$130+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
Oct 28 — Nov 41
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama City to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to KnoxvilleExplore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 28, 2026.
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 28, 2026.
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:19 am -
1 stop3h 21m
Mon 11/97:22 pm -
1 stop5h 02m
Deal found 9/25![Delta logo]()
$259
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:12 am -
1 stop5h 28m
Sat 10/315:40 am -
1 stop4h 27m
Deal found 9/26![Delta logo]()
$273
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:12 am -
1 stop5h 19m
Sat 10/315:40 am -
1 stop4h 27m
Deal found 9/24![Delta logo]()
$285
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:12 am -
1 stop5h 28m
Fri 11/134:00 pm -
1 stop3h 05m
Deal found 9/25![Delta logo]()
$287
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:00 am -
1 stop3h 45m
Thu 11/125:40 am -
1 stop4h 05m
Deal found 9/25![Delta logo]()
$294
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:59 pm -
1 stop3h 58m
Mon 12/76:17 pm -
1 stop6h 00m
Deal found 9/23![Delta logo]()
$299
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop3h 54m
Sun 11/157:22 pm -
1 stop5h 02m
Deal found 9/25![Delta logo]()
$308
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:12 am -
1 stop5h 19m
Sat 11/76:23 pm -
1 stop5h 55m
Deal found 9/26![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:59 pm -
1 stop5h 04m
Mon 1/45:57 pm -
1 stop5h 50m
Deal found 9/25![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:12 am -
1 stop5h 28m
Sun 11/15:40 am -
1 stop3h 34m
Deal found 9/26![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:00 am -
1 stop3h 45m
Sun 11/157:22 pm -
1 stop5h 02m
Deal found 9/25![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop3h 54m
Sun 11/15:40 am -
1 stop3h 34m
Deal found 9/26![Delta logo]()
$333
Best flights from Panama City to KnoxvilleDiscover carefully curated flight deals from Panama City to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 28, 2026.
Discover carefully curated flight deals from Panama City to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 28, 2026.
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/289:19 am -
1 stop5h 07m
Sat 10/315:40 am -
1 stop4h 27m
Deal found 9/26![Delta logo]()
$259
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:55 am -
2 stops11h 00m
Sat 10/316:40 am -
1 stop3h 35m
Deal found 9/24![Southwest logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:01 pm -
1 stop3h 57m
Mon 11/97:14 pm -
1 stop4h 38m
Deal found 9/24![American Airlines logo]()
$393
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:59 pm -
1 stop3h 58m
Mon 12/76:17 pm -
1 stop6h 00m
Deal found 9/26![Delta logo]()
$273
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:12 am -
1 stop5h 19m
Sat 10/315:40 am -
1 stop4h 27m
Deal found 9/24![Delta logo]()
$285
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:12 am -
1 stop5h 19m
Mon 11/97:22 pm -
1 stop5h 02m
Deal found 9/26![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
1 stop3h 53m
Sat 10/315:00 pm -
1 stop3h 06m
Deal found 9/26![Delta logo]()
$342
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:55 am -
2 stops7h 55m
Sun 11/87:05 am -
2 stops11h 15m
Deal found 9/26![Southwest logo]()
$580
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:19 am -
1 stop3h 12m
Sun 11/86:23 pm -
1 stop5h 55m
Deal found 9/26![Delta logo]()
$409
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:10 pm -
1 stop3h 55m
Sat 10/178:10 am -
2 stops10h 30m
Deal found 9/25![Southwest logo]()
$589
Last-minute flights from Panama City to KnoxvilleDiscover last-minute flight deals from Panama City to Knoxville. Data last updated September 28, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Knoxville. Data last updated September 28, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:42 pm -
1 stop4h 13m
Sat 10/177:58 pm -
1 stop4h 55m
Deal found 9/25![American Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop3h 54m
Sat 10/246:23 pm -
1 stop5h 55m
Deal found 9/26![Delta logo]()
$342
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:12 am -
1 stop5h 19m
Sat 10/315:40 am -
1 stop4h 27m
Deal found 9/24![Delta logo]()
$285
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:55 am -
2 stops11h 00m
Sat 10/316:40 am -
1 stop3h 35m
Deal found 9/24![Southwest logo]()
$334
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/289:19 am -
1 stop3h 21m
Sun 11/14:11 pm -
1 stop4h 42m
Deal found 9/26![Delta logo]()
$294
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:34 pm -
1 stop3h 48m
Sat 10/315:40 am -
1 stop4h 27m
Deal found 9/26![Delta logo]()
$259
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:12 am -
1 stop5h 28m
Sun 11/15:40 am -
1 stop3h 34m
Deal found 9/26![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:12 am -
1 stop5h 28m
Wed 11/115:40 am -
1 stop5h 50m
Deal found 9/25![Delta logo]()
$273
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:12 am -
1 stop5h 28m
Fri 11/134:00 pm -
1 stop3h 05m
Deal found 9/25![Delta logo]()
$287
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop3h 54m
Sun 11/157:22 pm -
1 stop5h 02m
Deal found 9/25![Delta logo]()
$308
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop3h 54m
Sun 11/15:40 am -
1 stop3h 34m
Deal found 9/26![Delta logo]()
$333
One-way flights from Panama City to KnoxvilleSearch for one-way flight options from Panama City to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 28, 2026.
Search for one-way flight options from Panama City to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 28, 2026.
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:12 am -
1 stop5h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Delta logo]()
$130
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:55 am -
2 stops9h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Southwest logo]()
$199
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop3h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Delta logo]()
$213
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:15 am -
1 stop6h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![American Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:55 am -
2 stops9h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Southwest logo]()
$334
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/114:30 pm -
1 stop4h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Delta logo]()
$440
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:10 pm -
1 stop3h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Southwest logo]()
$504
Find flight deals from Panama City to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $259 (Delta) |
One-way from | $130 (Delta) |
Popular in | August |
Cheapest in | June |
Average price | $350 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 28, 2026.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Thu 10/29
10:55 am-9:35 pm
2 stops9h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$199
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Thu 10/22
6:00 am-10:54 am
1 stop3h 54m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$213
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Wed 10/28
9:19 am-3:26 pm
1 stop5h 07m
Knoxville McGhee Tyson
Sat 10/31
5:40 am-9:07 am
1 stop4h 27m
$259
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Fri 12/4
6:59 pm-11:57 pm
1 stop3h 58m
Knoxville McGhee Tyson
Mon 12/7
6:17 pm-11:17 pm
1 stop6h 00m
$273
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Sat 10/24
7:12 am-1:31 pm
1 stop5h 19m
Knoxville McGhee Tyson
Sat 10/31
5:40 am-9:07 am
1 stop4h 27m
$285
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Thu 11/5
7:12 am-1:31 pm
1 stop5h 19m
Knoxville McGhee Tyson
Mon 11/9
7:22 pm-11:24 pm
1 stop5h 02m
$309
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Mon 10/5
7:15 am-3:12 pm
1 stop6h 57m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$329
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Thu 10/22
10:55 am-9:35 pm
2 stops9h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$334
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Sat 10/24
5:55 am-5:55 pm
2 stops11h 00m
Knoxville McGhee Tyson
Sat 10/31
6:40 am-9:15 am
1 stop3h 35m
$334
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Sat 10/31
6:00 am-10:53 am
1 stop3h 53m
Knoxville McGhee Tyson
Sat 10/31
5:00 pm-7:06 pm
1 stop3h 06m
$342
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Panama City to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
ECP-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 28, 2026.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Comfort
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Comfort
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Other flights from Panama City
Popular flights
Alternative routes for Panama City to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to Knoxville by cabin class
Find flights from Panama City to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 28, 2026.
Panama City and Knoxville flights
Browse other Panama City and Knoxville flight options. Last updated on September 28, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Knoxville
Discover the top airline that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$204 | Average$376 | FlexibilityNo cancel fee | On-timeN/A |