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$149+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$283
(American Airlines)

One-way from

$149
(American Airlines)

Popular in

January

Cheapest in

May

Average price

$559
From Harrisburg to Knoxville McGhee Tyson
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One-way flight from Harrisburg to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 12% potential increase in price ($58 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/166:10 amMDT - TYS
1 stop5h 31mDelta
Tue 9/235:45 amTYS - MDT
1 stop5h 13mDelta
Deal found 9/15$279
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:00 amMDT - TYS
1 stop3h 34mAmerican Airlines
Sun 11/236:30 amTYS - MDT
1 stop4h 24mAmerican Airlines
Deal found 9/17$283
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:15 amMDT - TYS
1 stop4h 14mUnited Airlines
Sun 10/57:00 amTYS - MDT
2 stops6h 54mUnited Airlines
Deal found 9/16$286
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:15 amMDT - TYS
1 stop4h 14mUnited Airlines
Sat 10/47:00 amTYS - MDT
2 stops6h 54mUnited Airlines
Deal found 9/15$304
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/186:00 amMDT - TYS
1 stop6h 31mAmerican Airlines
Sat 10/257:00 amTYS - MDT
1 stop4h 00mAmerican Airlines
Deal found 9/15$312
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:23 pmMDT - TYS
1 stop5h 21mDelta
Sun 9/285:45 amTYS - MDT
1 stop5h 13mDelta
Deal found 9/15$314
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amMDT - TYS
1 stop5h 29mAmerican Airlines
Thu 10/166:11 pmTYS - MDT
1 stop4h 28mAmerican Airlines
Deal found 9/15$337
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2910:57 amMDT - TYS
1 stop6h 37mMultiple Airlines
Thu 10/25:44 pmTYS - MDT
2 stops16h 28mMultiple Airlines
Deal found 9/15$355
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/182:33 pmMDT - TYS
2 stops8h 17mUnited Airlines
Sat 10/259:55 amTYS - MDT
1 stop3h 59mUnited Airlines
Deal found 9/15$358

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Harrisburg

Fly to

Knoxville

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 10/2

6:15 am-10:29 am

1 stop4h 14m

Knoxville McGhee Tyson

Sun 10/5

7:00 am-1:54 pm

2 stops6h 54m

$286

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 10/3

6:15 am-10:29 am

1 stop4h 14m

Knoxville McGhee Tyson

Sun 10/5

7:00 am-1:54 pm

2 stops6h 54m

$286

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 2/21

7:56 pm-11:41 pm

1 stop3h 45m

Knoxville McGhee Tyson

Wed 2/25

7:58 am-2:30 pm

1 stop6h 32m

$289

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 9/30

6:15 am-10:29 am

1 stop4h 14m

Knoxville McGhee Tyson

Sat 10/4

7:00 am-1:54 pm

2 stops6h 54m

$304

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 10/18

6:00 am-12:31 pm

1 stop6h 31m

Knoxville McGhee Tyson

Sat 10/25

7:00 am-11:00 am

1 stop4h 00m

$312

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 10/15

6:00 am-11:29 am

1 stop5h 29m

Knoxville McGhee Tyson

Thu 10/16

6:11 pm-10:39 pm

1 stop4h 28m

$337

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 10/15

6:00 am-9:52 am

1 stop3h 52m

$149

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 12/31

10:30 am-2:48 pm

1 stop4h 18m

$149

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 12/30

5:00 am-9:27 am

1 stop4h 27m

$149

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 11/13

11:43 am-7:55 am

1 stop20h 12m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 15 results
1
2

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $295). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to TYS?

Find hourly flight availability from Harrisburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

A simple way to save on the total cost of your ticket is to fly from Harrisburg to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 28% on your trip compared to booking a flight at noon.

How much does it cost to fly round-trip from Harrisburg to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 17, 2025.
See what other customers who have flown with Delta and American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Knoxville?

    Airlines like United Airlines and American Airlines fly from Harrisburg to Knoxville in about 3h 45m. The time it takes to get you to your destination can typically vary by up to 29m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Harrisburg to Knoxville round-trip?

    According to our current data, Delta ($198), and American Airlines ($258) offers the cheapest pricing from Harrisburg to Knoxville. Delta is 51% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Harrisburg to Knoxville one-way?

    $149 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Allegiant Air, with prices starting from $149 and $170, respectively.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $295). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Harrisburg to Knoxville

Discover the top 2 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$403FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$418FlexibilityNo cancel feeOn-time71%

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