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Knoxville

$157+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Dec 24 — Dec 311
Wed 12/24
Wed 12/31
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated November 24, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$218
(Kiwi.com)

One-way from

$157
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$376
Provider with most accurate pricing for New Orleans Louis Armstrong-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for New Orleans Louis Armstrong-Knoxville McGhee Tyson flights.
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From Louisiana to Knoxville McGhee Tyson
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One-way flight from Louisiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 6% potential increase in price ($24 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 24, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/711:12 amMSY - TYS
1 stop10h 30mMultiple Airlines
Thu 12/1112:21 pmTYS - MSY
1 stop25h 30mMultiple Airlines
Deal found 11/22$218
This Kiwi.com deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:05 amMSY - TYS
1 stop15h 48mMultiple Airlines
Tue 12/239:08 amTYS - MSY
1 stop24h 39mMultiple Airlines
Deal found 11/22$233
This Mytrip deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:34 amMSY - TYS
1 stop6h 34mMultiple Airlines
Tue 12/306:33 pmTYS - MSY
1 stop15h 14mMultiple Airlines
Deal found 11/20$241
This Mytrip deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/124:35 pmMSY - TYS
2 stops18h 28mMultiple Airlines
Mon 12/158:20 amTYS - MSY
1 stop5h 31mMultiple Airlines
Deal found 11/21$248
This Delta deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/147:39 amBTR - TYS
1 stop5h 05mDelta
Sun 12/217:05 amTYS - BTR
1 stop3h 44mDelta
Deal found 11/23$249
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:40 amMSY - TYS
1 stop13h 33mMultiple Airlines
Thu 12/2512:00 pmTYS - MSY
1 stop26h 16mMultiple Airlines
Deal found 11/20$263
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:20 pmMSY - TYS
1 stop21h 43mMultiple Airlines
Sun 12/2112:21 pmTYS - MSY
1 stop26h 00mMultiple Airlines
Deal found 11/23$269
This Delta deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:15 amMSY - TYS
1 stop6h 09mDelta
Wed 12/105:40 amTYS - MSY
1 stop4h 59mDelta
Deal found 11/21$277
This Delta deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:39 amBTR - TYS
1 stop3h 45mDelta
Wed 12/105:40 amTYS - BTR
1 stop5h 03mDelta
Deal found 11/21$279
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/262:06 pmMSY - TYS
1 stop6h 31mMultiple Airlines
Tue 12/309:08 amTYS - MSY
1 stop24h 39mMultiple Airlines
Deal found 11/23$283
This American Airlines deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/62:16 pmBTR - TYS
2 stops8h 41mAmerican Airlines
Wed 12/104:22 pmTYS - BTR
1 stop7h 29mAmerican Airlines
Deal found 11/21$284
This American Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:00 amLFT - TYS
1 stop4h 59mAmerican Airlines
Tue 12/24:27 pmTYS - LFT
1 stop7h 48mAmerican Airlines
Deal found 11/23$305

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 24, 2025.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Louisiana

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sun 12/7

11:12 am-10:42 pm

1 stop10h 30m

Knoxville McGhee Tyson

Thu 12/11

12:21 pm-12:51 pm

1 stop25h 30m

$218

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/25

11:34 am-7:08 pm

1 stop6h 34m

Knoxville McGhee Tyson

Tue 12/30

6:33 pm-8:47 am

1 stop15h 14m

$241

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 12/12

4:35 pm-12:03 pm

2 stops18h 28m

Knoxville McGhee Tyson

Mon 12/15

8:20 am-12:51 pm

1 stop5h 31m

$248

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Wed 1/7

5:15 pm-11:45 pm

1 stop5h 30m

Knoxville McGhee Tyson

Sat 1/10

5:40 am-10:41 am

1 stop6h 01m

$249

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Tue 1/27

5:40 pm-11:45 pm

1 stop5h 05m

Knoxville McGhee Tyson

Sat 1/31

5:00 pm-8:32 pm

1 stop4h 32m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Sun 12/14

7:39 am-1:44 pm

1 stop5h 05m

Knoxville McGhee Tyson

Sun 12/21

7:05 am-9:49 am

1 stop3h 44m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Tue 2/3

5:00 pm-11:45 pm

1 stop5h 45m

Knoxville McGhee Tyson

Sat 2/7

5:00 pm-10:01 pm

1 stop6h 01m

$249

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 12/19

6:40 am-9:53 pm

2 stops14h 13m

Knoxville McGhee Tyson

Tue 12/23

9:27 pm-8:47 am

1 stop12h 20m

$262

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/18

6:40 am-9:13 pm

1 stop13h 33m

Knoxville McGhee Tyson

Thu 12/25

12:00 pm-1:16 pm

1 stop26h 16m

$263

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 1/16

11:10 am-10:21 pm

1 stop10h 11m

Knoxville McGhee Tyson

Mon 1/19

12:55 pm-9:23 pm

2 stops33h 28m

$273

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/23

Showing 1-10 of 32 results
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Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $152). Flying from Louisiana to Knoxville in September is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from LA to TYS?

Find hourly flight availability from Louisiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 24, 2025.

One of the essential ways to save on airfare from Louisiana to Knoxville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 12% on airfare.

What is the cheapest day to fly from Louisiana to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Louisiana to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Louisiana to Knoxville flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Louisiana to Knoxville?

    For as low as $249, Delta can have you in Knoxville from Louisiana in 5h 30m. The distance from Louisiana to Knoxville is about 603 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is Baton Rouge Ryan - Knoxville McGhee Tyson. You may also consider New Orleans Louis Armstrong - Knoxville McGhee Tyson or Lafayette Regional - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $152). Flying from Louisiana to Knoxville in September is currently the most expensive (average of $245). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Louisiana to Knoxville

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Top 3 airlines flying from Louisiana to Knoxville

Discover the top 3 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$368FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$378FlexibilityNo cancel feeOn-time71%
DeltaCheapest$244Average$394FlexibilityNo cancel feeOn-timeN/A

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