$110+ Cheap flights from Knoxville (TYS) to Guatemala City (GUA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GUA
Mar 21 — Mar 281
1 adult, Economy
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Find cheap flights from Knoxville to Guatemala City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Guatemala City
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Best
Last-minute
One-way
Cheapest flights from Knoxville to Guatemala CityExplore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.
Explore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- GUA
1 stop15h 48m
Multiple Airlines
Sun 4/268:15 pm
GUA
- TYS
2 stops19h 15m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:05 pm
TYS
- GUA
2 stops20h 15m
Multiple Airlines
Tue 3/2412:23 pm
GUA
- TYS
1 stop20h 17m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- GUA
1 stop15h 48m
Multiple Airlines
Fri 4/2412:15 pm
GUA
- TYS
1 stop21h 51m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- GUA
1 stop15h 48m
Multiple Airlines
Wed 4/228:15 pm
GUA
- TYS
2 stops17h 26m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$388
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- GUA
1 stop15h 48m
Multiple Airlines
Sat 4/2510:00 am
GUA
- TYS
2 stops27h 41m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- GUA
1 stop15h 48m
Multiple Airlines
Thu 4/2312:15 pm
GUA
- TYS
1 stop22h 10m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$414
Best flights from Knoxville to Guatemala CityDiscover carefully curated flight deals from Knoxville to Guatemala City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 19, 2026.
Discover carefully curated flight deals from Knoxville to Guatemala City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- GUA
1 stop15h 48m
Multiple Airlines
Sun 4/268:15 pm
GUA
- TYS
2 stops19h 15m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- GUA
1 stop15h 48m
Multiple Airlines
Fri 4/2412:15 pm
GUA
- TYS
1 stop21h 51m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:05 pm
TYS
- GUA
2 stops20h 15m
Multiple Airlines
Tue 3/2412:23 pm
GUA
- TYS
1 stop20h 17m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$390
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- GUA
1 stop15h 48m
Multiple Airlines
Sat 4/2512:15 pm
GUA
- TYS
1 stop24h 30m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$420
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/229:32 pm
TYS
- GUA
2 stops14h 48m
Multiple Airlines
Sun 3/112:15 pm
GUA
- TYS
1 stop29h 16m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:36 pm
TYS
- GUA
2 stops14h 44m
Multiple Airlines
Mon 3/2312:59 am
GUA
- TYS
1 stop11h 11m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$440
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:10 pm
TYS
- GUA
1 stop8h 54m
Multiple Airlines
Mon 4/135:25 am
GUA
- TYS
2 stops10h 05m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$467
Last-minute flights from Knoxville to Guatemala CityDiscover last-minute flight deals from Knoxville to Guatemala City. Data last updated February 19, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Guatemala City. Data last updated February 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/229:32 pm
TYS
- GUA
2 stops14h 48m
Multiple Airlines
Sun 3/112:15 pm
GUA
- TYS
1 stop29h 16m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:36 pm
TYS
- GUA
2 stops14h 44m
Multiple Airlines
Mon 3/2312:59 am
GUA
- TYS
1 stop11h 11m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$440
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:05 pm
TYS
- GUA
2 stops20h 15m
Multiple Airlines
Tue 3/2412:23 pm
GUA
- TYS
1 stop20h 17m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/168:58 am
TYS
- GUA
1 stop17h 06m
Multiple Airlines
Sun 3/2212:59 am
GUA
- TYS
1 stop9h 40m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$503
One-way flights from Knoxville to Guatemala CitySearch for one-way flight options from Knoxville to Guatemala City. Find affordable one-way fares based on user searches. Data last updated February 19, 2026.
Search for one-way flight options from Knoxville to Guatemala City. Find affordable one-way fares based on user searches. Data last updated February 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:40 am
TYS
- GUA
1 stop18h 24m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:00 am
TYS
- GUA
1 stop30h 24m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$176
Find flight deals from Knoxville to Guatemala City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Guatemala City (GUA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $355 (Kiwi.com) |
One-way from | $110 (Kiwi.com) |
Popular in | December |
Cheapest in | May |
Average price | $627 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Guatemala City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Knoxville to Guatemala City that are best for you.
Fly from
Knoxville
Fly to
Guatemala City
Route
Depart
Return
Price
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sun 4/19
9:32 pm-11:20 am
1 stop15h 48m
Guatemala City La Aurora
Sun 4/26
8:15 pm-5:30 pm
2 stops19h 15m
$355
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sun 4/19
9:32 pm-11:20 am
1 stop15h 48m
Guatemala City La Aurora
Fri 4/24
12:15 pm-12:06 pm
1 stop21h 51m
$374
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Tue 3/10
4:05 pm-10:20 am
2 stops20h 15m
Guatemala City La Aurora
Tue 3/24
12:23 pm-10:40 am
1 stop20h 17m
$390
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sun 4/19
9:32 pm-11:20 am
1 stop15h 48m
Guatemala City La Aurora
Sat 4/25
12:15 pm-2:45 pm
1 stop24h 30m
$420
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sun 2/22
9:32 pm-11:20 am
2 stops14h 48m
Guatemala City La Aurora
Sun 3/1
12:15 pm-6:31 pm
1 stop29h 16m
$422
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Mon 3/9
9:36 pm-10:20 am
2 stops14h 44m
Guatemala City La Aurora
Mon 3/23
12:59 am-2:10 pm
1 stop11h 11m
$440
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Thu 4/9
5:10 pm-12:04 am
1 stop8h 54m
Guatemala City La Aurora
Mon 4/13
5:25 am-5:30 pm
2 stops10h 05m
$467
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Mon 3/23
7:40 am-12:04 am
1 stop18h 24m
$110
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sun 3/29
7:00 am-11:24 am
1 stop30h 24m
$176
Compare providers for flights from Knoxville to Guatemala City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Guatemala City in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on Knoxville-Guatemala City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Guatemala City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Guatemala City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Guatemala City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Guatemala City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Guatemala City
Have a flexible travel schedule? Discover the best time to fly to Guatemala City from Knoxville with our price prediction graph.
TYS-GUA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Guatemala City
Reviews of airlines servicing Guatemala City
Get insights into the airlines that provide service to Guatemala City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guatemala City. Reviews last updated February 19, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Guatemala City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Comfort
7.9
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Guatemala City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Guatemala City?
Book flights to Guatemala City if you plan to visit one of these locationsAntigua
Panajachel
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip
Complete your trip to Guatemala City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Guatemala City by cabin class
Find flights from Knoxville to Guatemala City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Guatemala City
Explore flights to Guatemala City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 19, 2026.
Knoxville and Guatemala City flights
Browse other Knoxville and Guatemala City flight options. Last updated on February 19, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on February 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Guatemala City
Discover the top 2 airlines that operate flights from Knoxville to Guatemala City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$463 | Average$598 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$571 | Average$752 | FlexibilityNo cancel fee | On-timeN/A |