$165+ Cheap flights from Charleston to Knoxville (CHS - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Oct 13 — Oct 201
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Knoxville
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Cheapest flights from Charleston to KnoxvilleExplore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:39 pm -
1 stop10h 06m
Mon 11/163:54 pm -
1 stop16h 44m
Deal found 9/10![Multiple Airlines logo]()
$250
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:31 pm -
1 stop3h 35m
Tue 10/63:46 pm -
1 stop5h 24m
Deal found 9/10![American Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop26h 13m
Mon 10/59:28 pm -
1 stop11h 10m
Deal found 9/11![Multiple Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop3h 04m
Thu 10/157:45 pm -
1 stop4h 14m
Deal found 9/8![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:08 pm -
1 stop3h 47m
Mon 10/127:58 pm -
1 stop3h 59m
Deal found 9/8![American Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:13 pm -
1 stop10h 02m
Mon 10/58:14 pm -
2 stops16h 17m
Deal found 9/10![Multiple Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Wed 11/117:30 am -
2 stops12h 20m
Sat 11/142:50 pm -
1 stop4h 15m
Deal found 9/11![Southwest logo]()
$330
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
1 stop5h 50m
Tue 10/135:40 am -
1 stop3h 12m
Deal found 9/8![Delta logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
2 stops28h 04m
Wed 9/3010:28 am -
1 stop22h 10m
Deal found 9/11![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:13 pm -
1 stop22h 28m
Mon 9/2812:22 pm -
1 stop20h 16m
Deal found 9/9![Multiple Airlines logo]()
$356
Best flights from Charleston to KnoxvilleDiscover carefully curated flight deals from Charleston to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
Discover carefully curated flight deals from Charleston to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop3h 04m
Thu 10/157:45 pm -
1 stop4h 14m
Deal found 9/8![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:35 am -
2 stops15h 05m
Mon 11/167:55 am -
2 stops11h 35m
Deal found 9/10![Southwest logo]()
$379
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:00 am -
1 stop3h 32m
Tue 10/207:13 pm -
1 stop3h 45m
Deal found 9/10![American Airlines logo]()
$416
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am -
2 stops28h 04m
Fri 9/188:20 am -
1 stop24h 18m
Deal found 9/11![Multiple Airlines logo]()
$491
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:52 pm -
1 stop9h 07m
Sat 10/315:45 am -
1 stop8h 38m
Deal found 9/10![United Airlines logo]()
$519
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop4h 45m
Sun 11/87:45 pm -
1 stop4h 14m
Deal found 9/12![Delta logo]()
$397
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:15 am -
1 stop5h 45m
Tue 10/68:20 am -
2 stops9h 15m
Deal found 9/10![Southwest logo]()
$422
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:10 am -
2 stops8h 30m
Tue 10/138:20 am -
1 stop5h 15m
Deal found 9/8![Southwest logo]()
$441
Last-minute flights from Charleston to KnoxvilleDiscover last-minute flight deals from Charleston to Knoxville. Data last updated September 13, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Knoxville. Data last updated September 13, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:13 pm -
1 stop22h 28m
Mon 9/2812:22 pm -
1 stop20h 16m
Deal found 9/9![Multiple Airlines logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
2 stops28h 04m
Wed 9/3010:28 am -
1 stop22h 10m
Deal found 9/11![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:13 pm -
1 stop10h 02m
Mon 10/58:14 pm -
2 stops16h 17m
Deal found 9/10![Multiple Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:31 pm -
1 stop3h 35m
Tue 10/63:46 pm -
1 stop5h 24m
Deal found 9/10![American Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
1 stop26h 13m
Mon 10/59:28 pm -
1 stop11h 10m
Deal found 9/11![Multiple Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:08 pm -
1 stop3h 47m
Mon 10/127:58 pm -
1 stop3h 59m
Deal found 9/8![American Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
1 stop5h 50m
Tue 10/135:40 am -
1 stop3h 12m
Deal found 9/8![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:00 am -
1 stop3h 23m
Wed 10/146:06 pm -
1 stop5h 51m
Deal found 9/13![American Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop3h 04m
Thu 10/157:45 pm -
1 stop4h 14m
Deal found 9/8![Delta logo]()
$289
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:35 pm -
1 stop4h 33m
Thu 10/225:40 am -
1 stop3h 12m
Deal found 9/12![Delta logo]()
$381
One-way flights from Charleston to KnoxvilleSearch for one-way flight options from Charleston to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
Search for one-way flight options from Charleston to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/272:13 pm -
1 stop26h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:57 pm -
1 stop20h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$201
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:00 am -
1 stop3h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:58 pm -
2 stops35h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$408
Find flight deals from Charleston to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $250 (Kiwi.com) |
One-way from | $165 (Kiwi.com) |
Popular in | February |
Cheapest in | January |
Average price | $508 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Fri 9/25
4:57 pm-1:04 pm
1 stop20h 07m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$201
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Sun 9/27
10:05 pm-6:14 pm
2 stops20h 09m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$214
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Thu 10/8
6:30 am-9:34 am
1 stop3h 04m
Knoxville McGhee Tyson
Thu 10/15
7:45 pm-11:59 pm
1 stop4h 14m
$289
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Thu 11/12
6:35 am-9:40 pm
2 stops15h 05m
Knoxville McGhee Tyson
Mon 11/16
7:55 am-7:30 pm
2 stops11h 35m
$379
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Wed 11/4
6:00 am-10:45 am
1 stop4h 45m
Knoxville McGhee Tyson
Sun 11/8
7:45 pm-11:59 pm
1 stop4h 14m
$397
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Fri 10/9
8:58 pm-8:30 am
2 stops35h 32m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$408
Quickest round-trip
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Fri 10/9
5:00 am-8:32 am
1 stop3h 32m
Knoxville McGhee Tyson
Tue 10/20
7:13 pm-10:58 pm
1 stop3h 45m
$416
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Sat 10/3
6:15 am-12:00 pm
1 stop5h 45m
Knoxville McGhee Tyson
Tue 10/6
8:20 am-5:35 pm
2 stops9h 15m
$422
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 10/6
8:10 am-4:40 pm
2 stops8h 30m
Knoxville McGhee Tyson
Tue 10/13
8:20 am-1:35 pm
1 stop5h 15m
$441
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Wed 9/16
6:00 am-10:04 am
2 stops28h 04m
Knoxville McGhee Tyson
Fri 9/18
8:20 am-8:38 am
1 stop24h 18m
$491
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Charleston to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
CHS-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 13, 2026.
Read reviews from past customers who have flown Delta from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Other flights to Knoxville
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Charleston and Knoxville flights
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Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on September 13, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Charleston to Knoxville
Discover the top airline that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$254 | Average$511 | FlexibilityNo cancel fee | On-timeN/A |