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Grand Cayman

$144+ Cheap flights from South Carolina to Grand Cayman

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — GCM
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from South Carolina to Grand Cayman

Keep the following information in mind while searching for South Carolina to Grand Cayman flight deals. Data was last updated September 17, 2025.

Round-trip from

$297
(American Airlines)

One-way from

$144
(Priceline)
From South Carolina to Grand Cayman
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One-way flight from South Carolina to Grand Cayman
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Find flight deals from South Carolina to Grand Cayman

Cheapest flights from South Carolina to Grand Cayman
Explore the most affordable flight options available from South Carolina to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/69:27 amCHS - GCM
1 stop5h 15mAmerican Airlines
Sat 12/138:45 amGCM - CHS
1 stop16h 01mAmerican Airlines
Deal found 9/15$297
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/299:30 amCLT - GCM
1 stop26h 55mMultiple Airlines
Sun 12/711:55 amGCM - CLT
1 stop13h 04mMultiple Airlines
Deal found 9/16$403
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/261:50 pmCLT - GCM
1 stop8h 25mMultiple Airlines
Mon 9/2912:50 pmGCM - CLT
1 stop24h 42mMultiple Airlines
Deal found 9/15$415
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2110:20 pmCLT - GCM
1 stop14h 15mMultiple Airlines
Thu 9/254:45 pmGCM - CLT
1 stop14h 26mMultiple Airlines
Deal found 9/15$441
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2210:20 pmCLT - GCM
1 stop18h 45mMultiple Airlines
Thu 9/257:00 amGCM - CLT
1 stop24h 11mMultiple Airlines
Deal found 9/15$448
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/259:30 pmCLT - GCM
1 stop14h 40mAmerican Airlines
Wed 10/2912:25 pmGCM - CLT
Nonstop3h 00mAmerican Airlines
Deal found 9/15$458
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2512:00 pmCLT - GCM
1 stop27h 00mMultiple Airlines
Fri 10/317:00 amGCM - CLT
1 stop13h 57mMultiple Airlines
Deal found 9/15$468
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/510:20 pmCLT - GCM
1 stop14h 15mMultiple Airlines
Sat 10/118:50 amGCM - CLT
1 stop26h 49mMultiple Airlines
Deal found 9/15$473
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1510:26 amGSP - GCM
1 stop9h 49mAmerican Airlines
Fri 12/194:30 pmGCM - GSP
1 stop7h 22mAmerican Airlines
Deal found 9/16$494
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:53 pmCHS - GCM
1 stop16h 04mAmerican Airlines
Sat 11/223:18 pmGCM - CHS
1 stop7h 01mAmerican Airlines
Deal found 9/15$497
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/97:43 pmCHS - GCM
1 stop16h 42mAmerican Airlines
Thu 10/1612:10 pmGCM - CHS
1 stop5h 54mAmerican Airlines
Deal found 9/17$498
This Expedia deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:20 amSAV - GCM
1 stop27h 11mJetBlue
Sat 11/221:52 pmGCM - SAV
1 stop30h 47mJetBlue
Deal found 9/16$499

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from South Carolina to Grand Cayman that are best for you.

Fly from

South Carolina

Fly to

Grand Cayman

Route

Depart

Return

Price

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Sat 12/6

9:27 am-2:42 pm

1 stop5h 15m

George Town Owen Roberts Intl

Sat 12/13

8:45 am-12:46 am

1 stop16h 01m

$297

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 1/24

5:45 am-11:00 am

1 stop5h 15m

George Town Owen Roberts Intl

Thu 1/29

11:55 am-8:41 pm

1 stop8h 46m

$391

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 11/29

9:30 am-12:25 pm

1 stop26h 55m

George Town Owen Roberts Intl

Sun 12/7

11:55 am-12:59 am

1 stop13h 04m

$403

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 1/17

5:45 am-11:00 am

1 stop5h 15m

George Town Owen Roberts Intl

Sat 1/24

11:55 am-8:41 pm

1 stop8h 46m

$456

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 10/25

10:25 pm-11:10 am

1 stop13h 45m

George Town Owen Roberts Intl

Wed 10/29

8:25 am-10:04 pm

1 stop12h 39m

$468

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Mon 1/26

6:05 am-1:45 pm

1 stop7h 40m

George Town Owen Roberts Intl

Mon 2/2

2:25 pm-11:45 pm

1 stop9h 20m

$472

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Tue 3/10

6:30 am-11:35 am

1 stop6h 05m

George Town Owen Roberts Intl

Wed 3/11

1:00 pm-8:40 pm

1 stop6h 40m

$472

GreenvilleGeorge Town

GSP - GCM

GSPGCM

Greenville

Tue 2/24

7:45 am-12:35 pm

1 stop4h 50m

George Town Owen Roberts Intl

Thu 2/26

2:00 pm-8:16 pm

1 stop6h 16m

$494

GreenvilleGeorge Town

GSP - GCM

GSPGCM

Greenville

Mon 12/15

10:26 am-8:15 pm

1 stop9h 49m

George Town Owen Roberts Intl

Fri 12/19

4:30 pm-11:52 pm

1 stop7h 22m

$494

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 11/29

10:45 pm-12:13 pm

1 stop13h 28m

George Town Owen Roberts Intl

Sun 12/7

12:55 pm-3:56 pm

Nonstop3h 01m

$496

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 41 results
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Best time to book a flight from South Carolina to Grand Cayman

Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Grand Cayman

What is the cheapest month to book a flight from South Carolina to Grand Cayman?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Grand Cayman (average of $467). Flying from South Carolina to Grand Cayman in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Grand Cayman?

    Airlines like American Airlines, Spirit Airlines, and United Airlines fly from South Carolina to Grand Cayman in about 5h 15m. The time it takes to get you to your destination can typically vary by up to 2h 25m. South Carolina and Grand Cayman are separated by a distance of 943 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Grand Cayman one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $144. However, be on the lookout for offers from Air Canada and American Airlines, as they are both options that can get you from South Carolina to Grand Cayman for a low price.

  • Can I find deals for flights from South Carolina to Grand Cayman that include hotel bookings?

    Yes. In addition to deals on South Carolina to Grand Cayman flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Grand Cayman?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Grand Cayman.

  • Can I find deals for business class flights from South Carolina to Grand Cayman?

    Yes. Cheapflights offers flight deals from South Carolina to Grand Cayman by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Grand Cayman?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Grand Cayman (average of $467). Flying from South Carolina to Grand Cayman in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Grand Cayman

See prices for flight routes from nearby airports that may be better suited for you.
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Portland to George Town flights

Top 2 airlines flying from South Carolina to Grand Cayman

Discover the top 2 airlines that operate flights from South Carolina to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$428Average$605FlexibilityNo cancel feeOn-time71%
DeltaCheapest$504Average$672FlexibilityNo cancel feeOn-timeN/A

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