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$410+ Cheap flights from Panama City (PTY) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — NAP
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$569
(Booking.com)

One-way from

$410
(Booking.com)

Popular in

January

Cheapest in

March

Average price

$829
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
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From Panama City Tocumen Intl to Italy
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One-way flight from Panama City Tocumen Intl to Italy
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Highest demand for flights based on searches. 6% potential increase in price ($62 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Booking.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:05 pmPTY - MXP
1 stop20h 15mCondor
Thu 1/157:55 amMXP - PTY
1 stop14h 50mCondor
Deal found 11/5$569
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:05 pmPTY - MXP
1 stop20h 15mCondor
Mon 1/57:55 amMXP - PTY
1 stop14h 50mCondor
Deal found 11/4$671
This KLM deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:45 pmPTY - LIN
1 stop15h 10mKLM
Wed 11/199:20 pmLIN - PTY
1 stop25h 10mKLM
Deal found 11/6$728
This KLM deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:45 pmPTY - LIN
1 stop19h 35mKLM
Wed 11/199:20 pmLIN - PTY
1 stop25h 10mKLM
Deal found 11/6$740
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:05 pmPTY - MXP
1 stop20h 15mMultiple Airlines
Sun 11/236:35 pmMXP - PTY
1 stop31h 15mMultiple Airlines
Deal found 11/5$742
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:05 pmPTY - MXP
1 stop20h 15mMultiple Airlines
Sun 11/236:35 pmMXP - PTY
1 stop31h 15mMultiple Airlines
Deal found 11/5$754
This Booking.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/229:45 pmPTY - FCO
1 stop18h 10mTurkish Airlines
Wed 11/266:45 amFCO - PTY
1 stop19h 05mTurkish Airlines
Deal found 11/5$760
This KLM deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:45 pmPTY - LIN
1 stop19h 35mMultiple Airlines
Thu 11/206:30 amLIN - PTY
1 stop19h 40mMultiple Airlines
Deal found 11/4$760
This KLM deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:45 pmPTY - LIN
1 stop15h 10mKLM
Thu 11/206:30 amLIN - PTY
1 stop16h 00mKLM
Deal found 11/6$764
This Turkish Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/89:45 pmPTY - MXP
1 stop29h 20mTurkish Airlines
Sun 11/2310:40 amMXP - PTY
1 stop39h 10mTurkish Airlines
Deal found 11/6$768
This KLM deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/106:45 pmPTY - LIN
1 stop22h 10mKLM
Wed 11/199:20 pmLIN - PTY
1 stop25h 10mKLM
Deal found 11/6$784
This Air France deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/910:20 pmPTY - MXP
1 stop13h 05mAir France
Thu 11/2011:35 amMXP - PTY
1 stop14h 35mAir France
Deal found 11/5$786

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Panama City

Fly to

Italy

Route

Depart

Return

Price

Panama CityMilan

PTY - LIN

PTYLIN

Panama City Tocumen Intl

Wed 11/12

6:45 pm-3:55 pm

1 stop15h 10m

Milan Linate

Wed 11/19

9:20 pm-4:30 pm

1 stop25h 10m

$728

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 4/27

10:15 pm-2:00 pm

1 stop32h 45m

Rome Fiumicino

Mon 6/1

7:05 am-6:30 pm

2 stops42h 25m

$734

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sun 4/19

8:10 pm-9:20 am

1 stop30h 10m

Rome Fiumicino

Thu 4/30

8:00 pm-6:30 pm

2 stops29h 30m

$749

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Tue 3/31

8:10 pm-2:25 pm

1 stop35h 15m

Rome Fiumicino

Sat 5/2

10:45 am-6:30 pm

2 stops38h 45m

$749

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Thu 4/30

8:10 pm-11:35 pm

1 stop20h 25m

Rome Fiumicino

Sun 5/17

3:25 pm-6:30 pm

2 stops34h 05m

$749

Panama CityNaples

PTY - NAP

PTYNAP

Panama City Tocumen Intl

Wed 4/1

8:10 pm-2:50 pm

1 stop35h 40m

Naples

Thu 4/30

8:45 pm-6:30 pm

2 stops28h 45m

$749

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 3/30

10:15 pm-9:20 am

1 stop28h 05m

Rome Fiumicino

Wed 4/8

10:45 am-6:30 pm

2 stops38h 45m

$757

Panama CityMilan

PTY - LIN

PTYLIN

Panama City Tocumen Intl

Wed 11/12

6:45 pm-3:55 pm

1 stop15h 10m

Milan Linate

Thu 11/20

6:30 am-4:30 pm

1 stop16h 00m

$764

Panama CityMilan

PTY - LIN

PTYLIN

Panama City Tocumen Intl

Wed 11/12

6:45 pm-3:55 pm

1 stop15h 10m

Milan Linate

Thu 11/20

12:20 pm-8:10 pm

1 stop13h 50m

$766

Panama CityMilan

PTY - LIN

PTYLIN

Panama City Tocumen Intl

Tue 11/11

6:45 pm-10:55 pm

1 stop22h 10m

Milan Linate

Thu 11/20

12:20 pm-8:10 pm

1 stop13h 50m

$766

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 60 results
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Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City to Italy?

Currently, June is the cheapest month in which you can book a flight from Panama City to Italy (average of $384). Flying from Panama City to Italy in January is currently the most expensive (average of $751). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to IT?

Find hourly flight availability from Panama City to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s optimal to fly from Panama City to Italy in the morning. By choosing this option you can save up to 22% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated November 6, 2025.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Air Europa from Panama City to Italy by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,484 reviews

Entertainment

7.0

Comfort

7.4

Boarding

7.4

Food

7.0

Crew

8.2

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air France
7.4
Good
1,484 reviews
Air France
7.4
Good
1,484 reviews

Entertainment

7.0

Comfort

7.4

Boarding

7.4

Food

7.0

Crew

8.2

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Turkish Airlines
7.3
Good
4,032 reviews
Air France
7.4
Good
1,484 reviews

Entertainment

7.0

Comfort

7.4

Boarding

7.4

Food

7.0

Crew

8.2

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air Europa
7.0
Good
569 reviews
Air France
7.4
Good
1,484 reviews

Entertainment

7.0

Comfort

7.4

Boarding

7.4

Food

7.0

Crew

8.2

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Iberia
7.0
Good
3,007 reviews
Air France
7.4
Good
1,484 reviews

Entertainment

7.0

Comfort

7.4

Boarding

7.4

Food

7.0

Crew

8.2

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Condor
6.4
Okay
387 reviews
Air France
7.4
Good
1,484 reviews

Entertainment

7.0

Comfort

7.4

Boarding

7.4

Food

7.0

Crew

8.2

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Most people fly from Panama City Tocumen Intl (PTY) if they book a flight from Panama City to Italy. Panama City Tocumen Intl is conveniently located just 11.4 mi from Panama City’s city center.

  • How long is the flight from Panama City to Italy?

    Airlines like KLM, Turkish Airlines, and Condor fly from Panama City to Italy in about 15h 10m. The time it takes to get you to your destination can typically vary by up to 17h 35m. The distance between Panama City and Italy is about 5704 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama City to Italy one-way?

    For one-way options, check prices for Condor. According to our data, you can fly for as low as $410. Users have also found prices from $541 and $542 on KLM and Air France, respectively.

  • What are the most popular routes from Panama City to Italy?

    When deciding which route to take from Panama City to Italy consider Panama City Tocumen Intl - Milan Malpensa, Panama City Tocumen Intl - Trieste Ronchi dei Legionari or Panama City Tocumen Intl - Rome Fiumicino as they are the most popular.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Italy?

    Currently, June is the cheapest month in which you can book a flight from Panama City to Italy (average of $384). Flying from Panama City to Italy in January is currently the most expensive (average of $751). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Panama City to Italy

Discover the top 4 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest$679Average$995FlexibilityNo cancel feeOn-time83%
Turkish AirlinesCheapest$690Average$788FlexibilityNo cancel feeOn-time77%
IberiaCheapest$767Average$778FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$783Average$928FlexibilityNo cancel feeOn-time77%

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