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$93+ Cheap flights from Knoxville to Indianapolis (TYS - IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Oct 13 — Oct 201
Mon 10/13
Mon 10/20
1 adult, Economy
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Cheap flight deals from Knoxville to Indianapolis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 13, 2025.

Round-trip from

$191
(American Airlines)

One-way from

$93
(Kiwi.com)

Popular in

March

Cheapest in

April

Average price

$348
From Knoxville McGhee Tyson to Indianapolis
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One-way flight from Knoxville McGhee Tyson to Indianapolis
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Highest demand for flights based on searches. 7% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Indianapolis

Cheapest flights from Knoxville to Indianapolis
Explore the most affordable flight options available from Knoxville to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/167:38 amTYS - IND
1 stop7h 41mAmerican Airlines
Thu 1/15:32 pmIND - TYS
1 stop4h 26mAmerican Airlines
Deal found 9/10$191
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/277:45 pmTYS - IND
1 stop3h 25mAmerican Airlines
Wed 10/15:32 pmIND - TYS
1 stop4h 09mAmerican Airlines
Deal found 9/11$216
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:30 amTYS - IND
1 stop28h 13mAllegiant Air
Sat 9/273:37 pmIND - TYS
1 stop5h 04mAllegiant Air
Deal found 9/10$231
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:05 amTYS - IND
1 stop4h 23mAmerican Airlines
Fri 11/281:59 pmIND - TYS
1 stop4h 02mAmerican Airlines
Deal found 9/12$239
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1612:46 pmTYS - IND
1 stop5h 52mAmerican Airlines
Wed 12/3110:55 amIND - TYS
1 stop4h 56mAmerican Airlines
Deal found 9/11$243
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2512:08 pmTYS - IND
1 stop8h 37mMultiple Airlines
Mon 9/295:45 amIND - TYS
1 stop11h 49mMultiple Airlines
Deal found 9/9$244
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:55 pmTYS - IND
2 stops15h 23mMultiple Airlines
Sat 9/273:37 pmIND - TYS
1 stop5h 04mMultiple Airlines
Deal found 9/10$248
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:32 pmTYS - IND
1 stop7h 25mAmerican Airlines
Mon 12/295:32 pmIND - TYS
1 stop6h 15mAmerican Airlines
Deal found 9/10$250
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:45 pmTYS - IND
1 stop4h 14mAmerican Airlines
Thu 1/15:32 pmIND - TYS
1 stop4h 26mAmerican Airlines
Deal found 9/11$251
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/38:38 amTYS - IND
1 stop15h 00mMultiple Airlines
Mon 10/65:30 amIND - TYS
1 stop7h 33mMultiple Airlines
Deal found 9/10$254
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/165:25 amTYS - IND
1 stop5h 04mDelta
Fri 1/22:42 pmIND - TYS
1 stop4h 45mDelta
Deal found 9/11$257

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 13, 2025.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Knoxville

Fly to

Indianapolis

Route

Depart

Return

Price

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

7:38 am-3:19 pm

1 stop7h 41m

Indianapolis

Thu 1/1

5:32 pm-9:58 pm

1 stop4h 26m

$191

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sat 9/27

7:45 pm-11:10 pm

1 stop3h 25m

Indianapolis

Wed 10/1

5:32 pm-9:41 pm

1 stop4h 09m

$216

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 9/25

8:30 am-12:43 pm

1 stop28h 13m

Indianapolis

Sat 9/27

3:37 pm-8:41 pm

1 stop5h 04m

$231

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sun 11/23

5:05 am-9:28 am

1 stop4h 23m

Indianapolis

Fri 11/28

1:59 pm-6:01 pm

1 stop4h 02m

$239

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 12/17

7:38 am-3:19 pm

1 stop7h 41m

Indianapolis

Wed 12/31

10:55 am-3:51 pm

1 stop4h 56m

$243

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

12:46 pm-6:38 pm

1 stop5h 52m

Indianapolis

Wed 12/31

10:55 am-3:51 pm

1 stop4h 56m

$243

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 9/25

12:08 pm-8:45 pm

1 stop8h 37m

Indianapolis

Mon 9/29

5:45 am-5:34 pm

1 stop11h 49m

$244

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 9/25

5:55 pm-9:18 am

2 stops15h 23m

Indianapolis

Sat 9/27

3:37 pm-8:41 pm

1 stop5h 04m

$248

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

4:32 pm-11:57 pm

1 stop7h 25m

Indianapolis

Mon 12/29

5:32 pm-11:47 pm

1 stop6h 15m

$250

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 10/3

8:38 am-11:38 pm

1 stop15h 00m

Indianapolis

Mon 10/6

5:30 am-1:03 pm

1 stop7h 33m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 20 results
1
2

Best time to book a flight from Knoxville to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indianapolis

What is the cheapest month to book a flight from Knoxville to Indianapolis?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $286). Flying from Knoxville to Indianapolis in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IND?

Find hourly flight availability from Knoxville to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 13, 2025.

When flying from Knoxville to Indianapolis, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 39% versus a flight at noon.

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated September 13, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Indianapolis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,936 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Indianapolis?

    Departing from Knoxville to Indianapolis will take you 7h 41m. The distance between Knoxville and Indianapolis is about 298 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Indianapolis round-trip?

    According to our current data, Delta ($208), American Airlines ($218), and United Airlines ($223) offers the cheapest pricing from Knoxville to Indianapolis. You may be able to fly from Knoxville to Indianapolis for 26% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indianapolis.

  • Can I find deals for business class flights from Knoxville to Indianapolis?

    Yes. Cheapflights offers flight deals from Knoxville to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indianapolis?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $286). Flying from Knoxville to Indianapolis in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Muncie
Terre Haute
Noblesville
Fishers
Anderson
Kokomo
Greenwood
Bloomington
Franklin
Plainfield
Carmel
Crawfordsville
Speedway

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Top 3 airlines flying from Knoxville to Indianapolis

Discover the top 3 airlines that operate flights from Knoxville to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$258FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$258FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$329FlexibilityNo cancel feeOn-time69%

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