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$155+ Cheap flights from Portland, ME to Knoxville (PWM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Portland to Knoxville McGhee Tyson are usually found in December or September, booked 57 days in advance, depart on a Saturday or Wednesday and return on a Wednesday

Cheap flight deals from Portland to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$203
(American Airlines)

One-way from

$155
(American Airlines)

Popular in

May

Cheapest in

December

Average price

$308
From Portland to Knoxville McGhee Tyson
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One-way flight from Portland to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 15% potential increase in price ($68 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Portland to Knoxville

Cheapest flights from Portland to Knoxville
Explore the most affordable flight options available from Portland to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:43 amPWM - TYS
1 stop5h 09mAmerican Airlines
Sat 11/86:06 amTYS - PWM
1 stop5h 42mAmerican Airlines
Deal found 9/11$203
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/95:43 amPWM - TYS
1 stop5h 11mAmerican Airlines
Wed 11/126:06 amTYS - PWM
1 stop5h 40mAmerican Airlines
Deal found 9/10$256
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:05 pmPWM - TYS
1 stop6h 02mAmerican Airlines
Tue 9/305:05 amTYS - PWM
2 stops6h 39mAmerican Airlines
Deal found 9/9$261
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/41:46 pmPWM - TYS
2 stops9h 36mDelta
Sat 11/82:41 pmTYS - PWM
2 stops9h 24mDelta
Deal found 9/11$278
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:00 amPWM - TYS
1 stop5h 56mAmerican Airlines
Wed 11/57:38 amTYS - PWM
1 stop4h 30mAmerican Airlines
Deal found 9/9$279
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:21 pmPWM - TYS
1 stop4h 12mAmerican Airlines
Sun 11/235:05 amTYS - PWM
2 stops7h 17mAmerican Airlines
Deal found 9/9$284
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:00 amPWM - TYS
1 stop5h 11mDelta
Sun 9/286:14 amTYS - PWM
1 stop6h 46mDelta
Deal found 9/9$309
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:00 amPWM - TYS
2 stops8h 46mDelta
Wed 11/123:51 pmTYS - PWM
1 stop6h 28mDelta
Deal found 9/11$322

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Portland

Fly to

Knoxville

Route

Depart

Return

Price

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 11/4

5:43 am-2:56 pm

2 stops9h 13m

Knoxville McGhee Tyson

Sat 11/8

6:06 am-11:48 am

1 stop5h 42m

$208

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 9/25

6:05 pm-12:07 am

1 stop6h 02m

Knoxville McGhee Tyson

Tue 9/30

7:18 am-12:29 pm

1 stop5h 11m

$256

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sun 11/9

5:43 am-10:54 am

1 stop5h 11m

Knoxville McGhee Tyson

Wed 11/12

6:06 am-11:46 am

1 stop5h 40m

$256

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 11/4

1:46 pm-11:22 pm

2 stops9h 36m

Knoxville McGhee Tyson

Sat 11/8

2:41 pm-12:05 am

2 stops9h 24m

$278

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 10/30

7:00 am-12:56 pm

1 stop5h 56m

Knoxville McGhee Tyson

Wed 11/5

7:38 am-12:08 pm

1 stop4h 30m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 11/20

5:21 pm-9:33 pm

1 stop4h 12m

Knoxville McGhee Tyson

Sun 11/23

5:05 am-12:22 pm

2 stops7h 17m

$284

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 9/24

6:00 am-11:11 am

1 stop5h 11m

Knoxville McGhee Tyson

Sun 9/28

6:14 am-1:00 pm

1 stop6h 46m

$309

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sun 11/9

6:00 am-12:09 pm

1 stop6h 09m

Knoxville McGhee Tyson

Wed 11/12

3:51 pm-11:54 pm

2 stops8h 03m

$322

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 9/23

6:00 am-10:37 am

1 stop4h 37m

$205

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Fri 9/26

6:00 am-5:18 pm

2 stops11h 18m

$224

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 14 results
1
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Best time to book a flight from Portland to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Knoxville

How far ahead should I book a flight from Portland, Maine to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Portland to Knoxville. Price data was last updated on August 29, 2025.

The best time to book flights from Portland, Maine to Knoxville is 57 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Portland, Maine to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Portland, Maine to Knoxville (average of $294). Flying from Portland, Maine to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PWM to TYS?

Find hourly flight availability from Portland to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s optimal to fly from Portland, Maine to Knoxville at noon. By choosing this option you can save up to 10% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Portland to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Portland to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland, Maine to Knoxville?

    There are many flights that can get you from Portland, Maine to Knoxville in 9h 13m. Fly via American Airlines to get the fastest option. The distance between Portland, Maine and Knoxville is about 904 mi.

  • What are the cheapest airlines flying from Portland, Maine to Knoxville round-trip?

    Cheapflights users have booked flights from Portland, Maine to Knoxville round-trip from $258. Other airlines that can offer you cheap pricing are Delta, from $258, and United Airlines, from $263. You may be able to fly from Portland, Maine to Knoxville for 31% less than the average price by searching for these airlines.

  • Can I find deals for flights from Portland to Knoxville that include hotel bookings?

    Yes. In addition to deals on Portland to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Knoxville.

  • Can I find deals for business class flights from Portland to Knoxville?

    Yes. Cheapflights offers flight deals from Portland to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Portland, Maine to Knoxville (average of $294). Flying from Portland, Maine to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Portland to Knoxville

Discover the top 3 airlines that operate flights from Portland to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$374FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$378FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$263Average$441FlexibilityNo cancel feeOn-time69%

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