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$127+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Apr 6 — Apr 131
Mon 4/6
Mon 4/13
1 adult, Economy
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Cheap flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 7, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/198:07 am
CHS
-
TYS
1 stop14h 19m
Multiple Airlines
Mon 3/232:06 pm
TYS
-
CHS
1 stop18h 32m
Multiple Airlines
Deal found 3/4$248
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/12:10 pm
CHS
-
TYS
1 stop7h 00m
Southwest
Wed 4/87:05 am
TYS
-
CHS
1 stop5h 20m
Southwest
Deal found 3/2$263
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/12:10 pm
CHS
-
TYS
1 stop7h 00m
Southwest
Sat 4/46:35 am
TYS
-
CHS
1 stop5h 25m
Southwest
Deal found 3/5$271
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:00 am
CHS
-
TYS
1 stop3h 32m
American Airlines
Wed 4/225:00 am
TYS
-
CHS
1 stop3h 32m
American Airlines
Deal found 3/7$279
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:35 am
CHS
-
TYS
1 stop7h 45m
Southwest
Wed 4/228:15 am
TYS
-
CHS
2 stops9h 25m
Southwest
Deal found 3/7$284
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:21 pm
CHS
-
TYS
1 stop8h 16m
Multiple Airlines
Fri 6/57:27 pm
TYS
-
CHS
1 stop13h 21m
Multiple Airlines
Deal found 3/2$286
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:05 am
CHS
-
TYS
2 stops12h 15m
Southwest
Wed 4/228:15 am
TYS
-
CHS
1 stop5h 20m
Southwest
Deal found 3/7$290

Find flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$248
(Kiwi.com)

One-way from

$127
(Kiwi.com)

Popular in

August

Cheapest in

January
Provider with most accurate pricing for Charleston-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Knoxville McGhee Tyson flights.
Search Deals
From Charleston to Knoxville McGhee Tyson
Search Deals
One-way flight from Charleston to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($139 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($55 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 4/1

2:10 pm-9:10 pm

1 stop7h 00m

Knoxville McGhee Tyson

Sat 4/4

6:35 am-12:00 pm

1 stop5h 25m

$271

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 4/1

7:55 am-5:40 pm

2 stops9h 45m

Knoxville McGhee Tyson

Wed 4/8

8:15 am-5:40 pm

2 stops9h 25m

$273

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 5/4

6:00 am-11:40 am

1 stop5h 40m

Knoxville McGhee Tyson

Sat 5/9

6:40 am-12:00 pm

1 stop5h 20m

$279

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 5/8

4:45 pm-9:15 pm

1 stop4h 30m

Knoxville McGhee Tyson

Sun 5/10

6:40 am-12:00 pm

1 stop5h 20m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 4/18

8:00 am-6:30 pm

2 stops10h 30m

Knoxville McGhee Tyson

Fri 4/24

6:35 am-5:05 pm

2 stops10h 30m

$320

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 4/17

10:55 am-6:10 pm

2 stops7h 15m

Knoxville McGhee Tyson

Sun 4/19

6:40 am-5:30 pm

2 stops10h 50m

$333
Quickest round-trip

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 6/1

5:15 am-9:34 am

1 stop4h 19m

Knoxville McGhee Tyson

Wed 6/3

5:45 am-9:38 am

1 stop3h 53m

$377

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 4/3

7:58 pm-11:57 pm

1 stop3h 59m

Knoxville McGhee Tyson

Sun 4/5

6:38 pm-12:16 am

1 stop5h 38m

$383

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 4/10

8:05 am-6:10 pm

2 stops10h 05m

Knoxville McGhee Tyson

Sun 4/12

6:40 am-4:00 pm

2 stops9h 20m

$387

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 5/1

4:50 pm-9:15 pm

1 stop4h 25m

Knoxville McGhee Tyson

Mon 5/4

6:35 am-7:20 pm

2 stops12h 45m

$393

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/4

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Compare providers for flights from Charleston to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Knoxville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, May is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $214). Flying from Charleston to Knoxville in December is currently the most expensive (average of $314). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 7, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,271 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Comfort

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,271 reviews
Delta
7.9
Good
8,271 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Comfort

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,399 reviews
Delta
7.9
Good
8,271 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Comfort

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Knoxville?

    Airlines like Southwest fly from Charleston to Knoxville in about 7h. The time it takes to get you to your destination can typically vary by up to . The distance between Charleston and Knoxville is about 302 mi.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on Delta is currently your cheapest option to Knoxville, with prices starting at $254. Another option worth looking into is American Airlines, starting at $326 round trip. You may be able to fly from Charleston to Knoxville for 48% less than the average price by searching for these airlines.

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, May is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $214). Flying from Charleston to Knoxville in December is currently the most expensive (average of $314). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$254Average$485FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$326Average$356FlexibilityNo cancel feeOn-time71%

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