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Knoxville

$259+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Panama City to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$259
(Delta)

Popular in

January

Cheapest in

August

Average price

$421
From Panama City NW Florida Beaches to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($69 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
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Find flight deals from Panama City to Knoxville

Cheapest flights from Panama City to Knoxville
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:00 pmECP - TYS
1 stop5h 22mDelta
Sat 11/86:15 amTYS - ECP
1 stop3h 04mDelta
Deal found 9/14$259
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/169:13 amECP - TYS
1 stop2h 54mDelta
Sat 9/206:08 pmTYS - ECP
1 stop5h 55mDelta
Deal found 9/14$329
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/147:00 amECP - TYS
1 stop2h 56mDelta
Sat 9/205:45 amTYS - ECP
1 stop3h 23mDelta
Deal found 9/14$396
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/206:06 pmECP - TYS
1 stop3h 57mAmerican Airlines
Sun 9/286:30 amTYS - ECP
1 stop4h 12mAmerican Airlines
Deal found 9/13$418
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/146:59 pmECP - TYS
1 stop4h 08mAmerican Airlines
Wed 9/248:23 amTYS - ECP
1 stop4h 08mAmerican Airlines
Deal found 9/14$426
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/147:00 amECP - TYS
1 stop2h 56mDelta
Mon 9/227:11 pmTYS - ECP
1 stop4h 52mDelta
Deal found 9/14$463
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/166:06 pmECP - TYS
1 stop3h 57mAmerican Airlines
Sun 9/215:05 amTYS - ECP
1 stop5h 37mAmerican Airlines
Deal found 9/14$491
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1612:01 pmECP - TYS
2 stops10h 49mAmerican Airlines
Mon 9/222:08 pmTYS - ECP
1 stop4h 28mAmerican Airlines
Deal found 9/14$496
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/95:30 amECP - TYS
1 stop4h 01mAmerican Airlines
Mon 10/138:37 pmTYS - ECP
1 stop4h 07mAmerican Airlines
Deal found 9/15$500
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/146:59 pmECP - TYS
1 stop4h 08mAmerican Airlines
Sun 9/215:05 amTYS - ECP
1 stop5h 37mAmerican Airlines
Deal found 9/14$528
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/95:30 amECP - TYS
1 stop4h 01mAmerican Airlines
Sun 10/128:37 pmTYS - ECP
1 stop4h 07mAmerican Airlines
Deal found 9/14$539
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/135:02 pmECP - TYS
1 stop5h 42mDelta
Mon 9/157:11 pmTYS - ECP
1 stop4h 52mDelta
Deal found 9/12$564

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.

Fly from

Panama City

Fly to

Knoxville

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 11/4

5:00 pm-11:22 pm

1 stop5h 22m

Knoxville McGhee Tyson

Sat 11/8

6:15 am-8:19 am

1 stop3h 04m

$259

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 2/26

7:45 am-1:26 pm

1 stop4h 41m

Knoxville McGhee Tyson

Sun 3/1

2:30 pm-7:38 pm

1 stop6h 08m

$387

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 10/9

5:30 am-10:31 am

1 stop4h 01m

Knoxville McGhee Tyson

Sun 10/12

8:37 pm-11:44 pm

1 stop4h 07m

$539

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 11/4

8:21 am-9:29 pm

2 stops12h 08m

Knoxville McGhee Tyson

Sat 11/8

6:30 am-10:00 am

1 stop4h 30m

$567

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sun 9/28

6:00 am-9:44 am

1 stop2h 44m

Knoxville McGhee Tyson

Thu 10/2

5:45 am-8:08 am

1 stop3h 23m

$577

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 1/2

1:59 pm-7:27 pm

1 stop4h 28m

Knoxville McGhee Tyson

Mon 1/5

2:30 pm-7:38 pm

1 stop6h 08m

$593

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 2/26

11:17 am-3:40 pm

1 stop3h 23m

Knoxville McGhee Tyson

Sun 3/1

7:52 pm-9:54 am

2 stops15h 02m

$657

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 11/4

5:00 pm-2:43 pm

2 stops20h 43m

Knoxville McGhee Tyson

Sat 11/8

4:50 pm-1:57 pm

2 stops22h 07m

$688

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 10/10

6:17 pm-11:46 pm

1 stop4h 29m

Knoxville McGhee Tyson

Mon 10/13

8:10 pm-11:10 pm

1 stop4h 00m

$689

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 10/8

6:44 am-11:29 am

1 stop3h 45m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 18 results
1
2

Best time to book a flight from Panama City to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Knoxville

What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $294). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to TYS?

Find hourly flight availability from Panama City to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Knoxville?

    There are many flights that can get you from Panama City, Florida to Knoxville in 4h 01m. Fly via Delta or American Airlines to get the fastest option. There are 390 mi between Panama City, Florida and Knoxville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City, Florida to Knoxville round-trip?

    Our cheapest airline available from Panama City, Florida to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $286 on this airline. An additional option worth looking into is American Airlines, starting at $312. You may be able to fly from Panama City, Florida to Knoxville for 41% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Knoxville that include hotel bookings?

    Yes. In addition to deals on Panama City to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Knoxville.

  • Can I find deals for business class flights from Panama City to Knoxville?

    Yes. Cheapflights offers flight deals from Panama City to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $294). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Panama City to Knoxville

Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$286Average$494FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$312Average$498FlexibilityNo cancel feeOn-time71%

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