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$97+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Dec 16 — Dec 231
Tue 12/16
Tue 12/23
1 adult, Economy
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Find flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/138:10 pmCHS - TYS
2 stops25h 27mMultiple Airlines
Sat 12/209:23 pmTYS - CHS
1 stop24h 00mMultiple Airlines
Deal found 11/15$260
This American Airlines deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:08 pmCHS - TYS
1 stop3h 44mAmerican Airlines
Mon 12/225:40 pmTYS - CHS
1 stop6h 25mAmerican Airlines
Deal found 11/15$327
This American Airlines deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:10 amCHS - TYS
1 stop3h 26mAmerican Airlines
Sun 12/148:13 pmTYS - CHS
1 stop3h 32mAmerican Airlines
Deal found 11/14$337
This Mytrip deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:50 amCHS - TYS
1 stop11h 11mMultiple Airlines
Fri 12/59:23 amTYS - CHS
1 stop11h 31mMultiple Airlines
Deal found 11/16$343
This Mytrip deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/296:50 amCHS - TYS
1 stop13h 59mMultiple Airlines
Wed 12/312:53 pmTYS - CHS
3 stops22h 07mMultiple Airlines
Deal found 11/14$345
This Kiwi.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/193:33 pmCHS - TYS
2 stops16h 30mMultiple Airlines
Mon 12/225:38 pmTYS - CHS
1 stop14h 59mMultiple Airlines
Deal found 11/15$386
This Mytrip deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/202:15 pmCHS - TYS
2 stops18h 03mMultiple Airlines
Mon 12/229:08 amTYS - CHS
1 stop12h 15mMultiple Airlines
Deal found 11/15$393

Cheap flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$189
(Mytrip)

One-way from

$97
(Kiwi.com)

Popular in

August

Cheapest in

June

Average price

$583
Provider with most accurate pricing for Charleston-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Knoxville McGhee Tyson flights.
Search Deals
From Charleston to Knoxville McGhee Tyson
Search Deals
One-way flight from Charleston to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($106 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($42 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 16, 2025.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Charleston

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 1/9

6:31 pm-11:09 am

1 stop16h 38m

Knoxville McGhee Tyson

Sun 1/11

9:29 am-5:36 pm

1 stop8h 07m

$237

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 12/13

8:10 pm-9:37 pm

2 stops25h 27m

Knoxville McGhee Tyson

Sat 12/20

9:23 pm-9:23 pm

1 stop24h 00m

$260

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 3/7

5:27 am-9:06 am

1 stop3h 39m

Knoxville McGhee Tyson

Tue 3/10

5:30 am-11:25 am

1 stop5h 55m

$295

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 2/17

6:10 am-11:49 am

1 stop5h 39m

Knoxville McGhee Tyson

Sat 2/21

11:42 am-4:00 pm

1 stop4h 18m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 1/15

7:00 am-11:05 pm

2 stops16h 05m

Knoxville McGhee Tyson

Mon 1/19

12:55 pm-8:38 am

1 stop19h 43m

$318

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 12/20

8:08 pm-11:52 pm

1 stop3h 44m

Knoxville McGhee Tyson

Mon 12/22

5:40 pm-12:05 am

1 stop6h 25m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 2/17

3:01 pm-10:08 am

2 stops19h 07m

Knoxville McGhee Tyson

Sat 2/21

9:24 pm-5:30 pm

1 stop20h 06m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 12/11

5:10 am-8:36 am

1 stop3h 26m

Knoxville McGhee Tyson

Sun 12/14

8:13 pm-11:45 pm

1 stop3h 32m

$337

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 12/5

9:49 pm-12:03 pm

1 stop14h 14m

$97

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 12/22

10:18 pm-8:37 pm

1 stop22h 19m

$159

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/14

Showing 1-10 of 15 results
1
2

Compare providers for flights from Charleston to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Knoxville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Charleston-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Charleston-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $190). Flying from Charleston to Knoxville in August is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to TYS?

Find hourly flight availability from Charleston to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 16, 2025.

When flying from Charleston to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 24% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 16, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,010 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,010 reviews
Delta
7.9
Good
8,010 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,010 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Knoxville?

    Airlines like Delta fly from Charleston to Knoxville in about 3h 39m. The time it takes to get you to your destination can typically vary by up to . The distance between Charleston and Knoxville is about 302 mi.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on American Airlines is currently your cheapest option to Knoxville, with prices starting at $326. Another option worth looking into is Delta, starting at $326 round trip. You may be able to fly from Charleston to Knoxville for 37% less than the average price by searching for these airlines.

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $190). Flying from Charleston to Knoxville in August is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$326Average$442FlexibilityNo cancel feeOn-time71%
DeltaCheapest$326Average$538FlexibilityNo cancel feeOn-timeN/A

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