HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$130+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
ago 25 — set 11
seg 8/25
seg 9/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 20, 2025.

Round-trip from

$259
(American Airlines)

One-way from

$130
(Delta)

Popular in

January

Cheapest in

August

Average price

$326
From Panama City NW Florida Beaches to Knoxville McGhee Tyson
Search Deals
One-way flight from Panama City NW Florida Beaches to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($51 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Panama City to Knoxville

Cheapest flights from Panama City to Knoxville
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 20, 2025.

This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 11/48:21 amECP - TYS
1 stop5h 31mAmerican Airlines
sáb 11/85:51 pmTYS - ECP
1 stop7h 02mAmerican Airlines
Deal found 8/18$259
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 9/229:13 amECP - TYS
1 stop5h 07mDelta
ter 10/285:44 amTYS - ECP
1 stop5h 35mDelta
Deal found 8/20$283
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 9/166:00 amECP - TYS
1 stop2h 44mDelta
sáb 9/205:45 amTYS - ECP
1 stop3h 23mDelta
Deal found 8/19$293
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 10/236:17 pmECP - TYS
1 stop4h 29mDelta
dom 10/268:10 pmTYS - ECP
1 stop4h 00mDelta
Deal found 8/17$307
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 9/106:00 amECP - TYS
1 stop3h 42mDelta
qui 9/185:45 amTYS - ECP
1 stop3h 23mDelta
Deal found 8/18$317
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 9/136:00 amECP - TYS
1 stop3h 25mDelta
ter 9/165:45 amTYS - ECP
1 stop5h 10mDelta
Deal found 8/18$327
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 10/249:29 amECP - TYS
1 stop4h 14mDelta
seg 10/2710:05 amTYS - ECP
1 stop3h 25mDelta
Deal found 8/17$337
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 9/117:00 amECP - TYS
1 stop2h 42mDelta
qua 9/175:45 amTYS - ECP
1 stop5h 10mDelta
Deal found 8/20$347
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 9/1012:01 pmECP - TYS
2 stops10h 49mAmerican Airlines
qua 9/172:08 pmTYS - ECP
1 stop4h 28mAmerican Airlines
Deal found 8/18$358
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 9/56:00 amECP - TYS
1 stop3h 42mDelta
seg 9/84:19 pmTYS - ECP
1 stop4h 29mDelta
Deal found 8/19$367
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 9/109:24 amECP - TYS
1 stop2h 44mDelta
sáb 9/136:08 pmTYS - ECP
2 stops21h 31mDelta
Deal found 8/18$376

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 20, 2025.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.

Fly from

Panama City

Fly to

Knoxville

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

ter 11/4

8:21 am-2:52 pm

1 stop5h 31m

Knoxville McGhee Tyson

sáb 11/8

5:51 pm-11:53 pm

1 stop7h 02m

$259

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

seg 9/29

4:46 pm-11:44 pm

1 stop5h 58m

Knoxville McGhee Tyson

ter 9/30

5:45 am-8:08 am

1 stop3h 23m

$283

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

seg 9/22

9:13 am-3:20 pm

1 stop5h 07m

Knoxville McGhee Tyson

ter 10/28

5:44 am-10:19 am

1 stop5h 35m

$283

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

ter 11/4

5:00 pm-11:22 pm

1 stop5h 22m

Knoxville McGhee Tyson

dom 11/9

7:15 pm-10:43 pm

1 stop4h 28m

$283

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

qui 9/18

6:00 am-10:42 am

1 stop3h 42m

Knoxville McGhee Tyson

ter 9/23

5:45 am-8:08 am

1 stop3h 23m

$283

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

qui 9/11

7:00 am-1:07 pm

1 stop5h 07m

Knoxville McGhee Tyson

qua 9/17

5:45 am-8:08 am

1 stop3h 23m

$293

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

seg 9/15

6:54 pm-11:44 pm

1 stop3h 50m

Knoxville McGhee Tyson

qua 9/17

5:45 am-9:55 am

1 stop5h 10m

$293

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

ter 9/16

6:00 am-9:44 am

1 stop2h 44m

Knoxville McGhee Tyson

qua 9/17

5:45 am-8:08 am

1 stop3h 23m

$293

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

sáb 9/13

5:02 pm-11:44 pm

1 stop5h 42m

Knoxville McGhee Tyson

qua 9/17

5:45 am-8:08 am

1 stop3h 23m

$293

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

ter 9/16

6:00 am-9:44 am

1 stop2h 44m

Knoxville McGhee Tyson

sáb 9/20

5:45 am-8:08 am

1 stop3h 23m

$293

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/18

Showing 1-10 of 19 results
1
2

Best time to book a flight from Panama City to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Knoxville

What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $295). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to TYS?

Find hourly flight availability from Panama City to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 20, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated agosto 20, 2025.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Overall

8.0

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Knoxville?

    There are many flights that can get you from Panama City, Florida to Knoxville in 5h 31m. Fly via American Airlines or Delta to get the fastest option. There are 390 mi between Panama City, Florida and Knoxville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City, Florida to Knoxville round-trip?

    Our cheapest airline available from Panama City, Florida to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $282 on this airline. An additional option worth looking into is Delta, starting at $286. You may be able to fly from Panama City, Florida to Knoxville for 43% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Knoxville that include hotel bookings?

    Yes. In addition to deals on Panama City to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Knoxville.

  • Can I find deals for business class flights from Panama City to Knoxville?

    Yes. Cheapflights offers flight deals from Panama City to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $295). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Nashville flights
Orlando to Nashville flights
Tampa to Nashville flights
Miami to Nashville flights
Fort Lauderdale to Knoxville flights
West Palm Beach to Nashville flights
Fort Myers to Nashville flights
Miami to Knoxville flights
Orlando to Memphis flights
Jacksonville to Nashville flights
Tampa to Memphis flights
Tampa to Knoxville flights
Orlando Sanford Intl to Knoxville flights
Panama City to Nashville flights
West Palm Beach to Knoxville flights
Sarasota to Nashville flights
St Petersburg to Knoxville flights
Miami to Memphis flights
Sarasota to Knoxville flights
Fort Myers to Knoxville flights
Orlando to Knoxville flights
Fort Lauderdale to Memphis flights
Jacksonville to Memphis flights
Daytona Beach to Nashville flights
Pensacola to Nashville flights
Fort Myers to Memphis flights
Jacksonville to Knoxville flights
Daytona Beach to Memphis flights
Tampa to Chattanooga flights
West Palm Beach to Memphis flights
Orlando to Chattanooga flights
Valparaiso to Nashville flights
Tampa to Blountville flights
West Palm Beach to Chattanooga flights
Tallahassee to Nashville flights
Gainesville to Nashville flights
Melbourne to Knoxville flights
Sarasota to Memphis flights
Jacksonville to Chattanooga flights
Pensacola to Knoxville flights
Fort Lauderdale to Chattanooga flights
Daytona Beach to Knoxville flights
Fort Myers to Chattanooga flights
Pensacola to Memphis flights
Miami to Chattanooga flights
Melbourne to Nashville flights
Sarasota to Chattanooga flights
Orlando to Blountville flights
Gainesville to Knoxville flights
West Palm Beach to Blountville flights

Top 2 airlines flying from Panama City to Knoxville

Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$282Average$508FlexibilityNo cancel feeOn-time71%
DeltaCheapest$286Average$519FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.