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$126+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Aug 22 — Aug 291
Fri 8/22
Fri 8/29
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 17, 2025.

Round-trip from

$233
(American Airlines)

One-way from

$126
(Kiwi.com)

Popular in

January

Cheapest in

May

Average price

$318
From Harrisburg to Knoxville McGhee Tyson
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One-way flight from Harrisburg to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 13% potential increase in price ($65 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2025.

This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/44:45 pmMDT - TYS
1 stop6h 18mAmerican Airlines
Tue 10/75:37 pmTYS - MDT
1 stop6h 11mAmerican Airlines
Deal found 8/15$233
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/66:45 amMDT - TYS
1 stop6h 40mUnited Airlines
Sat 9/277:00 amTYS - MDT
2 stops6h 54mUnited Airlines
Deal found 8/15$234
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/186:00 amMDT - TYS
1 stop4h 28mDelta
Sat 10/2512:47 pmTYS - MDT
2 stops10h 21mDelta
Deal found 8/16$254
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/188:00 amMDT - TYS
1 stop5h 47mAmerican Airlines
Sat 10/257:00 amTYS - MDT
1 stop4h 40mAmerican Airlines
Deal found 8/15$283
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/3010:30 amMDT - TYS
1 stop4h 10mUnited Airlines
Wed 9/32:00 pmTYS - MDT
1 stop5h 52mUnited Airlines
Deal found 8/15$299
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/28:21 pmMDT - TYS
1 stop13h 33mAllegiant Air
Sun 10/59:25 pmTYS - MDT
1 stop17h 18mAllegiant Air
Deal found 8/15$311
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:00 amMDT - TYS
1 stop3h 34mAmerican Airlines
Tue 11/258:04 pmTYS - MDT
1 stop4h 14mAmerican Airlines
Deal found 8/15$313
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/128:20 pmMDT - TYS
1 stop13h 47mAllegiant Air
Fri 9/198:30 amTYS - MDT
1 stop7h 14mAllegiant Air
Deal found 8/14$325

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2025.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Harrisburg

Fly to

Knoxville

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 10/4

4:45 pm-11:03 pm

1 stop6h 18m

Knoxville McGhee Tyson

Tue 10/7

5:37 pm-11:48 pm

1 stop6h 11m

$233

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 9/6

6:45 am-1:25 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sat 9/27

7:00 am-1:54 pm

2 stops6h 54m

$234

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 9/13

6:45 am-1:25 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sat 9/20

7:00 am-1:48 pm

2 stops6h 48m

$234

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 10/18

6:00 am-10:28 am

1 stop4h 28m

Knoxville McGhee Tyson

Sat 10/25

12:47 pm-11:08 pm

2 stops10h 21m

$254

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 10/18

8:00 am-1:47 pm

1 stop5h 47m

Knoxville McGhee Tyson

Sat 10/25

7:00 am-11:40 am

1 stop4h 40m

$283

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 9/5

4:34 pm-8:41 pm

1 stop28h 07m

$126

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 9/4

10:21 am-12:32 pm

1 stop26h 11m

$143

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 8/31

4:53 pm-9:06 pm

1 stop28h 13m

$188

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Mon 9/1

9:13 pm-7:24 pm

1 stop22h 11m

$189

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 9/4

12:17 pm-5:34 pm

2 stops29h 17m

$206

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/15

Showing 1-10 of 13 results
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Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $294). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to TYS?

Find hourly flight availability from Harrisburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 17, 2025.

A simple way to save on the total cost of your ticket is to fly from Harrisburg to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 28% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 17, 2025.
See what other customers who have flown with Delta and American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,986 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,986 reviews
Delta
8.0
Very good
7,986 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,986 reviews

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Harrisburg to Knoxville round-trip?

    According to our current data, Delta ($198), and American Airlines ($248) offers the cheapest pricing from Harrisburg to Knoxville. Delta is 50% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $294). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Alternative routes for Harrisburg to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Harrisburg to Knoxville

Discover the top 2 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$393FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$418FlexibilityNo cancel feeOn-time71%

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