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$170+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
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Find flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:13 pmCHS - TYS
1 stop17h 42mMultiple Airlines
Sun 11/2312:59 pmTYS - CHS
1 stop19h 58mMultiple Airlines
Deal found 11/3$281
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/177:00 amCHS - TYS
1 stop27h 34mMultiple Airlines
Thu 11/209:18 pmTYS - CHS
1 stop24h 47mMultiple Airlines
Deal found 11/3$288
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/92:59 pmCHS - TYS
1 stop22h 58mMultiple Airlines
Wed 11/126:13 pmTYS - CHS
1 stop14h 24mMultiple Airlines
Deal found 11/3$296
This Mytrip deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/179:02 amCHS - TYS
2 stops11h 17mMultiple Airlines
Fri 11/215:10 pmTYS - CHS
2 stops14h 16mMultiple Airlines
Deal found 11/2$308
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:59 pmCHS - TYS
1 stop22h 13mMultiple Airlines
Mon 11/172:22 pmTYS - CHS
2 stops18h 15mMultiple Airlines
Deal found 11/2$313
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:10 amCHS - TYS
1 stop3h 26mAmerican Airlines
Sun 12/145:05 amTYS - CHS
1 stop5h 50mAmerican Airlines
Deal found 11/4$327

Cheap flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 5, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$281
(Kiwi.com)

One-way from

$170
(Kiwi.com)

Popular in

August

Cheapest in

June

Average price

$583
Provider with most accurate pricing for Charleston-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Charleston-Knoxville McGhee Tyson flights.
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From Charleston to Knoxville McGhee Tyson
Search Deals
One-way flight from Charleston to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($93 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($41 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Charleston

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 11/17

7:00 am-10:34 am

1 stop27h 34m

Knoxville McGhee Tyson

Thu 11/20

9:18 pm-10:05 pm

1 stop24h 47m

$288

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 11/17

7:00 am-10:34 am

1 stop27h 34m

Knoxville McGhee Tyson

Fri 11/21

5:10 pm-7:26 am

2 stops14h 16m

$288

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sun 11/9

2:59 pm-12:56 pm

2 stops21h 57m

Knoxville McGhee Tyson

Wed 11/12

6:13 pm-8:37 am

1 stop14h 24m

$305

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 11/20

8:31 am-9:42 am

2 stops25h 11m

Knoxville McGhee Tyson

Sun 11/23

12:59 pm-8:57 am

1 stop19h 58m

$316

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 12/11

5:10 am-8:36 am

1 stop3h 26m

Knoxville McGhee Tyson

Sun 12/14

5:05 am-10:55 am

1 stop5h 50m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 12/11

5:10 am-8:36 am

1 stop3h 26m

Knoxville McGhee Tyson

Sat 12/13

10:59 am-3:35 pm

1 stop4h 36m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 12/19

5:10 am-8:56 am

1 stop3h 46m

Knoxville McGhee Tyson

Mon 12/22

5:40 pm-10:11 pm

1 stop4h 31m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 11/11

6:11 pm-10:14 pm

2 stops28h 03m

$170

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 12/24

2:15 pm-12:00 pm

1 stop21h 45m

$191

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 12/11

6:31 pm-10:58 pm

1 stop4h 27m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 12 results
1
2

Compare providers for flights from Charleston to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Knoxville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Charleston-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Charleston-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $190). Flying from Charleston to Knoxville in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to TYS?

Find hourly flight availability from Charleston to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 5, 2025.

When flying from Charleston to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 24% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 5, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,004 reviews

Entertainment

7.9

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,004 reviews
Delta
7.9
Good
8,004 reviews

Entertainment

7.9

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,042 reviews
Delta
7.9
Good
8,004 reviews

Entertainment

7.9

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on American Airlines is currently your cheapest option to Knoxville, with prices starting at $326. Another option worth looking into is Delta, starting at $326 round trip. You may be able to fly from Charleston to Knoxville for 39% less than the average price by searching for these airlines.

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $190). Flying from Charleston to Knoxville in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$326Average$442FlexibilityNo cancel feeOn-time71%
DeltaCheapest$326Average$538FlexibilityNo cancel feeOn-timeN/A

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