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$173+ Cheap flights from Harrisburg to Knoxville (MDT - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — TYS
Feb 10 — Feb 171
Tue 2/10
Tue 2/17
1 adult, Economy
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Cheap flight deals from Harrisburg to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 11, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(American Airlines)

One-way from

$173
(Kiwi.com)

Popular in

September

Cheapest in

May

Average price

$557
Provider with most accurate pricing for Harrisburg-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Harrisburg-Knoxville McGhee Tyson flights.
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From Harrisburg to Knoxville McGhee Tyson
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One-way flight from Harrisburg to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 3% potential increase in price ($16 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Harrisburg to Knoxville

Cheapest flights from Harrisburg to Knoxville
Explore the most affordable flight options available from Harrisburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 11, 2026.

This American Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/64:47 pmMDT - TYS
1 stop4h 34mAmerican Airlines
Mon 2/92:19 pmTYS - MDT
1 stop5h 55mAmerican Airlines
Deal found 1/10$249
This United Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/196:15 amMDT - TYS
1 stop4h 42mUnited Airlines
Tue 3/315:48 pmTYS - MDT
1 stop6h 34mUnited Airlines
Deal found 1/10$274
This United Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/318:29 amMDT - TYS
1 stop4h 48mUnited Airlines
Tue 3/317:20 pmTYS - MDT
1 stop4h 08mUnited Airlines
Deal found 1/10$293
This Delta deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/206:10 amMDT - TYS
1 stop6h 03mDelta
Tue 3/315:01 pmTYS - MDT
1 stop6h 36mDelta
Deal found 1/10$308
This United Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/36:30 amMDT - TYS
1 stop6h 54mUnited Airlines
Sat 2/76:45 amTYS - MDT
1 stop7h 30mUnited Airlines
Deal found 1/10$309
This United Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/156:30 amMDT - TYS
1 stop6h 54mUnited Airlines
Sat 1/1711:07 amTYS - MDT
1 stop5h 37mUnited Airlines
Deal found 1/11$319
This American Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/185:47 amMDT - TYS
1 stop3h 58mAmerican Airlines
Tue 3/317:02 amTYS - MDT
1 stop4h 59mAmerican Airlines
Deal found 1/10$334
This Delta deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:21 pmMDT - TYS
1 stop5h 30mDelta
Wed 4/112:03 pmTYS - MDT
1 stop5h 23mDelta
Deal found 1/10$338
This Delta deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/206:10 amMDT - TYS
1 stop6h 03mDelta
Wed 4/15:01 pmTYS - MDT
1 stop6h 36mDelta
Deal found 1/10$339
This American Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:00 amMDT - TYS
1 stop4h 45mAmerican Airlines
Sat 2/288:24 amTYS - MDT
2 stops6h 10mAmerican Airlines
Deal found 1/10$347

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 11, 2026.
Use the filters below to find and compare flights from Harrisburg to Knoxville that are best for you.

Fly from

Harrisburg

Fly to

Knoxville

Route

Depart

Return

Price

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 2/6

4:47 pm-9:21 pm

1 stop4h 34m

Knoxville McGhee Tyson

Mon 2/9

2:19 pm-8:14 pm

1 stop5h 55m

$249

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Fri 3/6

6:00 am-10:45 am

1 stop4h 45m

Knoxville McGhee Tyson

Mon 3/9

4:02 pm-10:18 pm

1 stop6h 16m

$249

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Mon 2/23

9:46 am-3:48 pm

1 stop6h 02m

Knoxville McGhee Tyson

Sat 2/28

6:38 pm-10:14 pm

1 stop3h 36m

$249

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 2/3

6:30 am-1:24 pm

1 stop6h 54m

Knoxville McGhee Tyson

Sat 2/7

6:45 am-2:15 pm

1 stop7h 30m

$309

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sat 1/24

6:30 am-1:24 pm

1 stop6h 54m

Knoxville McGhee Tyson

Wed 1/28

9:30 am-1:51 pm

1 stop4h 21m

$319

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 2/12

6:15 am-10:49 am

1 stop4h 34m

Knoxville McGhee Tyson

Sun 2/15

6:45 am-1:56 pm

2 stops7h 11m

$332

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Thu 2/19

6:00 am-12:11 pm

1 stop6h 11m

Knoxville McGhee Tyson

Sun 2/22

6:55 am-11:16 am

1 stop4h 21m

$339

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Mon 1/19

6:02 pm-11:45 pm

1 stop5h 43m

$250

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Sun 1/18

5:47 am-9:45 am

1 stop3h 58m

$250

HarrisburgKnoxville

MDT - TYS

MDTTYS

Harrisburg

Tue 1/20

6:02 pm-11:45 pm

1 stop5h 43m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/10

Showing 1-10 of 18 results
1
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Compare providers for flights from Harrisburg to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Harrisburg-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Harrisburg-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Knoxville

What is the cheapest month to book a flight from Harrisburg to Knoxville?

Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $123). Flying from Harrisburg to Knoxville in September is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 11, 2026.
See what other customers who have flown with American Airlines from Harrisburg to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,101 reviews

Entertainment

6.9

Crew

8.0

Comfort

7.2

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.
American Airlines
7.2
Good
11,101 reviews
American Airlines
7.2
Good
11,101 reviews

Entertainment

6.9

Crew

8.0

Comfort

7.2

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
4.0
Okay

Susie,Jan 2026

TPA - CLT

I was sitting at the back of the plane and the flight attendants were so loud, talking to each other and laughing! I thought they were having a party back there.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Knoxville?

    Airlines like American Airlines and United Airlines fly from Harrisburg to Knoxville in about 4h 34m. The time it takes to get you to your destination can typically vary by up to 2h 20m. The distance between Harrisburg and Knoxville is about 496 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Harrisburg to Knoxville round-trip?

    According to our current data, American Airlines ($228), offers the cheapest pricing from Harrisburg to Knoxville. American Airlines is 45% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Harrisburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Knoxville.

  • Can I find deals for business class flights from Harrisburg to Knoxville?

    Yes. Cheapflights offers flight deals from Harrisburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Knoxville?

    Currently, October is the cheapest month in which you can book a flight from Harrisburg to Knoxville (average of $123). Flying from Harrisburg to Knoxville in September is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from Harrisburg to Knoxville

Discover the top airline that operate flights from Harrisburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$420FlexibilityNo cancel feeOn-time71%

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