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$126+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$297
(Delta)

One-way from

$126
(Mytrip)

Popular in

August

Cheapest in

June

Average price

$728
From Charleston to Knoxville McGhee Tyson
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One-way flight from Charleston to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 6% potential increase in price ($39 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/410:21 amCHS - TYS
1 stop2h 49mDelta
Tue 10/77:11 amTYS - CHS
1 stop3h 09mDelta
Deal found 8/13$297
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/268:02 pmCHS - TYS
1 stop3h 42mDelta
Sun 9/285:45 amTYS - CHS
1 stop3h 31mDelta
Deal found 8/12$307
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:47 pmCHS - TYS
1 stop3h 18mAmerican Airlines
Sun 12/76:46 amTYS - CHS
1 stop3h 21mAmerican Airlines
Deal found 8/12$317
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:31 amCHS - TYS
1 stop9h 23mMultiple Airlines
Sun 10/129:15 pmTYS - CHS
1 stop12h 11mMultiple Airlines
Deal found 8/13$328
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/118:17 pmCHS - TYS
1 stop3h 50mAmerican Airlines
Sun 9/148:36 pmTYS - CHS
1 stop3h 29mAmerican Airlines
Deal found 8/11$343
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/294:22 pmCHS - TYS
1 stop5h 44mAmerican Airlines
Wed 9/37:45 pmTYS - CHS
1 stop3h 12mAmerican Airlines
Deal found 8/12$347
This Mytrip deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/119:40 pmCHS - TYS
2 stops23h 27mMultiple Airlines
Thu 9/1812:08 pmTYS - CHS
3 stops28h 59mMultiple Airlines
Deal found 8/12$353
This Mytrip deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/296:54 pmCHS - TYS
2 stops20h 57mMultiple Airlines
Wed 9/34:31 pmTYS - CHS
2 stops24h 36mMultiple Airlines
Deal found 8/12$354
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/271:00 pmCHS - TYS
1 stop4h 19mDelta
Sun 8/317:10 amTYS - CHS
1 stop4h 40mDelta
Deal found 8/12$367
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:40 amCHS - TYS
2 stops22h 24mMultiple Airlines
Mon 11/177:20 amTYS - CHS
1 stop9h 25mMultiple Airlines
Deal found 8/12$394
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/267:38 pmCHS - TYS
1 stop3h 21mAmerican Airlines
Tue 9/23:41 pmTYS - CHS
1 stop5h 19mAmerican Airlines
Deal found 8/14$396
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:32 pmCHS - TYS
1 stop4h 22mAmerican Airlines
Sat 11/298:04 pmTYS - CHS
1 stop3h 52mAmerican Airlines
Deal found 8/14$402

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Charleston

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 10/4

6:20 am-10:25 am

1 stop4h 05m

Knoxville McGhee Tyson

Tue 10/7

7:11 am-10:20 am

1 stop3h 09m

$297

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 9/24

8:02 am-10:56 am

1 stop2h 54m

Knoxville McGhee Tyson

Sat 9/27

5:45 am-9:16 am

1 stop3h 31m

$297

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 9/13

5:10 am-10:25 am

1 stop5h 15m

Knoxville McGhee Tyson

Wed 9/17

1:52 pm-6:57 pm

1 stop5h 05m

$297

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 9/12

7:28 pm-11:03 pm

1 stop3h 35m

Knoxville McGhee Tyson

Sun 9/14

8:36 pm-12:05 am

1 stop3h 29m

$307

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 9/11

4:30 pm-7:46 pm

1 stop3h 16m

Knoxville McGhee Tyson

Thu 9/18

4:28 pm-10:11 pm

1 stop5h 43m

$307

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 10/3

2:59 pm-7:05 pm

1 stop4h 06m

Knoxville McGhee Tyson

Mon 10/6

6:11 pm-9:39 pm

1 stop3h 28m

$307

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 9/26

8:02 pm-11:44 pm

1 stop3h 42m

Knoxville McGhee Tyson

Sun 9/28

5:45 am-9:16 am

1 stop3h 31m

$307

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/14

2:25 pm-6:13 pm

1 stop3h 48m

Knoxville McGhee Tyson

Mon 11/17

7:15 pm-11:41 pm

1 stop4h 26m

$307

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 9/15

10:10 am-4:37 pm

1 stop6h 27m

$126

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 8/21

8:17 pm-10:34 am

1 stop14h 17m

$144

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 17 results
1
2

Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $294). Flying from Charleston to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to TYS?

Find hourly flight availability from Charleston to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

When flying from Charleston to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 25% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 14, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on American Airlines is currently your cheapest option to Knoxville, with prices starting at $326. Another option worth looking into is Delta, starting at $356 round trip. You may be able to fly from Charleston to Knoxville for 37% less than the average price by searching for these airlines.

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $294). Flying from Charleston to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$326Average$508FlexibilityNo cancel feeOn-time71%
DeltaCheapest$356Average$588FlexibilityNo cancel feeOn-timeN/A

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