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$240+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
Feb 17 — Feb 241
Tue 2/17
Tue 2/24
1 adult, Economy
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Cheap flight deals from Panama City to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 18, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$240
(Southwest)

Popular in

January

Cheapest in

October

Average price

$608
Provider with most accurate pricing for Panama City NW Florida Beaches-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Knoxville McGhee Tyson flights.
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From Panama City NW Florida Beaches to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($106 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Panama City to Knoxville

Cheapest flights from Panama City to Knoxville
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 18, 2026.

This Southwest deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:55 am
ECP
-
TYS
2 stops10h 20m
Southwest
Tue 4/212:55 pm
TYS
-
ECP
1 stop6h 50m
Southwest
Deal found 1/17$240
This Southwest deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/72:50 pm
ECP
-
TYS
1 stop5h 15m
Southwest
Sat 3/147:50 am
TYS
-
ECP
1 stop10h 30m
Southwest
Deal found 1/17$263
This Southwest deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2012:05 pm
ECP
-
TYS
2 stops7h 45m
Southwest
Sat 5/237:45 am
TYS
-
ECP
1 stop11h 05m
Southwest
Deal found 1/16$268
This Southwest deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:55 am
ECP
-
TYS
1 stop5h 25m
Southwest
Sat 5/306:40 am
TYS
-
ECP
1 stop3h 20m
Southwest
Deal found 1/16$279
This Southwest deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:10 am
ECP
-
TYS
1 stop3h 30m
Southwest
Sat 5/237:45 am
TYS
-
ECP
1 stop11h 05m
Southwest
Deal found 1/16$285
This Southwest deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:55 am
ECP
-
TYS
1 stop7h 50m
Southwest
Tue 7/77:10 am
TYS
-
ECP
1 stop3h 20m
Southwest
Deal found 1/16$299

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 18, 2026.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.

Fly from

Panama City

Fly to

Knoxville

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 4/16

9:55 am-9:15 pm

2 stops10h 20m

Knoxville McGhee Tyson

Tue 4/21

2:55 pm-8:45 pm

1 stop6h 50m

$240

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 3/7

2:50 pm-9:05 pm

1 stop5h 15m

Knoxville McGhee Tyson

Sat 3/14

7:50 am-5:20 pm

1 stop10h 30m

$263

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 5/27

7:55 am-2:20 pm

1 stop5h 25m

Knoxville McGhee Tyson

Sat 5/30

6:40 am-9:00 am

1 stop3h 20m

$279

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 4/11

7:55 am-6:30 pm

2 stops9h 35m

Knoxville McGhee Tyson

Thu 4/16

2:45 pm-9:40 pm

1 stop7h 55m

$297

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 7/3

6:55 am-3:45 pm

1 stop7h 50m

Knoxville McGhee Tyson

Tue 7/7

7:10 am-9:30 am

1 stop3h 20m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/17

Compare providers for flights from Panama City to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Knoxville

What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $70). Flying from Panama City, Florida to Knoxville in November is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 18, 2026.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,075 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,075 reviews
Delta
7.9
Good
8,075 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,155 reviews
Delta
7.9
Good
8,075 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Knoxville?

    There are many flights that can get you from Panama City, Florida to Knoxville in 10h 20m. Fly via Southwest to get the fastest option. There are 390 mi between Panama City, Florida and Knoxville.

  • What are the cheapest airlines flying from Panama City, Florida to Knoxville round-trip?

    Our cheapest airline available from Panama City, Florida to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $228 on this airline. An additional option worth looking into is American Airlines, starting at $298. You may be able to fly from Panama City, Florida to Knoxville for 49% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Knoxville that include hotel bookings?

    Yes. In addition to deals on Panama City to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Knoxville.

  • Can I find deals for business class flights from Panama City to Knoxville?

    Yes. Cheapflights offers flight deals from Panama City to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $70). Flying from Panama City, Florida to Knoxville in November is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Panama City to Knoxville

Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$228Average$402FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$298Average$438FlexibilityNo cancel feeOn-time71%

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