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$145+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
May 29 — Jun 51
Fri 5/29
Fri 6/5
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:14 pm
MDT
-
TYS
1 stop13h 27m
Allegiant Air
Mon 6/110:03 pm
TYS
-
MDT
1 stop13h 26m
Allegiant Air
Deal found 4/25$273
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:20 pm
MDT
-
TYS
1 stop3h 44m
American Airlines
Sun 5/316:12 am
TYS
-
MDT
1 stop3h 56m
American Airlines
Deal found 4/27$309
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/253:45 pm
MDT
-
TYS
2 stops24h 30m
Multiple Airlines
Mon 6/110:03 pm
TYS
-
MDT
1 stop13h 26m
Multiple Airlines
Deal found 4/25$325
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:16 pm
MDT
-
TYS
1 stop16h 50m
Allegiant Air
Sun 5/109:40 pm
TYS
-
MDT
1 stop19h 46m
Allegiant Air
Deal found 4/26$338
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:37 pm
MDT
-
TYS
1 stop17h 40m
Allegiant Air
Sun 5/316:03 pm
TYS
-
MDT
1 stop14h 41m
Allegiant Air
Deal found 4/26$364
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:59 pm
MDT
-
TYS
1 stop3h 58m
United Airlines
Thu 9/245:45 am
TYS
-
MDT
1 stop3h 51m
United Airlines
Deal found 4/24$367
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:37 pm
MDT
-
TYS
2 stops20h 03m
Multiple Airlines
Sun 5/316:03 pm
TYS
-
MDT
1 stop14h 41m
Multiple Airlines
Deal found 4/26$385
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:03 pm
MDT
-
TYS
1 stop17h 06m
Allegiant Air
Sun 5/316:03 pm
TYS
-
MDT
1 stop14h 41m
Allegiant Air
Deal found 4/24$404
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:59 pm
MDT
-
TYS
1 stop3h 58m
United Airlines
Thu 9/35:45 am
TYS
-
MDT
1 stop3h 51m
United Airlines
Deal found 4/26$427
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:16 pm
MDT
-
TYS
1 stop16h 50m
Multiple Airlines
Sun 5/109:40 pm
TYS
-
MDT
2 stops18h 20m
Multiple Airlines
Deal found 4/26$430
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:15 am
MDT
-
TYS
2 stops10h 39m
United Airlines
Wed 5/137:18 pm
TYS
-
MDT
1 stop4h 10m
United Airlines
Deal found 4/24$438
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:15 am
MDT
-
TYS
1 stop4h 27m
United Airlines
Thu 6/47:19 pm
TYS
-
MDT
1 stop4h 11m
United Airlines
Deal found 4/27$447

Find flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$273
(Kiwi.com)

One-way from

$145
(Kiwi.com)

Popular in

March

Cheapest in

January

Average price

$358
Provider with most accurate pricing for Harrisburg-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Knoxville McGhee Tyson flights.
Search Deals
From Harrisburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Harrisburg to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($43 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 5/28

8:37 pm-2:17 pm

1 stop17h 40m

Knoxville McGhee Tyson

Sun 5/31

6:03 pm-8:44 am

1 stop14h 41m

$364
Quickest round-trip

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Mon 9/21

7:59 pm-11:57 pm

1 stop3h 58m

Knoxville McGhee Tyson

Thu 9/24

5:45 am-9:36 am

1 stop3h 51m

$367

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 8/30

7:59 pm-11:57 pm

1 stop3h 58m

Knoxville McGhee Tyson

Thu 9/3

5:45 am-9:36 am

1 stop3h 51m

$427

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 5/31

6:15 am-10:42 am

1 stop4h 27m

Knoxville McGhee Tyson

Thu 6/4

7:19 pm-11:30 pm

1 stop4h 11m

$447

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 6/5

10:13 am-3:07 pm

1 stop4h 54m

Knoxville McGhee Tyson

Fri 6/5

10:03 pm-2:18 pm

1 stop16h 15m

$453

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 5/21

8:37 pm-9:13 pm

1 stop24h 36m

Knoxville McGhee Tyson

Sun 5/24

8:00 am-5:07 pm

1 stop9h 07m

$515

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 10/15

2:56 pm-9:45 pm

1 stop6h 49m

Knoxville McGhee Tyson

Mon 10/19

7:20 pm-11:38 pm

1 stop4h 18m

$517
Cheapest one-way

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 6/28

8:50 pm-9:13 pm

1 stop24h 23m

$151

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 5/28

5:57 pm-11:37 pm

2 stops29h 40m

$162

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 5/28

5:00 pm-9:25 pm

1 stop4h 25m

$179

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/25

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Harrisburg to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $271). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $929). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Harrisburg to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 29, 2026.
See what other customers who have flown with United Airlines and American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,680 reviews

Boarding

7.7

Crew

8.1

Comfort

7.3

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
United Airlines
7.4
Good
9,680 reviews
United Airlines
7.4
Good
9,680 reviews

Boarding

7.7

Crew

8.1

Comfort

7.3

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
American Airlines
7.1
Good
11,678 reviews
United Airlines
7.4
Good
9,680 reviews

Boarding

7.7

Crew

8.1

Comfort

7.3

Overall

7.4

Food

6.6

Entertainment

7.1

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Knoxville?

    Airlines like Allegiant Air and United Airlines fly from Harrisburg to Knoxville in about 3h 58m. The time it takes to get you to your destination can typically vary by up to 13h 42m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Harrisburg to Knoxville round-trip?

    According to our current data, American Airlines ($228), and United Airlines ($281) offers the cheapest pricing from Harrisburg to Knoxville. American Airlines is 49% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $271). Flying from Harrisburg to Knoxville in March is currently the most expensive (average of $929). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Alternative routes for Harrisburg to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Harrisburg to Knoxville

Discover the top 2 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$437FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$281Average$327FlexibilityNo cancel feeOn-time69%

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