Key Largo

$123+ Cheap flights from San Francisco (SFO) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — MIA
Dec 21 — Dec 281
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Find cheap flights from San Francisco to Key Largo with Cheapflights

1. Tell us where you want to go

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Cheapflights Tip: The best prices from San Francisco to Key Largo are usually found in January or August, booked 21 days in advance, depart on a Monday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Key Largo

Keep the following information in mind while searching for San Francisco to Key Largo flight deals. Data was last updated November 21, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$244
(American Airlines)

One-way from

$123
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$405
Provider with most accurate pricing for San Francisco-Miami flight deals.
Provider most trusted by Cheapflights users for San Francisco-Miami flights.
From San Francisco to Key Largo
One-way flight from San Francisco to Key Largo
Highest demand for flights based on searches. 8% potential increase in price ($33 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Average for round-trip flights in November 2025

Find flight deals from San Francisco to Key Largo

Cheapest flights from San Francisco to Key Largo
Explore the most affordable flight options available from San Francisco to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.

This American Airlines deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/61:17 pmSFO - MIA
Nonstop5h 33mAmerican Airlines
Sat 12/137:35 pmMIA - SFO
Nonstop6h 24mAmerican Airlines
Deal found 11/21$244
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:43 amSFO - MIA
2 stops13h 03mFrontier
Thu 12/187:05 amMIA - SFO
1 stop27h 43mFrontier
Deal found 11/20$245
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/212:43 amSFO - MIA
1 stop7h 10mUnited Airlines
Sat 12/611:55 amMIA - SFO
1 stop8h 51mUnited Airlines
Deal found 11/19$246
This Frontier deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1311:33 pmSFO - MIA
1 stop8h 15mFrontier
Wed 12/247:05 amMIA - SFO
1 stop8h 29mFrontier
Deal found 11/19$247
This Kiwi.com deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:33 pmSFO - MIA
1 stop8h 15mMultiple Airlines
Fri 12/126:05 amMIA - SFO
1 stop10h 13mMultiple Airlines
Deal found 11/21$248
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:33 pmSFO - MIA
1 stop8h 15mMultiple Airlines
Sat 12/135:05 amMIA - SFO
2 stops19h 06mMultiple Airlines
Deal found 11/20$249
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/81:15 pmSFO - MIA
Nonstop5h 30mUnited Airlines
Wed 12/1011:55 amMIA - SFO
1 stop8h 51mUnited Airlines
Deal found 11/20$250
This Kiwi.com deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:30 amSFO - MIA
1 stop19h 49mMultiple Airlines
Tue 12/95:58 pmMIA - SFO
2 stops25h 53mMultiple Airlines
Deal found 11/19$251
This Frontier deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/711:33 pmSFO - MIA
1 stop8h 15mFrontier
Mon 12/155:30 amMIA - SFO
1 stop10h 58mFrontier
Deal found 11/20$252
This Kiwi.com deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amSFO - MIA
2 stops25h 48mFrontier
Sun 12/76:00 amMIA - SFO
1 stop21h 24mFrontier
Deal found 11/19$253
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:30 amSFO - MIA
1 stop10h 29mUnited Airlines
Wed 12/108:30 amMIA - SFO
Nonstop6h 33mUnited Airlines
Deal found 11/20$254
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1010:30 amSFO - MIA
2 stops11h 16mDelta
Tue 12/166:50 pmMIA - SFO
1 stop8h 13mDelta
Deal found 11/20$255

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 21, 2025.
Use the filters below to find and compare flights from San Francisco to Key Largo that are best for you.

Fly from

San Francisco

Fly to

Key Largo

Route

Depart

Return

Price

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Tue 2/24

12:43 am-1:48 pm

1 stop10h 05m

Miami

Tue 3/10

7:23 am-10:59 am

Nonstop6h 36m

$255

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Thu 12/11

6:00 am-6:25 pm

1 stop9h 25m

Miami

Thu 12/18

7:39 am-2:36 pm

1 stop9h 57m

$257

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Mon 12/29

11:03 pm-7:36 am

Nonstop5h 33m

Miami

Fri 1/9

6:05 am-9:43 am

Nonstop6h 38m

$259

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Sun 12/7

12:30 am-1:32 pm

1 stop10h 02m

Miami

Sat 12/13

7:00 am-6:56 pm

2 stops14h 56m

$266

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Fri 12/5

2:00 pm-12:46 am

1 stop7h 46m

Miami

Mon 12/15

7:39 am-2:36 pm

1 stop9h 57m

$267

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Sat 2/28

11:50 am-12:51 am

1 stop10h 01m

Miami

Sat 3/7

7:50 am-3:05 pm

1 stop10h 15m

$268

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Mon 1/19

5:55 am-5:56 pm

1 stop9h 01m

Miami

Sat 1/24

5:50 am-5:49 pm

2 stops14h 59m

$271

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Thu 1/8

8:31 am-5:07 pm

Nonstop5h 36m

Miami

Mon 1/12

11:05 am-7:00 pm

1 stop10h 55m

$277

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Sat 4/25

11:59 pm-11:52 am

1 stop8h 53m

Miami

Fri 5/1

5:00 pm-10:39 pm

1 stop8h 39m

$279

San FranciscoMiami

SFO - MIA

SFOMIA

San Francisco

Mon 3/16

12:43 am-10:55 am

1 stop7h 12m

Miami

Tue 6/23

12:15 pm-7:05 pm

1 stop9h 50m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Showing 1-10 of 23 results
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Best time to book a flight from San Francisco to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Key Largo

How far ahead should I book a flight from San Francisco to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Key Largo. Price data was last updated on November 14, 2025.

To ensure you get the cheapest price possible for a flight from San Francisco to Key Largo, you should look to book at least 21 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from San Francisco to Key Largo?

Currently, March is the cheapest month in which you can book a flight from San Francisco to Key Largo (average of $91). Flying from San Francisco to Key Largo in April is currently the most expensive (average of $179). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to KE9?

Find hourly flight availability from San Francisco to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 21, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 17% on flights from San Francisco to Key Largo by exploring options for tickets in the morning.

What is the cheapest day to fly from San Francisco to Key Largo?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to Key Largo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Francisco to Key Largo flight should consider departing on Friday mornings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from San Francisco to Key Largo

Explore weekly flight availability from San Francisco to Key Largo. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 21, 2025.

The most flights from SFO to KE9 are scheduled on a Thursday (26 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (19 on average).

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated November 21, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from San Francisco to Key Largo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from San Francisco to Key Largo?

    If you book a flight to Key Largo from San Francisco, you will be flying from San Francisco, which is the city’s only airport. San Francisco (SFO) is located 11.8 mi from the center of San Francisco. There are 21 flights from San Francisco to Key Largo per day from 8 different airlines.

  • How popular is this San Francisco to Key Largo flight route?

  • How long is the flight from San Francisco to Key Largo?

    Airlines like United Airlines and Delta fly from San Francisco to Key Largo in about 9h 25m. The time it takes to get you to your destination can typically vary by up to 40m. Airlines will cover a distance of 2579 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from San Francisco to Key Largo?

    Before booking your flight to Key Largo from San Francisco, check out the most reliable airlines to get you to your destination on time: United Airlines (92%), China Southern (91%), Air New Zealand( 90%).

  • What are the cheapest flights from San Francisco to Key Largo?

    While on average a flight from San Francisco to Key Largo is generally $1,219, our data shows the cheapest flight currently is $113. When looking at the most popular route, (San Francisco - Miami), you can expect to pay $163 for that flight.

  • Can I find deals for flights from San Francisco to Key Largo that include hotel bookings?

    Yes. In addition to deals on San Francisco to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Key Largo.

  • Can I find deals for business class flights from San Francisco to Key Largo?

    Yes. Cheapflights offers flight deals from San Francisco to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Key Largo?

    Currently, March is the cheapest month in which you can book a flight from San Francisco to Key Largo (average of $91). Flying from San Francisco to Key Largo in April is currently the most expensive (average of $179). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Francisco to Key Largo

See prices for flight routes from nearby airports that may be better suited for you.

Top 8 airlines flying from San Francisco to Key Largo

Discover the top 8 airlines that operate flights from San Francisco to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$105Average$300FlexibilityNo cancel feeOn-time65%
DeltaCheapest$138Average$353FlexibilityNo cancel feeOn-timeN/A
FrontierCheapest$138Average$221FlexibilityNo cancel feeOn-time62%
JetBlueCheapest$148Average$350FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$182Average$392FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$187Average$430FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$193Average$461FlexibilityNo cancel feeOn-time69%
Alaska AirlinesCheapest$217Average$474FlexibilityNo cancel feeOn-time75%

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