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$379+ Cheap flights from Santa Fe to Greenville (SAF - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — GSP
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Santa Fe to Greenville

Cheapest flights from Santa Fe to Greenville
Explore the most affordable flight options available from Santa Fe to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:30 pmSAF - GSP
1 stop7h 59mAmerican Airlines
Mon 12/294:17 pmGSP - SAF
1 stop7h 41mAmerican Airlines
Deal found 12/14$724
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:00 amSAF - GSP
2 stops11h 47mUnited Airlines
Mon 12/296:45 amGSP - SAF
2 stops28h 54mUnited Airlines
Deal found 12/14$787
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:43 pmSAF - GSP
1 stop5h 09mAmerican Airlines
Mon 12/294:17 pmGSP - SAF
1 stop7h 41mAmerican Airlines
Deal found 12/14$802
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:22 pmSAF - GSP
2 stops25h 41mUnited Airlines
Mon 12/296:45 amGSP - SAF
2 stops28h 54mUnited Airlines
Deal found 12/14$888

Find flight deals from Santa Fe to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 15, 2025.

Round-trip from

$379
(United Airlines)
From Santa Fe to Greenville
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Santa Fe to Greenville that are best for you.

Fly from

Santa Fe

Fly to

Greenville

Route

Depart

Return

Price

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Sat 1/17

10:45 am-11:48 pm

2 stops11h 03m

Greenville

Wed 1/21

10:00 am-8:47 pm

2 stops12h 47m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Best time to book a flight from Santa Fe to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Greenville

What is the cheapest month to book a flight from Santa Fe to Greenville?

Currently, March is the cheapest month in which you can book a flight from Santa Fe to Greenville (average of $214). Flying from Santa Fe to Greenville in June is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated December 15, 2025.
Get a feel of what it's like to fly with American Airlines from Santa Fe to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,051 reviews

Food

6.5

Comfort

7.2

Boarding

7.5

Overall

7.2

Entertainment

6.9

Crew

8.0

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,051 reviews
American Airlines
7.2
Good
11,051 reviews

Food

6.5

Comfort

7.2

Boarding

7.5

Overall

7.2

Entertainment

6.9

Crew

8.0

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Greenville?

    Departing from Santa Fe to Greenville will take you 11h 03m. There are 1343 mi between Santa Fe and Greenville.

  • Can I find deals for flights from Santa Fe to Greenville that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Greenville.

  • Can I find deals for business class flights from Santa Fe to Greenville?

    Yes. Cheapflights offers flight deals from Santa Fe to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Greenville?

    Currently, March is the cheapest month in which you can book a flight from Santa Fe to Greenville (average of $214). Flying from Santa Fe to Greenville in June is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Santa Fe to Greenville

Discover the top airline that operate flights from Santa Fe to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$513FlexibilityNo cancel feeOn-time71%

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