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$126+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated September 17, 2025.

Round-trip from

$230
(Kiwi.com)

One-way from

$126
(Delta)

Popular in

December

Cheapest in

July

Average price

$322
From Louisiana to Knoxville McGhee Tyson
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One-way flight from Louisiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 2% potential increase in price ($9 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:10 pmMSY - TYS
1 stop15h 23mMultiple Airlines
Thu 10/309:58 amTYS - MSY
1 stop14h 55mMultiple Airlines
Deal found 9/16$230
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:39 pmLFT - TYS
1 stop4h 29mAmerican Airlines
Mon 11/175:10 amTYS - LFT
1 stop5h 22mAmerican Airlines
Deal found 9/15$249
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:12 amMSY - TYS
1 stop10h 30mMultiple Airlines
Sun 12/76:30 amTYS - MSY
1 stop9h 05mMultiple Airlines
Deal found 9/15$249
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:46 pmBTR - TYS
1 stop4h 37mAmerican Airlines
Fri 10/314:41 pmTYS - BTR
1 stop6h 13mAmerican Airlines
Deal found 9/16$250
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/295:17 amMSY - TYS
1 stop7h 07mAmerican Airlines
Sat 11/15:15 amTYS - MSY
1 stop6h 07mAmerican Airlines
Deal found 9/17$251
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:25 amMSY - TYS
1 stop6h 17mDelta
Sun 11/98:05 pmTYS - MSY
1 stop4h 30mDelta
Deal found 9/15$260
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:10 amMSY - TYS
1 stop5h 53mMultiple Airlines
Mon 12/81:41 pmTYS - MSY
2 stops18h 54mMultiple Airlines
Deal found 9/16$262
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/211:02 amMSY - TYS
1 stop4h 42mMultiple Airlines
Sun 10/57:20 amTYS - MSY
1 stop27h 55mMultiple Airlines
Deal found 9/15$268
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2010:42 amMSY - TYS
1 stop3h 04mDelta
Sun 11/235:25 amTYS - MSY
1 stop3h 42mDelta
Deal found 9/15$269
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:34 amMSY - TYS
1 stop4h 16mAmerican Airlines
Mon 10/68:37 pmTYS - MSY
1 stop4h 36mAmerican Airlines
Deal found 9/15$274
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/45:11 pmSHV - TYS
1 stop4h 52mAmerican Airlines
Fri 10/106:00 amTYS - SHV
1 stop4h 45mAmerican Airlines
Deal found 9/14$279
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:48 pmMSY - TYS
1 stop4h 19mAmerican Airlines
Mon 10/68:37 pmTYS - MSY
1 stop4h 36mAmerican Airlines
Deal found 9/17$279

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Louisiana

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 10/27

6:10 pm-10:33 am

1 stop15h 23m

Knoxville McGhee Tyson

Thu 10/30

9:58 am-11:53 pm

1 stop14h 55m

$230

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 12/6

5:10 am-12:03 pm

1 stop5h 53m

Knoxville McGhee Tyson

Mon 12/8

8:20 am-12:51 pm

1 stop5h 31m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Sat 10/25

6:46 pm-12:23 am

1 stop4h 37m

Knoxville McGhee Tyson

Fri 10/31

4:41 pm-9:54 pm

1 stop6h 13m

$250

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 12/5

4:31 pm-12:03 pm

1 stop18h 32m

Knoxville McGhee Tyson

Mon 12/8

8:20 am-12:51 pm

1 stop5h 31m

$253

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 11/1

5:20 am-10:28 am

1 stop4h 08m

Knoxville McGhee Tyson

Mon 11/3

2:27 pm-4:47 pm

1 stop3h 20m

$260

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 11/20

10:42 am-2:46 pm

1 stop3h 04m

Knoxville McGhee Tyson

Sun 11/23

5:25 am-8:07 am

1 stop3h 42m

$269

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 11/20

9:12 am-2:46 pm

1 stop4h 34m

Knoxville McGhee Tyson

Tue 11/25

5:25 am-8:07 am

1 stop3h 42m

$269

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 10/3

6:34 am-11:50 am

1 stop4h 16m

Knoxville McGhee Tyson

Mon 10/6

8:37 pm-12:13 am

1 stop4h 36m

$274

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Sat 10/4

5:11 pm-11:03 pm

1 stop4h 52m

Knoxville McGhee Tyson

Fri 10/10

6:00 am-9:45 am

1 stop4h 45m

$279

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 10/2

11:02 am-4:44 pm

1 stop4h 42m

Knoxville McGhee Tyson

Sun 10/5

5:44 pm-3:47 pm

2 stops23h 03m

$281

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 43 results
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Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $295). Flying from Louisiana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from LA to TYS?

Find hourly flight availability from Louisiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from Louisiana to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Louisiana to Knoxville?

    For as low as $260, American Airlines can have you in Knoxville from Louisiana in 4h 08m. The distance from Louisiana to Knoxville is about 541 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Louisiana to Knoxville one-way?

    One-way options have recently been found by users for as low as $126 on Delta. Other airlines that offer cheap prices include American Airlines from $126 and United Airlines from $186 one-way.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is New Orleans Louis Armstrong - Knoxville McGhee Tyson. You may also consider Baton Rouge Ryan - Knoxville McGhee Tyson or Shreveport - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $295). Flying from Louisiana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Louisiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisiana to Knoxville

Discover the top 3 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$400FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$383FlexibilityNo cancel feeOn-time71%
DeltaCheapest$244Average$396FlexibilityNo cancel feeOn-timeN/A

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