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$180+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/5. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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Cheap flight deals from Panama City to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$367
(Delta)

One-way from

$180
(Delta)

Popular in

August

Cheapest in

September

Average price

$541
Provider with most accurate pricing for Panama City NW Florida Beaches-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Knoxville McGhee Tyson flights.
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From Panama City NW Florida Beaches to Knoxville McGhee Tyson
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One-way flight from Panama City NW Florida Beaches to Knoxville McGhee Tyson
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High demand for flights, 0% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Panama City to Knoxville

Cheapest flights from Panama City to Knoxville
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/126:00 amECP - TYS
1 stop4h 08mDelta
Sun 6/1512:03 pmTYS - ECP
1 stop2h 49mDelta
Deal found 4/27$367
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/75:30 amECP - TYS
1 stop4h 03mAmerican Airlines
Mon 6/95:57 pmTYS - ECP
1 stop6h 52mAmerican Airlines
Deal found 4/28$442
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/122:03 pmECP - TYS
1 stop19h 06mUnited Airlines
Sun 6/157:25 pmTYS - ECP
2 stops18h 41mUnited Airlines
Deal found 4/27$656

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.

Fly from

Panama City

Fly to

Knoxville

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 6/12

6:00 am-11:08 am

1 stop4h 08m

Knoxville McGhee Tyson

Sun 6/15

12:03 pm-1:52 pm

1 stop2h 49m

$367

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 6/7

5:30 am-10:33 am

1 stop4h 03m

Knoxville McGhee Tyson

Mon 6/9

5:57 pm-11:49 pm

1 stop6h 52m

$442

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 6/12

2:03 pm-10:09 am

1 stop19h 06m

Knoxville McGhee Tyson

Sun 6/15

7:25 pm-1:06 pm

2 stops18h 41m

$656

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 5/20

7:15 am-11:23 am

1 stop3h 08m

$249

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sun 5/4

4:55 pm-9:23 pm

1 stop3h 28m

$369

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Tue 5/20

2:15 pm-7:31 pm

2 stops28h 16m

$389

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Compare providers for flights from Panama City to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Knoxville

What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $296). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to TYS?

Find hourly flight availability from Panama City to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the afternoon.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 29, 2025.
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
Delta
8.0
Very good
7,929 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City, Florida to Knoxville round-trip?

    Our cheapest airline available from Panama City, Florida to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $367 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $442 and $656 round-trip. You may be able to fly from Panama City, Florida to Knoxville for 33% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Panama City, Florida to Knoxville one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $180. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Panama City, Florida to Knoxville for a low price.

  • Can I find deals for flights from Panama City to Knoxville that include hotel bookings?

    Yes. In addition to deals on Panama City to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Knoxville.

  • Can I find deals for business class flights from Panama City to Knoxville?

    Yes. Cheapflights offers flight deals from Panama City to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $296). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 2 airlines flying from Panama City to Knoxville

Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$358Average$552FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$368Average$556FlexibilityNo cancel feeOn-time71%

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