What are the cheapest airlines flying from Knoxville to Guatemala City round-trip?

Currently priced at $463, American Airlines will fly you from Knoxville to Guatemala City and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $504. American Airlines is 28% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest time of day to fly from TYS to GUA?

When flying from Knoxville to Guatemala City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Most accurate provider : When it comes to deals on Knoxville-Guatemala City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Guatemala City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Guatemala City flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-Guatemala City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Guatemala City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to Guatemala City that include hotel bookings?

Yes. In addition to deals on Knoxville to Guatemala City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Guatemala City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Guatemala City.

Can I find deals for business class flights from Knoxville to Guatemala City?

Yes. Cheapflights offers flight deals from Knoxville to Guatemala City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$291+ Flights from Knoxville to Guatemala City

Q: How much does it cost to fly round-trip from Knoxville to Guatemala City?

Airfare is below average for this route at the moment. Knoxville to Guatemala City flights typically cost between $786 and $1,130 in January. The cheapest round-trip price found within the last 3 days was $303 on Multiple Airlines (Jan 21-Jan 31).

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Find flight deals from Knoxville to Guatemala City

Cheapest flights from Knoxville to Guatemala City
Explore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 24, 2025.

Tue 12/305:42 pmTYS - GUA

1 stop18h 43mMultiple Airlines

Tue 1/61:17 pmGUA - TYS

2 stops51h 36mMultiple Airlines

Deal found 11/21

$562

Tue 12/307:01 pmTYS - GUA

1 stop20h 59mAmerican Airlines

Tue 1/612:25 pmGUA - TYS

1 stop10h 34mAmerican Airlines

Deal found 11/21

$982

Tue 12/307:23 pmTYS - GUA

1 stop27h 02mUnited Airlines

Mon 1/51:05 amGUA - TYS

1 stop8h 52mUnited Airlines

Deal found 11/21

$1,097

Best flights from Knoxville to Guatemala City
Discover carefully curated flight deals from Knoxville to Guatemala City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 24, 2025.

Wed 1/214:47 pmTYS - GUA

1 stop20h 37mMultiple Airlines

Sat 1/311:28 pmGUA - TYS

1 stop18h 11mMultiple Airlines

Deal found 11/23

$303

Mon 1/269:05 amTYS - GUA

1 stop7h 30mUnited Airlines

Sat 1/312:10 amGUA - TYS

1 stop10h 40mUnited Airlines

Deal found 11/24

$552

Mon 1/268:30 amTYS - GUA

1 stop28h 54mMultiple Airlines

Sun 2/11:58 pmGUA - TYS

2 stops24h 37mMultiple Airlines

Deal found 11/24

$374

Tue 12/305:42 pmTYS - GUA

1 stop18h 43mMultiple Airlines

Tue 1/61:17 pmGUA - TYS

2 stops51h 36mMultiple Airlines

Deal found 11/21

$562

Mon 1/266:59 amTYS - GUA

1 stop9h 36mUnited Airlines

Wed 1/282:10 amGUA - TYS

1 stop16h 40mUnited Airlines

Deal found 11/21

$642

Last-minute flights from Knoxville to Guatemala City
Discover last-minute flight deals from Knoxville to Guatemala City. Data last updated November 24, 2025 and is based on user searches.

Tue 12/305:42 pmTYS - GUA

1 stop18h 43mMultiple Airlines

Tue 1/61:17 pmGUA - TYS

2 stops51h 36mMultiple Airlines

Deal found 11/21

$562

Tue 12/307:01 pmTYS - GUA

1 stop20h 59mAmerican Airlines

Tue 1/612:25 pmGUA - TYS

1 stop10h 34mAmerican Airlines

Deal found 11/21

$982

Tue 12/307:23 pmTYS - GUA

1 stop27h 02mUnited Airlines

Mon 1/51:05 amGUA - TYS

1 stop8h 52mUnited Airlines

Deal found 11/21

$1,097

One-way flights from Knoxville to Guatemala City
Search for one-way flight options from Knoxville to Guatemala City. Find affordable one-way fares based on user searches. Data last updated November 24, 2025.

Mon 12/85:34 pmTYS - GUA

3 stops40h 26mMultiple Airlines

Deal found 11/22

$291

Thu 12/45:23 pmTYS - GUA

2 stops14h 57mMultiple Airlines

Deal found 11/22

$313

Fri 12/59:23 amTYS - GUA

3 stops45h 57mMultiple Airlines

Deal found 11/22

$314

Sat 12/612:53 pmTYS - GUA

3 stops35h 17mMultiple Airlines

Deal found 11/22

$320

Sun 12/75:23 pmTYS - GUA

3 stops50h 12mMultiple Airlines

Deal found 11/22

$324

Wed 12/312:53 pmTYS - GUA

2 stops26h 12mMultiple Airlines

Deal found 11/22

$417

Sat 12/67:00 amTYS - GUA

1 stop7h 35mUnited Airlines

Deal found 11/22

$424

Cheap flight deals from Knoxville to Guatemala City

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$303 (Kiwi.com)
One-way from	$291 (Kiwi.com)
Popular in	December
Cheapest in	August
Average price	$854

Provider with most accurate pricing for Knoxville McGhee Tyson-Guatemala City La Aurora flight deals.

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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Guatemala City La Aurora flights.

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From Knoxville McGhee Tyson to Guatemala City La Aurora

Search Deals

One-way flight from Knoxville McGhee Tyson to Guatemala City La Aurora

Search Deals

Highest demand for flights based on searches. 18% potential increase in price ($145 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($34 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in November 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Guatemala City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Wed 1/21

4:47 pm-12:24 pm

1 stop20h 37m

Guatemala City La Aurora

Sat 1/31

1:28 pm-8:39 am

1 stop18h 11m

$303

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Mon 1/26

8:30 am-12:24 pm

1 stop28h 54m

Guatemala City La Aurora

Sun 2/1

1:58 pm-3:35 pm

2 stops24h 37m

$374

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Mon 1/26

9:05 am-3:35 pm

1 stop7h 30m

Guatemala City La Aurora

Sat 1/31

2:10 am-1:50 pm

1 stop10h 40m

$552

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Tue 12/30

5:42 pm-11:25 am

1 stop18h 43m

Guatemala City La Aurora

Tue 1/6

1:17 pm-5:53 pm

2 stops51h 36m

$562

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Mon 1/26

6:59 am-3:35 pm

1 stop9h 36m

Guatemala City La Aurora

Wed 1/28

2:10 am-7:50 pm

1 stop16h 40m

$642

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Mon 12/8

5:34 pm-9:00 am

3 stops40h 26m

$291

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Thu 12/4

5:23 pm-7:20 am

2 stops14h 57m

$313

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Fri 12/5

9:23 am-6:20 am

3 stops45h 57m

$314

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sat 12/6

12:53 pm-11:10 pm

3 stops35h 17m

$320

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sun 12/7

5:23 pm-6:35 pm

3 stops50h 12m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/22

Showing 1-10 of 13 results

Compare providers for flights from Knoxville to Guatemala City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Guatemala City in November.

Provider	Price Accuracy	Trust Score*
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
AranGrant	Price Accuracy2 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-Guatemala City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Guatemala City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Guatemala City flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-Guatemala City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Guatemala City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Guatemala City

Have a flexible travel schedule? Discover the best time to fly to Guatemala City from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Guatemala City

What is the cheapest month to book a flight from Knoxville to Guatemala City?

Currently, June is the cheapest month in which you can book a flight from Knoxville to Guatemala City (average of $122). Flying from Knoxville to Guatemala City in September is currently the most expensive (average of $1,194). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Guatemala City?

Reviews of airlines servicing Guatemala City

Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Guatemala City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

7,997 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

7,997 reviews

Delta

7.9

Good

7,997 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,046 reviews

Delta

7.9

Good

7,997 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

What are the cheapest airlines flying from Knoxville to Guatemala City round-trip?
Currently priced at $463, American Airlines will fly you from Knoxville to Guatemala City and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $504. American Airlines is 28% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Knoxville to Guatemala City that include hotel bookings?
Yes. In addition to deals on Knoxville to Guatemala City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Guatemala City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Guatemala City.
Can I find deals for business class flights from Knoxville to Guatemala City?
Yes. Cheapflights offers flight deals from Knoxville to Guatemala City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Guatemala City?
Currently, June is the cheapest month in which you can book a flight from Knoxville to Guatemala City (average of $122). Flying from Knoxville to Guatemala City in September is currently the most expensive (average of $1,194). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Antigua

Panajachel

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Top 2 airlines flying from Knoxville to Guatemala City

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$463	Average$655	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$504	Average$731	FlexibilityNo cancel fee	On-timeN/A

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$291+ Cheap flights from Knoxville (TYS) to Guatemala City (GUA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to Guatemala City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Knoxville to Guatemala City

Cheapest flights from Knoxville to Guatemala CityExplore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 24, 2025.

Explore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 24, 2025.

Cheap flight deals from Knoxville to Guatemala City

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Guatemala City that are best for you.

Compare providers for flights from Knoxville to Guatemala City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Guatemala City in November.

Best time to book a flight from Knoxville to Guatemala City

Have a flexible travel schedule? Discover the best time to fly to Guatemala City from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Guatemala City

What is the cheapest month to book a flight from Knoxville to Guatemala City?

How much does it cost to fly round-trip from Knoxville to Guatemala City?

Reviews of airlines servicing Guatemala City

Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Guatemala City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Guatemala City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Knoxville to Guatemala City round-trip?

Can I find deals for flights from Knoxville to Guatemala City that include hotel bookings?

How can I find direct flights from Knoxville to Guatemala City?

Can I find deals for business class flights from Knoxville to Guatemala City?

What is the cheapest month to book a flight from Knoxville to Guatemala City?

Traveling to a place near Guatemala City?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Knoxville to Guatemala City

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Knoxville to Guatemala City

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Cheapest flights from Knoxville to Guatemala City
Explore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 24, 2025.