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Italy

$494+ Cheap flights from Panama City (PTY) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — NAP
mar 7 — mar 141
sáb 3/7
sáb 3/14
1 adult, Economy
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Cheap flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on fevereiro 5, 2026.

This KLM deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 2/210:05 pm
PTY
-
LIN
1 stop18h 50m
KLM
seg 2/169:20 pm
LIN
-
PTY
1 stop25h 10m
KLM
Deal found 2/2$683
This KLM deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 2/1110:05 pm
PTY
-
FCO
1 stop19h 05m
Multiple Airlines
qua 3/49:55 am
FCO
-
PTY
1 stop16h 15m
Multiple Airlines
Deal found 2/3$695
This Booking.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/2210:20 pm
PTY
-
MXP
1 stop18h 25m
Turkish Airlines
seg 5/116:50 am
MXP
-
PTY
1 stop20h 35m
Turkish Airlines
Deal found 2/4$699
This Turkish Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 3/3010:20 pm
PTY
-
FCO
1 stop37h 05m
Turkish Airlines
qua 4/87:05 am
FCO
-
PTY
1 stop20h 20m
Turkish Airlines
Deal found 2/1$700
This Gotogate deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 5/1310:20 pm
PTY
-
FCO
1 stop32h 45m
Turkish Airlines
dom 5/243:10 pm
FCO
-
PTY
1 stop36h 15m
Turkish Airlines
Deal found 2/3$705
This Turkish Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/2210:20 pm
PTY
-
MXP
1 stop32h 50m
Turkish Airlines
seg 9/216:50 am
MXP
-
PTY
1 stop20h 35m
Turkish Airlines
Deal found 2/3$707
This KLM deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 2/96:45 pm
PTY
-
FCO
1 stop22h 25m
KLM
ter 2/248:25 pm
FCO
-
PTY
1 stop29h 30m
KLM
Deal found 2/3$709
This Turkish Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/1510:20 pm
PTY
-
MXP
1 stop32h 50m
Turkish Airlines
qua 4/297:45 pm
MXP
-
PTY
2 stops29h 45m
Turkish Airlines
Deal found 2/4$711
This Turkish Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/2910:20 pm
PTY
-
FCO
1 stop28h 00m
Turkish Airlines
seg 5/117:05 am
FCO
-
PTY
2 stops42h 20m
Turkish Airlines
Deal found 2/2$711
This Gotogate deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 5/298:05 pm
PTY
-
MXP
1 stop20h 40m
Turkish Airlines
qua 6/176:50 am
MXP
-
PTY
1 stop20h 35m
Turkish Airlines
Deal found 2/5$717
This KLM deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 5/196:50 pm
PTY
-
FCO
1 stop20h 55m
KLM
sex 5/296:30 am
FCO
-
PTY
1 stop17h 20m
KLM
Deal found 2/4$720
This Turkish Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 4/2910:20 pm
PTY
-
FCO
1 stop18h 15m
Turkish Airlines
dom 5/248:00 pm
FCO
-
PTY
1 stop31h 25m
Turkish Airlines
Deal found 2/5$721

Find flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated fevereiro 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$695
(KLM)

One-way from

$494
(Mytrip)

Popular in

December

Cheapest in

April

Average price

$816
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
Search Deals
From Panama City Tocumen Intl to Italy
Search Deals
One-way flight from Panama City Tocumen Intl to Italy
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($52 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated fevereiro 5, 2026.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Panama City

Fly to

Italy

Route

Depart

Return

Price

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

seg 3/30

10:20 pm-6:25 pm

1 stop37h 05m

Rome Fiumicino

qua 4/8

7:05 am-8:25 pm

1 stop20h 20m

$700

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

seg 5/18

10:20 pm-11:45 pm

1 stop18h 25m

Milan Malpensa

sex 5/29

7:45 pm-8:25 pm

1 stop31h 40m

$707

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

sex 5/29

8:05 pm-11:45 pm

1 stop20h 40m

Milan Malpensa

qua 6/17

6:50 am-8:25 pm

1 stop20h 35m

$717

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

qua 4/29

10:20 pm-9:20 am

1 stop28h 00m

Rome Fiumicino

seg 5/11

7:05 am-8:25 pm

1 stop20h 20m

$721

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

qua 5/6

10:20 pm-8:40 am

1 stop27h 20m

Milan Malpensa

sex 5/15

7:45 pm-8:25 pm

1 stop31h 40m

$730

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

sáb 4/25

10:20 pm-9:20 am

1 stop28h 00m

Rome Fiumicino

sáb 5/16

8:00 pm-6:25 pm

2 stops29h 25m

$734

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

qua 4/29

10:20 pm-6:25 pm

1 stop37h 05m

Rome Fiumicino

sex 5/8

8:00 pm-6:30 pm

2 stops29h 30m

$743

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

seg 3/16

9:45 pm-9:55 pm

1 stop18h 10m

Rome Fiumicino

seg 3/30

7:05 am-8:25 pm

1 stop20h 20m

$743

Panama CityVenice

PTY - VCE

PTYVCE

Panama City Tocumen Intl

sex 6/12

8:25 pm-5:35 pm

1 stop14h 10m

Venice Marco Polo

seg 6/22

10:45 am-6:40 pm

1 stop14h 55m

$764

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

seg 4/27

8:25 pm-5:25 pm

1 stop14h 00m

Rome Fiumicino

qui 5/21

10:30 am-6:40 pm

1 stop15h 10m

$779

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Showing 1-10 of 58 results
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Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City to Italy?

Currently, June is the cheapest month in which you can book a flight from Panama City to Italy (average of $383). Flying from Panama City to Italy in January is currently the most expensive (average of $777). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated fevereiro 5, 2026.
Get a feel of what it's like to fly with Air France, Turkish Airlines, and Iberia from Panama City to Italy by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,532 reviews

Crew

8.1

Boarding

7.4

Comfort

7.3

Overall

7.4

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Air France
7.4
Good
1,532 reviews
Air France
7.4
Good
1,532 reviews

Crew

8.1

Boarding

7.4

Comfort

7.3

Overall

7.4

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Turkish Airlines
7.3
Good
4,211 reviews
Air France
7.4
Good
1,532 reviews

Crew

8.1

Boarding

7.4

Comfort

7.3

Overall

7.4

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Iberia
7.0
Good
3,104 reviews
Air France
7.4
Good
1,532 reviews

Crew

8.1

Boarding

7.4

Comfort

7.3

Overall

7.4

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Air Europa
6.9
Okay
587 reviews
Air France
7.4
Good
1,532 reviews

Crew

8.1

Boarding

7.4

Comfort

7.3

Overall

7.4

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class
Condor
6.4
Okay
399 reviews
Air France
7.4
Good
1,532 reviews

Crew

8.1

Boarding

7.4

Comfort

7.3

Overall

7.4

Entertainment

7.0

Food

7.0

Reviews

1 / 20
6.0
Good

Jayesh,Jan 2026

CDG - NMI

Entertainment needs more good Bollywood movies - as this flight was going to Mumbai, India. The Aircraft was a OLD - Is service to India cannot be improved ? The aircraft from Newark to Paris was great n new aircraft BUT aircraft from Paris to Mumbai was very old and poor class

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Most people fly from Panama City Tocumen Intl (PTY) if they book a flight from Panama City to Italy. Panama City Tocumen Intl is conveniently located just 11.4 mi from Panama City’s city center.

  • How long is the flight from Panama City to Italy?

    Airlines like Turkish Airlines, Air Europa, and KLM fly from Panama City to Italy in about 14h 10m. The time it takes to get you to your destination can typically vary by up to 22h 55m. The distance between Panama City and Italy is about 5851 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to Italy?

    When deciding which route to take from Panama City to Italy consider Panama City Tocumen Intl - Trieste Ronchi dei Legionari, Panama City Tocumen Intl - Rome Fiumicino or Panama City Tocumen Intl - Milan Malpensa as they are the most popular.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Italy?

    Currently, June is the cheapest month in which you can book a flight from Panama City to Italy (average of $383). Flying from Panama City to Italy in January is currently the most expensive (average of $777). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Panama City to Italy

Discover the top 4 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated fevereiro 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
Turkish AirlinesCheapest$678Average$878FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$679Average$1,138FlexibilityNo cancel feeOn-time83%
Air FranceCheapest$705Average$926FlexibilityNo cancel feeOn-time77%
IberiaCheapest$767Average$778FlexibilityNo cancel feeOn-time77%

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