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$99+ Cheap flights from Knoxville to Indianapolis (TYS - IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
Jan 19 — Jan 261
Mon 1/19
Mon 1/26
1 adult, Economy
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Cheap flight deals from Knoxville to Indianapolis

Cheapest flights from Knoxville to Indianapolis
Explore the most affordable flight options available from Knoxville to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 20, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:30 amTYS - IND
1 stop9h 40mMultiple Airlines
Wed 12/314:51 pmIND - TYS
1 stop19h 09mMultiple Airlines
Deal found 12/17$320
This Kiwi.com deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:35 amTYS - IND
1 stop10h 49mMultiple Airlines
Wed 12/314:51 pmIND - TYS
1 stop19h 09mMultiple Airlines
Deal found 12/19$326
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2810:04 pmTYS - IND
1 stop18h 06mMultiple Airlines
Wed 12/314:51 pmIND - TYS
1 stop19h 09mMultiple Airlines
Deal found 12/17$395
This Kiwi.com deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2010:15 amTYS - IND
1 stop20h 58mMultiple Airlines
Sat 1/39:43 pmIND - TYS
2 stops34h 20mMultiple Airlines
Deal found 12/18$398
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2711:51 amTYS - IND
1 stop11h 43mMultiple Airlines
Thu 1/15:06 pmIND - TYS
1 stop17h 09mMultiple Airlines
Deal found 12/17$413
This United Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:35 pmTYS - IND
1 stop6h 09mUnited Airlines
Thu 1/112:36 pmIND - TYS
1 stop4h 24mUnited Airlines
Deal found 12/19$415
This American Airlines deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:42 amTYS - IND
1 stop6h 54mAmerican Airlines
Sun 12/281:04 pmIND - TYS
1 stop7h 39mAmerican Airlines
Deal found 12/18$431
This American Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:42 amTYS - IND
1 stop6h 54mAmerican Airlines
Wed 12/315:32 pmIND - TYS
1 stop4h 26mAmerican Airlines
Deal found 12/19$445

Find flight deals from Knoxville to Indianapolis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$199
(Mytrip)

One-way from

$99
(Mytrip)

Popular in

March

Cheapest in

April

Average price

$242
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indianapolis
Search Deals
One-way flight from Knoxville McGhee Tyson to Indianapolis
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($28 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 20, 2025.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Knoxville

Fly to

Indianapolis

Route

Depart

Return

Price

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 2/2

12:55 pm-11:15 pm

1 stop10h 20m

Indianapolis

Thu 2/5

9:00 am-11:05 pm

1 stop14h 05m

$199

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 1/15

9:29 am-7:31 pm

1 stop10h 02m

Indianapolis

Thu 1/22

7:30 am-11:05 pm

1 stop15h 35m

$201

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sun 2/1

1:39 pm-11:43 am

2 stops22h 04m

Indianapolis

Sun 2/8

9:00 am-11:05 pm

1 stop14h 05m

$205

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 2/2

6:00 am-10:48 pm

2 stops16h 48m

Indianapolis

Thu 2/5

9:00 am-11:05 pm

1 stop14h 05m

$209

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 1/9

12:55 pm-2:43 pm

1 stop25h 48m

Indianapolis

Mon 1/12

10:38 am-5:28 pm

1 stop6h 50m

$222

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 1/7

11:10 am-2:57 pm

1 stop3h 47m

Indianapolis

Sat 1/10

2:00 pm-8:52 pm

1 stop6h 52m

$251

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 1/7

5:17 pm-11:27 pm

1 stop6h 10m

Indianapolis

Sat 1/10

6:10 am-1:54 pm

2 stops7h 44m

$256

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 1/16

11:00 am-10:24 am

1 stop23h 24m

Indianapolis

Mon 1/19

5:34 pm-12:10 pm

1 stop18h 36m

$269

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 3/4

6:45 am-1:11 pm

1 stop6h 26m

Indianapolis

Wed 3/18

3:47 pm-8:47 pm

1 stop5h 00m

$279

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 1/15

9:29 am-7:31 pm

1 stop10h 02m

$99

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/19

Showing 1-10 of 18 results
1
2

Compare providers for flights from Knoxville to Indianapolis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Indianapolis in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Indianapolis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Indianapolis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Indianapolis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Indianapolis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indianapolis

What is the cheapest month to book a flight from Knoxville to Indianapolis?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $172). Flying from Knoxville to Indianapolis in March is currently the most expensive (average of $263). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IND?

Find hourly flight availability from Knoxville to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 20, 2025.

When flying from Knoxville to Indianapolis, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 38% versus a flight at noon.

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated December 20, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Indianapolis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,018 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,018 reviews
Delta
7.9
Good
8,018 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,018 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Indianapolis?

    Departing from Knoxville to Indianapolis will take you 10h 20m. The distance between Knoxville and Indianapolis is about 298 mi.

  • What are the cheapest airlines flying from Knoxville to Indianapolis round-trip?

    According to our current data, Delta ($208), and American Airlines ($218) offers the cheapest pricing from Knoxville to Indianapolis. You may be able to fly from Knoxville to Indianapolis for 25% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indianapolis.

  • Can I find deals for business class flights from Knoxville to Indianapolis?

    Yes. Cheapflights offers flight deals from Knoxville to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indianapolis?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $172). Flying from Knoxville to Indianapolis in March is currently the most expensive (average of $263). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Muncie
Noblesville
Fishers
Greenwood
Plainfield
Anderson
Kokomo
Franklin
Carmel
Crawfordsville
Bloomington
Speedway

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Top 2 airlines flying from Knoxville to Indianapolis

Discover the top 2 airlines that operate flights from Knoxville to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$248FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$261FlexibilityNo cancel feeOn-time71%

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