$189+ Cheap flights from Knoxville (TYS) to Guatemala City (GUA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GUA
May 18 — May 251
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Guatemala City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Guatemala City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to Guatemala CityExplore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
Explore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- GUA
1 stop21h 22m
Multiple Airlines
Sun 7/128:15 pm
GUA
- TYS
2 stops25h 18m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:24 pm
TYS
- GUA
1 stop16h 59m
Multiple Airlines
Mon 5/255:25 am
GUA
- TYS
2 stops16h 12m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$441
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:15 pm
TYS
- GUA
1 stop23h 08m
Multiple Airlines
Sat 5/2312:17 pm
GUA
- TYS
1 stop22h 41m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:24 pm
TYS
- GUA
1 stop16h 59m
Multiple Airlines
Fri 6/511:18 am
GUA
- TYS
1 stop10h 21m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$500
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- GUA
1 stop21h 22m
Multiple Airlines
Mon 7/1312:08 pm
GUA
- TYS
1 stop9h 25m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$504
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:56 pm
TYS
- GUA
1 stop24h 09m
Multiple Airlines
Fri 5/111:51 am
GUA
- TYS
2 stops21h 15m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$532
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:46 pm
TYS
- GUA
2 stops20h 37m
Multiple Airlines
Sun 6/78:00 pm
GUA
- TYS
1 stop18h 40m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$548
Best flights from Knoxville to Guatemala CityDiscover carefully curated flight deals from Knoxville to Guatemala City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
Discover carefully curated flight deals from Knoxville to Guatemala City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- GUA
1 stop7h 30m
Delta
Sat 7/112:10 pm
GUA
- TYS
1 stop6h 29m
Delta
Deal found 4/13![Delta logo]()
$683
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:22 am
TYS
- GUA
2 stops31h 20m
Multiple Airlines
Sun 7/128:00 pm
GUA
- TYS
1 stop18h 42m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$714
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:12 pm
TYS
- GUA
2 stops12h 19m
American Airlines
Wed 6/310:08 am
GUA
- TYS
2 stops11h 39m
American Airlines
Deal found 4/14![American Airlines logo]()
$754
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:35 am
TYS
- GUA
1 stop7h 02m
United Airlines
Fri 5/156:15 am
GUA
- TYS
1 stop9h 56m
United Airlines
Deal found 4/17![United Airlines logo]()
$893
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:33 am
TYS
- GUA
1 stop5h 57m
Delta
Sat 7/112:10 pm
GUA
- TYS
1 stop6h 29m
Delta
Deal found 4/13![Delta logo]()
$763
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:05 am
TYS
- GUA
1 stop11h 32m
United Airlines
Thu 5/2111:55 pm
GUA
- TYS
1 stop8h 47m
United Airlines
Deal found 4/15![United Airlines logo]()
$893
Last-minute flights from Knoxville to Guatemala CityDiscover last-minute flight deals from Knoxville to Guatemala City. Data last updated April 18, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Guatemala City. Data last updated April 18, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
TYS
- GUA
2 stops25h 20m
Multiple Airlines
Sun 5/1712:17 pm
GUA
- TYS
1 stop6h 33m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$597
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:56 pm
TYS
- GUA
1 stop24h 09m
Multiple Airlines
Fri 5/111:51 am
GUA
- TYS
2 stops21h 15m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$532
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:15 pm
TYS
- GUA
1 stop23h 08m
Multiple Airlines
Sat 5/2312:17 pm
GUA
- TYS
1 stop22h 41m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:24 pm
TYS
- GUA
1 stop16h 59m
Multiple Airlines
Mon 5/255:25 am
GUA
- TYS
2 stops16h 12m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$441
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:24 pm
TYS
- GUA
1 stop16h 59m
Multiple Airlines
Fri 6/511:18 am
GUA
- TYS
1 stop10h 21m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$500
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:12 am
TYS
- GUA
2 stops14h 15m
American Airlines
Fri 6/56:00 am
GUA
- TYS
2 stops13h 31m
American Airlines
Deal found 4/14![American Airlines logo]()
$656
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:46 pm
TYS
- GUA
2 stops20h 37m
Multiple Airlines
Sun 6/78:00 pm
GUA
- TYS
1 stop18h 40m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$548
One-way flights from Knoxville to Guatemala CitySearch for one-way flight options from Knoxville to Guatemala City. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
Search for one-way flight options from Knoxville to Guatemala City. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:25 pm
TYS
- GUA
1 stop20h 47m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- GUA
1 stop21h 22m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:22 pm
TYS
- GUA
1 stop21h 20m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:11 pm
TYS
- GUA
2 stops43h 12m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:38 pm
TYS
- GUA
3 stops45h 35m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/48:40 pm
TYS
- GUA
2 stops40h 33m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$304
Find flight deals from Knoxville to Guatemala City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Guatemala City (GUA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $435 (Kiwi.com) |
One-way from | $189 (Kiwi.com) |
Popular in | December |
Cheapest in | May |
Average price | $344 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Guatemala City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Knoxville to Guatemala City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sat 7/4
6:00 am-11:30 am
1 stop7h 30m
Guatemala City La Aurora
Sat 7/11
2:10 pm-10:39 pm
1 stop6h 29m
$683
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sat 7/4
9:22 am-2:42 pm
2 stops31h 20m
Guatemala City La Aurora
Sun 7/12
8:00 pm-4:42 pm
1 stop18h 42m
$714
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sat 5/23
1:12 pm-11:31 pm
2 stops12h 19m
Guatemala City La Aurora
Wed 6/3
10:08 am-11:47 pm
2 stops11h 39m
$754
Quickest round-trip
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Fri 7/3
7:33 am-11:30 am
1 stop5h 57m
Guatemala City La Aurora
Sat 7/11
2:10 pm-10:39 pm
1 stop6h 29m
$763
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Mon 5/11
11:35 am-4:37 pm
1 stop7h 02m
Guatemala City La Aurora
Fri 5/15
6:15 am-6:11 pm
1 stop9h 56m
$893
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sun 5/17
7:05 am-4:37 pm
1 stop11h 32m
Guatemala City La Aurora
Thu 5/21
11:55 pm-10:42 am
1 stop8h 47m
$893
Cheapest one-way
Quickest one-way
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Wed 5/6
4:25 pm-11:12 am
1 stop20h 47m
$189
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Fri 7/3
7:20 pm-2:42 pm
1 stop21h 22m
$206
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Mon 6/15
7:22 pm-2:42 pm
1 stop21h 20m
$226
KnoxvilleGuatemala City
TYS - GUA
TYSGUA
Knoxville McGhee Tyson
Sat 5/30
5:11 pm-10:23 am
2 stops43h 12m
$229
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Guatemala City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Guatemala City in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Knoxville-Guatemala City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Guatemala City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Guatemala City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Guatemala City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Guatemala City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Guatemala City
Have a flexible travel schedule? Discover the best time to fly to Guatemala City from Knoxville with our price prediction graph.
TYS-GUA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Guatemala City
Reviews of airlines servicing Guatemala City
Get insights into the airlines that provide service to Guatemala City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guatemala City. Reviews last updated April 18, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Guatemala City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Food
7.2
Entertainment
7.8
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Food
7.2
Entertainment
7.8
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Food
7.2
Entertainment
7.8
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Guatemala City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Guatemala City?
Book flights to Guatemala City if you plan to visit one of these locationsAntigua
Panajachel
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to Guatemala City by adding a car rental and/or hotel reservation to your travel itinerary.
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Other flights to Guatemala City
Explore flights to Guatemala City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 18, 2026.
Knoxville and Guatemala City flights
Browse other Knoxville and Guatemala City flight options. Last updated on April 18, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on April 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Guatemala City
Discover the top 2 airlines that operate flights from Knoxville to Guatemala City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$463 | Average$598 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$576 | Average$752 | FlexibilityNo cancel fee | On-timeN/A |