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Key Largo

$101+ Cheap flights from Knoxville (TYS) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MIA
Nov 30 — Dec 71
Sun 11/30
Sun 12/7
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Key Largo are usually found in February or July, booked 42 days in advance, depart on a Friday or Saturday and return on a Tuesday

Cheap flight deals from Knoxville to Key Largo

Keep the following information in mind while searching for Knoxville to Key Largo flight deals. Data was last updated October 31, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$159
(American Airlines)

One-way from

$101
(Priceline)

Popular in

May

Cheapest in

February

Average price

$413
Provider with most accurate pricing for Knoxville McGhee Tyson-Miami flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Miami flights.
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From Knoxville McGhee Tyson to Key Largo
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One-way flight from Knoxville McGhee Tyson to Key Largo
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Highest demand for flights based on searches. 4% potential increase in price ($17 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Knoxville to Key Largo

Cheapest flights from Knoxville to Key Largo
Explore the most affordable flight options available from Knoxville to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 31, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:03 pmTYS - MIA
Nonstop2h 17mAmerican Airlines
Sat 12/139:34 pmMIA - TYS
Nonstop2h 23mAmerican Airlines
Deal found 10/28$159
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:00 pmTYS - MIA
1 stop6h 46mDelta
Tue 12/162:11 pmMIA - TYS
1 stop5h 54mDelta
Deal found 10/29$179
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:22 pmTYS - MIA
2 stops25h 36mMultiple Airlines
Fri 11/1411:31 amMIA - TYS
1 stop11h 25mMultiple Airlines
Deal found 10/28$192
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/311:00 amTYS - MIA
1 stop7h 47mMultiple Airlines
Fri 11/711:53 amMIA - TYS
1 stop10h 33mMultiple Airlines
Deal found 10/28$201
This Frontier deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:17 pmTYS - MIA
1 stop11h 02mFrontier
Sun 11/96:00 amMIA - TYS
1 stop12h 22mFrontier
Deal found 10/28$202
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:42 pmTYS - MIA
2 stops18h 06mMultiple Airlines
Tue 11/181:02 pmMIA - TYS
1 stop23h 55mMultiple Airlines
Deal found 10/27$206
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/97:17 pmTYS - MIA
2 stops29h 17mMultiple Airlines
Fri 11/1411:31 amMIA - TYS
1 stop11h 25mMultiple Airlines
Deal found 10/27$208
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/84:52 pmTYS - MIA
2 stops31h 05mMultiple Airlines
Fri 12/127:35 amMIA - TYS
1 stop11h 39mMultiple Airlines
Deal found 10/30$220
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:30 amTYS - MIA
1 stop12h 14mMultiple Airlines
Sun 11/169:59 pmMIA - TYS
2 stops36h 35mMultiple Airlines
Deal found 10/30$224
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:54 amTYS - MIA
2 stops14h 40mMultiple Airlines
Mon 11/1712:22 pmMIA - TYS
1 stop6h 14mMultiple Airlines
Deal found 10/29$225

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 31, 2025.
Use the filters below to find and compare flights from Knoxville to Key Largo that are best for you.

Fly from

Knoxville

Fly to

Key Largo

Route

Depart

Return

Price

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Mon 11/10

5:22 pm-6:58 pm

2 stops25h 36m

Miami

Fri 11/14

11:31 am-10:56 pm

1 stop11h 25m

$192

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 12/10

5:09 pm-10:18 pm

1 stop5h 09m

Miami

Sat 12/13

9:34 pm-11:57 pm

Nonstop2h 23m

$238

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Fri 1/23

5:30 am-10:40 am

1 stop5h 10m

Miami

Sat 1/31

7:15 am-1:52 pm

1 stop6h 37m

$259

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Thu 11/13

9:54 am-11:00 am

2 stops25h 06m

Miami

Mon 11/17

6:25 am-10:34 am

3 stops28h 09m

$279

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 1/3

7:15 am-11:17 pm

1 stop16h 02m

Miami

Sun 1/11

5:35 am-5:53 pm

2 stops12h 18m

$280

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Fri 1/16

5:36 pm-7:52 pm

Nonstop2h 16m

Miami

Fri 1/30

5:36 pm-10:54 pm

1 stop5h 18m

$284

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 11/26

12:53 pm-11:08 pm

1 stop10h 15m

Miami

Wed 12/3

5:58 pm-9:37 pm

2 stops27h 39m

$291

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 12/10

5:40 am-9:27 am

1 stop3h 47m

Miami

Sat 12/13

2:11 pm-6:58 pm

1 stop4h 47m

$299

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sun 11/2

5:30 am-10:46 pm

2 stops17h 16m

Miami

Fri 11/7

11:53 am-10:26 pm

1 stop10h 33m

$310

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 1/24

5:36 pm-7:52 pm

Nonstop2h 16m

Miami

Sun 2/1

8:35 am-1:54 pm

1 stop5h 19m

$316

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 17 results
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Best time to book a flight from Knoxville to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Key Largo

How far ahead should I book a flight from Knoxville to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Key Largo. Price data was last updated on October 24, 2025.

Booking 42 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Key Largo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Key Largo?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Key Largo (average of $77). Flying from Knoxville to Key Largo in December is currently the most expensive (average of $99). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to KE9?

Find hourly flight availability from Knoxville to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 31, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Key Largo in the afternoon. If you’re flexible enough to do this you can expect to save up to 45% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Knoxville to Key Largo?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Key Largo. Price data was last updated on October 26, 2025.

Travelers seeking maximum savings on their Knoxville to Key Largo flight should consider departing on Monday afternoons when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated October 31, 2025.
Get a feel of what it's like to fly with Delta, American Airlines, and Allegiant Air from Knoxville to Key Largo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
11,034 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Allegiant Air
7.2
Good
694 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Key Largo?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Key Largo. You should not have trouble finding flights to Key Largo from McGhee Tyson; the airport handles an average of 1 outbound flight to Key Largo per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Key Largo. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How popular is this Knoxville to Key Largo flight route?

    Within the past month, 2 users have taken a look at flights from Knoxville McGhee Tyson to Key Largo.

  • How long is the flight from Knoxville to Key Largo?

    A quick flight from Knoxville to Key Largo can take about 5h 09m. American Airlines provides one of the quickest options available for as low as $238. Airlines will cover a distance of 725 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Knoxville to Key Largo?

    Consider American Airlines (89%), Qatar Airways (89%) or Envoy Air (89%) when booking your flight. These represent the most reliable airlines when flying from Knoxville to Key Largo.

  • What are the cheapest flights from Knoxville to Key Largo?

    Looking for the cheapest flight from Knoxville to Key Largo? While on average our users pay $442, our data indicates the cheapest price to be $148. The most popular route (Knoxville McGhee Tyson - Miami), is priced around $179.

  • Can I find deals for flights from Knoxville to Key Largo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Key Largo.

  • Can I find deals for business class flights from Knoxville to Key Largo?

    Yes. Cheapflights offers flight deals from Knoxville to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Key Largo?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Key Largo (average of $77). Flying from Knoxville to Key Largo in December is currently the most expensive (average of $99). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 3 airlines flying from Knoxville to Key Largo

Discover the top 3 airlines that operate flights from Knoxville to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$80Average$189FlexibilityNo cancel feeOn-time88%
DeltaCheapest$182Average$385FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$239Average$395FlexibilityNo cancel feeOn-time71%

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