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$259+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Dec 21 — Dec 281
Sun 12/21
Sun 12/28
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 21, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$229
(American Airlines)

Popular in

September

Cheapest in

May

Average price

$391
Provider with most accurate pricing for Harrisburg-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Harrisburg-Knoxville McGhee Tyson flights.
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From Harrisburg to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 8% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.

This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:25 pmMDT - TYS
1 stop6h 30mAmerican Airlines
Mon 12/86:29 pmTYS - MDT
1 stop5h 10mAmerican Airlines
Deal found 11/18$259
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/191:52 pmMDT - TYS
1 stop6h 51mAmerican Airlines
Sat 1/102:19 pmTYS - MDT
1 stop5h 55mAmerican Airlines
Deal found 11/19$264
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:27 pmMDT - TYS
1 stop4h 01mDelta
Mon 12/155:39 pmTYS - MDT
1 stop5h 34mDelta
Deal found 11/19$288
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:40 amMDT - TYS
1 stop3h 39mAmerican Airlines
Tue 11/251:13 pmTYS - MDT
1 stop6h 27mAmerican Airlines
Deal found 11/19$319
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:30 amMDT - TYS
1 stop6h 47mUnited Airlines
Mon 12/225:35 pmTYS - MDT
1 stop6h 32mUnited Airlines
Deal found 11/19$323
This Kiwi.com deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:28 pmMDT - TYS
1 stop15h 04mMultiple Airlines
Mon 12/155:56 pmTYS - MDT
2 stops40h 24mMultiple Airlines
Deal found 11/19$401
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:15 amMDT - TYS
1 stop4h 41mUnited Airlines
Mon 12/295:45 amTYS - MDT
1 stop3h 51mUnited Airlines
Deal found 11/19$455
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:15 amMDT - TYS
1 stop4h 33mUnited Airlines
Mon 12/87:25 pmTYS - MDT
1 stop18h 27mUnited Airlines
Deal found 11/19$468
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:15 amMDT - TYS
2 stops7h 02mUnited Airlines
Tue 11/255:45 amTYS - MDT
1 stop3h 50mUnited Airlines
Deal found 11/19$470

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 21, 2025.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Harrisburg

Fly to

Knoxville

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 12/5

4:25 pm-10:55 pm

1 stop6h 30m

Knoxville McGhee Tyson

Mon 12/8

6:29 pm-11:39 pm

1 stop5h 10m

$259

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 12/12

7:27 pm-11:28 pm

1 stop4h 01m

Knoxville McGhee Tyson

Mon 12/15

5:39 pm-11:13 pm

1 stop5h 34m

$264

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 12/19

1:52 pm-8:43 pm

1 stop6h 51m

Knoxville McGhee Tyson

Sat 1/10

2:19 pm-8:14 pm

1 stop5h 55m

$264

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 1/8

10:34 am-8:52 pm

2 stops10h 18m

Knoxville McGhee Tyson

Mon 1/12

6:45 am-1:51 pm

2 stops7h 06m

$279

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 12/11

7:27 pm-11:28 pm

1 stop4h 01m

Knoxville McGhee Tyson

Mon 12/15

5:39 pm-11:13 pm

1 stop5h 34m

$288

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 1/20

12:53 pm-4:49 pm

1 stop3h 56m

Knoxville McGhee Tyson

Sat 1/24

6:05 am-12:13 pm

1 stop6h 08m

$289

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 1/25

10:34 am-2:49 pm

1 stop4h 15m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-4:34 pm

1 stop5h 24m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/18

Compare providers for flights from Harrisburg to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $123). Flying from Harrisburg to Knoxville in September is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to TYS?

Find hourly flight availability from Harrisburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 21, 2025.

A simple way to save on the total cost of your ticket is to fly from Harrisburg to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 27% on your trip compared to booking a flight at noon.

How much does it cost to fly round-trip from Harrisburg to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 21, 2025.
See what other customers who have flown with Delta and American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,002 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Knoxville?

    Airlines like American Airlines and Delta fly from Harrisburg to Knoxville in about 4h 01m. The time it takes to get you to your destination can typically vary by up to 2h 29m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Harrisburg to Knoxville round-trip?

    According to our current data, Delta ($198), and American Airlines ($228) offers the cheapest pricing from Harrisburg to Knoxville. Delta is 50% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $123). Flying from Harrisburg to Knoxville in September is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Harrisburg to Knoxville

Discover the top 2 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$403FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$422FlexibilityNo cancel feeOn-time71%

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