How long is the flight from Buffalo to Greenville?

Delta can get you from Buffalo to Greenville in just under 4h 52m. Your travel time can differ by up to . The distance between Buffalo and Greenville is about 586 mi.

What are the cheapest airlines flying from Buffalo to Greenville round-trip?

Our cheapest airline available from Buffalo to Greenville is American Airlines. Our recent data shows that you can find tickets from as low as $198 on this airline. Additional options worth looking into are Delta and Southwest, starting at $236 and $277 round-trip. You may be able to fly from Buffalo to Greenville for 46% less than the average price by searching for these airlines.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What are the most popular airlines that fly from Buffalo to Greenville?

Consider American Airlines, Delta or Southwest when booking your flight. These represent the most popular airlines when flying from Buffalo to Greenville.

Most accurate provider : When it comes to deals on Buffalo-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Buffalo-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Buffalo-Greenville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Buffalo-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Buffalo to Greenville that include hotel bookings?

Yes. In addition to deals on Buffalo to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Buffalo to Greenville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Greenville.

Can I find deals for business class flights from Buffalo to Greenville?

Yes. Cheapflights offers flight deals from Buffalo to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$136+ Flights from Buffalo to Greenville

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Cheap flight deals from Buffalo to Greenville

Cheapest flights from Buffalo to Greenville
Explore the most affordable flight options available from Buffalo to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.

Tue 12/306:00 amBUF - GSP

1 stop11h 51mAmerican Airlines

Sat 1/37:37 amGSP - BUF

1 stop9h 20mAmerican Airlines

Deal found 12/26

$640

Best flights from Buffalo to Greenville
Discover carefully curated flight deals from Buffalo to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 26, 2025.

Wed 2/256:01 amBUF - GSP

1 stop4h 52mDelta

Tue 3/36:01 pmGSP - BUF

1 stop4h 38mDelta

Deal found 12/24

$271

Mon 1/194:01 pmBUF - GSP

1 stop4h 58mAmerican Airlines

Sat 1/2410:32 amGSP - BUF

2 stops5h 58mAmerican Airlines

Deal found 12/26

$305

Tue 2/2412:05 pmBUF - GSP

1 stop6h 32mDelta

Tue 3/35:40 amGSP - BUF

1 stop5h 20mDelta

Deal found 12/24

$271

Sat 2/285:44 pmBUF - GSP

1 stop5h 16mDelta

Wed 3/47:20 amGSP - BUF

1 stop4h 23mDelta

Deal found 12/24

$284

Mon 3/25:44 pmBUF - GSP

1 stop4h 40mDelta

Wed 3/46:01 pmGSP - BUF

1 stop4h 38mDelta

Deal found 12/24

$287

Sat 2/286:01 amBUF - GSP

1 stop5h 27mDelta

Sat 2/286:37 pmGSP - BUF

1 stop4h 20mDelta

Deal found 12/24

$297

Mon 1/196:49 pmBUF - GSP

1 stop5h 01mDelta

Sat 1/246:45 pmGSP - BUF

1 stop4h 12mDelta

Deal found 12/26

$300

Sat 2/285:44 pmBUF - GSP

1 stop5h 16mDelta

Mon 3/26:01 pmGSP - BUF

1 stop4h 38mDelta

Deal found 12/24

$300

Wed 2/256:00 amBUF - GSP

1 stop5h 13mDelta

Fri 3/66:01 pmGSP - BUF

1 stop18h 35mDelta

Deal found 12/24

$308

Tue 2/245:41 pmBUF - GSP

1 stop4h 32mDelta

Fri 3/66:01 pmGSP - BUF

1 stop18h 35mDelta

Deal found 12/24

$308

Tue 2/245:41 pmBUF - GSP

1 stop4h 32mDelta

Sun 3/15:40 amGSP - BUF

1 stop5h 20mDelta

Deal found 12/24

$319

Last-minute flights from Buffalo to Greenville
Discover last-minute flight deals from Buffalo to Greenville. Data last updated December 26, 2025 and is based on user searches.

Fri 1/166:26 pmBUF - GSP

1 stop5h 29mDelta

Sun 1/187:20 amGSP - BUF

1 stop4h 02mDelta

Deal found 12/24

$321

Fri 1/164:01 pmBUF - GSP

2 stops7h 25mAmerican Airlines

Sun 1/187:21 amGSP - BUF

1 stop4h 47mAmerican Airlines

Deal found 12/24

$333

Fri 1/169:55 amBUF - GSP

2 stops10h 52mUnited Airlines

Sun 1/1810:51 amGSP - BUF

2 stops8h 34mUnited Airlines

Deal found 12/24

$456

Mon 1/196:49 pmBUF - GSP

1 stop5h 01mDelta

Sat 1/246:45 pmGSP - BUF

1 stop4h 12mDelta

Deal found 12/26

$300

Mon 1/194:01 pmBUF - GSP

1 stop4h 58mAmerican Airlines

Sat 1/2410:32 amGSP - BUF

2 stops5h 58mAmerican Airlines

Deal found 12/26

$305

Sun 1/256:20 pmBUF - GSP

1 stop5h 28mUnited Airlines

Sun 2/16:20 amGSP - BUF

1 stop4h 29mUnited Airlines

Deal found 12/26

$436

Sat 1/316:00 amBUF - GSP

1 stop5h 23mUnited Airlines

Tue 2/310:00 amGSP - BUF

1 stop4h 14mUnited Airlines

Deal found 12/25

$354

One-way flights from Buffalo to Greenville
Search for one-way flight options from Buffalo to Greenville. Find affordable one-way fares based on user searches. Data last updated December 26, 2025.

Tue 3/1010:23 amBUF - GSP

1 stop7h 18mDelta

Deal found 12/26

$136

Tue 3/1011:23 amBUF - GSP

2 stops7h 09mAmerican Airlines

Deal found 12/26

$141

Sun 3/86:02 amBUF - GSP

1 stop4h 56mDelta

Deal found 12/26

$184

Sun 1/119:08 amBUF - GSP

2 stops23h 50mMultiple Airlines

Deal found 12/25

$186

Sun 3/86:00 amBUF - GSP

2 stops6h 15mAmerican Airlines

Deal found 12/25

$211

Fri 2/137:15 amBUF - GSP

2 stops11h 50mSouthwest

Deal found 12/25

$323

Fri 2/131:29 pmBUF - GSP

3 stops47h 43mMultiple Airlines

Deal found 12/25

$386

Sun 6/75:50 pmBUF - GSP

1 stop27h 21mUnited Airlines

Deal found 12/26

$393

Find flight deals from Buffalo to Greenville

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$271 (Delta)
One-way from	$136 (Delta)
Popular in	December
Cheapest in	January
Average price	$466

Provider with most accurate pricing for Buffalo-Greenville flight deals.

Search Deals

Provider most trusted by Cheapflights users for Buffalo-Greenville flights.

Search Deals

From Buffalo to Greenville

Search Deals

One-way flight from Buffalo to Greenville

Search Deals

Highest demand for flights based on searches. 0% potential increase in price ($3 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 2/25

6:01 am-10:53 am

1 stop4h 52m

Greenville

Tue 3/3

6:01 pm-10:39 pm

1 stop4h 38m

$271

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Tue 2/24

12:05 pm-6:37 pm

1 stop6h 32m

Greenville

Tue 3/3

5:40 am-11:00 am

1 stop5h 20m

$271

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Sat 2/28

5:44 pm-11:00 pm

1 stop5h 16m

Greenville

Wed 3/4

7:20 am-11:43 am

1 stop4h 23m

$284

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Mon 3/2

5:44 pm-10:24 pm

1 stop4h 40m

Greenville

Wed 3/4

6:01 pm-10:39 pm

1 stop4h 38m

$287

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Sat 2/28

6:01 am-11:28 am

1 stop5h 27m

Greenville

Sat 2/28

6:37 pm-10:57 pm

1 stop4h 20m

$297

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Mon 1/19

6:49 pm-11:50 pm

1 stop5h 01m

Greenville

Sat 1/24

6:45 pm-10:57 pm

1 stop4h 12m

$300

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Sat 2/28

5:44 pm-11:00 pm

1 stop5h 16m

Greenville

Mon 3/2

6:01 pm-10:39 pm

1 stop4h 38m

$300

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Mon 1/19

4:01 pm-8:59 pm

1 stop4h 58m

Greenville

Sat 1/24

10:32 am-4:30 pm

2 stops5h 58m

$305

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 2/25

6:00 am-11:13 am

1 stop5h 13m

Greenville

Fri 3/6

6:01 pm-12:36 pm

1 stop18h 35m

$308

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Tue 2/24

5:41 pm-10:13 pm

1 stop4h 32m

Greenville

Fri 3/6

6:01 pm-12:36 pm

1 stop18h 35m

$308

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

Showing 1-10 of 17 results

Compare providers for flights from Buffalo to Greenville

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Greenville in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Buffalo-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Buffalo-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Buffalo-Greenville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Buffalo-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Buffalo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Greenville

What is the cheapest month to book a flight from Buffalo to Greenville?

Currently, January is the cheapest month in which you can book a flight from Buffalo to Greenville (average of $92). Flying from Buffalo to Greenville in November is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to GSP?

One of the essential ways to save on airfare from Buffalo to Greenville is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 28% on airfare.

Reviews of airlines servicing Greenville

Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Buffalo to Greenville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,258 reviews

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,012 reviews

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,061 reviews

Southwest

8.0

Very good

4,258 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

How long is the flight from Buffalo to Greenville?
Delta can get you from Buffalo to Greenville in just under 4h 52m. Your travel time can differ by up to . The distance between Buffalo and Greenville is about 586 mi.
What are the cheapest airlines flying from Buffalo to Greenville round-trip?
Our cheapest airline available from Buffalo to Greenville is American Airlines. Our recent data shows that you can find tickets from as low as $198 on this airline. Additional options worth looking into are Delta and Southwest, starting at $236 and $277 round-trip. You may be able to fly from Buffalo to Greenville for 46% less than the average price by searching for these airlines.
Can I find deals for flights from Buffalo to Greenville that include hotel bookings?
Yes. In addition to deals on Buffalo to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Buffalo to Greenville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Greenville.
Can I find deals for business class flights from Buffalo to Greenville?
Yes. Cheapflights offers flight deals from Buffalo to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Buffalo to Greenville?
Currently, January is the cheapest month in which you can book a flight from Buffalo to Greenville (average of $92). Flying from Buffalo to Greenville in November is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Simpsonville

Duncan

Greer

Seneca

Anderson

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Buffalo to Greenville

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$198	Average$332	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$236	Average$316	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$277	Average$406	FlexibilityNo cancel fee	On-time63%

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$136+ Cheap flights from Buffalo to Greenville (BUF - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Buffalo to Greenville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Buffalo to Greenville

Cheapest flights from Buffalo to GreenvilleExplore the most affordable flight options available from Buffalo to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.

Explore the most affordable flight options available from Buffalo to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.

Find flight deals from Buffalo to Greenville

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to Greenville that are best for you.

Compare providers for flights from Buffalo to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Greenville in December.

Best time to book a flight from Buffalo to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Buffalo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Greenville

What is the cheapest month to book a flight from Buffalo to Greenville?

What is the cheapest time of day to fly from BUF to GSP?

Reviews of airlines servicing Greenville

Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Buffalo to Greenville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Buffalo to Greenville?

What are the cheapest airlines flying from Buffalo to Greenville round-trip?

Can I find deals for flights from Buffalo to Greenville that include hotel bookings?

How can I find direct flights from Buffalo to Greenville?

Can I find deals for business class flights from Buffalo to Greenville?

What is the cheapest month to book a flight from Buffalo to Greenville?

Traveling to a place near Greenville?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Buffalo to Greenville

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Buffalo to Greenville

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Cheapest flights from Buffalo to Greenville
Explore the most affordable flight options available from Buffalo to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.