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$105+ Cheap flights from Knoxville to Indianapolis (TYS - IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
May 11 — May 181
Mon 5/11
Mon 5/18
1 adult, Economy
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Cheap flight deals from Knoxville to Indianapolis

Cheapest flights from Knoxville to Indianapolis
Explore the most affordable flight options available from Knoxville to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:48 pm
TYS
-
IND
1 stop19h 23m
Multiple Airlines
Thu 4/239:00 am
IND
-
TYS
1 stop28h 16m
Multiple Airlines
Deal found 4/9$202
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:32 pm
TYS
-
IND
1 stop26h 27m
Multiple Airlines
Mon 4/275:43 pm
IND
-
TYS
1 stop21h 15m
Multiple Airlines
Deal found 4/7$221
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:25 pm
TYS
-
IND
1 stop7h 34m
Multiple Airlines
Fri 5/111:22 am
IND
-
TYS
1 stop6h 08m
Multiple Airlines
Deal found 4/7$222
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/79:40 pm
TYS
-
IND
1 stop13h 41m
Multiple Airlines
Fri 5/86:40 pm
IND
-
TYS
1 stop16h 26m
Multiple Airlines
Deal found 4/9$231
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:25 pm
TYS
-
IND
1 stop18h 56m
Multiple Airlines
Wed 5/2012:26 pm
IND
-
TYS
1 stop26h 30m
Multiple Airlines
Deal found 4/7$232
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:35 pm
TYS
-
IND
1 stop8h 24m
Multiple Airlines
Sun 4/265:59 pm
IND
-
TYS
1 stop28h 25m
Multiple Airlines
Deal found 4/7$233
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:45 pm
TYS
-
IND
1 stop11h 13m
Multiple Airlines
Sun 4/265:59 pm
IND
-
TYS
1 stop23h 31m
Multiple Airlines
Deal found 4/7$235
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1612:37 pm
TYS
-
IND
1 stop24h 14m
Allegiant Air
Sun 4/199:00 am
IND
-
TYS
1 stop28h 16m
Allegiant Air
Deal found 4/7$253
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:40 pm
TYS
-
IND
1 stop13h 41m
Multiple Airlines
Sat 5/236:47 pm
IND
-
TYS
1 stop27h 47m
Multiple Airlines
Deal found 4/8$255

Find flight deals from Knoxville to Indianapolis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$202
(Kiwi.com)

One-way from

$105
(Kiwi.com)

Popular in

March

Cheapest in

May

Average price

$353
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indianapolis
Search Deals
One-way flight from Knoxville McGhee Tyson to Indianapolis
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($114 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($33 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2026.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 4/29

4:25 pm-11:32 am

2 stops19h 07m

Indianapolis

Fri 5/1

11:22 am-5:30 pm

1 stop6h 08m

$228

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sat 5/2

6:40 am-8:20 pm

2 stops13h 40m

Indianapolis

Sat 5/9

5:10 am-6:30 pm

2 stops13h 20m

$293

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 5/26

5:00 pm-2:25 pm

1 stop21h 25m

Indianapolis

Tue 6/2

1:46 pm-5:58 pm

2 stops28h 12m

$305

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 5/13

8:15 am-10:50 pm

2 stops14h 35m

Indianapolis

Wed 5/20

9:35 am-7:40 pm

2 stops10h 05m

$309

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 5/28

6:35 am-7:45 pm

2 stops13h 10m

Indianapolis

Wed 6/3

6:40 am-7:40 pm

2 stops13h 00m

$311

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 7/16

7:15 am-1:44 pm

1 stop6h 29m

Indianapolis

Thu 7/23

10:18 am-10:24 pm

1 stop12h 06m

$314

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 4/30

5:00 am-9:41 am

1 stop4h 41m

Indianapolis

Sun 5/3

3:48 pm-8:18 pm

1 stop4h 30m

$342
Quickest round-trip

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 5/21

7:33 pm-11:26 pm

1 stop3h 53m

Indianapolis

Sun 5/24

6:00 am-11:09 am

1 stop5h 09m

$342

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 8/3

3:54 pm-10:27 pm

1 stop6h 33m

Indianapolis

Fri 8/7

1:41 pm-7:53 pm

1 stop6h 12m

$357

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 5/8

7:00 am-1:11 pm

1 stop6h 11m

Indianapolis

Sun 5/10

9:40 am-4:39 pm

1 stop6h 59m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/10

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Indianapolis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Indianapolis in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Indianapolis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Indianapolis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Indianapolis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Indianapolis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indianapolis

What is the cheapest month to book a flight from Knoxville to Indianapolis?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $178). Flying from Knoxville to Indianapolis in January is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Indianapolis?

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated April 11, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Indianapolis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,406 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,406 reviews
Delta
7.9
Good
8,406 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,572 reviews
Delta
7.9
Good
8,406 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Indianapolis?

    Departing from Knoxville to Indianapolis will take you 13h 40m. The distance between Knoxville and Indianapolis is about 298 mi.

  • What are the cheapest airlines flying from Knoxville to Indianapolis round-trip?

    According to our current data, Delta ($208), and American Airlines ($218) offers the cheapest pricing from Knoxville to Indianapolis. You may be able to fly from Knoxville to Indianapolis for 44% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indianapolis.

  • Can I find deals for business class flights from Knoxville to Indianapolis?

    Yes. Cheapflights offers flight deals from Knoxville to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indianapolis?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $178). Flying from Knoxville to Indianapolis in January is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Muncie
Greenwood
Fishers
Kokomo
Plainfield
Mooresville
Anderson
Franklin
Carmel
Noblesville
Bloomington
Crawfordsville

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Indianapolis

Discover the top 2 airlines that operate flights from Knoxville to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$248FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$258FlexibilityNo cancel feeOn-time71%

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