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$322+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Panama City to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$327
(Delta)

One-way from

$322
(Delta)

Popular in

January

Cheapest in

August

Average price

$366
Provider with most accurate pricing for Panama City NW Florida Beaches-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Knoxville McGhee Tyson flights.
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From Panama City NW Florida Beaches to Knoxville McGhee Tyson
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One-way flight from Panama City NW Florida Beaches to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 13% potential increase in price ($74 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Panama City to Knoxville

Cheapest flights from Panama City to Knoxville
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:49 pmECP - TYS
1 stop4h 01mDelta
Mon 12/157:59 pmTYS - ECP
1 stop3h 59mDelta
Deal found 10/15$327
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:00 pmECP - TYS
1 stop5h 22mDelta
Sat 11/82:41 pmTYS - ECP
1 stop4h 53mDelta
Deal found 10/14$329
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:00 pmECP - TYS
1 stop5h 46mDelta
Mon 11/108:07 pmTYS - ECP
1 stop4h 00mDelta
Deal found 10/15$347
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:40 pmECP - TYS
1 stop4h 01mDelta
Sun 11/168:07 pmTYS - ECP
1 stop4h 00mDelta
Deal found 10/16$357
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/48:21 amECP - TYS
1 stop5h 35mAmerican Airlines
Sat 11/88:04 pmTYS - ECP
1 stop4h 49mAmerican Airlines
Deal found 10/16$367
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:58 amECP - TYS
1 stop3h 53mAmerican Airlines
Tue 10/2811:44 amTYS - ECP
1 stop4h 22mAmerican Airlines
Deal found 10/14$391
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:10 amECP - TYS
1 stop5h 32mDelta
Sun 11/98:07 pmTYS - ECP
1 stop4h 00mDelta
Deal found 10/16$403
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/161:35 pmECP - TYS
1 stop4h 30mDelta
Tue 10/215:44 amTYS - ECP
1 stop4h 00mDelta
Deal found 10/15$440
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/231:35 pmECP - TYS
1 stop4h 30mDelta
Tue 10/285:44 amTYS - ECP
1 stop5h 35mDelta
Deal found 10/14$457
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:09 pmECP - TYS
1 stop6h 38mAmerican Airlines
Sat 1/35:00 amTYS - ECP
1 stop6h 41mAmerican Airlines
Deal found 10/14$466
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1610:43 amECP - TYS
1 stop4h 10mAmerican Airlines
Wed 10/227:43 pmTYS - ECP
1 stop4h 10mAmerican Airlines
Deal found 10/15$476

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.

Fly from

Panama City

Fly to

Knoxville

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 12/12

6:49 pm-11:50 pm

1 stop4h 01m

Knoxville McGhee Tyson

Mon 12/15

7:59 pm-10:58 pm

1 stop3h 59m

$327

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 11/4

5:00 pm-11:22 pm

1 stop5h 22m

Knoxville McGhee Tyson

Sat 11/8

2:41 pm-6:34 pm

1 stop4h 53m

$329

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 11/4

8:21 am-2:56 pm

1 stop5h 35m

Knoxville McGhee Tyson

Sat 11/8

8:04 pm-11:53 pm

1 stop4h 49m

$347

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 11/7

5:00 pm-11:46 pm

1 stop5h 46m

Knoxville McGhee Tyson

Mon 11/10

8:07 pm-11:07 pm

1 stop4h 00m

$347

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 11/14

6:40 pm-11:41 pm

1 stop4h 01m

Knoxville McGhee Tyson

Sun 11/16

8:07 pm-11:07 pm

1 stop4h 00m

$357

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 10/23

1:35 pm-7:05 pm

1 stop4h 30m

Knoxville McGhee Tyson

Tue 10/28

5:44 am-10:19 am

1 stop5h 35m

$457

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Mon 12/29

4:09 pm-11:47 pm

1 stop6h 38m

Knoxville McGhee Tyson

Sat 1/3

5:00 am-10:41 am

1 stop6h 41m

$466

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 10/31

5:00 pm-11:07 pm

1 stop5h 07m

Knoxville McGhee Tyson

Tue 11/4

5:44 am-10:19 am

1 stop5h 35m

$503

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 12/30

4:09 pm-9:58 pm

1 stop4h 49m

Knoxville McGhee Tyson

Fri 1/2

5:40 pm-11:53 pm

1 stop7h 13m

$524

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 10/22

9:29 am-2:43 pm

1 stop4h 14m

$322

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Showing 1-10 of 16 results
1
2

Compare providers for flights from Panama City to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Knoxville

What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $70). Flying from Panama City, Florida to Knoxville in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to TYS?

Find hourly flight availability from Panama City to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 16, 2025.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Knoxville?

    There are many flights that can get you from Panama City, Florida to Knoxville in 4h 01m. Fly via Delta or American Airlines to get the fastest option. There are 390 mi between Panama City, Florida and Knoxville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City, Florida to Knoxville round-trip?

    Our cheapest airline available from Panama City, Florida to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $258 on this airline. An additional option worth looking into is American Airlines, starting at $298. You may be able to fly from Panama City, Florida to Knoxville for 46% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Knoxville that include hotel bookings?

    Yes. In addition to deals on Panama City to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Knoxville.

  • Can I find deals for business class flights from Panama City to Knoxville?

    Yes. Cheapflights offers flight deals from Panama City to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $70). Flying from Panama City, Florida to Knoxville in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Panama City to Knoxville

Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$478FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$298Average$498FlexibilityNo cancel feeOn-time71%

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