HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Italy

$435+ Cheap flights from Panama City (PTY) to Italy

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — NAP
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Italy with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated septiembre 11, 2025.

Round-trip from

$646
(Condor)

One-way from

$468
(Kiwi.com)

Popular in

January

Cheapest in

March

Average price

$876
From Panama City Tocumen Intl to Italy
Search Deals
One-way flight from Panama City Tocumen Intl to Italy
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($56 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Condor deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Condor is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/1511:05 amPTY - MXP
1 stop22h 10mCondor
dom. 9/215:35 pmMXP - PTY
1 stop16h 05mCondor
Deal found 9/10$435
This Condor deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Condor is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/1811:05 amPTY - FCO
1 stop22h 50mCondor
dom. 9/288:20 amFCO - PTY
1 stop25h 20mCondor
Deal found 9/11$609
This Condor deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Condor is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/2211:05 amPTY - MXP
1 stop22h 10mCondor
dom. 9/285:35 pmMXP - PTY
1 stop16h 05mCondor
Deal found 9/10$646
This FlightHub deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/29:30 pmPTY - FCO
1 stop13h 55mAir Europa
jue. 12/116:25 pmFCO - PTY
1 stop31h 20mAir Europa
Deal found 9/10$682
This Air France deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/2910:20 pmPTY - FCO
1 stop15h 25mMultiple Airlines
jue. 11/66:10 amFCO - PTY
1 stop16h 20mMultiple Airlines
Deal found 9/11$695
This KLM deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/66:45 pmPTY - FCO
1 stop18h 40mMultiple Airlines
sáb. 11/226:25 pmFCO - PTY
1 stop31h 45mMultiple Airlines
Deal found 9/10$707
This Trip.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/199:45 pmPTY - MXP
1 stop17h 55mTurkish Airlines
mié. 12/36:55 amMXP - PTY
1 stop18h 55mTurkish Airlines
Deal found 9/11$721
This FlightHub deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/69:30 pmPTY - FCO
1 stop30h 00mAir Europa
sáb. 11/2210:30 amFCO - PTY
1 stop15h 15mAir Europa
Deal found 9/11$721
This Turkish Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/199:55 pmPTY - MXP
1 stop27h 50mTurkish Airlines
sáb. 9/273:10 pmMXP - PTY
1 stop35h 50mTurkish Airlines
Deal found 9/10$722
This Turkish Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/266:45 pmPTY - MXP
1 stop20h 55mTurkish Airlines
vie. 11/72:30 pmMXP - PTY
1 stop35h 20mTurkish Airlines
Deal found 9/10$727
This SmartFares deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/59:45 pmPTY - FCO
1 stop18h 10mTurkish Airlines
mié. 11/126:45 amFCO - PTY
1 stop19h 05mTurkish Airlines
Deal found 9/11$728
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/219:55 pmPTY - MXP
1 stop18h 50mTurkish Airlines
mar. 9/303:10 pmMXP - PTY
1 stop35h 50mTurkish Airlines
Deal found 9/10$735

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Panama City

Fly to

Italy

Route

Depart

Return

Price

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

jue. 11/6

6:45 pm-7:25 pm

1 stop18h 40m

Rome Fiumicino

sáb. 11/22

4:20 pm-8:10 pm

1 stop33h 50m

$707

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

mié. 10/1

9:55 pm-8:45 am

1 stop27h 50m

Milan Malpensa

dom. 10/12

6:50 am-8:00 pm

1 stop20h 10m

$722

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

mié. 11/5

9:45 pm-1:30 pm

1 stop33h 45m

Milan Malpensa

sáb. 11/15

6:55 am-7:50 pm

1 stop18h 55m

$743

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

sáb. 11/1

9:45 pm-9:05 am

1 stop29h 20m

Milan Malpensa

vie. 11/7

11:05 am-7:50 pm

1 stop38h 45m

$743

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

sáb. 11/1

9:45 pm-9:40 pm

1 stop17h 55m

Milan Malpensa

sáb. 11/8

6:55 am-7:50 pm

1 stop18h 55m

$745

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

mié. 9/24

9:55 pm-11:45 pm

1 stop18h 50m

Milan Malpensa

sáb. 9/27

10:45 am-8:00 pm

1 stop40h 15m

$746

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

lun. 11/17

9:45 pm-1:30 pm

1 stop33h 45m

Milan Malpensa

mar. 12/2

6:35 pm-7:50 pm

1 stop31h 15m

$747

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

mié. 9/24

9:55 pm-8:45 am

1 stop27h 50m

Milan Malpensa

dom. 9/28

6:50 am-8:00 pm

1 stop20h 10m

$747

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

mié. 2/11

9:30 pm-5:20 pm

1 stop13h 50m

Milan Malpensa

dom. 2/15

10:50 am-7:45 pm

1 stop14h 55m

$755

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

dom. 11/16

9:30 pm-5:20 pm

1 stop13h 50m

Milan Malpensa

dom. 12/7

6:20 pm-7:45 pm

1 stop31h 25m

$757

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 59 results
1
2
3
...
6

Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City to Italy?

Currently, January is the cheapest month in which you can book a flight from Panama City to Italy (average of $703). Flying from Panama City to Italy in June is currently the most expensive (average of $1,202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to IT?

Find hourly flight availability from Panama City to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Italy as you normally would.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated septiembre 11, 2025.
Get a feel of what it's like to fly with Air France, United Airlines, and Turkish Airlines from Panama City to Italy by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,469 reviews

Entertainment

7.0

Crew

8.2

Boarding

7.4

Comfort

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air France
7.4
Good
1,469 reviews
Air France
7.4
Good
1,469 reviews

Entertainment

7.0

Crew

8.2

Boarding

7.4

Comfort

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
United Airlines
7.4
Good
8,937 reviews
Air France
7.4
Good
1,469 reviews

Entertainment

7.0

Crew

8.2

Boarding

7.4

Comfort

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Turkish Airlines
7.3
Good
3,968 reviews
Air France
7.4
Good
1,469 reviews

Entertainment

7.0

Crew

8.2

Boarding

7.4

Comfort

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air Europa
7.0
Good
556 reviews
Air France
7.4
Good
1,469 reviews

Entertainment

7.0

Crew

8.2

Boarding

7.4

Comfort

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Iberia
7.0
Good
2,929 reviews
Air France
7.4
Good
1,469 reviews

Entertainment

7.0

Crew

8.2

Boarding

7.4

Comfort

7.4

Overall

7.4

Food

7.0

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Most people fly from Panama City Tocumen Intl (PTY) if they book a flight from Panama City to Italy. Panama City Tocumen Intl is conveniently located just 11.4 mi from Panama City’s city center.

  • How long is the flight from Panama City to Italy?

    Airlines like Turkish Airlines, Air Europa, and KLM fly from Panama City to Italy in about 14h 05m. The time it takes to get you to your destination can typically vary by up to 13h 45m. The distance between Panama City and Italy is about 5851 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama City to Italy one-way?

    For one-way options, check prices for Air Europa. According to our data, you can fly for as low as $529. Users have also found prices from $651 and $718 on Turkish Airlines and KLM, respectively.

  • What are the most popular routes from Panama City to Italy?

    When deciding which route to take from Panama City to Italy consider Panama City Tocumen Intl - Rome Fiumicino, Panama City Tocumen Intl - Trieste Ronchi dei Legionari or Panama City Tocumen Intl - Milan Linate as they are the most popular.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Italy?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Italy (average of $703). Flying from Panama City to Italy in June is currently the most expensive (average of $1,202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Italy

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Madrid flights
Panama City to Charles de Gaulle flights
Panama City to Leonardo da Vinci/Fiumicino flights
Panama City to Amsterdam flights
Panama City to Barcelona-El Prat flights
Panama City to Istanbul flights
Panama City to Heathrow flights
Panama City to Bruxelles-National flights
Panama City to Munich flights
Panama City to Frankfurt flights
Panama City to Berlin flights
Panama City to Geneva flights
Panama City to Dublin flights
Panama City to Hamburg flights
Panama City to Vicenza flights
Panama City to Stuttgart flights
Panama City to Seville flights
Panama City to Zurich flights
Panama City to Copenhagen flights
Panama City to Porto flights
Panama City to Athens flights
Panama City to Bilbao flights
Panama City to Bergen flights

Top 4 airlines flying from Panama City to Italy

Discover the top 4 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Turkish AirlinesCheapest$690Average$788FlexibilityNo cancel feeOn-time77%
IberiaCheapest$747Average$886FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$770Average$1,003FlexibilityNo cancel feeOn-time83%
Air FranceCheapest$783Average$928FlexibilityNo cancel feeOn-time77%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.