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$125+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
May 16 — May 231
Sat 5/16
Sat 5/23
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 16, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:20 pm
MDT
-
TYS
1 stop17h 33m
Allegiant Air
Fri 4/247:30 am
TYS
-
MDT
1 stop9h 56m
Allegiant Air
Deal found 4/13$255
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:16 pm
MDT
-
TYS
1 stop16h 50m
Allegiant Air
Mon 5/117:30 am
TYS
-
MDT
1 stop9h 56m
Allegiant Air
Deal found 4/12$282
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:20 pm
MDT
-
TYS
1 stop17h 33m
Allegiant Air
Sun 5/38:20 am
TYS
-
MDT
1 stop24h 10m
Allegiant Air
Deal found 4/11$308
This Delta deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/44:19 pm
MDT
-
TYS
1 stop5h 01m
Delta
Tue 5/125:40 am
TYS
-
MDT
1 stop5h 27m
Delta
Deal found 4/11$309
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:42 am
MDT
-
TYS
1 stop6h 12m
United Airlines
Sat 5/91:52 pm
TYS
-
MDT
1 stop7h 27m
United Airlines
Deal found 4/11$312
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:20 pm
MDT
-
TYS
1 stop17h 33m
Allegiant Air
Mon 5/117:30 am
TYS
-
MDT
1 stop9h 56m
Allegiant Air
Deal found 4/12$316
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:20 pm
MDT
-
TYS
1 stop17h 33m
Allegiant Air
Sun 5/109:40 pm
TYS
-
MDT
1 stop19h 46m
Allegiant Air
Deal found 4/12$317
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:37 pm
MDT
-
TYS
1 stop5h 49m
American Airlines
Sat 5/26:38 pm
TYS
-
MDT
1 stop4h 20m
American Airlines
Deal found 4/13$319
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:31 pm
MDT
-
TYS
1 stop4h 24m
American Airlines
Sat 5/911:31 am
TYS
-
MDT
1 stop6h 30m
American Airlines
Deal found 4/11$329

Find flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$282
(Kiwi.com)

One-way from

$125
(Kiwi.com)

Popular in

March

Cheapest in

January

Average price

$358
Provider with most accurate pricing for Harrisburg-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Knoxville McGhee Tyson flights.
Search Deals
From Harrisburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Harrisburg to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($81 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($44 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 16, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 7/24

2:57 pm-7:53 pm

1 stop4h 56m

Knoxville McGhee Tyson

Mon 7/27

7:43 pm-11:53 pm

1 stop4h 10m

$309

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 5/2

6:15 am-4:54 pm

2 stops10h 39m

Knoxville McGhee Tyson

Sat 5/9

1:52 pm-9:19 pm

1 stop7h 27m

$314

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 5/8

6:16 pm-11:06 am

1 stop16h 50m

Knoxville McGhee Tyson

Mon 5/11

7:30 am-5:26 pm

1 stop9h 56m

$326

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 5/14

7:20 pm-12:53 pm

1 stop17h 33m

Knoxville McGhee Tyson

Thu 5/21

3:46 pm-8:44 am

1 stop16h 58m

$332

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 7/25

6:22 pm-10:39 pm

1 stop4h 17m

Knoxville McGhee Tyson

Tue 7/28

5:25 pm-11:09 pm

1 stop5h 44m

$333

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 5/8

6:33 pm-11:56 pm

1 stop5h 23m

Knoxville McGhee Tyson

Tue 5/12

5:40 am-11:07 am

1 stop5h 27m

$343

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 7/25

7:59 pm-11:54 pm

1 stop3h 55m

Knoxville McGhee Tyson

Tue 7/28

6:30 am-1:50 pm

2 stops7h 20m

$363

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 5/1

9:20 am-10:24 pm

1 stop13h 04m

Knoxville McGhee Tyson

Mon 5/4

2:06 pm-7:13 pm

1 stop5h 07m

$372

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 5/7

6:15 am-10:49 am

1 stop4h 34m

Knoxville McGhee Tyson

Mon 5/11

6:01 pm-12:55 am

1 stop6h 54m

$379

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 5/9

6:15 am-10:49 am

1 stop4h 34m

Knoxville McGhee Tyson

Mon 5/11

6:01 pm-12:55 am

1 stop6h 54m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 21 resultsSorted by cheapest first
1
2
3

Compare providers for flights from Harrisburg to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $271). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $929). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Harrisburg to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 16, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,412 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,412 reviews
Delta
7.9
Good
8,412 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,595 reviews
Delta
7.9
Good
8,412 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,587 reviews
Delta
7.9
Good
8,412 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Knoxville?

    Airlines like Delta, United Airlines, and Allegiant Air fly from Harrisburg to Knoxville in about 4h 56m. The time it takes to get you to your destination can typically vary by up to 11h 54m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Harrisburg to Knoxville round-trip?

    According to our current data, American Airlines ($228), United Airlines ($281), and Delta ($288) offers the cheapest pricing from Harrisburg to Knoxville. American Airlines is 49% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $271). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $929). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Alternative routes for Harrisburg to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Harrisburg to Knoxville

Discover the top 3 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$437FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$281Average$327FlexibilityNo cancel feeOn-time69%
DeltaCheapest$288Average$473FlexibilityNo cancel feeOn-timeN/A

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