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$493+ Cheap flights from Panama City (PTY) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — NAP
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated May 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$670
(Expedia)

One-way from

$493
(Kiwi.com)

Popular in

July

Cheapest in

March

Average price

$798
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
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From Panama City Tocumen Intl to Italy
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One-way flight from Panama City Tocumen Intl to Italy
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Highest demand for flights based on searches. 8% potential increase in price ($85 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Expedia deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2311:05 amPTY - MXP
1 stop22h 10mCondor
Sun 6/299:00 amMXP - PTY
1 stop24h 40mCondor
Deal found 4/29$670
This Turkish Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/239:55 pmPTY - MXP
1 stop27h 50mTurkish Airlines
Wed 5/286:50 amMXP - PTY
1 stop20h 10mTurkish Airlines
Deal found 4/30$691
This Turkish Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/119:55 pmPTY - FCO
1 stop18h 35mTurkish Airlines
Sat 5/3110:55 amFCO - PTY
1 stop40h 05mTurkish Airlines
Deal found 4/30$726
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1611:05 amPTY - FCO
2 stops17h 20mMultiple Airlines
Sun 6/226:40 amFCO - PTY
2 stops27h 00mMultiple Airlines
Deal found 4/29$742
This Gotogate deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/1611:05 amPTY - FCO
1 stop22h 50mCondor
Sun 6/228:20 amFCO - PTY
1 stop25h 20mCondor
Deal found 4/29$750
This Air France deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/146:50 pmPTY - BLQ
1 stop30h 50mMultiple Airlines
Sat 6/212:40 pmBLQ - PTY
1 stop34h 05mMultiple Airlines
Deal found 4/30$779
This KLM deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/36:50 pmPTY - LIN
1 stop21h 00mKLM
Mon 6/164:50 pmLIN - PTY
1 stop31h 00mKLM
Deal found 4/28$787
This KLM deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/27:55 pmPTY - LIN
1 stop16h 50mMultiple Airlines
Mon 6/161:00 pmLIN - PTY
1 stop34h 50mMultiple Airlines
Deal found 4/30$788
This Air France deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/27:55 pmPTY - MXP
1 stop20h 05mAir France
Mon 6/162:55 pmMXP - PTY
1 stop33h 50mAir France
Deal found 4/30$801
This KLM deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/147:55 pmPTY - FLR
1 stop16h 40mMultiple Airlines
Thu 9/186:30 amFLR - PTY
2 stops18h 15mMultiple Airlines
Deal found 4/30$804
This Air Europa deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/278:25 pmPTY - FCO
1 stop14h 00mAir Europa
Tue 6/310:30 amFCO - PTY
1 stop15h 10mAir Europa
Deal found 4/30$806
This KLM deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/116:50 pmPTY - VCE
1 stop20h 30mMultiple Airlines
Fri 7/49:00 amVCE - PTY
1 stop17h 02mMultiple Airlines
Deal found 4/30$810

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Panama City

Fly to

Italy

Route

Depart

Return

Price

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Mon 6/23

11:05 am-4:15 pm

1 stop22h 10m

Milan Malpensa

Sun 6/29

9:00 am-2:40 am

1 stop24h 40m

$670

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Fri 5/30

9:55 pm-11:45 pm

1 stop18h 50m

Milan Malpensa

Fri 6/6

6:50 am-8:00 pm

1 stop20h 10m

$685

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sun 5/11

9:55 pm-11:30 pm

1 stop18h 35m

Rome Fiumicino

Thu 5/15

10:45 am-8:00 pm

1 stop40h 15m

$726

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 6/16

11:05 am-11:25 am

2 stops17h 20m

Rome Fiumicino

Sun 6/22

6:40 am-2:40 am

2 stops27h 00m

$742

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Mon 6/16

11:05 am-4:55 pm

1 stop22h 50m

Rome Fiumicino

Sun 6/22

8:20 am-2:40 am

1 stop25h 20m

$750

Panama CityBologna

PTY - BLQ

PTYBLQ

Panama City Tocumen Intl

Sat 6/14

6:50 pm-8:40 am

1 stop30h 50m

Bologna Guglielmo Marconi

Sat 6/21

2:40 pm-5:45 pm

1 stop34h 05m

$779

Panama CityMilan

PTY - LIN

PTYLIN

Panama City Tocumen Intl

Tue 6/3

6:50 pm-10:50 pm

1 stop21h 00m

Milan Linate

Mon 6/16

4:50 pm-4:50 pm

1 stop31h 00m

$787

Panama CityMilan

PTY - LIN

PTYLIN

Panama City Tocumen Intl

Mon 6/2

7:55 pm-7:45 pm

1 stop16h 50m

Milan Linate

Mon 6/16

1:00 pm-4:50 pm

1 stop34h 50m

$788

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Mon 6/2

7:55 pm-11:00 pm

1 stop20h 05m

Milan Malpensa

Mon 6/16

2:55 pm-5:45 pm

1 stop33h 50m

$801

Panama CityFlorence

PTY - FLR

PTYFLR

Panama City Tocumen Intl

Sun 9/14

7:55 pm-7:35 pm

1 stop16h 40m

Florence Peretola

Thu 9/18

6:30 am-5:45 pm

2 stops18h 15m

$804

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 44 results
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Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City to Italy?

Currently, January is the cheapest month in which you can book a flight from Panama City to Italy (average of $703). Flying from Panama City to Italy in June is currently the most expensive (average of $1,238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to IT?

Find hourly flight availability from Panama City to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Italy as you normally would.

Rainfall in Italy by month

Plan your trip to Italy by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Italy ranges from 0.6 - 4.4 inches per month. November is typically the wettest month, when rainfall can reach 4.4 in. June is typically the driest time to visit Italy when rainfall is around 0.6 in.

Temperature in Italy by month

Plan your trip to Italy by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Italy, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated May 1, 2025.
Read through reviews of airlines operating flights from Panama City to Italy, such as Delta, KLM and Air France. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
KLM
7.8
Good
1,334 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Air France
7.4
Good
1,446 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Turkish Airlines
7.3
Good
3,790 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Most people fly from Panama City Tocumen Intl (PTY) if they book a flight from Panama City to Italy. Panama City Tocumen Intl is conveniently located just 11.4 mi from Panama City’s city center.

  • What are the cheapest airlines to fly from Panama City to Italy one-way?

    For one-way options, check prices for Air Europa. According to our data, you can fly for as low as $527. Users have also found prices from $545 and $665 on Turkish Airlines and Iberia, respectively.

  • What are the most popular routes from Panama City to Italy?

    When deciding which route to take from Panama City to Italy consider Panama City Tocumen Intl - Rome Fiumicino, Panama City Tocumen Intl - Milan Malpensa or Panama City Tocumen Intl - Milan Linate as they are the most popular.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Italy?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Italy (average of $703). Flying from Panama City to Italy in June is currently the most expensive (average of $1,238). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Italy

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Panama City to Italy

Discover the top 5 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
IberiaCheapest$696Average$882FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$709Average$925FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$763Average$880FlexibilityNo cancel feeOn-time69%
Air EuropaCheapest$771Average$864FlexibilityNo cancel feeOn-time83%
KLMCheapest$1,576Average$1,744FlexibilityNo cancel feeOn-time75%

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