HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$264+ Cheap flights from Santa Fe (SAF) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/21. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — CHS
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santa Fe to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santa Fe to South Carolina

Keep the following information in mind while searching for Santa Fe to South Carolina flight deals. Data was last updated November 5, 2025.

Round-trip from

$264
(American Airlines)
From Santa Fe to South Carolina
Search Deals

Find flight deals from Santa Fe to South Carolina

Cheapest flights from Santa Fe to South Carolina
Explore the most affordable flight options available from Santa Fe to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:43 pmSAF - GSP
1 stop5h 09mAmerican Airlines
Mon 1/126:25 amGSP - SAF
1 stop8h 04mAmerican Airlines
Deal found 11/3$264
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/197:00 amSAF - GSP
1 stop5h 59mUnited Airlines
Sun 11/234:17 pmGSP - SAF
1 stop7h 42mUnited Airlines
Deal found 11/3$423
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:15 amSAF - HHH
2 stops10h 18mAmerican Airlines
Sat 12/1311:47 amHHH - SAF
2 stops12h 01mAmerican Airlines
Deal found 11/4$429
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:15 amSAF - GSP
1 stop7h 18mAmerican Airlines
Sun 11/235:15 amGSP - SAF
2 stops11h 37mAmerican Airlines
Deal found 11/3$473
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/224:43 pmSAF - GSP
1 stop5h 09mAmerican Airlines
Mon 1/124:40 pmGSP - SAF
1 stop6h 29mAmerican Airlines
Deal found 11/3$504
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:43 pmSAF - CLT
1 stop15h 47mAmerican Airlines
Mon 12/2910:37 pmCLT - SAF
1 stop12h 58mAmerican Airlines
Deal found 11/5$657
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:10 pmSAF - GSP
1 stop5h 08mAmerican Airlines
Mon 12/294:17 pmGSP - SAF
1 stop7h 41mAmerican Airlines
Deal found 11/5$705
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:50 pmSAF - CLT
1 stop8h 53mAmerican Airlines
Mon 12/293:06 pmCLT - SAF
1 stop8h 52mAmerican Airlines
Deal found 11/5$713
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:40 pmSAF - CLT
2 stops19h 33mUnited Airlines
Mon 12/298:00 amCLT - SAF
1 stop27h 39mUnited Airlines
Deal found 11/5$775
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:02 pmSAF - CLT
2 stops14h 29mUnited Airlines
Mon 12/296:22 amCLT - SAF
2 stops29h 17mUnited Airlines
Deal found 11/5$784
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/121:20 pmSAF - GSP
2 stops20h 24mUnited Airlines
Mon 12/295:44 pmGSP - SAF
2 stops17h 55mUnited Airlines
Deal found 11/5$844

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Santa Fe to South Carolina that are best for you.

Fly from

Santa Fe

Fly to

South Carolina

Route

Depart

Return

Price

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Wed 1/14

12:59 pm-10:34 pm

1 stop7h 35m

Charleston

Thu 1/22

3:16 pm-9:09 pm

1 stop7h 53m

$264

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Sun 12/21

4:43 pm-11:52 pm

1 stop5h 09m

Greenville

Mon 1/12

6:25 am-12:29 pm

1 stop8h 04m

$264

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Wed 11/19

7:00 am-2:59 pm

1 stop5h 59m

Greenville

Sun 11/23

4:17 pm-9:59 pm

1 stop7h 42m

$423

Santa FeHilton Head Island

SAF - HHH

SAFHHH

Santa Fe

Wed 12/10

6:15 am-6:33 pm

2 stops10h 18m

Hilton Head Island

Sat 12/13

11:47 am-9:48 pm

2 stops12h 01m

$429

Santa FeCharleston

SAF - CHS

SAFCHS

Santa Fe

Tue 3/3

6:15 am-2:53 pm

1 stop6h 38m

Charleston

Sat 3/7

3:46 pm-8:50 pm

1 stop7h 04m

$444

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Wed 11/19

6:15 am-3:33 pm

1 stop7h 18m

Greenville

Sun 11/23

5:15 am-2:52 pm

2 stops11h 37m

$473

Santa FeGreenville

SAF - GSP

SAFGSP

Santa Fe

Mon 12/22

4:43 pm-11:52 pm

1 stop5h 09m

Greenville

Mon 1/12

4:40 pm-9:09 pm

1 stop6h 29m

$504

Santa FeSavannah

SAF - SAV

SAFSAV

Santa Fe

Tue 3/3

10:45 am-11:26 pm

2 stops10h 41m

Savannah/Hilton Head

Sat 3/7

7:20 pm-8:38 am

2 stops15h 18m

$524

Santa FeSavannah

SAF - SAV

SAFSAV

Santa Fe

Tue 3/3

6:15 am-2:55 pm

1 stop6h 40m

Savannah/Hilton Head

Sat 3/7

7:00 am-12:22 pm

1 stop7h 22m

$635

Santa FeCharlotte

SAF - CLT

SAFCLT

Santa Fe

Tue 12/23

4:43 pm-10:30 am

1 stop15h 47m

Charlotte Douglas

Mon 12/29

10:37 pm-9:35 am

1 stop12h 58m

$657

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 20 results
1
2

Best time to book a flight from Santa Fe to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to South Carolina

What is the cheapest month to book a flight from Santa Fe to South Carolina?

Currently, November is the cheapest month in which you can book a flight from Santa Fe to South Carolina (average of $263). Flying from Santa Fe to South Carolina in January is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 5, 2025.
See what other customers who have flown with American Airlines from Santa Fe to South Carolina have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,042 reviews

Crew

8.0

Comfort

7.2

Food

6.4

Entertainment

6.9

Boarding

7.5

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
11,042 reviews
American Airlines
7.2
Good
11,042 reviews

Crew

8.0

Comfort

7.2

Food

6.4

Entertainment

6.9

Boarding

7.5

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Santa Fe to South Carolina?

    Most people fly from Santa Fe (SAF) if they book a flight from Santa Fe to South Carolina. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • How long is the flight from Santa Fe to South Carolina?

    A quick flight from Santa Fe to South Carolina can take about 5h 59m. American Airlines provides one of the quickest options available for as low as $423. Airlines will cover a distance of 1343 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Santa Fe to South Carolina?

    When deciding which route to take from Santa Fe to South Carolina consider Santa Fe - Charleston, Santa Fe - Greenville or Santa Fe - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from Santa Fe to South Carolina that include hotel bookings?

    Yes. In addition to deals on Santa Fe to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to South Carolina.

  • Can I find deals for business class flights from Santa Fe to South Carolina?

    Yes. Cheapflights offers flight deals from Santa Fe to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Santa Fe to South Carolina (average of $263). Flying from Santa Fe to South Carolina in January is currently the most expensive (average of $393). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santa Fe to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
El Paso to Dallas/Fort Worth flights
El Paso to Los Angeles flights
Albuquerque to Las Vegas flights
El Paso to Las Vegas flights
Albuquerque to O'Hare Intl flights
El Paso to Denver flights
Albuquerque to Dallas/Fort Worth flights
El Paso to Hobby flights
Albuquerque to Los Angeles flights
El Paso to Sky Harbor Intl flights
El Paso to Austin flights
El Paso to Ontario flights
Albuquerque to San Francisco flights
Albuquerque to John F Kennedy Intl flights
El Paso to John F Kennedy Intl flights
El Paso to George Bush Intcntl flights
El Paso to O'Hare Intl flights
Albuquerque to Hobby flights
El Paso to Seattle flights
Albuquerque to Miami flights
Albuquerque to LaGuardia flights
Albuquerque to Orlando flights
Albuquerque to Denver flights
Albuquerque to Sky Harbor Intl flights
Albuquerque to Seattle flights
El Paso to Atlanta flights
El Paso to San Antonio flights
Albuquerque to George Bush Intcntl flights
El Paso to LaGuardia flights
Albuquerque to Newark flights
El Paso to Newark flights
Albuquerque to Atlanta flights
El Paso to Love Field flights
El Paso to San Diego flights
Albuquerque to Austin flights
Albuquerque to Dulles Intl flights
Albuquerque to Ontario flights
El Paso to Santa Ana flights
Albuquerque to San Diego flights
Albuquerque to Portland flights
Albuquerque to Midway flights
Albuquerque to Baltimore flights
El Paso to Reagan-National flights
El Paso to Midway flights
Albuquerque to Honolulu flights
El Paso to Orlando flights
Albuquerque to Love Field flights
Albuquerque to Boston flights
Albuquerque to San Antonio flights
Albuquerque to Fort Lauderdale flights

Top airline flying from Santa Fe to South Carolina

Discover the top airline that operate flights from Santa Fe to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$374Average$534FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.