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$72+ Cheap flights from St. Louis (STL) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from St. Louis to Iowa

Cheapest flights from St. Louis to Iowa
Explore the most affordable flight options available from St. Louis to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:53 pmSTL - DSM
1 stop6h 53mAmerican Airlines
Wed 12/311:09 pmDSM - STL
1 stop6h 13mAmerican Airlines
Deal found 12/15$296
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1610:00 amSTL - FOD
1 stop4h 01mUnited Airlines
Tue 12/2310:05 amFOD - STL
1 stop4h 21mUnited Airlines
Deal found 12/15$361
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:10 pmSTL - DSM
1 stop6h 30mUnited Airlines
Sun 1/46:46 pmDSM - STL
1 stop3h 57mUnited Airlines
Deal found 12/16$406
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amSTL - DSM
1 stop4h 38mDelta
Wed 12/315:55 pmDSM - STL
1 stop4h 21mDelta
Deal found 12/17$497
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:00 amSTL - OMA
1 stop7h 11mUnited Airlines
Sat 12/276:10 amOMA - STL
1 stop6h 17mUnited Airlines
Deal found 12/16$521
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:30 pmSTL - DSM
1 stop5h 29mAmerican Airlines
Tue 12/236:56 pmDSM - STL
1 stop4h 56mAmerican Airlines
Deal found 12/16$521
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:00 amSTL - OMA
1 stop8h 16mUnited Airlines
Sun 12/286:20 pmOMA - STL
1 stop4h 23mUnited Airlines
Deal found 12/16$555
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/243:10 pmSTL - DSM
1 stop4h 19mUnited Airlines
Sun 12/286:46 pmDSM - STL
1 stop3h 57mUnited Airlines
Deal found 12/16$555
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/223:30 pmSTL - OMA
1 stop7h 29mAmerican Airlines
Mon 12/297:34 pmOMA - STL
1 stop4h 10mAmerican Airlines
Deal found 12/17$589
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/189:34 amSTL - DSM
1 stop5h 34mAmerican Airlines
Mon 12/226:35 pmDSM - STL
1 stop5h 09mAmerican Airlines
Deal found 12/16$589
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2110:45 pmSTL - OMA
Nonstop1h 20mSouthwest
Fri 1/26:35 pmOMA - STL
Nonstop1h 20mSouthwest
Deal found 12/16$608
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:51 amSTL - DSM
1 stop10h 45mMultiple Airlines
Mon 12/228:29 pmDSM - STL
2 stops24h 56mMultiple Airlines
Deal found 12/16$624

Find flight deals from St. Louis to Iowa

Keep the following information in mind while searching for St. Louis to Iowa flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$157
(Delta)

One-way from

$72
(Kiwi.com)

Popular in

July

Cheapest in

June
Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.
Search Deals
From Lambert-St Louis to Iowa
Search Deals
One-way flight from Lambert-St Louis to Iowa
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($32 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from St. Louis to Iowa that are best for you.

Fly from

St. Louis

Fly to

Iowa

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 1/6

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Wed 1/14

10:59 am-4:45 pm

1 stop5h 46m

$157

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

3:37 pm-11:23 pm

1 stop7h 46m

Des Moines

Tue 1/27

11:42 am-6:16 pm

1 stop6h 34m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Sun 1/25

6:54 am-10:43 am

1 stop3h 49m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 1/15

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Thu 1/22

10:59 am-4:45 pm

1 stop5h 46m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 1/6

12:25 pm-7:20 pm

1 stop6h 55m

Des Moines

Wed 1/14

6:10 am-7:30 am

Nonstop1h 20m

$162

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 1/18

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Tue 1/20

5:35 am-11:54 am

1 stop6h 19m

$188

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/9

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Mon 1/12

5:16 pm-11:39 pm

1 stop6h 23m

$189

St. LouisOmaha

STL - OMA

STLOMA

Lambert-St Louis

Sat 1/10

1:15 pm-5:36 pm

1 stop4h 21m

Omaha Eppley Airfield

Sat 1/24

3:21 pm-7:27 pm

1 stop4h 06m

$191

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

2:35 pm-7:20 pm

1 stop4h 45m

Des Moines

Tue 1/27

6:10 am-7:30 am

Nonstop1h 20m

$231

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 1/21

9:57 am-2:33 pm

1 stop4h 36m

Des Moines

Sat 1/24

7:50 am-2:28 pm

1 stop6h 38m

$241

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 36 results
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Best time to book a flight from St. Louis to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Iowa

What is the cheapest time of day to fly from STL to IA?

Find hourly flight availability from St. Louis to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

A simple way to save on the total cost of your ticket is to fly from St. Louis to Iowa in the evening. If you’re flexible enough to do this you can expect to save up to 72% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated December 18, 2025.
Read reviews from past customers who have flown Southwest, American Airlines, and Southern / Mokulele from St. Louis to Iowa. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,250 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,054 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southern / Mokulele
6.8
Okay
30 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to Iowa?

    Most people fly from Lambert-St Louis (STL) if they book a flight from St. Louis to Iowa. Lambert-St Louis is conveniently located just 12.7 mi from St. Louis’s city center.

  • How popular is this St. Louis to Iowa flight route?

    Within the past month, 3 users have taken a look at flights from Lambert-St Louis to Iowa.

  • How long is the flight from St. Louis to Iowa?

    Departing from St. Louis to Iowa will take you 4h 09m. Airlines will cover a distance of 259 mi. This flight may include one or multiple stops.

  • What are the most popular routes from St. Louis to Iowa?

    The most popular flight routes from St. Louis to Iowa are Lambert-St Louis - Omaha Eppley Airfield, Lambert-St Louis - Des Moines and Lambert-St Louis - Fort Dodge.

  • Can I find deals for flights from St. Louis to Iowa that include hotel bookings?

    Yes. In addition to deals on St. Louis to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Iowa.

  • Can I find deals for business class flights from St. Louis to Iowa?

    Yes. Cheapflights offers flight deals from St. Louis to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for St. Louis to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from St. Louis to Iowa

Discover the top 3 airlines that operate flights from St. Louis to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Southern / MokuleleCheapest$49Average$108FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$77Average$309FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$142Average$298FlexibilityNo cancel feeOn-time71%

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