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$367+ Cheap flights from Medford to Greenville (MFR - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — GSP
May 21 — May 281
Thu 5/21
Thu 5/28
1 adult, Economy
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Cheap flight deals from Medford to Greenville

Cheapest flights from Medford to Greenville
Explore the most affordable flight options available from Medford to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.

This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:15 am
MFR
-
GSP
2 stops13h 01m
American Airlines
Wed 9/1612:55 pm
GSP
-
MFR
2 stops12h 55m
American Airlines
Deal found 4/18$367
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:00 am
MFR
-
GSP
1 stop7h 10m
United Airlines
Wed 9/1610:25 am
GSP
-
MFR
2 stops13h 51m
United Airlines
Deal found 4/18$388
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:21 pm
MFR
-
GSP
2 stops13h 04m
Delta
Sat 10/2412:00 pm
GSP
-
MFR
2 stops14h 12m
Delta
Deal found 4/20$425
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:21 pm
MFR
-
GSP
2 stops13h 04m
Delta
Mon 10/263:42 pm
GSP
-
MFR
2 stops11h 07m
Delta
Deal found 4/20$449
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 am
MFR
-
GSP
1 stop6h 49m
United Airlines
Tue 5/512:07 pm
GSP
-
MFR
2 stops12h 24m
United Airlines
Deal found 4/18$454
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:10 am
MFR
-
GSP
2 stops13h 36m
Delta
Tue 5/55:50 pm
GSP
-
MFR
2 stops9h 02m
Delta
Deal found 4/18$459
This Alaska Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:45 am
MFR
-
GSP
2 stops10h 30m
Alaska Airlines
Sat 10/242:12 pm
GSP
-
MFR
2 stops13h 21m
Alaska Airlines
Deal found 4/20$477
This Alaska Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:45 am
MFR
-
GSP
2 stops10h 30m
Alaska Airlines
Sat 10/242:12 pm
GSP
-
MFR
2 stops13h 21m
Alaska Airlines
Deal found 4/20$493
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:34 pm
MFR
-
GSP
2 stops14h 22m
United Airlines
Wed 10/214:26 pm
GSP
-
MFR
1 stop7h 42m
United Airlines
Deal found 4/20$496
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:34 pm
MFR
-
GSP
2 stops12h 14m
United Airlines
Thu 10/298:40 am
GSP
-
MFR
2 stops12h 10m
United Airlines
Deal found 4/20$509
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:34 pm
MFR
-
GSP
2 stops12h 14m
United Airlines
Sat 10/244:26 pm
GSP
-
MFR
1 stop7h 42m
United Airlines
Deal found 4/20$513
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:25 pm
MFR
-
GSP
2 stops17h 00m
Delta
Tue 10/273:42 pm
GSP
-
MFR
2 stops11h 07m
Delta
Deal found 4/20$514

Find flight deals from Medford to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$367
(American Airlines)
Provider with most accurate pricing for Medford-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Medford-Greenville flights.
Search Deals
From Medford to Greenville
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from Medford to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Wed 9/9

5:00 am-3:10 pm

1 stop7h 10m

Greenville

Wed 9/16

10:25 am-9:16 pm

2 stops13h 51m

$388

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Wed 10/14

6:34 pm-11:56 am

2 stops14h 22m

Greenville

Wed 10/21

4:26 pm-9:08 pm

1 stop7h 42m

$496
Quickest round-trip

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 5/2

5:00 am-2:49 pm

1 stop6h 49m

Greenville

Tue 5/5

4:35 pm-9:31 pm

1 stop7h 56m

$530

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sun 10/18

6:34 pm-9:48 am

2 stops12h 14m

Greenville

Thu 10/29

8:40 am-5:50 pm

2 stops12h 10m

$639

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

5:15 am-9:38 pm

2 stops13h 23m

Greenville

Tue 6/9

5:44 am-1:01 pm

2 stops10h 17m

$649

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/11

5:00 am-3:19 pm

1 stop7h 19m

Greenville

Tue 6/16

10:30 am-10:59 pm

2 stops15h 29m

$654

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Thu 6/4

5:00 am-3:19 pm

1 stop7h 19m

Greenville

Tue 6/9

4:15 pm-9:16 pm

1 stop8h 01m

$679

MedfordGreenville

MFR - GSP

MFRGSP

Medford

Sat 10/17

2:03 pm-11:56 am

3 stops18h 53m

Greenville

Thu 10/29

8:40 am-5:50 pm

2 stops12h 10m

$681

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/18

Sorted by cheapest first

Compare providers for flights from Medford to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Greenville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated April 21, 2026.
Read through reviews of airlines operating flights from Medford to Greenville, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,613 reviews

Entertainment

7.1

Boarding

7.7

Overall

7.4

Comfort

7.3

Crew

8.1

Food

6.6

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
United Airlines
7.4
Good
9,613 reviews
United Airlines
7.4
Good
9,613 reviews

Entertainment

7.1

Boarding

7.7

Overall

7.4

Comfort

7.3

Crew

8.1

Food

6.6

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.

Related info for your journey

Find useful and relevant information for your journey from Medford to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Greenville?

    For as low as $388, United Airlines can have you in Greenville from Medford in 7h 10m. There are 2230 mi between Medford and Greenville. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Medford to Greenville round-trip?

    Our cheapest airline available from Medford to Greenville is United Airlines. Our recent data shows that you can find tickets from as low as $360 on this airline.

  • Can I find deals for flights from Medford to Greenville that include hotel bookings?

    Yes. In addition to deals on Medford to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Greenville.

  • Can I find deals for business class flights from Medford to Greenville?

    Yes. Cheapflights offers flight deals from Medford to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Greer
Simpsonville
Greenwood
Duncan
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Medford to Greenville

Discover the top airline that operate flights from Medford to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$360Average$683FlexibilityNo cancel feeOn-time69%

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