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$111+ Cheap flights from St. Louis to Greenville (STL - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GSP
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from St. Louis to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$280
(American Airlines)

One-way from

$111
(Kiwi.com)

Popular in

November

Cheapest in

August

Average price

$296
Provider with most accurate pricing for Lambert-St Louis-Greenville flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Greenville flights.
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From Lambert-St Louis to Greenville
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One-way flight from Lambert-St Louis to Greenville
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Highest demand for flights based on searches. 2% potential increase in price ($10 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from St. Louis to Greenville

Cheapest flights from St. Louis to Greenville
Explore the most affordable flight options available from St. Louis to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:30 pmSTL - GSP
1 stop5h 48mAmerican Airlines
Wed 12/176:00 amGSP - STL
1 stop10h 29mAmerican Airlines
Deal found 10/15$280
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:45 amSTL - GSP
1 stop7h 45mSouthwest
Wed 12/173:05 pmGSP - STL
2 stops7h 30mSouthwest
Deal found 10/15$302
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:45 pmSTL - GSP
1 stop4h 13mAmerican Airlines
Fri 11/287:38 amGSP - STL
1 stop7h 03mAmerican Airlines
Deal found 10/15$320
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:05 amSTL - GSP
1 stop7h 18mMultiple Airlines
Fri 11/211:27 pmGSP - STL
1 stop20h 30mMultiple Airlines
Deal found 10/15$331
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:00 amSTL - GSP
1 stop4h 50mAmerican Airlines
Fri 12/56:01 amGSP - STL
1 stop4h 31mAmerican Airlines
Deal found 10/13$340
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/129:45 amSTL - GSP
1 stop8h 38mMultiple Airlines
Sun 1/115:09 pmGSP - STL
1 stop15h 41mMultiple Airlines
Deal found 10/14$346
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:15 amSTL - GSP
2 stops9h 25mSouthwest
Fri 11/214:15 pmGSP - STL
1 stop7h 30mSouthwest
Deal found 10/15$360
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:15 amSTL - GSP
2 stops9h 25mSouthwest
Sun 1/118:20 amGSP - STL
2 stops8h 00mSouthwest
Deal found 10/14$365
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:15 amSTL - GSP
1 stop8h 24mUnited Airlines
Tue 11/49:10 amGSP - STL
1 stop6h 14mUnited Airlines
Deal found 10/16$380

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from St. Louis to Greenville that are best for you.

Fly from

St. Louis

Fly to

Greenville

Route

Depart

Return

Price

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Mon 12/15

5:30 pm-12:18 am

1 stop5h 48m

Greenville

Wed 12/17

6:00 am-3:29 pm

1 stop10h 29m

$280

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Mon 12/15

5:45 am-2:30 pm

1 stop7h 45m

Greenville

Wed 12/17

3:05 pm-9:35 pm

2 stops7h 30m

$302

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 11/26

6:45 pm-11:58 pm

1 stop4h 13m

Greenville

Fri 11/28

7:38 am-1:41 pm

1 stop7h 03m

$320

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Fri 11/28

5:00 am-10:50 am

1 stop4h 50m

Greenville

Fri 12/5

6:01 am-9:32 am

1 stop4h 31m

$340

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Fri 12/12

9:45 am-7:23 pm

1 stop8h 38m

Greenville

Sun 1/11

5:09 pm-7:50 am

1 stop15h 41m

$346

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Fri 12/12

5:15 am-3:40 pm

2 stops9h 25m

Greenville

Sun 1/11

8:20 am-3:20 pm

2 stops8h 00m

$365

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Fri 11/14

5:15 am-3:40 pm

2 stops9h 25m

Greenville

Fri 11/21

8:00 am-6:05 pm

2 stops11h 05m

$375

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Fri 10/31

6:15 am-3:39 pm

1 stop8h 24m

Greenville

Tue 11/4

9:10 am-2:24 pm

1 stop6h 14m

$380

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Tue 10/28

6:30 am-2:20 pm

2 stops6h 50m

Greenville

Fri 10/31

12:25 pm-3:46 pm

1 stop4h 21m

$397

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Sun 1/11

12:20 pm-8:58 am

1 stop19h 38m

$111

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 18 results
1
2

Compare providers for flights from St. Louis to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Greenville in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Greenville

What is the cheapest month to book a flight from St. Louis to Greenville?

Currently, February is the cheapest month in which you can book a flight from St. Louis to Greenville (average of $153). Flying from St. Louis to Greenville in December is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to GSP?

Find hourly flight availability from St. Louis to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 18% on flights from St. Louis to Greenville by exploring options for tickets at noon.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated October 16, 2025.
See what other customers who have flown with Delta and American Airlines from St. Louis to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Greenville?

    American Airlines and Southwest can get you from St. Louis to Greenville in just under 5h 48m. Your travel time can differ by up to 1h 57m. Airlines will cover a distance of 523 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from St. Louis to Greenville round-trip?

    According to our current data, Delta ($259), and American Airlines ($271) offers the cheapest pricing from St. Louis to Greenville. Users have found that Delta is 29% cheaper than the other options available to this destination.

  • Can I find deals for flights from St. Louis to Greenville that include hotel bookings?

    Yes. In addition to deals on St. Louis to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Greenville.

  • Can I find deals for business class flights from St. Louis to Greenville?

    Yes. Cheapflights offers flight deals from St. Louis to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Greenville?

    Currently, February is the cheapest month in which you can book a flight from St. Louis to Greenville (average of $153). Flying from St. Louis to Greenville in December is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 2 airlines flying from St. Louis to Greenville

Discover the top 2 airlines that operate flights from St. Louis to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$259Average$356FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$271Average$406FlexibilityNo cancel feeOn-time71%

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