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$100+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated November 13, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$207
(Kiwi.com)

One-way from

$100
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$376
Provider with most accurate pricing for New Orleans Louis Armstrong-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for New Orleans Louis Armstrong-Knoxville McGhee Tyson flights.
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From Louisiana to Knoxville McGhee Tyson
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One-way flight from Louisiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:14 amMSY - TYS
1 stop12h 40mMultiple Airlines
Wed 12/2412:01 pmTYS - MSY
2 stops29h 26mMultiple Airlines
Deal found 11/12$207
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:20 pmMSY - TYS
1 stop16h 13mMultiple Airlines
Sun 12/75:23 pmTYS - MSY
2 stops24h 04mMultiple Airlines
Deal found 11/12$218
This Mytrip deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:20 pmMSY - TYS
2 stops19h 11mMultiple Airlines
Mon 12/85:34 pmTYS - MSY
1 stop6h 16mMultiple Airlines
Deal found 11/12$219
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/93:20 pmMSY - TYS
1 stop19h 43mMultiple Airlines
Wed 12/172:53 pmTYS - MSY
1 stop18h 54mMultiple Airlines
Deal found 11/10$223
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:52 pmMSY - TYS
1 stop6h 57mMultiple Airlines
Sun 12/75:23 pmTYS - MSY
2 stops24h 04mMultiple Airlines
Deal found 11/12$231
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2111:12 amMSY - TYS
1 stop10h 30mMultiple Airlines
Mon 12/226:00 amTYS - MSY
1 stop8h 21mMultiple Airlines
Deal found 11/13$233
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1111:12 amMSY - TYS
1 stop10h 30mMultiple Airlines
Sun 12/145:23 pmTYS - MSY
2 stops24h 04mMultiple Airlines
Deal found 11/11$244
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:20 pmMSY - TYS
2 stops29h 17mMultiple Airlines
Wed 12/172:53 pmTYS - MSY
1 stop18h 54mMultiple Airlines
Deal found 11/12$246
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:23 pmBTR - TYS
1 stop6h 36mAmerican Airlines
Mon 12/86:18 pmTYS - BTR
1 stop5h 33mAmerican Airlines
Deal found 11/12$249
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:33 pmBTR - TYS
1 stop4h 26mAmerican Airlines
Tue 12/166:00 amTYS - BTR
2 stops8h 45mAmerican Airlines
Deal found 11/11$254
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2710:02 amLFT - TYS
1 stop4h 56mAmerican Airlines
Tue 12/26:38 pmTYS - LFT
1 stop5h 37mAmerican Airlines
Deal found 11/12$260
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/27:29 amSHV - TYS
1 stop6h 23mDelta
Tue 12/95:40 amTYS - SHV
1 stop5h 32mDelta
Deal found 11/12$264

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Louisiana

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 12/6

3:20 pm-11:31 am

2 stops19h 11m

Knoxville McGhee Tyson

Mon 12/8

5:34 pm-10:50 pm

1 stop6h 16m

$219

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sun 12/21

8:14 am-9:54 pm

1 stop12h 40m

Knoxville McGhee Tyson

Wed 12/24

11:08 am-11:59 pm

1 stop13h 51m

$220

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/4

3:20 pm-8:33 am

1 stop16h 13m

Knoxville McGhee Tyson

Sun 12/7

12:21 pm-12:51 pm

1 stop25h 30m

$220

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 12/9

3:20 pm-12:03 pm

1 stop19h 43m

Knoxville McGhee Tyson

Wed 12/17

2:53 pm-8:47 am

1 stop18h 54m

$223

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/11

11:12 am-10:42 pm

1 stop10h 30m

Knoxville McGhee Tyson

Sun 12/14

12:21 pm-12:51 pm

1 stop25h 30m

$233

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 12/12

6:20 am-5:20 pm

2 stops10h 00m

Knoxville McGhee Tyson

Fri 12/19

6:00 am-1:21 pm

1 stop8h 21m

$234

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 12/5

1:52 pm-9:49 pm

1 stop6h 57m

Knoxville McGhee Tyson

Sun 12/7

12:21 pm-12:51 pm

1 stop25h 30m

$234

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Fri 2/6

10:30 am-5:42 pm

1 stop6h 12m

Knoxville McGhee Tyson

Mon 2/9

5:14 pm-9:03 pm

1 stop4h 49m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Wed 1/28

1:55 pm-7:50 pm

1 stop4h 55m

Knoxville McGhee Tyson

Sun 2/1

6:59 am-11:25 am

1 stop5h 26m

$249

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Sat 1/31

7:00 am-3:20 pm

1 stop7h 20m

Knoxville McGhee Tyson

Mon 2/2

4:00 pm-11:01 pm

1 stop8h 01m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 42 results
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Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $152). Flying from Louisiana to Knoxville in September is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from LA to TYS?

Find hourly flight availability from Louisiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

One of the essential ways to save on airfare from Louisiana to Knoxville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 12% on airfare.

What is the cheapest day to fly from Louisiana to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Louisiana to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Louisiana to Knoxville flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Louisiana to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Louisiana to Knoxville?

    For as low as $249, American Airlines can have you in Knoxville from Louisiana in 4h 55m. The distance from Louisiana to Knoxville is about 551 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is New Orleans Louis Armstrong - Knoxville McGhee Tyson. You may also consider Shreveport - Knoxville McGhee Tyson or Baton Rouge Ryan - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $152). Flying from Louisiana to Knoxville in September is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Louisiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisiana to Knoxville

Discover the top 3 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$368FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$378FlexibilityNo cancel feeOn-time71%
DeltaCheapest$244Average$394FlexibilityNo cancel feeOn-timeN/A

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