 am

1 stop5h 37m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

lun. 11/17

4:40 pm-11:41 pm

2 stops7h 01m

Knoxville McGhee Tyson

jue. 11/20

5:35 am-12:30 pm

1 stop6h 55m

$284

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

jue. 12/4

5:46 am-2:29 pm

2 stops8h 43m

Knoxville McGhee Tyson

lun. 12/8

6:00 am-11:37 am

1 stop5h 37m

$284

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

mié. 12/3

6:00 am-2:52 pm

2 stops8h 52m

Knoxville McGhee Tyson

mié. 12/10

3:57 pm-11:21 pm

2 stops7h 24m

$289

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

jue. 2/12

5:35 am-11:03 am

1 stop5h 28m

$140

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

vie. 2/13

5:35 am-11:03 am

1 stop5h 28m

$170

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

sáb. 11/29

5:30 am-10:48 am

1 stop5h 18m

$294

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

lun. 12/1

4:52 pm-10:55 pm

1 stop6h 03m

$294

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

vie. 2/13

11:29 am-12:12 pm

3 stops48h 43m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 11 results
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Compare providers for flights from Portland to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
Trip.comPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Portland, Maine-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Portland, Maine-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Portland, Maine-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Portland, Maine-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Portland to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Knoxville

What is the cheapest month to book a flight from Portland, Maine to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Portland, Maine to Knoxville (average of $54). Flying from Portland, Maine to Knoxville in January is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PWM to TYS?

Find hourly flight availability from Portland to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 28, 2025.

It’s optimal to fly from Portland, Maine to Knoxville at noon. By choosing this option you can save up to 10% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated octubre 28, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Portland to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Portland to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland, Maine to Knoxville?

    There are many flights that can get you from Portland, Maine to Knoxville in 5h 43m. Fly via American Airlines or Delta to get the fastest option. The distance between Portland, Maine and Knoxville is about 904 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Portland, Maine to Knoxville round-trip?

    Cheapflights users have booked flights from Portland, Maine to Knoxville round-trip from $258. Other airlines that can offer you cheap pricing are American Airlines, from $258, and Delta, from $258. You may be able to fly from Portland, Maine to Knoxville for 33% less than the average price by searching for these airlines.

  • Can I find deals for flights from Portland to Knoxville that include hotel bookings?

    Yes. In addition to deals on Portland to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Knoxville.

  • Can I find deals for business class flights from Portland to Knoxville?

    Yes. Cheapflights offers flight deals from Portland to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Portland, Maine to Knoxville (average of $54). Flying from Portland, Maine to Knoxville in January is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Portland to Knoxville

Discover the top 3 airlines that operate flights from Portland to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$258Average$476FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$387FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$343FlexibilityNo cancel feeOn-timeN/A

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