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$99+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 11, 2025.

Round-trip from

$197
(Delta)

One-way from

$99
(Delta)

Popular in

August

Cheapest in

June

Average price

$508
From Charleston to Knoxville McGhee Tyson
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One-way flight from Charleston to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 3% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/56:10 amCHS - TYS
1 stop3h 40mAmerican Airlines
sáb. 11/84:56 pmTYS - CHS
1 stop7h 03mAmerican Airlines
Deal found 9/11$183
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/46:20 amCHS - TYS
1 stop4h 05mDelta
mar. 10/75:44 amTYS - CHS
1 stop6h 02mDelta
Deal found 9/9$197
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/410:31 amCHS - TYS
1 stop6h 18mAmerican Airlines
mar. 10/75:00 amTYS - CHS
1 stop4h 31mAmerican Airlines
Deal found 9/10$243
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/145:40 pmCHS - TYS
1 stop16h 24mMultiple Airlines
dom. 11/169:00 amTYS - CHS
2 stops11h 13mMultiple Airlines
Deal found 9/8$282
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/265:36 pmCHS - TYS
1 stop3h 14mAmerican Airlines
mar. 9/307:45 pmTYS - CHS
1 stop3h 12mAmerican Airlines
Deal found 9/11$285
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/149:00 amCHS - TYS
1 stop5h 46mDelta
lun. 11/178:05 pmTYS - CHS
1 stop3h 52mDelta
Deal found 9/11$289
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/2610:11 amCHS - TYS
1 stop10h 14mMultiple Airlines
dom. 11/29:53 amTYS - CHS
1 stop23h 08mMultiple Airlines
Deal found 9/11$305
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/1910:10 amCHS - TYS
2 stops34h 31mMultiple Airlines
lun. 9/226:34 pmTYS - CHS
1 stop14h 03mMultiple Airlines
Deal found 9/9$307
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/216:32 pmCHS - TYS
1 stop5h 19mAmerican Airlines
dom. 11/236:30 amTYS - CHS
1 stop4h 17mAmerican Airlines
Deal found 9/10$308
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/1010:11 amCHS - TYS
1 stop24h 07mMultiple Airlines
dom. 10/129:15 pmTYS - CHS
1 stop11h 51mMultiple Airlines
Deal found 9/9$316
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/189:40 pmCHS - TYS
2 stops21h 04mMultiple Airlines
lun. 9/226:34 pmTYS - CHS
1 stop14h 03mMultiple Airlines
Deal found 9/9$334

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Charleston

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

mié. 11/5

6:10 am-9:50 am

1 stop3h 40m

Knoxville McGhee Tyson

sáb. 11/8

4:56 pm-11:59 pm

1 stop7h 03m

$183

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

sáb. 10/4

6:20 am-10:25 am

1 stop4h 05m

Knoxville McGhee Tyson

mar. 10/7

5:44 am-11:46 am

1 stop6h 02m

$197

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

sáb. 10/4

10:31 am-4:49 pm

1 stop6h 18m

Knoxville McGhee Tyson

mar. 10/7

5:00 am-9:31 am

1 stop4h 31m

$243

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vie. 11/14

5:40 pm-10:04 am

1 stop16h 24m

Knoxville McGhee Tyson

dom. 11/16

9:00 am-8:13 pm

2 stops11h 13m

$282

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

dom. 10/26

10:11 am-8:25 pm

1 stop10h 14m

Knoxville McGhee Tyson

dom. 11/2

9:00 am-8:13 pm

2 stops11h 13m

$285

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vie. 9/26

5:36 pm-8:50 pm

1 stop3h 14m

Knoxville McGhee Tyson

mar. 9/30

7:45 pm-10:57 pm

1 stop3h 12m

$285

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vie. 11/14

9:00 am-2:46 pm

1 stop5h 46m

Knoxville McGhee Tyson

lun. 11/17

3:51 pm-8:27 pm

1 stop4h 36m

$289

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vie. 11/21

6:32 pm-10:54 pm

1 stop4h 22m

Knoxville McGhee Tyson

dom. 11/23

8:04 pm-12:08 am

1 stop4h 04m

$308

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

vie. 10/10

10:11 am-10:18 am

1 stop24h 07m

Knoxville McGhee Tyson

dom. 10/12

9:15 pm-9:06 am

1 stop11h 51m

$316

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

mié. 10/8

5:35 am-9:00 am

1 stop3h 25m

$99

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 17 results
1
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Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $294). Flying from Charleston to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to TYS?

Find hourly flight availability from Charleston to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

When flying from Charleston to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 25% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated septiembre 11, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Knoxville?

    Airlines like American Airlines and Delta fly from Charleston to Knoxville in about 3h 40m. The time it takes to get you to your destination can typically vary by up to 25m. The distance between Charleston and Knoxville is about 302 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on American Airlines is currently your cheapest option to Knoxville, with prices starting at $326. Another option worth looking into is Delta, starting at $326 round trip. You may be able to fly from Charleston to Knoxville for 36% less than the average price by searching for these airlines.

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $294). Flying from Charleston to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$326Average$498FlexibilityNo cancel feeOn-time71%
DeltaCheapest$326Average$560FlexibilityNo cancel feeOn-timeN/A

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