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Greenville

$149+ Cheap flights from St. Louis to Greenville (STL - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GSP
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from St. Louis to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$209
(United Airlines)

One-way from

$149
(American Airlines)

Popular in

February

Cheapest in

August

Average price

$346
From Lambert-St Louis to Greenville
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One-way flight from Lambert-St Louis to Greenville
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Highest demand for flights based on searches. 4% potential increase in price ($18 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from St. Louis to Greenville

Cheapest flights from St. Louis to Greenville
Explore the most affordable flight options available from St. Louis to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:15 pmSTL - GSP
1 stop5h 40mDelta
Tue 10/2110:04 amGSP - STL
1 stop3h 31mDelta
Deal found 9/14$277
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:16 amSTL - GSP
1 stop11h 18mAmerican Airlines
Tue 10/148:04 pmGSP - STL
1 stop4h 50mAmerican Airlines
Deal found 9/14$279
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:35 amSTL - GSP
2 stops6h 50mSouthwest
Wed 10/296:05 amGSP - STL
1 stop6h 20mSouthwest
Deal found 9/13$282
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:00 amSTL - GSP
1 stop3h 09mDelta
Sat 10/186:00 amGSP - STL
1 stop4h 15mDelta
Deal found 9/15$287
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/259:58 amSTL - GSP
1 stop11h 13mAmerican Airlines
Mon 10/274:46 pmGSP - STL
1 stop8h 10mAmerican Airlines
Deal found 9/15$289
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/78:42 amSTL - GSP
1 stop9h 52mAmerican Airlines
Fri 10/244:46 pmGSP - STL
1 stop8h 10mAmerican Airlines
Deal found 9/15$291
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/135:30 amSTL - GSP
1 stop4h 15mAmerican Airlines
Mon 10/204:46 pmGSP - STL
1 stop8h 10mAmerican Airlines
Deal found 9/15$297
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:30 amSTL - GSP
2 stops6h 41mUnited Airlines
Fri 10/246:05 pmGSP - STL
1 stop6h 52mUnited Airlines
Deal found 9/15$303
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:15 pmSTL - GSP
1 stop5h 40mDelta
Mon 10/277:41 pmGSP - STL
1 stop5h 00mDelta
Deal found 9/15$308
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:52 pmSTL - GSP
1 stop4h 03mDelta
Wed 10/227:52 amGSP - STL
1 stop5h 43mDelta
Deal found 9/15$322
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/139:06 pmSTL - GSP
1 stop17h 22mMultiple Airlines
Mon 10/208:03 pmGSP - STL
2 stops38h 04mMultiple Airlines
Deal found 9/15$325
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/67:05 amSTL - GSP
1 stop4h 45mDelta
Tue 10/77:52 amGSP - STL
1 stop3h 34mDelta
Deal found 9/14$332

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from St. Louis to Greenville that are best for you.

Fly from

St. Louis

Fly to

Greenville

Route

Depart

Return

Price

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 10/11

9:20 am-4:53 pm

1 stop6h 33m

Greenville

Wed 10/29

6:00 am-11:04 am

1 stop6h 04m

$209

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 10/11

5:25 pm-11:55 pm

1 stop5h 30m

Greenville

Wed 10/29

1:45 pm-6:02 pm

1 stop5h 17m

$217

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 10/25

3:59 pm-10:18 pm

1 stop5h 19m

Greenville

Mon 10/27

7:41 pm-11:41 pm

1 stop5h 00m

$227

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 10/11

8:20 am-6:15 pm

1 stop8h 55m

Greenville

Wed 10/29

6:05 am-2:10 pm

2 stops9h 05m

$267

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 10/28

7:55 am-2:25 pm

1 stop5h 30m

Greenville

Wed 10/29

6:05 am-11:25 am

1 stop6h 20m

$277

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 10/14

5:15 pm-11:55 pm

1 stop5h 40m

Greenville

Tue 10/21

10:04 am-12:35 pm

1 stop3h 31m

$277

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sat 10/11

7:16 am-7:34 pm

1 stop11h 18m

Greenville

Tue 10/14

7:27 am-12:57 pm

1 stop6h 30m

$279

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 10/9

6:00 am-1:03 pm

1 stop6h 03m

Greenville

Mon 10/13

4:46 pm-11:56 pm

1 stop8h 10m

$291

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Thu 10/16

9:20 am-4:53 pm

1 stop6h 33m

$184

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Mon 10/6

10:55 am-9:25 pm

2 stops9h 30m

$199

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 13 results
1
2

Best time to book a flight from St. Louis to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Greenville

What is the cheapest month to book a flight from St. Louis to Greenville?

Currently, August is the cheapest month in which you can book a flight from St. Louis to Greenville (average of $321). Flying from St. Louis to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to GSP?

Find hourly flight availability from St. Louis to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 19% on flights from St. Louis to Greenville by exploring options for tickets at noon.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated September 15, 2025.
See what other customers who have flown with Delta and American Airlines from St. Louis to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Greenville?

    United Airlines, Delta, and Southwest can get you from St. Louis to Greenville in just under 5h 30m. Your travel time can differ by up to 3h 25m. Airlines will cover a distance of 523 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Greenville round-trip?

    According to our current data, American Airlines ($271), and Delta ($272) offers the cheapest pricing from St. Louis to Greenville. Users have found that American Airlines is 27% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from St. Louis to Greenville one-way?

    $184 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on Southwest and American Airlines, with prices starting from $199 and $404, respectively.

  • Can I find deals for flights from St. Louis to Greenville that include hotel bookings?

    Yes. In addition to deals on St. Louis to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Greenville.

  • Can I find deals for business class flights from St. Louis to Greenville?

    Yes. Cheapflights offers flight deals from St. Louis to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Greenville?

    Currently, August is the cheapest month in which you can book a flight from St. Louis to Greenville (average of $321). Flying from St. Louis to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 2 airlines flying from St. Louis to Greenville

Discover the top 2 airlines that operate flights from St. Louis to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$271Average$406FlexibilityNo cancel feeOn-time71%
DeltaCheapest$272Average$386FlexibilityNo cancel feeOn-timeN/A

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