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Knoxville

$105+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:40 amMSY - TYS
1 stop13h 33mMultiple Airlines
Sun 12/219:56 pmTYS - MSY
1 stop20h 54mMultiple Airlines
Deal found 12/2$215
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/165:15 amMSY - TYS
1 stop9h 47mMultiple Airlines
Mon 12/226:00 amTYS - MSY
1 stop8h 21mMultiple Airlines
Deal found 12/1$218
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:05 amMSY - TYS
1 stop15h 48mMultiple Airlines
Mon 12/226:00 amTYS - MSY
1 stop8h 21mMultiple Airlines
Deal found 12/2$244
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1411:12 amMSY - TYS
1 stop10h 30mMultiple Airlines
Sat 12/209:23 pmTYS - MSY
1 stop12h 24mMultiple Airlines
Deal found 12/3$250
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1411:12 amMSY - TYS
1 stop10h 30mMultiple Airlines
Mon 12/158:20 amTYS - MSY
1 stop5h 31mMultiple Airlines
Deal found 12/3$260
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:42 amSHV - TYS
1 stop4h 53mAmerican Airlines
Sun 12/211:24 pmTYS - SHV
1 stop7h 07mAmerican Airlines
Deal found 12/2$265
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:55 pmMSY - TYS
1 stop27h 43mMultiple Airlines
Sat 1/32:23 pmTYS - MSY
2 stops27h 04mMultiple Airlines
Deal found 12/2$279
This Mytrip deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/71:19 pmMSY - TYS
1 stop25h 38mFrontier
Sun 12/144:52 pmTYS - MSY
1 stop21h 06mFrontier
Deal found 12/3$281
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:33 pmSHV - TYS
1 stop4h 26mAmerican Airlines
Mon 12/155:24 amTYS - SHV
1 stop5h 13mAmerican Airlines
Deal found 12/1$309
This Delta deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:00 amSHV - TYS
1 stop6h 44mDelta
Mon 12/155:40 amTYS - SHV
1 stop5h 32mDelta
Deal found 12/3$354
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/81:22 pmSHV - TYS
2 stops8h 33mAmerican Airlines
Mon 12/154:22 pmTYS - SHV
1 stop6h 20mAmerican Airlines
Deal found 12/3$359
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:19 pmSHV - TYS
1 stop4h 26mAmerican Airlines
Tue 1/66:00 amTYS - SHV
1 stop6h 50mAmerican Airlines
Deal found 12/2$363

Find flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated December 4, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$168
(Kiwi.com)

One-way from

$105
(United Airlines)

Popular in

December

Cheapest in

July

Average price

$425
Provider with most accurate pricing for New Orleans Louis Armstrong-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for New Orleans Louis Armstrong-Knoxville McGhee Tyson flights.
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From Louisiana to Knoxville McGhee Tyson
Search Deals
One-way flight from Louisiana to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($24 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Louisiana

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 1/30

7:00 am-10:28 pm

1 stop14h 28m

Knoxville McGhee Tyson

Mon 2/2

11:00 am-6:47 pm

1 stop8h 47m

$168

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 1/15

2:26 pm-8:52 pm

1 stop5h 26m

Knoxville McGhee Tyson

Mon 1/19

6:45 am-1:24 pm

1 stop7h 39m

$209

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 1/22

9:55 am-5:06 pm

1 stop6h 11m

Knoxville McGhee Tyson

Mon 1/26

5:14 pm-9:07 pm

1 stop4h 53m

$209

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/18

6:40 am-9:13 pm

1 stop13h 33m

Knoxville McGhee Tyson

Sun 12/21

9:56 pm-5:50 pm

1 stop20h 54m

$215

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 12/16

5:15 am-4:02 pm

1 stop9h 47m

Knoxville McGhee Tyson

Mon 12/22

6:00 am-1:21 pm

1 stop8h 21m

$218

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 1/22

10:47 am-12:05 pm

3 stops24h 18m

Knoxville McGhee Tyson

Mon 1/26

12:55 pm-10:58 pm

1 stop11h 03m

$228

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 1/2

6:55 pm-11:38 pm

1 stop27h 43m

Knoxville McGhee Tyson

Mon 1/5

12:48 pm-11:55 pm

1 stop12h 07m

$239

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 1/8

9:53 am-3:19 pm

1 stop4h 26m

Knoxville McGhee Tyson

Sun 1/11

5:40 am-10:45 am

1 stop6h 05m

$243

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 12/19

5:05 am-9:53 pm

1 stop15h 48m

Knoxville McGhee Tyson

Mon 12/22

6:00 am-1:21 pm

1 stop8h 21m

$244

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Tue 1/27

6:00 am-11:08 am

1 stop4h 08m

Knoxville McGhee Tyson

Sat 1/31

5:00 pm-8:32 pm

1 stop4h 32m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/3

Showing 1-10 of 44 results
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Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $152). Flying from Louisiana to Knoxville in September is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from LA to TYS?

Find hourly flight availability from Louisiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

One of the essential ways to save on airfare from Louisiana to Knoxville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 12% on airfare.

What is the cheapest day to fly from Louisiana to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Louisiana to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Louisiana to Knoxville flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Louisiana to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Louisiana to Knoxville?

    For as low as $249, United Airlines can have you in Knoxville from Louisiana in 4h 08m. The distance from Louisiana to Knoxville is about 608 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is New Orleans Louis Armstrong - Knoxville McGhee Tyson. You may also consider Baton Rouge Ryan - Knoxville McGhee Tyson or Shreveport - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $152). Flying from Louisiana to Knoxville in September is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Louisiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisiana to Knoxville

Discover the top 3 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$369FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$364FlexibilityNo cancel feeOn-time71%
DeltaCheapest$244Average$368FlexibilityNo cancel feeOn-timeN/A

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