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$383+ Cheap flights from Panama City (PTY) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — NAP
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Cheap flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$558
(Condor)

One-way from

$403
(Mytrip)

Popular in

January

Cheapest in

March

Average price

$849
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
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From Panama City Tocumen Intl to Italy
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One-way flight from Panama City Tocumen Intl to Italy
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Highest demand for flights based on searches. 6% potential increase in price ($62 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This Condor deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Condor is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:05 pmPTY - MXP
1 stop20h 15mCondor
Mon 11/177:55 amMXP - PTY
1 stop14h 50mCondor
Deal found 10/13$558
This Turkish Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/109:45 pmPTY - MXP
1 stop17h 55mTurkish Airlines
Sat 11/226:55 amMXP - PTY
1 stop18h 55mTurkish Airlines
Deal found 10/13$699
This KLM deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:45 pmPTY - FCO
1 stop15h 40mMultiple Airlines
Sat 11/226:25 pmFCO - PTY
1 stop31h 45mMultiple Airlines
Deal found 10/13$706
This Booking.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/269:45 pmPTY - FCO
1 stop38h 35mTurkish Airlines
Wed 12/36:45 amFCO - PTY
1 stop19h 05mTurkish Airlines
Deal found 10/12$715
This Air France deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/106:45 pmPTY - MXP
2 stops16h 40mAir France
Sat 11/226:25 pmMXP - PTY
1 stop31h 45mAir France
Deal found 10/13$723
This Turkish Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/249:45 pmPTY - MXP
1 stop17h 55mTurkish Airlines
Mon 12/86:55 amMXP - PTY
1 stop18h 55mTurkish Airlines
Deal found 10/14$724
This Air France deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:20 pmPTY - MXP
1 stop31h 20mAir France
Wed 12/3112:35 pmMXP - PTY
1 stop13h 35mAir France
Deal found 10/13$727
This KLM deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/186:45 pmPTY - FCO
1 stop22h 25mMultiple Airlines
Tue 11/256:25 pmFCO - PTY
1 stop31h 45mMultiple Airlines
Deal found 10/12$740
This Turkish Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/229:45 pmPTY - MXP
1 stop37h 55mTurkish Airlines
Sun 12/76:35 pmMXP - PTY
1 stop31h 15mTurkish Airlines
Deal found 10/14$747
This Turkish Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/89:45 pmPTY - FCO
1 stop34h 05mTurkish Airlines
Sat 11/226:45 amFCO - PTY
1 stop19h 05mTurkish Airlines
Deal found 10/13$747
This Booking.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/279:45 pmPTY - FCO
1 stop30h 05mTurkish Airlines
Sat 11/296:45 amFCO - PTY
1 stop19h 05mTurkish Airlines
Deal found 10/13$748
This KLM deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:50 pmPTY - BLQ
1 stop30h 50mMultiple Airlines
Wed 11/266:05 amBLQ - PTY
1 stop20h 05mMultiple Airlines
Deal found 10/11$756

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Panama City

Fly to

Italy

Route

Depart

Return

Price

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Mon 11/10

7:05 pm-9:20 pm

1 stop20h 15m

Milan Malpensa

Mon 11/17

7:55 am-4:45 pm

1 stop14h 50m

$558

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Mon 11/10

9:45 pm-9:40 pm

1 stop17h 55m

Milan Malpensa

Sat 11/22

6:55 am-7:50 pm

1 stop18h 55m

$699

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Thu 11/6

6:45 pm-4:25 pm

1 stop15h 40m

Rome Fiumicino

Sat 11/22

6:25 pm-8:10 pm

1 stop31h 45m

$706

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Wed 2/18

9:45 pm-1:30 pm

1 stop33h 45m

Milan Malpensa

Wed 2/25

6:55 am-7:50 pm

1 stop18h 55m

$721

Panama CityFlorence

PTY - FLR

PTYFLR

Panama City Tocumen Intl

Sat 2/7

10:05 pm-11:40 am

1 stop31h 35m

Florence Peretola

Wed 2/11

6:40 am-7:55 pm

1 stop19h 15m

$737

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Tue 11/18

6:45 pm-11:10 pm

1 stop22h 25m

Rome Fiumicino

Tue 11/25

6:25 pm-8:10 pm

1 stop31h 45m

$740

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Mon 11/10

9:45 pm-5:40 pm

1 stop37h 55m

Milan Malpensa

Tue 11/18

10:40 am-7:50 pm

1 stop39h 10m

$747

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Sat 11/8

9:45 pm-1:50 pm

1 stop34h 05m

Rome Fiumicino

Sat 11/22

6:45 am-7:50 pm

1 stop19h 05m

$747

Panama CityVenice

PTY - VCE

PTYVCE

Panama City Tocumen Intl

Wed 2/4

10:05 pm-10:15 pm

1 stop18h 10m

Venice Marco Polo

Fri 2/13

5:35 pm-7:55 pm

1 stop32h 20m

$750

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Wed 10/29

9:45 pm-9:40 pm

1 stop17h 55m

Milan Malpensa

Fri 11/14

6:35 pm-7:50 pm

1 stop31h 15m

$768

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/11

Showing 1-10 of 58 results
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Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City to Italy?

Currently, June is the cheapest month in which you can book a flight from Panama City to Italy (average of $384). Flying from Panama City to Italy in January is currently the most expensive (average of $751). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to IT?

Find hourly flight availability from Panama City to Italy. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

It’s optimal to fly from Panama City to Italy in the morning. By choosing this option you can save up to 23% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated October 14, 2025.
Get a feel of what it's like to fly with Air France, United Airlines, and Turkish Airlines from Panama City to Italy by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,475 reviews

Boarding

7.4

Comfort

7.4

Crew

8.2

Food

7.0

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air France
7.4
Good
1,475 reviews
Air France
7.4
Good
1,475 reviews

Boarding

7.4

Comfort

7.4

Crew

8.2

Food

7.0

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
United Airlines
7.4
Good
8,977 reviews
Air France
7.4
Good
1,475 reviews

Boarding

7.4

Comfort

7.4

Crew

8.2

Food

7.0

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Turkish Airlines
7.3
Good
4,010 reviews
Air France
7.4
Good
1,475 reviews

Boarding

7.4

Comfort

7.4

Crew

8.2

Food

7.0

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air Europa
7.0
Good
568 reviews
Air France
7.4
Good
1,475 reviews

Boarding

7.4

Comfort

7.4

Crew

8.2

Food

7.0

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Iberia
7.0
Good
2,990 reviews
Air France
7.4
Good
1,475 reviews

Boarding

7.4

Comfort

7.4

Crew

8.2

Food

7.0

Entertainment

7.0

Overall

7.4

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Most people fly from Panama City Tocumen Intl (PTY) if they book a flight from Panama City to Italy. Panama City Tocumen Intl is conveniently located just 11.4 mi from Panama City’s city center.

  • How long is the flight from Panama City to Italy?

    Airlines like Condor, Turkish Airlines, and KLM fly from Panama City to Italy in about 17h 55m. The time it takes to get you to your destination can typically vary by up to 13h 40m. The distance between Panama City and Italy is about 5677 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama City to Italy one-way?

    For one-way options, check prices for Air Europa. According to our data, you can fly for as low as $529. Users have also found prices from $540 and $748 on KLM and Iberia, respectively.

  • What are the most popular routes from Panama City to Italy?

    When deciding which route to take from Panama City to Italy consider Panama City Tocumen Intl - Rome Fiumicino, Panama City Tocumen Intl - Trieste Ronchi dei Legionari or Panama City Tocumen Intl - Milan Malpensa as they are the most popular.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Italy?

    Currently, June is the cheapest month in which you can book a flight from Panama City to Italy (average of $384). Flying from Panama City to Italy in January is currently the most expensive (average of $751). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Panama City to Italy

Discover the top 4 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
Air EuropaCheapest$679Average$987FlexibilityNo cancel feeOn-time83%
Turkish AirlinesCheapest$690Average$788FlexibilityNo cancel feeOn-time77%
IberiaCheapest$767Average$886FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$783Average$928FlexibilityNo cancel feeOn-time77%

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