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$126+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Find flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:23 pmCHS - TYS
1 stop19h 59mMultiple Airlines
Mon 11/179:29 pmTYS - CHS
1 stop11h 08mMultiple Airlines
Deal found 10/15$226
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:23 pmCHS - TYS
1 stop12h 04mMultiple Airlines
Sun 11/169:00 amTYS - CHS
2 stops11h 13mMultiple Airlines
Deal found 10/16$288
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3010:11 amCHS - TYS
1 stop12h 08mMultiple Airlines
Mon 11/38:30 amTYS - CHS
1 stop24h 07mMultiple Airlines
Deal found 10/15$304
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/147:00 amCHS - TYS
1 stop27h 04mMultiple Airlines
Fri 11/218:53 amTYS - CHS
2 stops13h 35mMultiple Airlines
Deal found 10/15$314
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:39 pmCHS - TYS
1 stop3h 38mAmerican Airlines
Fri 11/215:07 pmTYS - CHS
1 stop6h 56mAmerican Airlines
Deal found 10/15$327
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:15 pmCHS - TYS
1 stop3h 26mDelta
Mon 11/173:53 pmTYS - CHS
1 stop4h 49mDelta
Deal found 10/16$337
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:10 amCHS - TYS
1 stop5h 09mAmerican Airlines
Fri 11/281:25 pmTYS - CHS
1 stop4h 17mAmerican Airlines
Deal found 10/15$351
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:56 amCHS - TYS
1 stop24h 07mMultiple Airlines
Tue 11/411:23 amTYS - CHS
2 stops29h 43mMultiple Airlines
Deal found 10/16$352
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:53 pmCHS - TYS
1 stop3h 58mAmerican Airlines
Sun 11/235:07 pmTYS - CHS
1 stop6h 56mAmerican Airlines
Deal found 10/16$357
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2010:11 amCHS - TYS
1 stop24h 22mMultiple Airlines
Wed 10/224:26 pmTYS - CHS
1 stop16h 40mMultiple Airlines
Deal found 10/16$369

Cheap flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$226
(Kiwi.com)

One-way from

$126
(Kiwi.com)

Popular in

August

Cheapest in

June

Average price

$658
Provider with most accurate pricing for Charleston-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Knoxville McGhee Tyson flights.
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From Charleston to Knoxville McGhee Tyson
Search Deals
One-way flight from Charleston to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($93 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($41 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Charleston

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/14

9:23 pm-9:27 am

1 stop12h 04m

Knoxville McGhee Tyson

Sun 11/16

9:00 am-8:13 pm

2 stops11h 13m

$288

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 10/30

10:11 am-10:19 pm

1 stop12h 08m

Knoxville McGhee Tyson

Mon 11/3

8:30 am-8:37 am

1 stop24h 07m

$304

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/14

7:00 am-10:04 am

1 stop27h 04m

Knoxville McGhee Tyson

Fri 11/21

8:53 am-10:28 pm

2 stops13h 35m

$314

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 3/7

5:30 am-9:13 am

1 stop3h 43m

Knoxville McGhee Tyson

Tue 3/10

5:30 am-8:42 am

1 stop3h 12m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 12/11

5:10 am-8:36 am

1 stop3h 26m

Knoxville McGhee Tyson

Sun 12/14

5:44 pm-10:00 pm

1 stop4h 16m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 12/11

6:31 pm-11:57 pm

1 stop5h 26m

Knoxville McGhee Tyson

Sat 12/13

9:04 am-12:28 pm

1 stop3h 24m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/14

5:39 pm-9:17 pm

1 stop3h 38m

Knoxville McGhee Tyson

Mon 11/17

4:38 pm-11:19 pm

1 stop6h 41m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/14

5:39 pm-9:17 pm

1 stop3h 38m

Knoxville McGhee Tyson

Fri 11/21

5:07 pm-12:03 am

1 stop6h 56m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/14

8:15 pm-11:41 pm

1 stop3h 26m

Knoxville McGhee Tyson

Mon 11/17

3:53 pm-8:42 pm

1 stop4h 49m

$337

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/28

5:10 am-10:19 am

1 stop5h 09m

Knoxville McGhee Tyson

Fri 11/28

1:25 pm-5:42 pm

1 stop4h 17m

$351

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 16 results
1
2

Compare providers for flights from Charleston to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Knoxville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, March is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $190). Flying from Charleston to Knoxville in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to TYS?

Find hourly flight availability from Charleston to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

When flying from Charleston to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 24% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 16, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Food

7.3

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Food

7.3

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Food

7.3

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Knoxville?

    Airlines like Delta fly from Charleston to Knoxville in about 3h 43m. The time it takes to get you to your destination can typically vary by up to . The distance between Charleston and Knoxville is about 302 mi.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on American Airlines is currently your cheapest option to Knoxville, with prices starting at $326. Another option worth looking into is Delta, starting at $326 round trip. You may be able to fly from Charleston to Knoxville for 39% less than the average price by searching for these airlines.

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, March is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $190). Flying from Charleston to Knoxville in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$326Average$496FlexibilityNo cancel feeOn-time71%
DeltaCheapest$326Average$560FlexibilityNo cancel feeOn-timeN/A

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