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$104+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated August 18, 2025.

Round-trip from

$193
(Mytrip)

One-way from

$104
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$313
From Louisiana to Knoxville McGhee Tyson
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One-way flight from Louisiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 4% potential increase in price ($14 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/238:19 pmMSY - TYS
1 stop18h 22mMultiple Airlines
Sat 9/274:31 pmTYS - MSY
1 stop7h 12mMultiple Airlines
Deal found 8/16$213
This Mytrip deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/129:12 amMSY - TYS
1 stop9h 47mMultiple Airlines
Sun 9/147:35 pmTYS - MSY
2 stops24h 07mMultiple Airlines
Deal found 8/16$217
This Mytrip deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/138:22 pmMSY - TYS
1 stop13h 11mMultiple Airlines
Sat 10/184:26 pmTYS - MSY
2 stops16h 34mMultiple Airlines
Deal found 8/17$218
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/228:22 pmMSY - TYS
1 stop23h 03mMultiple Airlines
Mon 10/276:27 pmTYS - MSY
1 stop6h 26mMultiple Airlines
Deal found 8/16$227
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/39:12 amMSY - TYS
1 stop6h 54mMultiple Airlines
Mon 10/65:31 pmTYS - MSY
1 stop7h 22mMultiple Airlines
Deal found 8/17$229
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/169:28 pmMSY - TYS
2 stops17h 13mMultiple Airlines
Tue 9/2311:25 amTYS - MSY
1 stop12h 30mMultiple Airlines
Deal found 8/17$231
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/308:19 pmMSY - TYS
2 stops22h 05mMultiple Airlines
Tue 10/711:23 amTYS - MSY
1 stop13h 30mMultiple Airlines
Deal found 8/15$232
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:30 amMSY - TYS
1 stop8h 06mMultiple Airlines
Sun 10/129:15 pmTYS - MSY
1 stop11h 52mMultiple Airlines
Deal found 8/16$234
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/156:30 amMSY - TYS
1 stop9h 07mMultiple Airlines
Mon 9/221:22 pmTYS - MSY
1 stop10h 33mMultiple Airlines
Deal found 8/16$235
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:30 amMSY - TYS
1 stop8h 06mMultiple Airlines
Sun 10/199:01 pmTYS - MSY
1 stop12h 06mMultiple Airlines
Deal found 8/18$237
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/45:15 pmSHV - TYS
1 stop5h 29mDelta
Thu 10/92:27 pmTYS - SHV
1 stop6h 51mDelta
Deal found 8/16$249
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/105:38 pmBTR - TYS
1 stop4h 25mAmerican Airlines
Mon 9/157:45 pmTYS - BTR
1 stop4h 21mAmerican Airlines
Deal found 8/15$249

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Louisiana

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 10/13

8:22 pm-10:33 am

1 stop13h 11m

Knoxville McGhee Tyson

Sat 10/18

4:26 pm-11:53 pm

1 stop8h 27m

$193

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 9/23

8:19 pm-3:41 pm

1 stop18h 22m

Knoxville McGhee Tyson

Sat 9/27

4:31 pm-10:43 pm

1 stop7h 12m

$213

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 9/12

9:12 am-7:59 pm

1 stop9h 47m

Knoxville McGhee Tyson

Sun 9/14

7:35 pm-6:42 pm

2 stops24h 07m

$217

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 9/16

8:19 pm-3:41 pm

1 stop18h 22m

Knoxville McGhee Tyson

Tue 9/23

11:25 am-7:55 am

1 stop21h 30m

$225

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 10/22

8:22 pm-8:25 pm

1 stop23h 03m

Knoxville McGhee Tyson

Mon 10/27

6:27 pm-11:53 pm

1 stop6h 26m

$227

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 10/3

9:12 am-5:06 pm

1 stop6h 54m

Knoxville McGhee Tyson

Mon 10/6

5:31 pm-11:53 pm

1 stop7h 22m

$229

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 9/30

8:19 pm-7:24 pm

2 stops22h 05m

Knoxville McGhee Tyson

Tue 10/7

11:23 am-11:53 pm

1 stop13h 30m

$232

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 10/8

6:30 am-3:36 pm

1 stop8h 06m

Knoxville McGhee Tyson

Sun 10/12

9:15 pm-8:07 am

1 stop11h 52m

$234

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Sat 10/4

5:15 pm-11:44 pm

1 stop5h 29m

Knoxville McGhee Tyson

Thu 10/9

2:27 pm-8:18 pm

1 stop6h 51m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Wed 9/10

5:38 pm-11:03 pm

1 stop4h 25m

Knoxville McGhee Tyson

Mon 9/15

7:45 pm-11:06 pm

1 stop4h 21m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/16

Showing 1-10 of 51 results
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Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $294). Flying from Louisiana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from LA to TYS?

Find hourly flight availability from Louisiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 18, 2025.

When flying from Louisiana to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Louisiana to Knoxville?

    For as low as $249, Delta can have you in Knoxville from Louisiana in 4h 25m. The distance from Louisiana to Knoxville is about 551 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Louisiana to Knoxville one-way?

    One-way options have recently been found by users for as low as $155 on Delta. Other airlines that offer cheap prices include United Airlines from $155 and American Airlines from $160 one-way.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is New Orleans Louis Armstrong - Knoxville McGhee Tyson. You may also consider Shreveport - Knoxville McGhee Tyson or Baton Rouge Ryan - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $294). Flying from Louisiana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Louisiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisiana to Knoxville

Discover the top 3 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$104Average$369FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$198Average$369FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$381FlexibilityNo cancel feeOn-time71%

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