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Knoxville

$232+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Sep 11 — Sep 181
Fri 9/11
Fri 9/18
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 12, 2026.

This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:54 pm -
1 stop4h 55m
Tue 9/157:20 pm -
1 stop4h 10m
Deal found 8/10$299
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:59 pm -
1 stop4h 00m
Sat 9/196:00 am -
2 stops7h 39m
Deal found 8/7$304
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:15 am -
1 stop4h 05m
Tue 8/256:12 pm -
1 stop5h 31m
Deal found 8/7$329
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:56 am -
1 stop27h 39m
Thu 8/278:00 am -
1 stop5h 36m
Deal found 8/7$331
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:57 am -
2 stops9h 56m
Mon 8/245:45 am -
1 stop3h 52m
Deal found 8/7$334
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:56 am -
1 stop27h 39m
Wed 8/2610:54 am -
1 stop26h 42m
Deal found 8/7$337
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:00 am -
1 stop3h 36m
Mon 8/247:41 pm -
1 stop4h 02m
Deal found 8/7$349
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:15 am -
2 stops7h 02m
Mon 8/245:45 am -
1 stop3h 52m
Deal found 8/10$354
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:59 pm -
1 stop4h 00m
Thu 9/176:00 am -
2 stops7h 39m
Deal found 8/11$366
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:18 pm -
1 stop5h 17m
Tue 10/277:50 am -
1 stop3h 52m
Deal found 8/11$369

Find flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$299
(United Airlines)

One-way from

$232
(Kiwi.com)

Popular in

March

Cheapest in

January

Average price

$699
Provider with most accurate pricing for Harrisburg-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Knoxville McGhee Tyson flights.
Search Deals
From Harrisburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Harrisburg to Knoxville McGhee Tyson
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Fri 9/18

7:59 pm-11:59 pm

1 stop4h 00m

Knoxville McGhee Tyson

Sat 9/19

7:20 pm-11:30 pm

1 stop4h 10m

$299

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Sun 9/6

6:30 am-1:18 pm

1 stop6h 48m

Knoxville McGhee Tyson

Sun 9/13

5:45 am-9:37 am

1 stop3h 52m

$299

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Tue 1/26

2:12 pm-9:05 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sat 1/30

12:00 pm-9:20 pm

2 stops9h 20m

$374

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Sat 9/12

2:52 pm-10:49 pm

2 stops7h 57m

Knoxville McGhee Tyson

Wed 9/16

6:00 am-1:39 pm

2 stops7h 39m

$393

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Tue 8/25

2:52 pm-8:24 pm

1 stop5h 32m

Knoxville McGhee Tyson

Sat 8/29

7:00 am-1:32 pm

1 stop6h 32m

$399

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Thu 9/10

7:59 pm-11:59 pm

1 stop4h 00m

Knoxville McGhee Tyson

Wed 9/16

6:00 am-1:39 pm

2 stops7h 39m

$413
Cheapest one-way

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Fri 10/9

9:11 pm-9:43 am

1 stop12h 32m

$232
Quickest one-way

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Tue 9/15

7:59 pm-11:59 pm

1 stop4h 00m

$239

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Fri 10/9

9:11 pm-5:21 pm

3 stops44h 10m

$250

HarrisburgKnoxville

MDT Harrisburg - TYS Knoxville McGhee Tyson

MDTTYS

Harrisburg

Thu 8/27

12:44 pm-7:00 pm

1 stop6h 16m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/11

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Harrisburg to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in August.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $271). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $712). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 12, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,505 reviews

Crew

8.5

Entertainment

7.8

Overall

7.8

Comfort

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.8
Good
8,505 reviews
Delta
7.8
Good
8,505 reviews

Crew

8.5

Entertainment

7.8

Overall

7.8

Comfort

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
United Airlines
7.4
Good
10,111 reviews
Delta
7.8
Good
8,505 reviews

Crew

8.5

Entertainment

7.8

Overall

7.8

Comfort

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,913 reviews
Delta
7.8
Good
8,505 reviews

Crew

8.5

Entertainment

7.8

Overall

7.8

Comfort

7.8

Boarding

8.1

Food

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Knoxville?

    Airlines like United Airlines and Allegiant Air fly from Harrisburg to Knoxville in about 4h 55m. The time it takes to get you to your destination can typically vary by up to 22h 44m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Harrisburg to Knoxville round-trip?

    According to our current data, American Airlines ($228), United Airlines ($281), and Delta ($312) offers the cheapest pricing from Harrisburg to Knoxville. American Airlines is 51% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $271). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $712). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Alternative routes for Harrisburg to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Harrisburg to Knoxville

Discover the top 3 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$426FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$281Average$327FlexibilityNo cancel feeOn-time69%
DeltaCheapest$312Average$459FlexibilityNo cancel feeOn-timeN/A

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