Italy

$564+ Cheap flights from Panama City (PTY) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/28. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — NAP
Jul 5 — Jul 121
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Cheap flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2026.

This Expedia deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/29:05 pm
PTY
-
FCO
1 stop20h 10m
Iberia
Mon 8/2412:00 pm
FCO
-
PTY
1 stop14h 35m
Iberia
Deal found 6/2$821
This Booking.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:20 pm
PTY
-
MXP
1 stop32h 50m
Turkish Airlines
Thu 10/223:15 pm
MXP
-
PTY
1 stop36h 10m
Turkish Airlines
Deal found 6/4$826
This KLM deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/309:55 pm
PTY
-
MXP
1 stop18h 05m
Air France
Mon 8/316:45 am
MXP
-
PTY
2 stops17h 05m
Air France
Deal found 6/4$829
This KLM deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/309:55 pm
PTY
-
LIN
1 stop17h 35m
Air France
Wed 9/28:45 pm
LIN
-
PTY
2 stops27h 05m
Air France
Deal found 6/4$831
This Orbitz deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:35 pm
PTY
-
FCO
1 stop18h 55m
Iberia
Tue 11/172:45 pm
FCO
-
PTY
1 stop32h 20m
Iberia
Deal found 6/4$832
This KLM deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/309:55 pm
PTY
-
LIN
1 stop17h 35m
Air France
Mon 8/316:25 am
LIN
-
PTY
2 stops17h 25m
Air France
Deal found 6/4$833
This Turkish Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:20 pm
PTY
-
MXP
1 stop27h 25m
Turkish Airlines
Fri 10/236:50 am
MXP
-
PTY
1 stop20h 35m
Turkish Airlines
Deal found 5/31$834
This Gotogate deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:45 pm
PTY
-
FCO
1 stop34h 05m
Turkish Airlines
Thu 11/127:45 pm
FCO
-
PTY
1 stop30h 20m
Turkish Airlines
Deal found 5/31$840
This Booking.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:20 pm
PTY
-
FCO
1 stop37h 05m
Turkish Airlines
Fri 10/237:05 am
FCO
-
PTY
1 stop20h 20m
Turkish Airlines
Deal found 6/2$841
This Turkish Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:20 pm
PTY
-
MXP
1 stop18h 25m
Turkish Airlines
Fri 10/236:50 am
MXP
-
PTY
1 stop20h 35m
Turkish Airlines
Deal found 6/3$844
This KLM deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/29:55 pm
PTY
-
FCO
2 stops17h 50m
Multiple Airlines
Mon 8/246:05 am
FCO
-
PTY
1 stop20h 40m
Multiple Airlines
Deal found 6/2$855
This Turkish Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/99:45 pm
PTY
-
FCO
1 stop30h 05m
Turkish Airlines
Mon 11/236:40 am
FCO
-
PTY
1 stop19h 25m
Turkish Airlines
Deal found 6/2$856

Find flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated June 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$821
(Expedia)

One-way from

$564
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$953
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
From Panama City Tocumen Intl to Italy
One-way flight from Panama City Tocumen Intl to Italy
Highest demand for flights based on searches. 5% potential increase in price ($51 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
Average for round-trip flights in June 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 11/2

9:45 pm-9:55 pm

1 stop18h 10m

Rome Fiumicino

Thu 11/12

11:15 am-8:05 pm

1 stop38h 50m

$857

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 11/9

6:50 pm-6:20 pm

1 stop17h 30m

Rome Fiumicino

Mon 11/23

6:40 am-8:05 pm

1 stop19h 25m

$857

Panama CityNaples

PTY - NAP

PTYNAP

Panama City Tocumen Intl

Fri 10/30

9:45 pm-8:20 am

1 stop28h 35m

Naples

Sun 11/15

7:35 pm-8:05 pm

1 stop30h 30m

$868

Panama CityTurin

PTY - TRN

PTYTRN

Panama City Tocumen Intl

Thu 10/1

8:10 pm-9:30 am

1 stop30h 20m

Turin Citta Di Torino

Sun 10/4

6:50 pm-8:25 pm

1 stop32h 35m

$886

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Sat 10/31

9:45 pm-5:50 pm

1 stop38h 05m

Milan Malpensa

Wed 11/4

2:35 pm-5:10 pm

2 stops32h 35m

$887

Panama CityFlorence

PTY - FLR

PTYFLR

Panama City Tocumen Intl

Mon 9/28

9:55 pm-10:30 pm

2 stops17h 35m

Florence Peretola

Wed 10/7

8:35 pm-4:50 pm

2 stops27h 15m

$914

Panama CityVenice

PTY - VCE

PTYVCE

Panama City Tocumen Intl

Mon 10/19

10:20 pm-1:05 pm

1 stop31h 45m

Venice Marco Polo

Fri 10/23

9:20 am-8:25 pm

1 stop18h 05m

$917

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sun 8/30

10:55 pm-7:55 am

2 stops26h 00m

Rome Fiumicino

Wed 9/9

12:55 pm-7:31 pm

1 stop37h 36m

$918

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sun 8/30

10:55 pm-7:55 am

2 stops26h 00m

Rome Fiumicino

Fri 9/11

12:55 pm-7:31 pm

1 stop37h 36m

$918

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Fri 11/6

10:00 am-7:55 am

1 stop15h 55m

Rome Fiumicino

Mon 11/16

11:00 am-8:02 pm

2 stops39h 02m

$919

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/1

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City to Italy?

Currently, September is the cheapest month in which you can book a flight from Panama City to Italy (average of $312). Flying from Panama City to Italy in January is currently the most expensive (average of $743). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How far ahead should I book a flight from Panama City to Italy?

The best time to book flights from Panama City to Italy is 88 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated June 5, 2026.
Get a feel of what it's like to fly with KLM,Air France, andTurkish Airlines from Panama City to Italy by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

7.7

Crew

8.4

Food

7.3

Boarding

7.8

Entertainment

7.2

Overall

7.8

Reviews

1 / 20
6.0
Good

Anonymous,Apr 2026

OKC - ATL

Flight was ok - difficult as I had seat next to bathroom.. Food awful

Comfort

7.7

Crew

8.4

Food

7.3

Boarding

7.8

Entertainment

7.2

Overall

7.8

Reviews

1 / 20
6.0
Good

Anonymous,Apr 2026

OKC - ATL

Flight was ok - difficult as I had seat next to bathroom.. Food awful

Comfort

7.7

Crew

8.4

Food

7.3

Boarding

7.8

Entertainment

7.2

Overall

7.8

Reviews

1 / 20
6.0
Good

Anonymous,Apr 2026

OKC - ATL

Flight was ok - difficult as I had seat next to bathroom.. Food awful

Comfort

7.7

Crew

8.4

Food

7.3

Boarding

7.8

Entertainment

7.2

Overall

7.8

Reviews

1 / 20
6.0
Good

Anonymous,Apr 2026

OKC - ATL

Flight was ok - difficult as I had seat next to bathroom.. Food awful

Comfort

7.7

Crew

8.4

Food

7.3

Boarding

7.8

Entertainment

7.2

Overall

7.8

Reviews

1 / 20
6.0
Good

Anonymous,Apr 2026

OKC - ATL

Flight was ok - difficult as I had seat next to bathroom.. Food awful

Comfort

7.7

Crew

8.4

Food

7.3

Boarding

7.8

Entertainment

7.2

Overall

7.8

Reviews

1 / 20
6.0
Good

Anonymous,Apr 2026

OKC - ATL

Flight was ok - difficult as I had seat next to bathroom.. Food awful

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Panama City to Italy?

    Most people fly from Panama City Tocumen Intl (PTY) if they book a flight from Panama City to Italy. Panama City Tocumen Intl is conveniently located just 11.4 mi from Panama City’s city center.

  • How long is the flight from Panama City to Italy?

    Airlines like Turkish Airlines, United Airlines, and Air France fly from Panama City to Italy in about 14h 50m. The time it takes to get you to your destination can typically vary by up to 11h 10m. The distance between Panama City and Italy is about 5704 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to Italy?

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Italy?

    Currently, September is the cheapest month in which you can book a flight from Panama City to Italy (average of $312). Flying from Panama City to Italy in January is currently the most expensive (average of $743). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Panama City to Italy

Discover the top 3 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest$679Average$1,113FlexibilityNo cancel feeOn-time83%
Turkish AirlinesCheapest$690Average$854FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$883Average$972FlexibilityNo cancel feeOn-time77%

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