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$135+ Cheap flights from Knoxville to Indianapolis (TYS - IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IND
mar. 5 — mar. 121
jue. 3/5
jue. 3/12
1 adult, Economy
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Cheap flight deals from Knoxville to Indianapolis

Cheapest flights from Knoxville to Indianapolis
Explore the most affordable flight options available from Knoxville to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on febrero 3, 2026.

This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/85:00 am
TYS
-
IND
1 stop4h 41m
American Airlines
sáb. 5/97:13 am
IND
-
TYS
1 stop4h 05m
American Airlines
Deal found 2/1$300
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/37:20 pm
TYS
-
IND
1 stop5h 14m
Delta
vie. 8/76:25 pm
IND
-
TYS
1 stop5h 21m
Delta
Deal found 2/2$317
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/612:55 pm
TYS
-
IND
1 stop10h 20m
Allegiant Air
dom. 2/89:00 am
IND
-
TYS
1 stop14h 10m
Allegiant Air
Deal found 2/2$349
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/86:35 am
TYS
-
IND
2 stops9h 30m
Southwest
sáb. 5/96:45 am
IND
-
TYS
1 stop4h 55m
Southwest
Deal found 2/1$350
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/241:15 pm
TYS
-
IND
1 stop20h 34m
Multiple Airlines
dom. 4/2612:12 pm
IND
-
TYS
2 stops9h 45m
Multiple Airlines
Deal found 2/2$356
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/66:00 am
TYS
-
IND
2 stops18h 18m
Multiple Airlines
dom. 2/89:00 am
IND
-
TYS
1 stop14h 10m
Multiple Airlines
Deal found 2/2$375
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/159:43 pm
TYS
-
IND
1 stop24h 49m
Multiple Airlines
dom. 3/2212:16 pm
IND
-
TYS
2 stops30h 11m
Multiple Airlines
Deal found 2/1$398
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/147:00 am
TYS
-
IND
1 stop6h 08m
United Airlines
jue. 5/287:01 am
IND
-
TYS
2 stops16h 56m
United Airlines
Deal found 2/1$405
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/176:45 am
TYS
-
IND
1 stop4h 41m
United Airlines
sáb. 2/214:05 pm
IND
-
TYS
1 stop4h 32m
United Airlines
Deal found 2/2$407
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/174:04 pm
TYS
-
IND
2 stops43h 00m
Multiple Airlines
sáb. 2/215:45 am
IND
-
TYS
1 stop7h 19m
Multiple Airlines
Deal found 2/2$421
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/149:40 am
TYS
-
IND
1 stop9h 17m
United Airlines
mié. 2/187:53 pm
IND
-
TYS
1 stop19h 22m
United Airlines
Deal found 1/31$427

Find flight deals from Knoxville to Indianapolis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated febrero 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$300
(American Airlines)

One-way from

$135
(Kiwi.com)

Popular in

March

Cheapest in

April

Average price

$268
Provider with most accurate pricing for Knoxville McGhee Tyson-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Indianapolis flights.
Search Deals
From Knoxville McGhee Tyson to Indianapolis
Search Deals
One-way flight from Knoxville McGhee Tyson to Indianapolis
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($10 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 3, 2026.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Knoxville

Fly to

Indianapolis

Route

Depart

Return

Price

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

jue. 5/14

7:00 am-1:11 pm

1 stop6h 11m

Indianapolis

jue. 5/28

8:05 am-3:10 pm

1 stop7h 05m

$317

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

vie. 4/24

7:00 am-11:17 am

1 stop4h 17m

Indianapolis

dom. 4/26

11:04 am-4:52 pm

1 stop5h 48m

$317

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

vie. 5/8

6:35 am-4:05 pm

2 stops9h 30m

Indianapolis

sáb. 5/9

6:45 am-11:40 am

1 stop4h 55m

$350

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

vie. 4/24

1:15 pm-9:49 am

1 stop20h 34m

Indianapolis

dom. 4/26

12:12 pm-9:57 pm

2 stops9h 45m

$356

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

dom. 3/15

9:43 pm-10:32 pm

1 stop24h 49m

Indianapolis

dom. 3/22

12:16 pm-6:27 pm

2 stops30h 11m

$398

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

jue. 5/14

7:00 am-1:08 pm

1 stop6h 08m

Indianapolis

jue. 5/28

7:01 am-11:57 pm

2 stops16h 56m

$405

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

mar. 2/17

6:45 am-11:26 am

1 stop4h 41m

Indianapolis

sáb. 2/21

4:05 pm-8:37 pm

1 stop4h 32m

$407

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

sáb. 2/14

9:40 am-6:57 pm

1 stop9h 17m

Indianapolis

mié. 2/18

7:53 pm-3:15 pm

1 stop19h 22m

$427

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

lun. 3/16

4:20 pm-7:38 pm

1 stop27h 18m

$135

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

dom. 3/15

6:30 am-8:39 am

2 stops50h 09m

$141

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/1

Showing 1-10 of 12 results
1
2

Compare providers for flights from Knoxville to Indianapolis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Indianapolis in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Indianapolis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Indianapolis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Indianapolis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Indianapolis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Indianapolis

What is the cheapest month to book a flight from Knoxville to Indianapolis?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $172). Flying from Knoxville to Indianapolis in March is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated febrero 3, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Indianapolis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,132 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,132 reviews
Delta
7.9
Good
8,132 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,212 reviews
Delta
7.9
Good
8,132 reviews

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Indianapolis?

    Departing from Knoxville to Indianapolis will take you 4h 17m. The distance between Knoxville and Indianapolis is about 298 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Indianapolis round-trip?

    According to our current data, Delta ($208), and American Airlines ($218) offers the cheapest pricing from Knoxville to Indianapolis. You may be able to fly from Knoxville to Indianapolis for 29% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Knoxville to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Indianapolis.

  • Can I find deals for business class flights from Knoxville to Indianapolis?

    Yes. Cheapflights offers flight deals from Knoxville to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Indianapolis?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Indianapolis (average of $172). Flying from Knoxville to Indianapolis in March is currently the most expensive (average of $247). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Muncie
Terre Haute
Fishers
Noblesville
Greenwood
Plainfield
Anderson
Kokomo
Mooresville
Franklin
Carmel
Crawfordsville
Bloomington

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Top 2 airlines flying from Knoxville to Indianapolis

Discover the top 2 airlines that operate flights from Knoxville to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$248FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$218Average$268FlexibilityNo cancel feeOn-time71%

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