$129+ Cheap flights from Charleston to Knoxville (CHS - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
May 21 — May 281
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Charleston to KnoxvilleExplore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:10 am
CHS
- TYS
1 stop4h 28m
Delta
Wed 6/106:05 pm
TYS
- CHS
1 stop4h 01m
Delta
Deal found 4/21![Delta logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Mon 7/1310:05 pm
TYS
- CHS
1 stop10h 33m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:44 pm
CHS
- TYS
1 stop20h 40m
Multiple Airlines
Tue 5/123:48 pm
TYS
- CHS
1 stop17h 50m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:30 am
CHS
- TYS
1 stop7h 05m
Southwest
Fri 8/218:25 am
TYS
- CHS
1 stop7h 00m
Southwest
Deal found 4/21![Southwest logo]()
$292
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:40 am
CHS
- TYS
1 stop5h 20m
Southwest
Sun 6/78:00 am
TYS
- CHS
1 stop5h 25m
Southwest
Deal found 4/17![Southwest logo]()
$308
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:30 am
CHS
- TYS
1 stop5h 18m
Delta
Tue 5/197:33 pm
TYS
- CHS
1 stop4h 26m
Delta
Deal found 4/20![Delta logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:05 am
CHS
- TYS
2 stops14h 43m
Multiple Airlines
Fri 5/81:15 pm
TYS
- CHS
1 stop19h 33m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$320
Best flights from Charleston to KnoxvilleDiscover carefully curated flight deals from Charleston to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
Discover carefully curated flight deals from Charleston to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:00 pm
CHS
- TYS
2 stops8h 50m
Southwest
Sun 6/78:00 am
TYS
- CHS
1 stop5h 25m
Southwest
Deal found 4/17![Southwest logo]()
$313
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:15 am
CHS
- TYS
1 stop3h 19m
Delta
Mon 5/117:33 pm
TYS
- CHS
1 stop4h 26m
Delta
Deal found 4/18![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/84:10 pm
CHS
- TYS
1 stop6h 20m
Southwest
Wed 6/108:10 am
TYS
- CHS
1 stop5h 20m
Southwest
Deal found 4/18![Southwest logo]()
$337
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:35 am
CHS
- TYS
2 stops10h 55m
Southwest
Tue 5/128:15 am
TYS
- CHS
2 stops9h 25m
Southwest
Deal found 4/17![Southwest logo]()
$387
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:10 pm
CHS
- TYS
1 stop6h 20m
Southwest
Sun 7/127:05 am
TYS
- CHS
1 stop5h 25m
Southwest
Deal found 4/17![Southwest logo]()
$387
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:00 am
CHS
- TYS
2 stops13h 20m
Southwest
Sun 6/288:00 am
TYS
- CHS
1 stop5h 25m
Southwest
Deal found 4/17![Southwest logo]()
$388
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:20 am
CHS
- TYS
1 stop4h 02m
Delta
Sun 4/265:40 am
TYS
- CHS
1 stop4h 29m
Delta
Deal found 4/17![Delta logo]()
$567
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:15 pm
CHS
- TYS
2 stops8h 00m
Southwest
Sun 5/107:45 am
TYS
- CHS
2 stops10h 30m
Southwest
Deal found 4/19![Southwest logo]()
$433
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:35 am
CHS
- TYS
2 stops10h 55m
Southwest
Wed 5/68:15 am
TYS
- CHS
2 stops9h 25m
Southwest
Deal found 4/17![Southwest logo]()
$447
Last-minute flights from Charleston to KnoxvilleDiscover last-minute flight deals from Charleston to Knoxville. Data last updated April 21, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Knoxville. Data last updated April 21, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:00 am
CHS
- TYS
2 stops33h 30m
Multiple Airlines
Mon 4/271:15 pm
TYS
- CHS
1 stop19h 23m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:05 am
CHS
- TYS
2 stops14h 43m
Multiple Airlines
Fri 5/81:15 pm
TYS
- CHS
1 stop19h 33m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$320
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:00 am
CHS
- TYS
1 stop3h 32m
American Airlines
Mon 5/113:58 pm
TYS
- CHS
1 stop6h 18m
American Airlines
Deal found 4/20![American Airlines logo]()
$388
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:15 am
CHS
- TYS
1 stop4h 19m
Delta
Mon 5/117:33 pm
TYS
- CHS
1 stop3h 23m
Delta
Deal found 4/19![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:15 pm
CHS
- TYS
2 stops8h 00m
Southwest
Sun 5/107:45 am
TYS
- CHS
2 stops10h 30m
Southwest
Deal found 4/19![Southwest logo]()
$433
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:44 pm
CHS
- TYS
1 stop20h 40m
Multiple Airlines
Tue 5/123:48 pm
TYS
- CHS
1 stop17h 50m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:35 am
CHS
- TYS
2 stops10h 55m
Southwest
Tue 5/128:15 am
TYS
- CHS
2 stops9h 25m
Southwest
Deal found 4/17![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:15 am
CHS
- TYS
1 stop4h 19m
Delta
Tue 5/197:33 pm
TYS
- CHS
1 stop4h 26m
Delta
Deal found 4/18![Delta logo]()
$428
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:30 am
CHS
- TYS
1 stop5h 18m
Delta
Tue 5/197:33 pm
TYS
- CHS
1 stop4h 26m
Delta
Deal found 4/20![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:35 am
CHS
- TYS
1 stop7h 45m
Southwest
Tue 5/198:15 am
TYS
- CHS
2 stops9h 25m
Southwest
Deal found 4/20![Southwest logo]()
$382
One-way flights from Charleston to KnoxvilleSearch for one-way flight options from Charleston to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
Search for one-way flight options from Charleston to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:44 pm
CHS
- TYS
2 stops45h 32m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:16 pm
CHS
- TYS
2 stops44h 00m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$131
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:00 am
CHS
- TYS
1 stop3h 34m
American Airlines
Deal found 4/21![American Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:39 pm
CHS
- TYS
2 stops19h 57m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:38 pm
CHS
- TYS
2 stops31h 12m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$147
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:03 pm
CHS
- TYS
1 stop5h 53m
Delta
Deal found 4/17![Delta logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:39 pm
CHS
- TYS
2 stops20h 27m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$165
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:10 am
CHS
- TYS
1 stop5h 59m
Delta
Deal found 4/21![Delta logo]()
$169
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:00 am
CHS
- TYS
1 stop3h 34m
American Airlines
Deal found 4/17![American Airlines logo]()
$179
Find flight deals from Charleston to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $243 (Delta) |
One-way from | $129 (Kiwi.com) |
Popular in | August |
Cheapest in | January |
Average price | $595 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Tue 6/2
12:00 pm-8:50 pm
2 stops8h 50m
Knoxville McGhee Tyson
Sun 6/7
8:00 am-1:25 pm
1 stop5h 25m
$313
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Mon 6/8
4:10 pm-10:30 pm
1 stop6h 20m
Knoxville McGhee Tyson
Wed 6/10
8:10 am-1:30 pm
1 stop5h 20m
$337
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Sat 5/9
7:35 am-6:30 pm
2 stops10h 55m
Knoxville McGhee Tyson
Tue 5/12
8:15 am-5:40 pm
2 stops9h 25m
$387
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Fri 7/10
4:10 pm-10:30 pm
1 stop6h 20m
Knoxville McGhee Tyson
Sun 7/12
7:05 am-12:30 pm
1 stop5h 25m
$387
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Wed 6/24
7:00 am-8:20 pm
2 stops13h 20m
Knoxville McGhee Tyson
Sun 6/28
8:00 am-1:25 pm
1 stop5h 25m
$388
Quickest round-trip
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Thu 5/7
6:15 am-9:34 am
1 stop3h 19m
Knoxville McGhee Tyson
Mon 5/11
7:33 pm-11:59 pm
1 stop4h 26m
$407
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Fri 5/8
1:15 pm-9:15 pm
2 stops8h 00m
Knoxville McGhee Tyson
Sun 5/10
7:45 am-6:15 pm
2 stops10h 30m
$433
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Sat 5/2
7:35 am-6:30 pm
2 stops10h 55m
Knoxville McGhee Tyson
Wed 5/6
8:15 am-5:40 pm
2 stops9h 25m
$447
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Fri 4/24
5:20 am-9:22 am
1 stop4h 02m
Knoxville McGhee Tyson
Sun 4/26
5:40 am-10:09 am
1 stop4h 29m
$567
Cheapest one-way
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Sat 5/23
5:00 am-8:34 am
1 stop3h 34m
$133
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Charleston to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Knoxville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
CHS-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 21, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 21, 2026.
Charleston and Knoxville flights
Browse other Charleston and Knoxville flight options. Last updated on April 21, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on April 21, 2026.
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Top 2 airlines flying from Charleston to Knoxville
Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$254 | Average$498 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$316 | Average$356 | FlexibilityNo cancel fee | On-time71% |