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Italy

$572+ Cheap flights from Panama City (PTY) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — NAP
Jan 4 — Jan 111
Sun 1/4
Sun 1/11
1 adult, Economy
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Cheap flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 5, 2025.

This KLM deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - LIN
1 stop22h 10mKLM
Mon 1/266:30 amLIN - PTY
1 stop19h 25mKLM
Deal found 12/5$708
This Air France deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:20 pmPTY - MXP
1 stop18h 40mAir France
Sat 1/316:25 pmMXP - PTY
1 stop31h 45mAir France
Deal found 12/3$807
This Air France deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/73:46 pmPTY - MXP
1 stop35h 19mAir France
Wed 12/3111:35 amMXP - PTY
1 stop14h 35mAir France
Deal found 12/5$1,018
This Air France deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1510:20 pmPTY - FCO
1 stop15h 25mAir France
Fri 12/2612:40 pmFCO - PTY
1 stop37h 20mAir France
Deal found 12/3$1,025
This Air France deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:40 pmPTY - BLQ
2 stops16h 40mAir France
Sun 1/116:15 pmBLQ - PTY
1 stop31h 55mAir France
Deal found 12/2$1,038
This Turkish Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:45 pmPTY - MXP
1 stop37h 55mTurkish Airlines
Mon 3/26:55 amMXP - PTY
2 stops40h 10mTurkish Airlines
Deal found 12/4$1,044
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:05 pmPTY - MXP
1 stop20h 15mMultiple Airlines
Sun 1/115:10 pmMXP - PTY
3 stops26h 50mMultiple Airlines
Deal found 12/2$1,083
This SmartFares deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:05 pmPTY - MXP
1 stop20h 15mCondor
Sun 1/114:45 pmMXP - PTY
1 stop30h 00mCondor
Deal found 12/2$1,113
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:00 amPTY - FCO
1 stop15h 55mUnited Airlines
Thu 12/1111:00 amFCO - PTY
2 stops32h 55mUnited Airlines
Deal found 12/3$1,132
This KLM deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - BLQ
1 stop22h 20mMultiple Airlines
Sun 1/116:15 pmBLQ - PTY
1 stop31h 55mMultiple Airlines
Deal found 12/2$1,141
This KLM deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:45 pmPTY - LIN
1 stop22h 10mKLM
Sun 1/114:50 pmLIN - PTY
1 stop29h 40mKLM
Deal found 12/2$1,154
This KLM deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:45 pmPTY - FCO
1 stop32h 25mMultiple Airlines
Sun 12/2812:40 pmFCO - PTY
1 stop37h 20mMultiple Airlines
Deal found 12/3$1,196

Find flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated December 5, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$699
(Turkish Airlines)

One-way from

$572
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$981
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
Search Deals
From Panama City Tocumen Intl to Italy
Search Deals
One-way flight from Panama City Tocumen Intl to Italy
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($63 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 5, 2025.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Panama City

Fly to

Italy

Route

Depart

Return

Price

Panama CityBologna

PTY - BLQ

PTYBLQ

Panama City Tocumen Intl

Mon 2/23

9:45 pm-9:55 am

1 stop30h 10m

Bologna Guglielmo Marconi

Mon 3/9

7:35 pm-5:05 pm

2 stops27h 30m

$701

Panama CityMilan

PTY - LIN

PTYLIN

Panama City Tocumen Intl

Mon 2/16

10:05 pm-10:55 pm

1 stop18h 50m

Milan Linate

Thu 2/26

6:30 am-4:30 pm

1 stop16h 00m

$702

Panama CityMilan

PTY - LIN

PTYLIN

Panama City Tocumen Intl

Thu 12/25

6:45 pm-10:55 pm

1 stop22h 10m

Milan Linate

Mon 1/26

6:30 am-7:55 pm

1 stop19h 25m

$708

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 5/18

8:25 pm-5:25 pm

1 stop14h 00m

Rome Fiumicino

Fri 5/22

10:30 am-6:40 pm

1 stop15h 10m

$713

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Mon 2/23

7:05 pm-9:20 pm

1 stop20h 15m

Milan Malpensa

Mon 3/9

7:55 am-4:45 pm

1 stop14h 50m

$714

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sat 4/25

10:15 pm-9:20 am

1 stop28h 05m

Rome Fiumicino

Sat 5/16

8:00 pm-6:30 pm

2 stops29h 30m

$724

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 4/27

10:15 pm-9:20 am

1 stop28h 05m

Rome Fiumicino

Wed 5/6

7:05 am-6:30 pm

2 stops42h 25m

$724

Panama CityNaples

PTY - NAP

PTYNAP

Panama City Tocumen Intl

Mon 4/13

10:15 pm-2:50 pm

1 stop33h 35m

Naples

Fri 5/22

8:45 pm-8:20 pm

1 stop30h 35m

$749

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Mon 5/18

8:25 pm-5:15 pm

1 stop13h 50m

Milan Malpensa

Thu 5/21

11:05 am-6:40 pm

1 stop14h 35m

$763

Panama CityNaples

PTY - NAP

PTYNAP

Panama City Tocumen Intl

Mon 4/13

6:50 pm-2:35 pm

1 stop36h 45m

Naples

Fri 5/22

10:45 pm-4:50 pm

1 stop25h 05m

$778

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 49 results
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Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City to Italy?

Currently, June is the cheapest month in which you can book a flight from Panama City to Italy (average of $383). Flying from Panama City to Italy in January is currently the most expensive (average of $766). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to IT?

Find hourly flight availability from Panama City to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 5, 2025.

It’s optimal to fly from Panama City to Italy in the morning. By choosing this option you can save up to 23% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated December 5, 2025.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama City to Italy by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,500 reviews

Food

7.0

Entertainment

7.0

Boarding

7.4

Crew

8.2

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Air France
7.4
Good
1,500 reviews
Air France
7.4
Good
1,500 reviews

Food

7.0

Entertainment

7.0

Boarding

7.4

Crew

8.2

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Turkish Airlines
7.3
Good
4,077 reviews
Air France
7.4
Good
1,500 reviews

Food

7.0

Entertainment

7.0

Boarding

7.4

Crew

8.2

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Air Europa
7.0
Good
569 reviews
Air France
7.4
Good
1,500 reviews

Food

7.0

Entertainment

7.0

Boarding

7.4

Crew

8.2

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Iberia
7.0
Good
3,040 reviews
Air France
7.4
Good
1,500 reviews

Food

7.0

Entertainment

7.0

Boarding

7.4

Crew

8.2

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.
Condor
6.4
Okay
389 reviews
Air France
7.4
Good
1,500 reviews

Food

7.0

Entertainment

7.0

Boarding

7.4

Crew

8.2

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Hazel,Nov 2025

CDG - FCO

My experience with Air France was very disappointing. They claimed the flight was full and required me to check in my carry-on bag, yet once on board, there was plenty of overhead compartment space available. Several passengers with larger and heavier bags were allowed to bring theirs on without any issue. The inconsistency felt unfair and frustrating.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Most people fly from Panama City Tocumen Intl (PTY) if they book a flight from Panama City to Italy. Panama City Tocumen Intl is conveniently located just 11.4 mi from Panama City’s city center.

  • How long is the flight from Panama City to Italy?

    Airlines like Turkish Airlines, KLM, and Air Europa fly from Panama City to Italy in about 14h. The time it takes to get you to your destination can typically vary by up to 16h 10m. The distance between Panama City and Italy is about 5881 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to Italy?

    When deciding which route to take from Panama City to Italy consider Panama City Tocumen Intl - Milan Malpensa, Panama City Tocumen Intl - Rome Fiumicino or Panama City Tocumen Intl - Trieste Ronchi dei Legionari as they are the most popular.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Italy?

    Currently, June is the cheapest month in which you can book a flight from Panama City to Italy (average of $383). Flying from Panama City to Italy in January is currently the most expensive (average of $766). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Panama City to Italy

Discover the top 4 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
Turkish AirlinesCheapest$678Average$879FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$679Average$976FlexibilityNo cancel feeOn-time83%
IberiaCheapest$767Average$778FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$783Average$928FlexibilityNo cancel feeOn-time77%

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