How long is the flight from Harrisburg to Knoxville?

Airlines like American Airlines and United Airlines fly from Harrisburg to Knoxville in about 4h 41m. The time it takes to get you to your destination can typically vary by up to 1h 44m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What is the cheapest airline to fly from Harrisburg to Knoxville round-trip?

According to our current data, American Airlines ($228), offers the cheapest pricing from Harrisburg to Knoxville. American Airlines is 41% cheaper than the average price of flights available within the next 90 days to this destination.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Most accurate provider : When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Harrisburg to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

Can I find deals for business class flights from Harrisburg to Knoxville?

Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$149+ Flights from Harrisburg to Knoxville

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Cheap flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Wed 12/318:09 amMDT - TYS

1 stop7h 47mAmerican Airlines

Sun 1/45:42 amTYS - MDT

1 stop3h 28mAmerican Airlines

Deal found 12/16

$259

Fri 12/195:00 amMDT - TYS

1 stop3h 56mAmerican Airlines

Sat 1/107:11 pmTYS - MDT

1 stop4h 47mAmerican Airlines

Deal found 12/17

$284

Thu 12/251:58 pmMDT - TYS

1 stop4h 09mAmerican Airlines

Fri 12/266:25 pmTYS - MDT

1 stop3h 47mAmerican Airlines

Deal found 12/17

$299

Tue 12/236:15 amMDT - TYS

1 stop4h 41mUnited Airlines

Fri 1/25:45 amTYS - MDT

1 stop3h 51mUnited Airlines

Deal found 12/17

$323

Tue 12/236:15 amMDT - TYS

1 stop4h 41mUnited Airlines

Thu 1/19:50 amTYS - MDT

1 stop4h 04mUnited Airlines

Deal found 12/16

$406

Fri 12/196:15 amMDT - TYS

1 stop4h 41mUnited Airlines

Sat 1/106:45 amTYS - MDT

2 stops12h 14mUnited Airlines

Deal found 12/17

$453

Tue 12/238:52 pmMDT - TYS

1 stop25h 59mAllegiant Air

Fri 1/26:30 amTYS - MDT

1 stop25h 50mAllegiant Air

Deal found 12/17

$514

Sun 12/281:52 pmMDT - TYS

1 stop6h 51mAmerican Airlines

Fri 1/25:42 amTYS - MDT

1 stop3h 28mAmerican Airlines

Deal found 12/16

$518

Tue 12/238:52 pmMDT - TYS

2 stops26h 08mAllegiant Air

Thu 1/112:00 pmTYS - MDT

1 stop23h 01mAllegiant Air

Deal found 12/16

$520

Tue 12/239:40 amMDT - TYS

2 stops30h 35mMultiple Airlines

Fri 1/26:30 amTYS - MDT

1 stop25h 50mMultiple Airlines

Deal found 12/17

$530

Best flights from Harrisburg to Knoxville
Discover carefully curated flight deals from Harrisburg to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

Thu 2/193:35 pmMDT - TYS

1 stop6h 25mAmerican Airlines

Mon 2/234:56 pmTYS - MDT

1 stop6h 51mAmerican Airlines

Deal found 12/15

$249

Thu 1/16:15 amMDT - TYS

1 stop4h 41mUnited Airlines

Mon 1/55:45 amTYS - MDT

1 stop3h 51mUnited Airlines

Deal found 12/17

$259

Thu 4/26:00 amMDT - TYS

1 stop4h 11mDelta

Sun 4/55:01 pmTYS - MDT

1 stop6h 46mDelta

Deal found 12/17

$354

Wed 12/318:09 amMDT - TYS

1 stop7h 47mAmerican Airlines

Sun 1/45:42 amTYS - MDT

1 stop3h 28mAmerican Airlines

Deal found 12/16

$259

Tue 1/206:30 amMDT - TYS

1 stop6h 54mUnited Airlines

Thu 1/2211:07 amTYS - MDT

1 stop5h 27mUnited Airlines

Deal found 12/17

$272

Sat 1/103:10 pmMDT - TYS

1 stop5h 42mUnited Airlines

Wed 1/141:59 pmTYS - MDT

1 stop7h 06mUnited Airlines

Deal found 12/15

$309

Tue 1/1310:34 amMDT - TYS

1 stop4h 15mUnited Airlines

Mon 1/197:20 pmTYS - MDT

1 stop14h 15mUnited Airlines

Deal found 12/15

$393

Last-minute flights from Harrisburg to Knoxville
Discover last-minute flight deals from Harrisburg to Knoxville. Data last updated December 18, 2025 and is based on user searches.

Fri 12/195:00 amMDT - TYS

1 stop3h 56mAmerican Airlines

Sat 1/107:11 pmTYS - MDT

1 stop4h 47mAmerican Airlines

Deal found 12/17

$284

Tue 12/236:15 amMDT - TYS

1 stop4h 41mUnited Airlines

Fri 1/25:45 amTYS - MDT

1 stop3h 51mUnited Airlines

Deal found 12/17

$323

Thu 12/251:58 pmMDT - TYS

1 stop4h 09mAmerican Airlines

Fri 12/266:25 pmTYS - MDT

1 stop3h 47mAmerican Airlines

Deal found 12/17

$299

Wed 12/318:09 amMDT - TYS

1 stop7h 47mAmerican Airlines

Sun 1/45:42 amTYS - MDT

1 stop3h 28mAmerican Airlines

Deal found 12/16

$259

Thu 1/13:00 pmMDT - TYS

2 stops7h 39mUnited Airlines

Mon 1/55:45 amTYS - MDT

1 stop3h 51mUnited Airlines

Deal found 12/17

$325

Sat 1/103:10 pmMDT - TYS

1 stop5h 42mUnited Airlines

Wed 1/141:59 pmTYS - MDT

1 stop7h 06mUnited Airlines

Deal found 12/15

$309

Tue 1/1310:34 amMDT - TYS

2 stops10h 18mUnited Airlines

Mon 1/197:20 pmTYS - MDT

1 stop14h 15mUnited Airlines

Deal found 12/15

$398

Tue 1/206:30 amMDT - TYS

1 stop6h 54mUnited Airlines

Thu 1/2211:07 amTYS - MDT

1 stop5h 27mUnited Airlines

Deal found 12/17

$272

Tue 1/203:08 pmMDT - TYS

2 stops7h 46mAmerican Airlines

Thu 1/2212:15 pmTYS - MDT

1 stop3h 47mAmerican Airlines

Deal found 12/17

$277

One-way flights from Harrisburg to Knoxville
Search for one-way flight options from Harrisburg to Knoxville. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

Fri 2/205:01 pmMDT - TYS

1 stop6h 53mAmerican Airlines

Deal found 12/17

$149

Tue 12/238:52 pmMDT - TYS

1 stop25h 59mAllegiant Air

Deal found 12/16

$218

Tue 12/2310:56 amMDT - TYS

2 stops29h 19mMultiple Airlines

Deal found 12/16

$272

Fri 2/205:25 pmMDT - TYS

3 stops42h 47mMultiple Airlines

Deal found 12/17

$338

Fri 2/202:33 pmMDT - TYS

2 stops23h 13mUnited Airlines

Deal found 12/17

$400

Find flight deals from Harrisburg to Knoxville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$249 (American Airlines)
One-way from	$149 (American Airlines)
Popular in	September
Cheapest in	May
Average price	$311

Provider with most accurate pricing for Harrisburg-Knoxville McGhee Tyson flight deals.

Search Deals

Provider most trusted by Cheapflights users for Harrisburg-Knoxville McGhee Tyson flights.

Search Deals

From Harrisburg to Knoxville McGhee Tyson

Search Deals

One-way flight from Harrisburg to Knoxville McGhee Tyson

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($41 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 2/19

3:35 pm-10:00 pm

1 stop6h 25m

Knoxville McGhee Tyson

Mon 2/23

4:56 pm-11:47 pm

1 stop6h 51m

$249

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 1/1

6:15 am-10:56 am

1 stop4h 41m

Knoxville McGhee Tyson

Mon 1/5

5:45 am-9:36 am

1 stop3h 51m

$259

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 12/31

8:09 am-3:56 pm

1 stop7h 47m

Knoxville McGhee Tyson

Sun 1/4

5:42 am-9:10 am

1 stop3h 28m

$259

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 1/20

6:30 am-1:24 pm

1 stop6h 54m

Knoxville McGhee Tyson

Thu 1/22

11:07 am-4:34 pm

1 stop5h 27m

$272

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 1/10

3:10 pm-8:52 pm

1 stop5h 42m

Knoxville McGhee Tyson

Wed 1/14

1:59 pm-9:05 pm

1 stop7h 06m

$309

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 4/2

6:00 am-10:11 am

1 stop4h 11m

Knoxville McGhee Tyson

Sun 4/5

5:01 pm-11:47 pm

1 stop6h 46m

$354

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 1/13

10:34 am-2:49 pm

1 stop4h 15m

Knoxville McGhee Tyson

Mon 1/19

7:20 pm-9:35 am

1 stop14h 15m

$393

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 2/20

5:01 pm-11:54 pm

1 stop6h 53m

$149

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 12/23

8:52 pm-10:51 pm

1 stop25h 59m

$218

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 12/23

10:56 am-4:15 pm

2 stops29h 19m

$272

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 12 results

Compare providers for flights from Harrisburg to Knoxville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $123). Flying from Harrisburg to Knoxville in April is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to TYS?

A simple way to save on the total cost of your ticket is to fly from Harrisburg to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 27% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Knoxville

See what other customers who have flown with American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,054 reviews

Reviews

1 / 20

10.0

Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

American Airlines

7.2

Good

11,054 reviews

American Airlines

7.2

Good

11,054 reviews

Reviews

1 / 20

10.0

Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

How long is the flight from Harrisburg to Knoxville?
Airlines like American Airlines and United Airlines fly from Harrisburg to Knoxville in about 4h 41m. The time it takes to get you to your destination can typically vary by up to 1h 44m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What is the cheapest airline to fly from Harrisburg to Knoxville round-trip?
According to our current data, American Airlines ($228), offers the cheapest pricing from Harrisburg to Knoxville. American Airlines is 41% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?
Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Harrisburg to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.
Can I find deals for business class flights from Harrisburg to Knoxville?
Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Harrisburg to Knoxville?
Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $123). Flying from Harrisburg to Knoxville in April is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Cherokee

Crossville

Corbin

Morristown

Bryson City

Alcoa

Oak Ridge

Murphy

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Harrisburg to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$228	Average$420	FlexibilityNo cancel fee	On-time71%

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$149+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Harrisburg to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to KnoxvilleExplore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Find flight deals from Harrisburg to Knoxville

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Compare providers for flights from Harrisburg to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in December.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

What is the cheapest time of day to fly from MDT to TYS?

Reviews of airlines servicing Knoxville

See what other customers who have flown with American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Harrisburg to Knoxville?

What is the cheapest airline to fly from Harrisburg to Knoxville round-trip?

Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

How can I find direct flights from Harrisburg to Knoxville?

Can I find deals for business class flights from Harrisburg to Knoxville?

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Traveling to a place near Knoxville?

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Alternative routes for Harrisburg to Knoxville

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Top airline flying from Harrisburg to Knoxville

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Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.