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$124+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/31. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated January 7, 2026.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$205
(Mytrip)

One-way from

$124
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$283
Provider with most accurate pricing for New Orleans Louis Armstrong-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for New Orleans Louis Armstrong-Knoxville McGhee Tyson flights.
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From Louisiana to Knoxville McGhee Tyson
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One-way flight from Louisiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 6% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/239:51 pmMSY - TYS
1 stop17h 33mMultiple Airlines
Wed 2/253:50 pmTYS - MSY
1 stop6h 05mMultiple Airlines
Deal found 1/5$201
This Mytrip deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:05 amMSY - TYS
1 stop8h 52mMultiple Airlines
Fri 2/612:55 pmTYS - MSY
1 stop11h 03mMultiple Airlines
Deal found 1/6$205
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/3011:10 amMSY - TYS
1 stop10h 11mMultiple Airlines
Sat 1/315:59 pmTYS - MSY
1 stop15h 23mMultiple Airlines
Deal found 1/5$206
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/237:42 pmMSY - TYS
1 stop14h 27mMultiple Airlines
Sun 1/252:00 pmTYS - MSY
1 stop21h 20mMultiple Airlines
Deal found 1/6$211
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/62:40 pmMSY - TYS
1 stop6h 44mMultiple Airlines
Mon 3/99:36 pmTYS - MSY
1 stop11h 45mMultiple Airlines
Deal found 1/6$217
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:27 pmMSY - TYS
1 stop13h 39mMultiple Airlines
Sat 2/282:54 pmTYS - MSY
1 stop9h 04mMultiple Airlines
Deal found 1/5$225
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/77:00 amMSY - TYS
1 stop8h 40mMultiple Airlines
Fri 2/139:36 pmTYS - MSY
1 stop10h 45mMultiple Airlines
Deal found 1/7$231
This Mytrip deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/258:36 pmMSY - TYS
1 stop12h 34mMultiple Airlines
Wed 1/284:47 pmTYS - MSY
1 stop5h 42mMultiple Airlines
Deal found 1/6$232
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:27 pmSHV - TYS
1 stop5h 01mAmerican Airlines
Wed 3/45:47 pmTYS - SHV
1 stop6h 04mAmerican Airlines
Deal found 1/6$251
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/67:00 amLFT - TYS
1 stop7h 20mAmerican Airlines
Fri 2/134:29 pmTYS - LFT
1 stop7h 29mAmerican Airlines
Deal found 1/5$269
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:45 pmSHV - TYS
1 stop4h 28mDelta
Tue 10/277:20 pmTYS - SHV
1 stop5h 16mDelta
Deal found 1/6$269
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:00 amBTR - TYS
1 stop5h 31mAmerican Airlines
Sun 3/15:40 amTYS - BTR
1 stop5h 14mAmerican Airlines
Deal found 1/6$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Louisiana

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 2/4

6:05 am-3:57 pm

1 stop8h 52m

Knoxville McGhee Tyson

Fri 2/6

12:55 pm-10:58 pm

1 stop11h 03m

$205

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 1/23

7:42 pm-11:09 am

1 stop14h 27m

Knoxville McGhee Tyson

Sun 1/25

2:00 pm-10:20 am

1 stop21h 20m

$211

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 2/7

7:00 am-4:40 pm

1 stop8h 40m

Knoxville McGhee Tyson

Fri 2/13

9:36 pm-7:21 am

1 stop10h 45m

$231

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 2/20

8:36 pm-2:04 pm

1 stop16h 28m

Knoxville McGhee Tyson

Mon 2/23

6:30 am-6:06 pm

1 stop12h 36m

$231

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 2/26

6:20 am-2:35 pm

1 stop7h 15m

Knoxville McGhee Tyson

Sun 3/1

11:50 am-4:31 pm

1 stop5h 41m

$234

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 2/6

11:10 am-10:21 pm

1 stop10h 11m

Knoxville McGhee Tyson

Thu 2/12

9:44 pm-2:55 pm

1 stop18h 11m

$242

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 2/14

5:25 am-11:08 am

1 stop4h 43m

Knoxville McGhee Tyson

Tue 2/17

5:35 am-8:50 am

1 stop4h 15m

$243

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 2/14

7:05 pm-11:52 pm

1 stop3h 47m

Knoxville McGhee Tyson

Wed 2/18

5:35 am-8:50 am

1 stop4h 15m

$243

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 2/19

10:43 am-10:10 pm

2 stops10h 27m

Knoxville McGhee Tyson

Sat 2/21

9:24 pm-8:21 am

1 stop11h 57m

$247

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 2/6

11:10 am-10:21 pm

1 stop10h 11m

Knoxville McGhee Tyson

Thu 2/12

9:32 pm-4:05 pm

2 stops19h 33m

$253

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/6

Showing 1-10 of 46 results
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Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $144). Flying from Louisiana to Knoxville in September is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Louisiana to Knoxville?

    For as low as $279, American Airlines can have you in Knoxville from Louisiana in 4h 20m. The distance from Louisiana to Knoxville is about 608 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is New Orleans Louis Armstrong - Knoxville McGhee Tyson. You may also consider Baton Rouge Ryan - Knoxville McGhee Tyson or Lafayette Regional - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $144). Flying from Louisiana to Knoxville in September is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Louisiana to Knoxville

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Top 3 airlines flying from Louisiana to Knoxville

Discover the top 3 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$368FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$363FlexibilityNo cancel feeOn-time71%
DeltaCheapest$244Average$364FlexibilityNo cancel feeOn-timeN/A

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