$264+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from Harrisburg to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Harrisburg to Knoxville
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Cheapest flights from Harrisburg to KnoxvilleExplore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:36 am -
1 stop5h 51m
Sat 12/1212:42 pm -
1 stop6h 20m
Deal found 9/7![American Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:11 pm -
1 stop20h 42m
Fri 10/910:07 pm -
1 stop19h 18m
Deal found 9/6![Allegiant Air logo]()
$306
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:13 pm -
1 stop3h 46m
Sun 11/226:45 am -
2 stops7h 13m
Deal found 9/9![United Airlines logo]()
$312
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:17 am -
1 stop6h 14m
Sat 9/267:00 am -
1 stop3h 36m
Deal found 9/5![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:00 am -
1 stop5h 27m
Sat 12/127:06 am -
1 stop4h 34m
Deal found 9/8![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:08 pm -
1 stop6h 41m
Sat 10/246:00 am -
2 stops7h 59m
Deal found 9/6![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:13 am -
1 stop5h 08m
Mon 11/234:00 pm -
1 stop6h 45m
Deal found 9/9![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:10 pm -
1 stop6h 44m
Tue 11/174:30 pm -
2 stops7h 14m
Deal found 9/7![United Airlines logo]()
$335
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:59 pm -
1 stop4h 00m
Sat 9/266:00 am -
2 stops7h 59m
Deal found 9/5![United Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:11 pm -
1 stop20h 42m
Tue 10/61:50 pm -
1 stop23h 29m
Deal found 9/9![Allegiant Air logo]()
$346
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:03 pm -
1 stop5h 04m
Sat 9/197:00 am -
1 stop3h 36m
Deal found 9/4![American Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:30 am -
2 stops10h 24m
Sat 11/146:45 am -
2 stops7h 13m
Deal found 9/7![United Airlines logo]()
$368
Best flights from Harrisburg to KnoxvilleDiscover carefully curated flight deals from Harrisburg to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Harrisburg to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/26:00 am -
2 stops11h 03m
Sat 2/66:40 am -
2 stops7h 09m
Deal found 9/8![United Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:25 pm -
1 stop4h 41m
Mon 10/56:56 am -
2 stops7h 11m
Deal found 9/5![American Airlines logo]()
$578
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:55 pm -
1 stop23h 47m
Tue 10/66:00 am -
2 stops7h 59m
Deal found 9/9![United Airlines logo]()
$485
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:59 pm -
1 stop4h 00m
Thu 9/246:00 am -
2 stops7h 59m
Deal found 9/8![United Airlines logo]()
$553
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:08 pm -
1 stop6h 41m
Wed 9/309:45 am -
1 stop4h 14m
Deal found 9/7![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:54 pm -
1 stop4h 55m
Fri 9/251:35 pm -
1 stop24h 24m
Deal found 9/6![United Airlines logo]()
$598
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:54 pm -
1 stop4h 55m
Thu 9/246:00 am -
2 stops7h 59m
Deal found 9/4![United Airlines logo]()
$627
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:54 pm -
1 stop15h 51m
Fri 10/97:25 pm -
1 stop18h 34m
Deal found 9/6![United Airlines logo]()
$721
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:59 pm -
1 stop4h 00m
Sun 9/276:00 am -
1 stop7h 27m
Deal found 9/8![United Airlines logo]()
$754
Last-minute flights from Harrisburg to KnoxvilleDiscover last-minute flight deals from Harrisburg to Knoxville. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Harrisburg to Knoxville. Data last updated September 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:17 am -
1 stop4h 05m
Mon 9/146:15 am -
1 stop4h 02m
Deal found 9/5![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:52 pm -
2 stops7h 57m
Sun 9/135:45 am -
1 stop3h 52m
Deal found 9/7![United Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:17 am -
1 stop6h 14m
Sat 9/267:00 am -
1 stop3h 36m
Deal found 9/5![American Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:59 pm -
1 stop4h 00m
Sat 9/266:00 am -
2 stops7h 59m
Deal found 9/5![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:25 pm -
1 stop4h 41m
Mon 10/56:05 pm -
1 stop4h 54m
Deal found 9/5![American Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:09 pm -
1 stop4h 18m
Mon 10/55:28 pm -
1 stop5h 47m
Deal found 9/5![Delta logo]()
$439
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:11 pm -
1 stop20h 42m
Fri 10/910:07 pm -
1 stop19h 18m
Deal found 9/6![Allegiant Air logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:11 pm -
1 stop20h 42m
Tue 10/61:50 pm -
1 stop23h 29m
Deal found 9/9![Allegiant Air logo]()
$346
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:00 pm -
1 stop3h 40m
Mon 10/127:45 pm -
1 stop3h 54m
Deal found 9/7![Delta logo]()
$392
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:32 pm -
1 stop5h 46m
Sat 10/246:00 am -
1 stop4h 17m
Deal found 9/6![American Airlines logo]()
$299
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:08 pm -
1 stop6h 41m
Sat 10/246:00 am -
2 stops7h 59m
Deal found 9/6![United Airlines logo]()
$324
One-way flights from Harrisburg to KnoxvilleSearch for one-way flight options from Harrisburg to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from Harrisburg to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:46 am -
1 stop10h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Allegiant Air logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:28 pm -
2 stops43h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$299
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:55 pm -
1 stop19h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![United Airlines logo]()
$462
Find flight deals from Harrisburg to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $299 (American Airlines) |
One-way from | $264 (Kiwi.com) |
Popular in | March |
Cheapest in | January |
Average price | $529 |
Cheapflights Fare Finder
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Thu 9/17
11:46 am-10:36 pm
1 stop10h 50m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$264
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Thu 9/17
2:28 pm-10:14 am
2 stops43h 46m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$299
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Tue 2/2
6:00 am-5:03 pm
2 stops11h 03m
Knoxville McGhee Tyson
Sat 2/6
6:40 am-1:49 pm
2 stops7h 09m
$379
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Fri 10/2
2:55 pm-10:37 am
1 stop19h 42m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$462
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Fri 10/2
2:55 pm-2:42 pm
1 stop23h 47m
Knoxville McGhee Tyson
Tue 10/6
6:00 am-1:59 pm
2 stops7h 59m
$485
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Tue 9/22
7:59 pm-11:59 pm
1 stop4h 00m
Knoxville McGhee Tyson
Thu 9/24
6:00 am-1:59 pm
2 stops7h 59m
$553
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Sat 9/26
4:25 pm-9:06 pm
1 stop4h 41m
Knoxville McGhee Tyson
Mon 10/5
6:56 am-2:07 pm
2 stops7h 11m
$578
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Tue 9/29
2:08 pm-8:49 pm
1 stop6h 41m
Knoxville McGhee Tyson
Wed 9/30
9:45 am-1:59 pm
1 stop4h 14m
$579
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Mon 9/21
5:54 pm-10:49 pm
1 stop4h 55m
Knoxville McGhee Tyson
Fri 9/25
1:35 pm-1:59 pm
1 stop24h 24m
$598
HarrisburgKnoxville
MDT Harrisburg - TYS Knoxville McGhee Tyson
MDTTYS
Harrisburg
Sun 9/20
5:54 pm-10:49 pm
1 stop4h 55m
Knoxville McGhee Tyson
Thu 9/24
6:00 am-1:59 pm
2 stops7h 59m
$627
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Harrisburg to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Harrisburg to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
MDT-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Harrisburg to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 9, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
Harrisburg and Knoxville flights
Browse other Harrisburg and Knoxville flight options. Last updated on September 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Harrisburg to Knoxville
Discover the top 3 airlines that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$399 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$281 | Average$329 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$298 | Average$459 | FlexibilityNo cancel fee | On-timeN/A |