$164+ Cheap flights from Charleston to Knoxville (CHS - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Knoxville
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Best
Last-minute
One-way
Cheapest flights from Charleston to KnoxvilleExplore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:10 pm -
1 stop3h 25m
Tue 12/812:19 pm -
1 stop6h 26m
Deal found 11/3![American Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/223:00 pm -
1 stop7h 46m
Tue 12/296:00 am -
1 stop26h 38m
Deal found 11/2![Multiple Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:19 am -
1 stop5h 08m
Sun 12/135:40 am -
1 stop4h 35m
Deal found 11/1![Delta logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:21 pm -
1 stop20h 51m
Tue 12/81:57 pm -
2 stops24h 08m
Deal found 11/3![Multiple Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:35 am -
1 stop5h 45m
Tue 12/87:55 am -
2 stops11h 40m
Deal found 11/3![Southwest logo]()
$318
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:35 am -
1 stop5h 45m
Sun 12/137:25 pm -
2 stops14h 55m
Deal found 11/1![Southwest logo]()
$323
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/101:30 pm -
1 stop7h 20m
Sun 12/137:25 pm -
2 stops14h 55m
Deal found 11/3![Southwest logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:57 pm -
1 stop24h 21m
Mon 11/169:10 am -
1 stop23h 28m
Deal found 10/31![Multiple Airlines logo]()
$345
Best flights from Charleston to KnoxvilleDiscover carefully curated flight deals from Charleston to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Charleston to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/102:04 pm -
1 stop4h 26m
Sun 12/137:26 pm -
1 stop4h 38m
Deal found 11/3![Delta logo]()
$312
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:35 am -
1 stop5h 45m
Tue 12/87:55 am -
2 stops11h 40m
Deal found 11/3![Southwest logo]()
$318
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/47:51 pm -
1 stop18h 56m
Mon 2/87:10 pm -
1 stop23h 58m
Deal found 10/30![United Airlines logo]()
$602
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:30 am -
2 stops16h 02m
Mon 11/237:11 pm -
1 stop25h 15m
Deal found 10/31![Multiple Airlines logo]()
$603
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:35 am -
1 stop5h 45m
Sun 12/137:25 pm -
2 stops14h 55m
Deal found 11/1![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:19 am -
1 stop3h 36m
Mon 11/238:35 am -
1 stop3h 17m
Deal found 10/31![Delta logo]()
$412
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:00 am -
2 stops9h 50m
Tue 12/87:55 am -
2 stops11h 40m
Deal found 11/3![Southwest logo]()
$383
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1711:00 am -
2 stops9h 50m
Sat 11/213:10 pm -
2 stops9h 05m
Deal found 11/2![Southwest logo]()
$497
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:56 pm -
1 stop18h 57m
Tue 12/157:45 pm -
1 stop19h 47m
Deal found 11/3![United Airlines logo]()
$603
Last-minute flights from Charleston to KnoxvilleDiscover last-minute flight deals from Charleston to Knoxville. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Knoxville. Data last updated November 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:57 pm -
1 stop24h 21m
Mon 11/169:10 am -
1 stop23h 28m
Deal found 10/31![Multiple Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:10 pm -
1 stop3h 25m
Tue 12/812:19 pm -
1 stop6h 26m
Deal found 11/3![American Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:21 pm -
1 stop20h 51m
Tue 12/81:57 pm -
2 stops24h 08m
Deal found 11/3![Multiple Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:35 am -
1 stop5h 45m
Tue 12/87:55 am -
2 stops11h 40m
Deal found 11/3![Southwest logo]()
$318
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:19 am -
1 stop5h 08m
Sun 12/135:40 am -
1 stop4h 35m
Deal found 11/1![Delta logo]()
$312
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:35 am -
1 stop5h 45m
Sun 12/137:25 pm -
2 stops14h 55m
Deal found 11/1![Southwest logo]()
$323
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/101:30 pm -
1 stop7h 20m
Sun 12/137:25 pm -
2 stops14h 55m
Deal found 11/3![Southwest logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/223:00 pm -
1 stop7h 46m
Tue 12/296:00 am -
1 stop26h 38m
Deal found 11/2![Multiple Airlines logo]()
$309
One-way flights from Charleston to KnoxvilleSearch for one-way flight options from Charleston to Knoxville. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Charleston to Knoxville. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:57 pm -
1 stop24h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Multiple Airlines logo]()
$164
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:04 pm -
1 stop4h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Delta logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:58 pm -
3 stops37h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$313
Find flight deals from Charleston to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $287 (American Airlines) |
One-way from | $164 (Kiwi.com) |
Popular in | September |
Cheapest in | January |
Average price | $526 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Mon 11/16
4:57 pm-5:18 pm
1 stop24h 21m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$164
Quickest round-trip
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Fri 11/20
7:04 pm-11:59 pm
1 stop4h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$270
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Thu 12/10
2:04 pm-6:30 pm
1 stop4h 26m
Knoxville McGhee Tyson
Sun 12/13
7:26 pm-12:04 am
1 stop4h 38m
$312
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Fri 11/20
8:58 pm-10:14 am
3 stops37h 16m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$313
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Mon 12/7
6:35 am-12:20 pm
1 stop5h 45m
Knoxville McGhee Tyson
Tue 12/8
7:55 am-7:35 pm
2 stops11h 40m
$318
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Wed 12/9
6:35 am-12:20 pm
1 stop5h 45m
Knoxville McGhee Tyson
Sun 12/13
7:25 pm-10:20 am
2 stops14h 55m
$323
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 12/1
11:00 am-8:50 pm
2 stops9h 50m
Knoxville McGhee Tyson
Tue 12/8
7:55 am-7:35 pm
2 stops11h 40m
$383
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Fri 11/20
11:19 am-2:55 pm
1 stop3h 36m
Knoxville McGhee Tyson
Mon 11/23
8:35 am-11:52 am
1 stop3h 17m
$412
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 11/17
11:00 am-8:50 pm
2 stops9h 50m
Knoxville McGhee Tyson
Sat 11/21
3:10 pm-12:15 am
2 stops9h 05m
$497
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Thu 2/4
7:51 pm-2:47 pm
1 stop18h 56m
Knoxville McGhee Tyson
Mon 2/8
7:10 pm-7:08 pm
1 stop23h 58m
$602
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Charleston to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Knoxville in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
CHS-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 4, 2026.
Read reviews from past customers who have flown Delta from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Morristown
Newport
Bryson City
Crossville
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
Charleston and Knoxville flights
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Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Charleston to Knoxville
Discover the top airline that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$254 | Average$511 | FlexibilityNo cancel fee | On-timeN/A |