HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$229+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Harrisburg to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$229
(American Airlines)

One-way from

$229
(United Airlines)

Popular in

January

Cheapest in

May

Average price

$386
Provider with most accurate pricing for Harrisburg-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Knoxville McGhee Tyson flights.
Search Deals
From Harrisburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Harrisburg to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($62 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Find flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:00 amMDT - TYS
1 stop3h 56mAmerican Airlines
Thu 1/15:42 amTYS - MDT
1 stop3h 28mAmerican Airlines
Deal found 10/26$229
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:00 amMDT - TYS
1 stop6h 43mAmerican Airlines
Sat 11/151:13 pmTYS - MDT
1 stop6h 27mAmerican Airlines
Deal found 10/27$239
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/55:40 pmMDT - TYS
1 stop5h 15mUnited Airlines
Wed 11/195:45 amTYS - MDT
1 stop3h 50mUnited Airlines
Deal found 10/27$254
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/74:57 pmMDT - TYS
1 stop19h 54mAllegiant Air
Thu 12/118:30 amTYS - MDT
1 stop10h 08mAllegiant Air
Deal found 10/28$258
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:55 pmMDT - TYS
1 stop6h 08mAmerican Airlines
Wed 11/197:20 pmTYS - MDT
1 stop4h 33mAmerican Airlines
Deal found 10/28$264
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:57 pmMDT - TYS
1 stop11h 19mMultiple Airlines
Mon 11/179:45 amTYS - MDT
1 stop10h 27mMultiple Airlines
Deal found 10/29$286
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:10 amMDT - TYS
1 stop4h 54mDelta
Wed 11/55:44 amTYS - MDT
1 stop5h 15mDelta
Deal found 10/27$289
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amMDT - TYS
1 stop3h 52mAmerican Airlines
Tue 11/48:07 amTYS - MDT
2 stops6h 22mAmerican Airlines
Deal found 10/28$294
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:15 amMDT - TYS
2 stops7h 02mUnited Airlines
Sat 11/151:52 pmTYS - MDT
1 stop7h 12mUnited Airlines
Deal found 10/27$304
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/299:33 amMDT - TYS
1 stop4h 02mAmerican Airlines
Wed 11/53:37 pmTYS - MDT
1 stop3h 29mAmerican Airlines
Deal found 10/29$309

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Harrisburg

Fly to

Knoxville

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 12/18

5:00 am-8:56 am

1 stop3h 56m

Knoxville McGhee Tyson

Thu 1/1

5:42 am-9:10 am

1 stop3h 28m

$229

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 11/11

6:00 am-12:43 pm

1 stop6h 43m

Knoxville McGhee Tyson

Sat 11/15

1:13 pm-7:40 pm

1 stop6h 27m

$239

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 11/5

5:40 pm-10:55 pm

1 stop5h 15m

Knoxville McGhee Tyson

Wed 11/19

5:45 am-9:35 am

1 stop3h 50m

$254

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 12/7

4:57 pm-12:51 pm

1 stop19h 54m

Knoxville McGhee Tyson

Thu 12/11

8:30 am-6:38 pm

1 stop10h 08m

$258

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Wed 11/5

2:55 pm-9:03 pm

1 stop6h 08m

Knoxville McGhee Tyson

Wed 11/19

7:20 pm-11:53 pm

1 stop4h 33m

$264

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 11/14

8:57 pm-8:16 am

1 stop11h 19m

Knoxville McGhee Tyson

Mon 11/17

9:45 am-8:12 pm

1 stop10h 27m

$286

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 1/9

3:10 pm-9:02 pm

1 stop5h 52m

Knoxville McGhee Tyson

Sun 1/11

6:45 am-1:51 pm

2 stops7h 06m

$305

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 11/11

6:15 am-1:17 pm

2 stops7h 02m

Knoxville McGhee Tyson

Sat 11/15

6:45 am-1:58 pm

2 stops7h 13m

$309

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 11/15

5:40 pm-10:55 pm

1 stop5h 15m

$229

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 12/12

6:30 am-1:17 pm

1 stop6h 47m

$360

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Compare providers for flights from Harrisburg to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $99). Flying from Harrisburg to Knoxville in September is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to TYS?

Find hourly flight availability from Harrisburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

A simple way to save on the total cost of your ticket is to fly from Harrisburg to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 27% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 29, 2025.
See what other customers who have flown with Delta and American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Overall

7.9

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Overall

7.9

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,992 reviews

Boarding

8.2

Overall

7.9

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Knoxville?

    Airlines like American Airlines, United Airlines, and Allegiant Air fly from Harrisburg to Knoxville in about 3h 56m. The time it takes to get you to your destination can typically vary by up to 15h 58m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Harrisburg to Knoxville round-trip?

    According to our current data, Delta ($198), and American Airlines ($258) offers the cheapest pricing from Harrisburg to Knoxville. Delta is 52% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $99). Flying from Harrisburg to Knoxville in September is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Harrisburg to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Nashville flights
Newark to Nashville flights
LaGuardia to Nashville flights
Dulles Intl to Nashville flights
Reagan-National to Nashville flights
Philadelphia to Nashville flights
John F Kennedy Intl to Memphis flights
LaGuardia to Knoxville flights
Newark to Memphis flights
LaGuardia to Memphis flights
John F Kennedy Intl to Knoxville flights
Reagan-National to Memphis flights
Dulles Intl to Memphis flights
Reagan-National to Knoxville flights
Newark to Knoxville flights
Philadelphia to Memphis flights
Dulles Intl to Knoxville flights
Pittsburgh to Nashville flights
Harrisburg to Nashville flights
Philadelphia to Knoxville flights
LaGuardia to Chattanooga flights
Allentown to Nashville flights
Newark to Chattanooga flights
John F Kennedy Intl to Chattanooga flights
Dulles Intl to Chattanooga flights
Scranton to Nashville flights
Philadelphia to Chattanooga flights
Pittsburgh to Memphis flights
Newark to Blountville flights
Reagan-National to Chattanooga flights
Pittsburgh to Knoxville flights
John F Kennedy Intl to Blountville flights
Harrisburg to Memphis flights
Allentown to Knoxville flights
LaGuardia to Blountville flights
Harrisburg to Chattanooga flights
State College to Nashville flights
Pittsburgh to Chattanooga flights
Dulles Intl to Blountville flights
Allentown to Memphis flights
Elmira to Nashville flights
Allentown to Chattanooga flights
Scranton to Memphis flights
State College to Knoxville flights
Philadelphia to Blountville flights
Reagan-National to Blountville flights
Erie to Nashville flights
Scranton to Knoxville flights
Elmira to Chattanooga flights

Top 2 airlines flying from Harrisburg to Knoxville

Discover the top 2 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$403FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$427FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.