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Knoxville

$104+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated October 30, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$200
(Kiwi.com)

One-way from

$107
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$394
Provider with most accurate pricing for New Orleans Louis Armstrong-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for New Orleans Louis Armstrong-Knoxville McGhee Tyson flights.
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From Louisiana to Knoxville McGhee Tyson
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One-way flight from Louisiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 4% potential increase in price ($14 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:21 pmMSY - TYS
2 stops30h 35mMultiple Airlines
Mon 11/179:09 pmTYS - MSY
1 stop16h 53mMultiple Airlines
Deal found 10/28$200
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:52 pmMSY - TYS
1 stop6h 57mMultiple Airlines
Mon 12/85:34 pmTYS - MSY
1 stop6h 16mMultiple Airlines
Deal found 10/29$217
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:59 pmMSY - TYS
1 stop12h 05mMultiple Airlines
Tue 11/1811:24 amTYS - MSY
1 stop23h 41mMultiple Airlines
Deal found 10/29$220
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/263:56 pmMSY - TYS
1 stop24h 33mMultiple Airlines
Wed 12/312:53 pmTYS - MSY
1 stop6h 26mMultiple Airlines
Deal found 10/29$226
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/173:20 pmMSY - TYS
1 stop15h 58mMultiple Airlines
Sun 12/215:42 pmTYS - MSY
1 stop23h 23mMultiple Airlines
Deal found 10/29$230
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:20 pmMSY - TYS
2 stops17h 43mMultiple Airlines
Thu 12/412:43 pmTYS - MSY
1 stop9h 59mMultiple Airlines
Deal found 10/30$232
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:59 pmMSY - TYS
1 stop12h 05mMultiple Airlines
Sun 11/169:54 amTYS - MSY
1 stop5h 54mMultiple Airlines
Deal found 10/28$239
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/183:10 pmMSY - TYS
1 stop5h 03mMultiple Airlines
Sun 12/219:08 amTYS - MSY
1 stop15h 51mMultiple Airlines
Deal found 10/30$247
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:44 amLFT - TYS
1 stop6h 14mDelta
Wed 12/105:40 amTYS - LFT
1 stop6h 24mDelta
Deal found 10/29$249
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:27 pmBTR - TYS
1 stop5h 24mAmerican Airlines
Sun 11/234:27 pmTYS - BTR
1 stop7h 14mAmerican Airlines
Deal found 10/30$249
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/61:44 pmLFT - TYS
2 stops9h 13mAmerican Airlines
Wed 12/106:18 pmTYS - LFT
1 stop5h 55mAmerican Airlines
Deal found 10/29$254
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/91:44 pmLFT - TYS
2 stops9h 13mAmerican Airlines
Sat 12/131:37 pmTYS - LFT
2 stops10h 36mAmerican Airlines
Deal found 10/29$259

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Louisiana

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 11/13

3:21 pm-10:56 pm

2 stops30h 35m

Knoxville McGhee Tyson

Mon 11/17

9:09 pm-1:02 pm

1 stop16h 53m

$200

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 11/26

3:56 pm-5:29 pm

1 stop24h 33m

Knoxville McGhee Tyson

Sun 12/7

5:23 pm-12:57 pm

2 stops20h 34m

$212

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 12/5

1:52 pm-9:49 pm

1 stop6h 57m

Knoxville McGhee Tyson

Mon 12/8

5:34 pm-10:50 pm

1 stop6h 16m

$217

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 12/17

3:20 pm-8:18 am

1 stop15h 58m

Knoxville McGhee Tyson

Sun 12/21

5:42 pm-4:05 pm

1 stop23h 23m

$230

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 11/17

9:40 am-10:34 am

1 stop23h 54m

Knoxville McGhee Tyson

Thu 11/20

5:49 pm-1:45 pm

2 stops20h 56m

$243

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 11/14

8:59 pm-10:04 am

1 stop12h 05m

Knoxville McGhee Tyson

Tue 11/18

11:24 am-6:52 am

2 stops20h 28m

$246

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/18

3:10 pm-9:13 pm

1 stop5h 03m

Knoxville McGhee Tyson

Sun 12/21

9:08 am-11:59 pm

1 stop15h 51m

$247

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 11/6

11:05 am-10:26 pm

2 stops34h 21m

Knoxville McGhee Tyson

Mon 11/10

6:11 pm-1:02 pm

1 stop19h 51m

$248

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Tue 12/9

6:29 pm-11:59 pm

1 stop4h 30m

Knoxville McGhee Tyson

Sat 12/13

5:51 pm-9:57 pm

1 stop5h 06m

$249

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Sat 12/6

11:44 am-6:58 pm

1 stop6h 14m

Knoxville McGhee Tyson

Wed 12/10

5:40 am-11:04 am

1 stop6h 24m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 43 results
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Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $152). Flying from Louisiana to Knoxville in October is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from LA to TYS?

Find hourly flight availability from Louisiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Louisiana to Knoxville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 12% on airfare.

What is the cheapest day to fly from Louisiana to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Louisiana to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Louisiana to Knoxville flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Louisiana to Knoxville?

    For as low as $249, American Airlines can have you in Knoxville from Louisiana in 4h 30m. The distance from Louisiana to Knoxville is about 603 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is New Orleans Louis Armstrong - Knoxville McGhee Tyson. You may also consider Shreveport - Knoxville McGhee Tyson or Lafayette Regional - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $152). Flying from Louisiana to Knoxville in October is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Louisiana to Knoxville

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Top 3 airlines flying from Louisiana to Knoxville

Discover the top 3 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$368FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$380FlexibilityNo cancel feeOn-time71%
DeltaCheapest$244Average$394FlexibilityNo cancel feeOn-timeN/A

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