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Key Largo

$108+ Cheap flights from Knoxville (TYS) to Key Largo, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MIA
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Key Largo are usually found in July or August, booked 42 days in advance, depart on a Saturday or Friday and return on a Tuesday

Cheap flight deals from Knoxville to Key Largo

Keep the following information in mind while searching for Knoxville to Key Largo flight deals. Data was last updated September 17, 2025.

Round-trip from

$163
(American Airlines)

One-way from

$108
(Kiwi.com)

Popular in

May

Cheapest in

July

Average price

$395
From Knoxville McGhee Tyson to Key Largo
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One-way flight from Knoxville McGhee Tyson to Key Largo
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Highest demand for flights based on searches. 5% potential increase in price ($24 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Key Largo

Cheapest flights from Knoxville to Key Largo
Explore the most affordable flight options available from Knoxville to Key Largo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:03 pmTYS - MIA
Nonstop2h 17mAmerican Airlines
Sat 12/139:34 pmMIA - TYS
Nonstop2h 23mAmerican Airlines
Deal found 9/15$163
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/238:17 pmTYS - MIA
1 stop10h 02mFrontier
Mon 10/276:00 amMIA - TYS
1 stop13h 32mFrontier
Deal found 9/15$182
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:44 amTYS - MIA
1 stop3h 51mDelta
Wed 10/226:00 amMIA - TYS
1 stop4h 45mDelta
Deal found 9/15$183
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:17 pmTYS - MIA
2 stops14h 54mFrontier
Thu 11/66:00 amMIA - TYS
1 stop12h 22mFrontier
Deal found 9/15$210
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:15 amTYS - MIA
Nonstop2h 07mAmerican Airlines
Tue 10/2111:50 amMIA - TYS
1 stop5h 01mAmerican Airlines
Deal found 9/16$218
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:44 amTYS - MIA
1 stop3h 51mDelta
Tue 10/218:11 amMIA - TYS
1 stop6h 32mDelta
Deal found 9/16$221
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/226:15 amTYS - MIA
Nonstop2h 07mAmerican Airlines
Mon 10/279:24 pmMIA - TYS
Nonstop2h 15mAmerican Airlines
Deal found 9/15$230
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:15 amTYS - MIA
Nonstop2h 07mAmerican Airlines
Thu 11/69:40 pmMIA - TYS
Nonstop2h 19mAmerican Airlines
Deal found 9/15$231
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:15 amTYS - MIA
Nonstop2h 07mAmerican Airlines
Tue 10/289:24 pmMIA - TYS
Nonstop2h 15mAmerican Airlines
Deal found 9/15$233

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Key Largo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to Key Largo that are best for you.

Fly from

Knoxville

Fly to

Key Largo

Route

Depart

Return

Price

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Tue 10/21

11:44 am-6:25 pm

1 stop6h 41m

Miami

Tue 10/28

10:40 am-4:31 pm

1 stop5h 51m

$183

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 10/15

5:44 am-11:04 am

1 stop5h 20m

Miami

Wed 10/22

6:00 am-10:45 am

1 stop4h 45m

$183

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 11/8

4:56 pm-7:08 pm

Nonstop2h 12m

Miami

Tue 11/11

2:21 pm-4:37 pm

Nonstop2h 16m

$198

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Tue 10/28

2:27 pm-8:51 pm

1 stop6h 24m

Miami

Thu 11/6

8:11 am-2:51 pm

1 stop6h 40m

$221

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 12/6

8:45 am-3:50 pm

1 stop7h 05m

Miami

Fri 12/12

8:05 am-2:51 pm

1 stop6h 46m

$249

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Fri 1/16

5:15 pm-7:34 pm

Nonstop2h 19m

Miami

Sat 1/24

8:00 am-2:13 pm

1 stop6h 13m

$274

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Tue 12/9

6:00 am-8:17 am

Nonstop2h 17m

Miami

Sun 12/14

10:19 pm-12:41 am

Nonstop2h 22m

$298

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 10/15

7:15 am-6:07 pm

1 stop10h 52m

Miami

Sat 10/18

6:00 am-1:33 pm

1 stop31h 33m

$303

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Thu 12/11

5:03 pm-7:20 pm

Nonstop2h 17m

Miami

Mon 12/15

3:27 pm-10:55 pm

1 stop7h 28m

$306

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Thu 12/11

7:59 pm-12:46 am

1 stop4h 47m

Miami

Mon 12/15

7:30 pm-11:51 pm

1 stop4h 21m

$316

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 19 results
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Best time to book a flight from Knoxville to Key Largo

Have a flexible travel schedule? Discover the best time to fly to Key Largo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Key Largo

How far ahead should I book a flight from Knoxville to Key Largo?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Key Largo. Price data was last updated on September 12, 2025.

Booking 42 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Key Largo. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Key Largo?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Key Largo (average of $232). Flying from Knoxville to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to KE9?

Find hourly flight availability from Knoxville to Key Largo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Key Largo as you normally would.

What is the cheapest day to fly from Knoxville to Key Largo?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Key Largo. Price data was last updated on September 14, 2025.

Travelers seeking maximum savings on their Knoxville to Key Largo flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Knoxville to Key Largo

Explore weekly flight availability from Knoxville to Key Largo. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 17, 2025.

The most flights from TYS to KE9 are scheduled on a Monday (2 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Key Largo

Get insights into the airlines that provide service to Key Largo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key Largo. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Delta, American Airlines, and Allegiant Air from Knoxville to Key Largo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Allegiant Air
7.2
Good
699 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Key Largo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Key Largo?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Key Largo. You should not have trouble finding flights to Key Largo from McGhee Tyson; the airport handles an average of 2 outbound flights to Key Largo per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Key Largo. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How popular is this Knoxville to Key Largo flight route?

    Within the past month, 2 users have taken a look at flights from Knoxville McGhee Tyson to Key Largo.

  • How long is the flight from Knoxville to Key Largo?

    A quick flight from Knoxville to Key Largo can take about 2h 12m. Delta provides one of the quickest options available for as low as $198. Airlines will cover a distance of 725 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Knoxville to Key Largo?

    Consider Envoy Air (83%), Qatar Airways (77%) or American Airlines (74%) when booking your flight. These represent the most reliable airlines when flying from Knoxville to Key Largo.

  • What are the cheapest flights from Knoxville to Key Largo?

    Looking for the cheapest flight from Knoxville to Key Largo? While on average our users pay $585, our data indicates the cheapest price to be $252. The most popular route (Knoxville McGhee Tyson - Miami), is priced around $183.

  • Can I find deals for flights from Knoxville to Key Largo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Key Largo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Key Largo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Key Largo.

  • Can I find deals for business class flights from Knoxville to Key Largo?

    Yes. Cheapflights offers flight deals from Knoxville to Key Largo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Key Largo?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Key Largo (average of $232). Flying from Knoxville to Key Largo in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 3 airlines flying from Knoxville to Key Largo

Discover the top 3 airlines that operate flights from Knoxville to Key Largo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$78Average$188FlexibilityNo cancel feeOn-time88%
DeltaCheapest$178Average$371FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$241Average$399FlexibilityNo cancel feeOn-time71%

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