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Florida Keys

$129+ Cheap flights from San Diego (SAN) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — EYW
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from San Diego to Florida Keys

Keep the following information in mind while searching for San Diego to Florida Keys flight deals. Data was last updated May 1, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$268
(Gotogate)

One-way from

$129
(Delta)

Popular in

December

Cheapest in

September

Average price

$407
Provider with most accurate pricing for San Diego-Miami flight deals.
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Provider most trusted by Cheapflights users for San Diego-Miami flights.
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From San Diego to Florida Keys
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One-way flight from San Diego to Florida Keys
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from San Diego to Florida Keys

Cheapest flights from San Diego to Florida Keys
Explore the most affordable flight options available from San Diego to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Gotogate deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/246:15 amSAN - MIA
1 stop11h 35mSpirit Airlines
Sun 6/298:55 pmMIA - SAN
1 stop13h 18mSpirit Airlines
Deal found 4/30$268
This Trip.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/46:25 amSAN - MIA
1 stop19h 57mMultiple Airlines
Sun 5/119:07 pmMIA - SAN
2 stops29h 51mMultiple Airlines
Deal found 4/29$271
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/316:15 amSAN - EYW
1 stop8h 15mDelta
Tue 6/311:48 amEYW - SAN
1 stop9h 14mDelta
Deal found 4/30$283
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2810:25 pmSAN - MIA
Nonstop4h 47mAmerican Airlines
Wed 6/48:15 pmMIA - SAN
Nonstop5h 22mAmerican Airlines
Deal found 4/29$292
This Frontier deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/36:10 pmSAN - MIA
1 stop8h 12mFrontier
Tue 5/66:00 amMIA - SAN
1 stop9h 23mFrontier
Deal found 4/30$300
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1610:30 pmSAN - EYW
1 stop10h 29mAmerican Airlines
Sat 8/235:56 pmEYW - SAN
1 stop6h 49mAmerican Airlines
Deal found 4/30$309
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/137:15 pmSAN - MIA
1 stop8h 11mDelta
Tue 6/172:13 pmMIA - SAN
1 stop8h 47mDelta
Deal found 4/30$338
This Alaska Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2812:59 pmSAN - MIA
2 stops25h 22mAlaska Airlines
Wed 6/46:21 pmMIA - SAN
1 stop30h 24mAlaska Airlines
Deal found 4/30$339
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/57:00 amSAN - MIA
2 stops11h 50mSouthwest
Tue 11/1111:40 amMIA - SAN
1 stop10h 05mSouthwest
Deal found 4/29$341
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/217:10 amSAN - MIA
2 stops12h 19mUnited Airlines
Sun 5/256:00 amMIA - SAN
1 stop10h 10mUnited Airlines
Deal found 4/29$382
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/3010:20 pmSAN - EYW
1 stop11h 56mUnited Airlines
Fri 6/66:45 pmEYW - SAN
2 stops21h 17mUnited Airlines
Deal found 4/30$401
This Sun Country Air deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Sun Country Air is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/275:25 pmSAN - MIA
1 stop14h 45mSun Country Air
Sun 6/2912:38 pmMIA - SAN
1 stop31h 05mSun Country Air
Deal found 4/30$425

Cheapflights Fare Finder

Customize your flight search to find flights from San Diego to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from San Diego to Florida Keys that are best for you.

Fly from

San Diego

Fly to

Florida Keys

Route

Depart

Return

Price

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Tue 6/24

6:15 am-8:50 pm

1 stop11h 35m

Miami

Sun 6/29

8:55 pm-7:13 am

1 stop13h 18m

$268

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Fri 5/30

12:51 pm-12:55 am

2 stops33h 04m

Miami

Tue 6/3

8:55 pm-7:13 am

1 stop13h 18m

$273

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Sat 5/31

6:15 am-5:30 pm

1 stop8h 15m

Key West

Tue 6/3

11:48 am-6:02 pm

1 stop9h 14m

$283

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Wed 5/28

10:25 pm-6:12 am

Nonstop4h 47m

Miami

Wed 6/4

8:15 pm-10:37 pm

Nonstop5h 22m

$292

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Sat 5/31

11:26 am-10:45 pm

1 stop8h 19m

Miami

Wed 6/4

12:06 pm-7:47 pm

2 stops10h 41m

$293

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Sat 8/16

10:30 pm-11:59 am

1 stop10h 29m

Key West

Sat 8/23

5:56 pm-9:45 pm

1 stop6h 49m

$309

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Wed 6/4

12:50 pm-5:55 am

1 stop14h 05m

Miami

Sun 6/8

6:00 am-11:17 am

2 stops32h 17m

$313

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Wed 5/28

8:25 pm-10:16 am

1 stop10h 51m

Miami

Wed 6/4

11:11 am-7:15 pm

1 stop11h 04m

$325

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Fri 6/13

7:15 pm-6:26 am

1 stop8h 11m

Miami

Tue 6/17

2:13 pm-8:00 pm

1 stop8h 47m

$338

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Wed 5/28

12:59 pm-5:21 pm

2 stops25h 22m

Miami

Wed 6/4

6:21 pm-9:45 pm

1 stop30h 24m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/1

Showing 1-10 of 25 results
1
2
3

Best time to book a flight from San Diego to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Florida Keys

What is the cheapest month to book a flight from San Diego to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from San Diego to Florida Keys (average of $328). Flying from San Diego to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated May 1, 2025.
To help decide which airline to fly from San Diego to Florida Keys, see what other customers have to say about Alaska Airlines, Southwest and Delta. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,972 reviews

Entertainment

7.1

Boarding

8.1

Food

7.1

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,972 reviews
Alaska Airlines
8.0
Very good
9,972 reviews

Entertainment

7.1

Boarding

8.1

Food

7.1

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,293 reviews
Alaska Airlines
8.0
Very good
9,972 reviews

Entertainment

7.1

Boarding

8.1

Food

7.1

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,934 reviews
Alaska Airlines
8.0
Very good
9,972 reviews

Entertainment

7.1

Boarding

8.1

Food

7.1

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,972 reviews

Entertainment

7.1

Boarding

8.1

Food

7.1

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
JetBlue
7.3
Good
2,923 reviews
Alaska Airlines
8.0
Very good
9,972 reviews

Entertainment

7.1

Boarding

8.1

Food

7.1

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to Florida Keys?

    Most people fly from San Diego (SAN) if they book a flight from San Diego to Florida Keys. San Diego is conveniently located just 2.6 mi from San Diego’s city center.

  • What are the cheapest airlines to fly from San Diego to Florida Keys one-way?

    The cheapest airlines for a one-way flight from San Diego to Florida Keys are Delta ($129), Spirit Airlines ($135), and American Airlines ($139).

  • Can I find deals for flights from San Diego to Florida Keys that include hotel bookings?

    Yes. In addition to deals on San Diego to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Florida Keys.

  • Can I find deals for business class flights from San Diego to Florida Keys?

    Yes. Cheapflights offers flight deals from San Diego to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from San Diego to Florida Keys (average of $328). Flying from San Diego to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from San Diego to Florida Keys

Discover the top 2 airlines that operate flights from San Diego to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$285Average$553FlexibilityNo cancel feeOn-time71%
DeltaCheapest$308Average$478FlexibilityNo cancel feeOn-timeN/A

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