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Knoxville

$149+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
févr. 23 — mars 21
lun. 2/23
lun. 3/2
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on janvier 24, 2026.

This Delta deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 2/256:00 am
MDT
-
TYS
1 stop6h 11m
Delta
dim. 3/16:55 am
TYS
-
MDT
1 stop4h 21m
Delta
Deal found 1/22$297
This American Airlines deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 1/235:10 pm
MDT
-
TYS
1 stop4h 59m
American Airlines
mar. 1/278:09 am
TYS
-
MDT
1 stop4h 04m
American Airlines
Deal found 1/23$319
This United Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 2/43:10 pm
MDT
-
TYS
1 stop5h 42m
United Airlines
sam. 2/71:59 pm
TYS
-
MDT
1 stop7h 06m
United Airlines
Deal found 1/22$339
This American Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 8/128:10 am
MDT
-
TYS
1 stop6h 48m
American Airlines
dim. 8/166:21 am
TYS
-
MDT
1 stop5h 30m
American Airlines
Deal found 1/22$358
This United Airlines deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 4/225:47 pm
MDT
-
TYS
1 stop5h 16m
United Airlines
dim. 4/265:48 pm
TYS
-
MDT
1 stop6h 34m
United Airlines
Deal found 1/22$362
This Kiwi.com deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/911:40 am
MDT
-
TYS
1 stop10h 48m
Allegiant Air
mar. 2/101:00 pm
TYS
-
MDT
1 stop21h 19m
Allegiant Air
Deal found 1/23$387
This United Airlines deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 4/16:15 am
MDT
-
TYS
1 stop4h 35m
United Airlines
lun. 4/65:48 pm
TYS
-
MDT
1 stop6h 34m
United Airlines
Deal found 1/23$388
This Delta deal was found by Cheapflights users on 1/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 3/206:21 pm
MDT
-
TYS
1 stop5h 36m
Delta
mar. 3/245:10 pm
TYS
-
MDT
1 stop6h 27m
Delta
Deal found 1/22$394
This United Airlines deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 2/710:34 am
MDT
-
TYS
2 stops10h 18m
United Airlines
mer. 2/1111:10 am
TYS
-
MDT
2 stops7h 49m
United Airlines
Deal found 1/23$404

Find flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated janvier 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$297
(Delta)

One-way from

$149
(Delta)

Popular in

January

Cheapest in

May

Average price

$826
Provider with most accurate pricing for Harrisburg-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Knoxville McGhee Tyson flights.
Search Deals
From Harrisburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Harrisburg to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($129 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated janvier 24, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Harrisburg

Fly to

Knoxville

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

mer. 2/25

6:00 am-12:11 pm

1 stop6h 11m

Knoxville McGhee Tyson

dim. 3/1

6:55 am-11:16 am

1 stop4h 21m

$297

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

ven. 2/6

6:15 am-10:57 am

1 stop4h 42m

Knoxville McGhee Tyson

mar. 2/10

9:30 am-1:51 pm

1 stop4h 21m

$319

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

mer. 2/4

3:10 pm-8:52 pm

1 stop5h 42m

Knoxville McGhee Tyson

sam. 2/7

6:45 am-2:15 pm

1 stop7h 30m

$319

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

sam. 2/7

3:10 pm-8:52 pm

1 stop5h 42m

Knoxville McGhee Tyson

mer. 2/11

2:25 pm-6:59 pm

1 stop4h 34m

$319

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

mer. 4/22

6:15 am-4:52 pm

2 stops10h 37m

Knoxville McGhee Tyson

dim. 4/26

5:48 pm-12:22 am

1 stop6h 34m

$367

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

mer. 4/1

6:15 am-10:50 am

1 stop4h 35m

Knoxville McGhee Tyson

lun. 4/6

5:48 pm-12:22 am

1 stop6h 34m

$388

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

ven. 3/20

6:21 pm-11:57 pm

1 stop5h 36m

Knoxville McGhee Tyson

mar. 3/24

5:10 pm-11:37 pm

1 stop6h 27m

$394

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

mer. 3/11

6:21 pm-11:57 pm

1 stop5h 36m

$149

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

sam. 4/25

5:39 pm-10:29 pm

1 stop4h 50m

$149

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

mer. 3/11

8:00 am-3:48 pm

2 stops7h 48m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/22

Showing 1-10 of 17 results
1
2

Compare providers for flights from Harrisburg to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $123). Flying from Harrisburg to Knoxville in September is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated janvier 24, 2026.
See what other customers who have flown with American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,193 reviews

Crew

8.0

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Overall

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,193 reviews
American Airlines
7.2
Good
11,193 reviews

Crew

8.0

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Overall

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Knoxville?

    Airlines like Delta and United Airlines fly from Harrisburg to Knoxville in about 4h 42m. The time it takes to get you to your destination can typically vary by up to 1h 29m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Harrisburg to Knoxville round-trip?

    According to our current data, American Airlines ($228), offers the cheapest pricing from Harrisburg to Knoxville. American Airlines is 48% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $123). Flying from Harrisburg to Knoxville in September is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Alternative routes for Harrisburg to Knoxville

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Top airline flying from Harrisburg to Knoxville

Discover the top airline that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated janvier 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$418FlexibilityNo cancel feeOn-time71%

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