Departing on a Wednesday is a good option for securing a great price. You can expect to save up to 22% when planning your travel around this day of the week.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from State College to Hilton Head Island as you normally would.
This is defined as State College University Park Airport (SCE) and Hilton Head Island Airport (HHH). Codes like Hilton Head Island Airport are often used to just call airports uniquely.