HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$389+ Cheap flights from Medford to Greenville (MFR - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/12. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — GSP
Apr 27 — May 41
Mon 4/27
Mon 5/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Medford to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Medford to Greenville

Cheapest flights from Medford to Greenville
Explore the most affordable flight options available from Medford to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.

This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:00 am
MFR
-
GSP
1 stop7h 10m
United Airlines
Tue 9/224:15 pm
GSP
-
MFR
1 stop8h 01m
United Airlines
Deal found 3/27$389
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:35 pm
MFR
-
GSP
2 stops12h 20m
United Airlines
Mon 6/84:15 pm
GSP
-
MFR
1 stop8h 01m
United Airlines
Deal found 3/24$511
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:25 pm
MFR
-
GSP
2 stops12h 39m
Delta
Tue 6/95:44 am
GSP
-
MFR
2 stops10h 17m
Delta
Deal found 3/27$544
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:25 pm
MFR
-
GSP
2 stops12h 39m
Delta
Mon 6/85:44 am
GSP
-
MFR
2 stops10h 17m
Delta
Deal found 3/24$624
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:00 am
MFR
-
GSP
1 stop7h 19m
United Airlines
Tue 6/95:41 pm
GSP
-
MFR
2 stops21h 23m
United Airlines
Deal found 3/26$754

Find flight deals from Medford to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$389
(United Airlines)

One-way from

$298
(Kiwi.com)
Provider with most accurate pricing for Medford-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Medford-Greenville flights.
Search Deals
From Medford to Greenville
Search Deals
One-way flight from Medford to Greenville
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Medford to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 9/12

2:06 pm-9:50 am

3 stops16h 44m

Greenville

Tue 9/22

4:15 pm-9:16 pm

1 stop8h 01m

$509
Quickest round-trip

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Wed 6/3

6:35 pm-9:55 am

2 stops12h 20m

Greenville

Mon 6/8

4:15 pm-9:16 pm

1 stop8h 01m

$511

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

5:25 pm-9:04 am

2 stops12h 39m

Greenville

Tue 6/9

5:44 am-1:01 pm

2 stops10h 17m

$544

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

5:00 am-3:19 pm

1 stop7h 19m

Greenville

Tue 6/9

5:41 pm-12:04 pm

2 stops21h 23m

$754

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Sorted by cheapest first

Compare providers for flights from Medford to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Greenville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Greenville

What is the cheapest month to book a flight from Medford to Greenville?

Currently, March is the cheapest month in which you can book a flight from Medford to Greenville (average of $314). Flying from Medford to Greenville in February is currently the most expensive (average of $584). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated March 28, 2026.
Read through reviews of airlines operating flights from Medford to Greenville, such as Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,356 reviews

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,356 reviews
Delta
7.9
Good
8,356 reviews

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,499 reviews
Delta
7.9
Good
8,356 reviews

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Medford to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Greenville?

    For as low as $544, United Airlines can have you in Greenville from Medford in 12h 39m. There are 2230 mi between Medford and Greenville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Medford to Greenville round-trip?

    Our cheapest airline available from Medford to Greenville is United Airlines. Our recent data shows that you can find tickets from as low as $175 on this airline. An additional option worth looking into is Delta, starting at $261.

  • Can I find deals for flights from Medford to Greenville that include hotel bookings?

    Yes. In addition to deals on Medford to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Greenville.

  • Can I find deals for business class flights from Medford to Greenville?

    Yes. Cheapflights offers flight deals from Medford to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Medford to Greenville?

    Currently, March is the cheapest month in which you can book a flight from Medford to Greenville (average of $314). Flying from Medford to Greenville in February is currently the most expensive (average of $584). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Greer
Simpsonville
Duncan
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Medford to Greenville

Discover the top 2 airlines that operate flights from Medford to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$175Average$683FlexibilityNo cancel feeOn-time69%
DeltaCheapest$261Average$369FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.