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Italy

$649+ Cheap flights from Panama City (PTY) to Italy

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — NAP
May 18 — May 251
Mon 5/18
Mon 5/25
1 adult, Economy
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Cheap flight deals from Panama City to Italy

Cheapest flights from Panama City to Italy
Explore the most affordable flight options available from Panama City to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.

This Turkish Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:20 pm
PTY
-
FCO
1 stop37h 05m
Turkish Airlines
Wed 6/107:05 am
FCO
-
PTY
1 stop20h 20m
Turkish Airlines
Deal found 4/14$773
This Booking.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:20 pm
PTY
-
MXP
1 stop27h 20m
Turkish Airlines
Sun 5/242:55 pm
MXP
-
PTY
1 stop36h 30m
Turkish Airlines
Deal found 4/13$776
This Turkish Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:20 pm
PTY
-
MXP
1 stop18h 25m
Turkish Airlines
Fri 5/296:50 am
MXP
-
PTY
2 stops42h 40m
Turkish Airlines
Deal found 4/16$794
This Gotogate deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/218:25 pm
PTY
-
FCO
1 stop14h 00m
Air Europa
Wed 9/234:35 pm
FCO
-
PTY
1 stop33h 05m
Air Europa
Deal found 4/14$815
This Turkish Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:20 pm
PTY
-
MXP
1 stop27h 20m
Turkish Airlines
Fri 5/153:15 pm
MXP
-
PTY
1 stop36h 10m
Turkish Airlines
Deal found 4/14$823
This FlightHub deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:25 pm
PTY
-
FCO
1 stop14h 00m
Air Europa
Wed 9/304:35 pm
FCO
-
PTY
1 stop33h 05m
Air Europa
Deal found 4/16$833
This Air France deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:27 pm
PTY
-
VCE
1 stop35h 28m
Multiple Airlines
Sat 5/162:00 pm
VCE
-
PTY
1 stop33h 50m
Multiple Airlines
Deal found 4/13$834
This Air France deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/262:27 pm
PTY
-
MXP
2 stops20h 08m
Air France
Mon 5/43:45 pm
MXP
-
PTY
1 stop35h 00m
Air France
Deal found 4/14$839
This Air France deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:27 pm
PTY
-
MXP
1 stop35h 58m
Air France
Sun 5/176:45 am
MXP
-
PTY
1 stop20h 00m
Air France
Deal found 4/15$840
This Air Europa deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:25 pm
PTY
-
FCO
1 stop30h 05m
Air Europa
Wed 9/304:35 pm
FCO
-
PTY
1 stop33h 05m
Air Europa
Deal found 4/13$841
This Air France deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:27 pm
PTY
-
FCO
1 stop37h 23m
Multiple Airlines
Fri 5/86:30 am
FCO
-
PTY
1 stop17h 20m
Multiple Airlines
Deal found 4/15$843
This Turkish Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:20 pm
PTY
-
MXP
1 stop18h 25m
Turkish Airlines
Mon 5/256:50 am
MXP
-
PTY
1 stop20h 35m
Turkish Airlines
Deal found 4/13$845

Find flight deals from Panama City to Italy

Keep the following information in mind while searching for Panama City to Italy flight deals. Data was last updated April 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$773
(Turkish Airlines)

One-way from

$649
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$752
Provider with most accurate pricing for Panama City Tocumen Intl-Rome (ROM) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Rome (ROM) flights.
Search Deals
From Panama City Tocumen Intl to Italy
Search Deals
One-way flight from Panama City Tocumen Intl to Italy
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($59 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Panama City to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Wed 5/6

10:20 pm-2:10 pm

1 stop32h 50m

Milan Malpensa

Fri 5/15

3:15 pm-8:25 pm

1 stop36h 10m

$824

Panama CityVenice

PTY - VCE

PTYVCE

Panama City Tocumen Intl

Sat 5/2

2:27 pm-8:55 am

1 stop35h 28m

Venice Marco Polo

Sat 5/16

2:00 pm-4:50 pm

1 stop33h 50m

$834

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Mon 5/4

10:20 pm-11:45 pm

1 stop18h 25m

Milan Malpensa

Sun 5/24

2:55 pm-8:25 pm

1 stop36h 30m

$845
Quickest round-trip

Panama CityVenice

PTY - VCE

PTYVCE

Panama City Tocumen Intl

Sun 5/17

8:25 pm-5:35 pm

1 stop14h 10m

Venice Marco Polo

Thu 5/21

10:45 am-6:40 pm

1 stop14h 55m

$849

Panama CityVenice

PTY - VCE

PTYVCE

Panama City Tocumen Intl

Sat 5/2

2:27 pm-8:55 am

1 stop35h 28m

Venice Marco Polo

Sat 5/16

5:55 am-4:50 pm

2 stops17h 55m

$866

Panama CityVenice

PTY - VCE

PTYVCE

Panama City Tocumen Intl

Fri 6/12

8:25 pm-5:35 pm

1 stop14h 10m

Venice Marco Polo

Mon 6/22

6:35 pm-6:40 pm

1 stop31h 05m

$890

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Sat 5/9

10:20 pm-8:40 am

1 stop27h 20m

Milan Malpensa

Sun 5/31

6:50 am-6:30 pm

2 stops42h 40m

$906

Panama CityVenice

PTY - VCE

PTYVCE

Panama City Tocumen Intl

Thu 6/11

8:25 pm-5:35 pm

1 stop14h 10m

Venice Marco Polo

Sun 6/21

10:45 am-6:40 pm

1 stop14h 55m

$908

Panama CityMilan

PTY - MXP

PTYMXP

Panama City Tocumen Intl

Sat 5/9

10:20 pm-8:40 am

1 stop27h 20m

Milan Malpensa

Sat 5/23

6:50 am-8:25 pm

1 stop20h 35m

$909

Panama CityRome

PTY - FCO

PTYFCO

Panama City Tocumen Intl

Tue 6/2

7:55 am-1:15 pm

2 stops22h 20m

Rome Fiumicino

Thu 6/11

11:30 am-7:31 pm

2 stops39h 01m

$931

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Italy

Have a flexible travel schedule? Discover the best time to fly to Italy from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Italy

What is the cheapest month to book a flight from Panama City to Italy?

Currently, September is the cheapest month in which you can book a flight from Panama City to Italy (average of $312). Flying from Panama City to Italy in January is currently the most expensive (average of $688). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Italy

Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated April 18, 2026.
Get a feel of what it's like to fly with Air France,Turkish Airlines, andIberia from Panama City to Italy by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,572 reviews

Crew

8.1

Comfort

7.3

Boarding

7.5

Food

7.0

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Air France
7.4
Good
1,572 reviews
Air France
7.4
Good
1,572 reviews

Crew

8.1

Comfort

7.3

Boarding

7.5

Food

7.0

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Turkish Airlines
7.3
Good
4,306 reviews
Air France
7.4
Good
1,572 reviews

Crew

8.1

Comfort

7.3

Boarding

7.5

Food

7.0

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Iberia
7.0
Good
3,182 reviews
Air France
7.4
Good
1,572 reviews

Crew

8.1

Comfort

7.3

Boarding

7.5

Food

7.0

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Air Europa
6.9
Okay
599 reviews
Air France
7.4
Good
1,572 reviews

Crew

8.1

Comfort

7.3

Boarding

7.5

Food

7.0

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Condor
6.5
Okay
406 reviews
Air France
7.4
Good
1,572 reviews

Crew

8.1

Comfort

7.3

Boarding

7.5

Food

7.0

Overall

7.4

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Italy?

    Most people fly from Panama City Tocumen Intl (PTY) if they book a flight from Panama City to Italy. Panama City Tocumen Intl is conveniently located just 11.4 mi from Panama City’s city center.

  • How long is the flight from Panama City to Italy?

    Airlines like Turkish Airlines, Air Europa, and Air France fly from Panama City to Italy in about 14h 10m. The time it takes to get you to your destination can typically vary by up to 21h 18m. The distance between Panama City and Italy is about 5851 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to Italy?

    When deciding which route to take from Panama City to Italy consider Panama City Tocumen Intl - Rome Fiumicino, Panama City Tocumen Intl - Milan Malpensa or Panama City Tocumen Intl - Trieste Ronchi dei Legionari as they are the most popular.

  • Can I find deals for flights from Panama City to Italy that include hotel bookings?

    Yes. In addition to deals on Panama City to Italy flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Italy?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Italy.

  • Can I find deals for business class flights from Panama City to Italy?

    Yes. Cheapflights offers flight deals from Panama City to Italy by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Italy?

    Currently, September is the cheapest month in which you can book a flight from Panama City to Italy (average of $312). Flying from Panama City to Italy in January is currently the most expensive (average of $688). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Panama City to Italy

Discover the top 3 airlines that operate flights from Panama City to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
Turkish AirlinesCheapest$678Average$775FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$679Average$1,113FlexibilityNo cancel feeOn-time83%
Air FranceCheapest$781Average$972FlexibilityNo cancel feeOn-time77%

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