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$132+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Mar 21 — Mar 281
Sat 3/21
Sat 3/28
1 adult, Economy
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Cheap flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:35 pm
CHS
-
TYS
1 stop18h 28m
Multiple Airlines
Mon 3/162:06 pm
TYS
-
CHS
1 stop8h 07m
Multiple Airlines
Deal found 2/18$239
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:15 am
CHS
-
TYS
1 stop5h 35m
Southwest
Wed 3/257:50 am
TYS
-
CHS
1 stop5h 45m
Southwest
Deal found 2/18$263
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:39 pm
CHS
-
TYS
1 stop8h 09m
Multiple Airlines
Thu 5/73:55 pm
TYS
-
CHS
1 stop5h 54m
Multiple Airlines
Deal found 2/16$282
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:00 am
CHS
-
TYS
1 stop5h 25m
Multiple Airlines
Fri 5/151:15 pm
TYS
-
CHS
1 stop19h 33m
Multiple Airlines
Deal found 2/17$287
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:35 pm
CHS
-
TYS
1 stop15h 05m
Multiple Airlines
Tue 3/104:05 pm
TYS
-
CHS
2 stops24h 00m
Multiple Airlines
Deal found 2/19$298
This Southwest deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
CHS
-
TYS
1 stop5h 40m
Southwest
Sun 4/126:40 am
TYS
-
CHS
2 stops9h 20m
Southwest
Deal found 2/17$303
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:35 pm
CHS
-
TYS
1 stop16h 26m
Multiple Airlines
Mon 3/99:36 pm
TYS
-
CHS
2 stops18h 29m
Multiple Airlines
Deal found 2/16$313
This Southwest deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:45 pm
CHS
-
TYS
1 stop4h 30m
Southwest
Sun 4/196:40 am
TYS
-
CHS
1 stop5h 20m
Southwest
Deal found 2/15$317

Find flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$239
(Kiwi.com)

One-way from

$132
(Delta)

Popular in

August

Cheapest in

January

Average price

$478
Provider with most accurate pricing for Charleston-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Knoxville McGhee Tyson flights.
Search Deals
From Charleston to Knoxville McGhee Tyson
Search Deals
One-way flight from Charleston to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($164 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($52 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Charleston

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 3/6

6:35 pm-1:03 pm

1 stop18h 28m

Knoxville McGhee Tyson

Mon 3/16

2:06 pm-10:13 pm

1 stop8h 07m

$239

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 3/18

6:15 am-11:50 am

1 stop5h 35m

Knoxville McGhee Tyson

Wed 3/25

7:50 am-1:35 pm

1 stop5h 45m

$263

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 3/18

5:27 am-9:16 am

1 stop3h 49m

Knoxville McGhee Tyson

Wed 3/25

5:40 am-8:41 am

1 stop3h 01m

$263

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 5/4

1:39 pm-9:48 pm

1 stop8h 09m

Knoxville McGhee Tyson

Thu 5/7

3:55 pm-9:49 pm

1 stop5h 54m

$282

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 3/6

6:35 pm-9:40 am

1 stop15h 05m

Knoxville McGhee Tyson

Tue 3/10

4:05 pm-4:05 pm

2 stops24h 00m

$298

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 4/17

4:45 pm-9:15 pm

1 stop4h 30m

Knoxville McGhee Tyson

Sun 4/19

6:40 am-12:00 pm

1 stop5h 20m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 4/9

4:45 pm-9:15 pm

1 stop4h 30m

Knoxville McGhee Tyson

Sun 4/12

7:45 am-1:25 pm

1 stop5h 40m

$318

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 4/21

7:25 am-11:17 am

1 stop3h 52m

$132

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 4/1

6:09 pm-11:57 pm

1 stop5h 48m

$132

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 4/21

12:00 pm-8:50 pm

2 stops8h 50m

$137

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 17 results
1
2

Compare providers for flights from Charleston to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Knoxville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $190). Flying from Charleston to Knoxville in February is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 19, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,212 reviews

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,212 reviews
Delta
7.9
Good
8,212 reviews

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,313 reviews
Delta
7.9
Good
8,212 reviews

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Knoxville?

    Airlines like Southwest and Delta fly from Charleston to Knoxville in about 3h 49m. The time it takes to get you to your destination can typically vary by up to 1h 46m. The distance between Charleston and Knoxville is about 302 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on Delta is currently your cheapest option to Knoxville, with prices starting at $254. Another option worth looking into is American Airlines, starting at $316 round trip. You may be able to fly from Charleston to Knoxville for 45% less than the average price by searching for these airlines.

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $190). Flying from Charleston to Knoxville in February is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$254Average$485FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$316Average$356FlexibilityNo cancel feeOn-time71%

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