$319+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Nov 12 — Nov 191
Round-trip
1 adult, Economy
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Find cheap flights from Harrisburg to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Harrisburg to Knoxville
Cheapest
Best
Last-minute
Cheapest flights from Harrisburg to KnoxvilleExplore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/72:56 pm -
1 stop5h 53m
Sat 11/147:50 am -
1 stop6h 41m
Deal found 10/11![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:15 am -
1 stop5h 15m
Tue 11/176:45 am -
2 stops7h 13m
Deal found 10/11![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:34 am -
1 stop3h 59m
Sat 10/316:00 am -
1 stop4h 17m
Deal found 10/12![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:15 am -
1 stop4h 58m
Sat 11/146:45 am -
2 stops7h 13m
Deal found 10/11![United Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:18 pm -
1 stop5h 17m
Sun 10/256:00 am -
1 stop4h 17m
Deal found 10/11![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop5h 58m
Wed 10/217:58 pm -
1 stop4h 26m
Deal found 10/13![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:15 am -
1 stop5h 06m
Sat 11/287:50 am -
1 stop5h 42m
Deal found 10/10![American Airlines logo]()
$407
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:30 am -
2 stops10h 24m
Sat 10/316:45 am -
2 stops7h 13m
Deal found 10/12![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:08 pm -
1 stop6h 41m
Fri 10/305:45 am -
1 stop4h 00m
Deal found 10/9![United Airlines logo]()
$444
Best flights from Harrisburg to KnoxvilleDiscover carefully curated flight deals from Harrisburg to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
Discover carefully curated flight deals from Harrisburg to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:15 am -
1 stop5h 15m
Tue 11/176:45 am -
2 stops7h 13m
Deal found 10/11![United Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:15 am -
1 stop4h 58m
Sat 11/146:45 am -
2 stops7h 13m
Deal found 10/11![United Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/26:20 am -
1 stop7h 00m
Sat 2/61:55 pm -
1 stop6h 54m
Deal found 10/9![United Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:30 am -
2 stops10h 24m
Sat 10/316:45 am -
2 stops7h 13m
Deal found 10/12![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:13 pm -
1 stop3h 46m
Fri 11/135:45 am -
1 stop4h 00m
Deal found 10/8![United Airlines logo]()
$477
Last-minute flights from Harrisburg to KnoxvilleDiscover last-minute flight deals from Harrisburg to Knoxville. Data last updated October 13, 2026 and is based on user searches.
Discover last-minute flight deals from Harrisburg to Knoxville. Data last updated October 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop5h 58m
Wed 10/217:58 pm -
1 stop4h 26m
Deal found 10/13![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:08 pm -
1 stop6h 41m
Fri 10/305:45 am -
1 stop4h 00m
Deal found 10/9![United Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:18 pm -
1 stop5h 17m
Sun 10/256:00 am -
1 stop4h 17m
Deal found 10/11![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:34 am -
1 stop3h 59m
Sat 10/316:00 am -
1 stop4h 17m
Deal found 10/12![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:30 am -
2 stops10h 24m
Sat 10/316:45 am -
2 stops7h 13m
Deal found 10/12![United Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/72:56 pm -
1 stop5h 53m
Sat 11/147:50 am -
1 stop6h 41m
Deal found 10/11![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:15 am -
1 stop4h 58m
Sat 11/146:45 am -
2 stops7h 13m
Deal found 10/11![United Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:15 am -
1 stop5h 15m
Tue 11/176:45 am -
2 stops7h 13m
Deal found 10/11![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:15 am -
1 stop5h 06m
Sat 11/287:50 am -
1 stop5h 42m
Deal found 10/10![American Airlines logo]()
$407
Find flight deals from Harrisburg to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (American Airlines) |
Popular in | March |
Cheapest in | January |
Average price | $604 |
Cheapflights Fare Finder
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Sat 11/14
6:15 am-11:30 am
1 stop5h 15m
Knoxville McGhee Tyson
Tue 11/17
6:45 am-1:58 pm
2 stops7h 13m
$324
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Sat 11/7
8:15 am-1:13 pm
1 stop4h 58m
Knoxville McGhee Tyson
Sat 11/14
6:45 am-1:58 pm
2 stops7h 13m
$352
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Tue 2/2
6:20 am-1:20 pm
1 stop7h 00m
Knoxville McGhee Tyson
Sat 2/6
1:55 pm-8:49 pm
1 stop6h 54m
$409
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Tue 10/27
10:30 am-8:54 pm
2 stops10h 24m
Knoxville McGhee Tyson
Sat 10/31
6:45 am-1:58 pm
2 stops7h 13m
$418
Quickest round-trip
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Fri 11/6
8:13 pm-11:59 pm
1 stop3h 46m
Knoxville McGhee Tyson
Fri 11/13
5:45 am-9:45 am
1 stop4h 00m
$477
Sorted by cheapest first
Compare providers for flights from Harrisburg to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Harrisburg to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
MDT-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Harrisburg to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 13, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Boarding
8.1
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Entertainment
7.8
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Boarding
8.1
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Entertainment
7.8
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Boarding
8.1
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Entertainment
7.8
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Boarding
8.1
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Newport
Bryson City
Murphy
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Complete your trip
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 13, 2026.
Harrisburg and Knoxville flights
Browse other Harrisburg and Knoxville flight options. Last updated on October 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Harrisburg to Knoxville
Discover the top 3 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$392 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$281 | Average$329 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$298 | Average$459 | FlexibilityNo cancel fee | On-timeN/A |