HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Key Largo

$111+ Cheap flights from Knoxville (TYS) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/31. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MIA
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Key Largo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Key Largo are usually found in August or July, booked 11 days in advance, depart on a Tuesday or Friday and return on a Wednesday

Cheap flight deals from Knoxville to Key Largo

Keep the following information in mind while searching for Knoxville to Key Largo flight deals. Data was last updated April 30, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$159
(American Airlines)

One-way from

$111
(Trip.com)

Popular in

March

Cheapest in

August

Average price

$375
Provider with most accurate pricing for Knoxville McGhee Tyson-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Miami flights.
Search Deals
From Knoxville McGhee Tyson to Key Largo
Search Deals
One-way flight from Knoxville McGhee Tyson to Key Largo
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($18 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Knoxville to Key Largo

Cheapest flights from Knoxville to Key Largo
Explore the most affordable flight options available from Knoxville to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/116:00 amTYS - MIA
Nonstop2h 10mAmerican Airlines
Wed 6/1810:00 pmMIA - TYS
Nonstop2h 14mAmerican Airlines
Deal found 4/28$159
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/115:57 pmTYS - MIA
1 stop7h 00mDelta
Wed 6/187:00 amMIA - TYS
1 stop6h 47mDelta
Deal found 4/28$179
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/135:01 pmTYS - MIA
1 stop27h 29mMultiple Airlines
Thu 6/198:45 pmMIA - TYS
1 stop20h 02mMultiple Airlines
Deal found 4/28$250
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/115:45 amTYS - MIA
2 stops10h 26mUnited Airlines
Wed 6/1812:06 pmMIA - TYS
1 stop6h 05mUnited Airlines
Deal found 4/28$392
This Frontier deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/295:25 pmTYS - MIA
1 stop13h 05mFrontier
Sun 7/66:00 amMIA - TYS
1 stop10h 29mFrontier
Deal found 4/27$412

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from Knoxville to Key Largo that are best for you.

Fly from

Knoxville

Fly to

Key Largo

Route

Depart

Return

Price

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 5/28

4:22 pm-9:51 pm

1 stop5h 29m

Miami

Wed 6/4

5:35 am-9:40 am

1 stop4h 05m

$189

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 7/12

6:55 pm-9:08 pm

Nonstop2h 13m

Miami

Thu 7/17

10:05 pm-11:59 pm

Nonstop1h 54m

$199

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Thu 6/19

4:25 pm-11:59 pm

2 stops31h 34m

Miami

Sun 6/22

9:35 pm-11:47 am

1 stop14h 12m

$333

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Thu 6/19

5:25 pm-6:30 am

1 stop13h 05m

Miami

Sun 6/22

6:00 am-4:29 pm

1 stop10h 29m

$382

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 5/28

7:00 am-4:11 pm

2 stops9h 11m

Miami

Wed 6/4

12:06 pm-7:56 pm

1 stop7h 50m

$462

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Fri 5/9

2:56 pm-5:01 pm

2 stops26h 05m

Miami

Thu 5/15

6:21 pm-11:58 pm

2 stops29h 37m

$1,341

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sun 6/8

5:25 pm-6:30 am

1 stop13h 05m

$136

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 5/14

7:10 am-11:33 am

2 stops28h 23m

$138

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Mon 5/19

5:58 pm-12:34 am

1 stop6h 36m

$156

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 8/2

9:55 am-11:49 am

1 stop25h 54m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 11 results
1
2

Best time to book a flight from Knoxville to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Key Largo

How far ahead should I book a flight from Knoxville to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Key Largo. Price data was last updated on April 25, 2025.

Booking 11 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Key Largo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Key Largo?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Key Largo (average of $228). Flying from Knoxville to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to KE9?

Find hourly flight availability from Knoxville to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Key Largo as you normally would.

What is the cheapest day to fly from Knoxville to Key Largo?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Key Largo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Key Largo flight should consider departing on Monday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Knoxville to Key Largo

Explore weekly flight availability from Knoxville to Key Largo. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 30, 2025.

The most flights from TYS to KE9 are scheduled on a Monday (2 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (1 on average).

Rainfall in Key Largo by month

Plan your trip to Key Largo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Key Largo ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Key Largo when rainfall is around 1.6 in.

Temperature in Key Largo by month

Plan your trip to Key Largo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Key Largo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated April 30, 2025.
See what other customers who have flown with Alaska Airlines, Delta and United Airlines from Knoxville to Key Largo have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,961 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,961 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,929 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
6.0
Okay
3,284 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Key Largo?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Key Largo. You should not have trouble finding flights to Key Largo from McGhee Tyson; the airport handles an average of 1 outbound flight to Key Largo per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Key Largo. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How popular is this Knoxville to Key Largo flight route?

    Within the past month, 2 users have taken a look at flights from Knoxville McGhee Tyson to Key Largo.

  • What are the cheapest airlines to fly from Knoxville to Key Largo one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $136. American Airlines flights start at $156 while deals on Delta start at $185 one-way.

  • What are the most reliable airlines from Knoxville to Key Largo?

    Consider Envoy Air (83%), American Airlines (77%) or Qatar Airways (69%) when booking your flight. These represent the most reliable airlines when flying from Knoxville to Key Largo.

  • What are the cheapest flights from Knoxville to Key Largo?

    Looking for the cheapest flight from Knoxville to Key Largo? While on average our users pay $407, our data indicates the cheapest price to be $125. The most popular route (Knoxville McGhee Tyson - Miami), is priced around $179.

  • Can I find deals for flights from Knoxville to Key Largo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Key Largo.

  • Can I find deals for business class flights from Knoxville to Key Largo?

    Yes. Cheapflights offers flight deals from Knoxville to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Key Largo (average of $228). Flying from Knoxville to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Key Largo

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Orlando flights
Memphis to Miami flights
Nashville to Fort Lauderdale flights
Memphis to Orlando flights
Nashville to Miami flights
Nashville to Tampa flights
Chattanooga to Orlando flights
Nashville to Pensacola flights
Nashville to Key West flights
Knoxville to Orlando flights
Memphis to Fort Lauderdale flights
Knoxville to Miami flights
Chattanooga to Miami flights
Chattanooga to Sarasota flights
Nashville to Jacksonville flights
Memphis to Tampa flights
Knoxville to Orlando Sanford Intl flights
Nashville to West Palm Beach flights
Chattanooga to Fort Lauderdale flights
Chattanooga to Tampa flights
Knoxville to Fort Lauderdale flights
Nashville to Fort Myers flights
Knoxville to Tampa flights
Nashville to Panama City flights
Chattanooga to West Palm Beach flights
Nashville to Sarasota flights
Memphis to Fort Myers flights
Chattanooga to Fort Myers flights
Blountville to Miami flights
Chattanooga to Pensacola flights
Chattanooga to Jacksonville flights
Knoxville to Pensacola flights
Chattanooga to Orlando Sanford Intl flights
Memphis to Panama City flights
Memphis to Pensacola flights
Memphis to Valparaiso flights
Memphis to Jacksonville flights
Chattanooga to Panama City flights
Memphis to Orlando Sanford Intl flights
Chattanooga to Daytona Beach flights
Knoxville to Key West flights
Knoxville to Panama City flights
Memphis to Sarasota flights
Blountville to Orlando flights
Nashville to Melbourne flights
Memphis to West Palm Beach flights
Nashville to Daytona Beach flights
Memphis to St Petersburg flights
Nashville to Valparaiso flights
Knoxville to St Petersburg flights

Top 3 airlines flying from Knoxville to Key Largo

Discover the top 3 airlines that operate flights from Knoxville to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$78Average$203FlexibilityNo cancel feeOn-time88%
DeltaCheapest$178Average$393FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$227Average$403FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.