HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$485+ Cheap flights from Santa Fe to Greenville (SAF - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — GSP
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santa Fe to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santa Fe to Greenville

Cheapest flights from Santa Fe to Greenville
Explore the most affordable flight options available from Santa Fe to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/107:00 am
SAF
-
GSP
1 stop6h 20m
United Airlines
Sat 2/144:16 pm
GSP
-
SAF
1 stop6h 15m
United Airlines
Deal found 1/26$485

Find flight deals from Santa Fe to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Round-trip from

$485
(United Airlines)
From Santa Fe to Greenville
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Santa Fe to Greenville that are best for you.

Fly from

Santa Fe

Fly to

Greenville

Route

Depart

Return

Price

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Tue 2/10

7:00 am-3:20 pm

1 stop6h 20m

Greenville

Sat 2/14

4:16 pm-8:31 pm

1 stop6h 15m

$485

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Best time to book a flight from Santa Fe to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Greenville

What is the cheapest month to book a flight from Santa Fe to Greenville?

Currently, March is the cheapest month in which you can book a flight from Santa Fe to Greenville (average of $214). Flying from Santa Fe to Greenville in June is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated January 28, 2026.
Get a feel of what it's like to fly with American Airlines from Santa Fe to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,201 reviews

Food

6.4

Boarding

7.5

Crew

8.0

Entertainment

6.9

Comfort

7.2

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,201 reviews
American Airlines
7.2
Good
11,201 reviews

Food

6.4

Boarding

7.5

Crew

8.0

Entertainment

6.9

Comfort

7.2

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Greenville?

    Departing from Santa Fe to Greenville will take you 6h 20m. There are 1343 mi between Santa Fe and Greenville.

  • Can I find deals for flights from Santa Fe to Greenville that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Greenville.

  • Can I find deals for business class flights from Santa Fe to Greenville?

    Yes. Cheapflights offers flight deals from Santa Fe to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Greenville?

    Currently, March is the cheapest month in which you can book a flight from Santa Fe to Greenville (average of $214). Flying from Santa Fe to Greenville in June is currently the most expensive (average of $301). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Santa Fe to Greenville

Discover the top airline that operate flights from Santa Fe to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$513FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
Cookie settings©2026 Cheapflights