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$117+ Cheap flights from Knoxville to Indianapolis (TYS - IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Mar 28 — Apr 41
Sat 3/28
Sat 4/4
1 adult, Economy
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Cheap flight deals from Knoxville to Indianapolis

Cheapest flights from Knoxville to Indianapolis
Explore the most affordable flight options available from Knoxville to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 26, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:06 pm
TYS
-
IND
1 stop18h 26m
Multiple Airlines
Tue 3/39:23 pm
IND
-
TYS
1 stop21h 03m
Multiple Airlines
Deal found 2/22$220
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/259:40 am
TYS
-
IND
1 stop5h 01m
United Airlines
Wed 4/14:10 pm
IND
-
TYS
1 stop6h 53m
United Airlines
Deal found 2/23$251
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/233:29 pm
TYS
-
IND
1 stop17h 10m
Multiple Airlines
Mon 3/309:00 am
IND
-
TYS
1 stop12h 47m
Multiple Airlines
Deal found 2/23$253
This Southwest deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:30 pm
TYS
-
IND
2 stops9h 35m
Southwest
Wed 4/17:45 am
IND
-
TYS
1 stop5h 55m
Southwest
Deal found 2/25$256
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:56 pm
TYS
-
IND
1 stop6h 59m
United Airlines
Sat 5/95:45 am
IND
-
TYS
1 stop5h 04m
United Airlines
Deal found 2/22$262
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/137:10 am
TYS
-
IND
1 stop16h 58m
Multiple Airlines
Tue 6/165:12 pm
IND
-
TYS
1 stop19h 00m
Multiple Airlines
Deal found 2/22$271
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/287:00 am
TYS
-
IND
1 stop6h 06m
United Airlines
Sat 4/44:10 pm
IND
-
TYS
1 stop6h 19m
United Airlines
Deal found 2/25$273
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:00 am
TYS
-
IND
1 stop5h 52m
United Airlines
Sun 4/195:45 am
IND
-
TYS
1 stop5h 05m
United Airlines
Deal found 2/25$277
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:19 pm
TYS
-
IND
1 stop19h 09m
Allegiant Air
Tue 6/165:12 pm
IND
-
TYS
1 stop19h 00m
Allegiant Air
Deal found 2/22$278

Find flight deals from Knoxville to Indianapolis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(United Airlines)

One-way from

$117
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$560
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indianapolis
Search Deals
One-way flight from Knoxville McGhee Tyson to Indianapolis
Search Deals
Highest demand for flights based on searches. 35% potential increase in price ($197 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 3/25

12:30 pm-10:05 pm

2 stops9h 35m

Indianapolis

Wed 4/1

7:45 am-1:40 pm

1 stop5h 55m

$256

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 5/7

5:56 pm-12:55 am

1 stop6h 59m

Indianapolis

Sat 5/9

5:45 am-10:49 am

1 stop5h 04m

$262

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sat 3/28

7:00 am-1:06 pm

1 stop6h 06m

Indianapolis

Sat 4/4

4:10 pm-10:29 pm

1 stop6h 19m

$273

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 4/15

7:00 am-12:52 pm

1 stop5h 52m

Indianapolis

Sun 4/19

5:45 am-10:50 am

1 stop5h 05m

$277

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 4/15

4:25 pm-11:32 am

2 stops19h 07m

Indianapolis

Sun 4/19

7:36 pm-5:30 pm

1 stop21h 54m

$290

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 6/12

5:57 pm-12:34 am

1 stop6h 37m

Indianapolis

Wed 6/17

10:02 am-3:06 pm

1 stop5h 04m

$312

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 8/3

5:00 am-8:52 am

1 stop3h 52m

Indianapolis

Fri 8/7

6:04 am-10:05 am

1 stop4h 01m

$317

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 5/8

5:56 pm-11:31 pm

1 stop5h 35m

Indianapolis

Sun 5/10

1:55 pm-8:45 pm

1 stop6h 50m

$317

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 6/11

5:57 pm-11:15 pm

1 stop5h 18m

Indianapolis

Sat 6/20

6:00 am-9:11 am

1 stop3h 11m

$337

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 4/15

8:15 am-10:50 pm

2 stops14h 35m

Indianapolis

Sun 4/19

12:55 pm-10:00 pm

2 stops9h 05m

$356

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Indianapolis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Indianapolis in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Indianapolis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Indianapolis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Indianapolis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Indianapolis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indianapolis

What is the cheapest month to book a flight from Knoxville to Indianapolis?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $172). Flying from Knoxville to Indianapolis in January is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated February 26, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Indianapolis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,237 reviews

Food

7.2

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,237 reviews
Delta
7.9
Good
8,237 reviews

Food

7.2

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,352 reviews
Delta
7.9
Good
8,237 reviews

Food

7.2

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Indianapolis?

    Departing from Knoxville to Indianapolis will take you 6h 06m. The distance between Knoxville and Indianapolis is about 298 mi.

  • What are the cheapest airlines flying from Knoxville to Indianapolis round-trip?

    According to our current data, Delta ($208), and American Airlines ($218) offers the cheapest pricing from Knoxville to Indianapolis. You may be able to fly from Knoxville to Indianapolis for 41% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indianapolis.

  • Can I find deals for business class flights from Knoxville to Indianapolis?

    Yes. Cheapflights offers flight deals from Knoxville to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indianapolis?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $172). Flying from Knoxville to Indianapolis in January is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Muncie
Terre Haute
Fishers
Noblesville
Greenwood
Plainfield
Kokomo
Mooresville
Franklin
Anderson
Carmel
Crawfordsville
Bloomington

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Indianapolis

Discover the top 2 airlines that operate flights from Knoxville to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$258FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$258FlexibilityNo cancel feeOn-time71%

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