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Florida Keys

$80+ Cheap flights from San Diego (SAN) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — EYW
Jul 28 — Aug 41
Mon 7/28
Mon 8/4
1 adult, Economy
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Cheap flight deals from San Diego to Florida Keys

Keep the following information in mind while searching for San Diego to Florida Keys flight deals. Data was last updated July 23, 2025.

Round-trip from

$223
(FlightHub)

One-way from

$80
(CheapOair)

Popular in

December

Cheapest in

September

Average price

$455
From San Diego to Florida Keys
Search Deals
One-way flight from San Diego to Florida Keys
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Highest demand for flights based on searches. 5% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from San Diego to Florida Keys

Cheapest flights from San Diego to Florida Keys
Explore the most affordable flight options available from San Diego to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2025.

This FlightHub deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:15 amSAN - MIA
1 stop9h 33mSpirit Airlines
Mon 9/226:28 pmMIA - SAN
1 stop20h 58mSpirit Airlines
Deal found 7/23$223
This Trip.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/286:25 amSAN - MIA
1 stop9h 58mMultiple Airlines
Mon 9/18:23 pmMIA - SAN
1 stop28h 59mMultiple Airlines
Deal found 7/23$231
This Frontier deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2312:12 pmSAN - MIA
1 stop15h 18mFrontier
Sat 8/306:15 amMIA - SAN
1 stop7h 55mFrontier
Deal found 7/23$260
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1610:17 pmSAN - EYW
1 stop9h 36mAmerican Airlines
Thu 8/2112:50 pmEYW - SAN
1 stop9h 01mAmerican Airlines
Deal found 7/22$309
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1210:30 pmSAN - EYW
1 stop9h 25mDelta
Mon 9/152:00 pmEYW - SAN
1 stop8h 27mDelta
Deal found 7/22$339
This Trip.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2412:02 pmSAN - EYW
2 stops18h 41mMultiple Airlines
Wed 8/272:13 pmEYW - SAN
2 stops23h 54mMultiple Airlines
Deal found 7/21$397
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:55 pmSAN - EYW
3 stops18h 24mUnited Airlines
Sun 11/233:05 pmEYW - SAN
2 stops21h 34mUnited Airlines
Deal found 7/21$608

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2025.
Use the filters below to find and compare flights from San Diego to Florida Keys that are best for you.

Fly from

San Diego

Fly to

Florida Keys

Route

Depart

Return

Price

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Thu 9/18

6:15 am-6:48 pm

1 stop9h 33m

Miami

Mon 9/22

6:28 pm-12:26 pm

1 stop20h 58m

$223

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Thu 8/28

6:25 am-7:23 pm

1 stop9h 58m

Miami

Mon 9/1

8:23 pm-10:22 pm

1 stop28h 59m

$231

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Sat 8/23

12:12 pm-6:30 am

1 stop15h 18m

Miami

Sat 8/30

6:15 am-11:10 am

1 stop7h 55m

$260

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Sat 8/16

10:17 pm-10:53 am

1 stop9h 36m

Key West

Thu 8/21

12:50 pm-6:51 pm

1 stop9h 01m

$309

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Fri 9/12

10:30 pm-10:55 am

1 stop9h 25m

Key West

Mon 9/15

2:00 pm-7:27 pm

1 stop8h 27m

$339

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Sun 8/24

12:02 pm-9:43 am

2 stops18h 41m

Key West

Wed 8/27

2:13 pm-11:07 am

2 stops23h 54m

$397

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Fri 9/12

4:11 pm-2:11 pm

3 stops19h 00m

Key West

Mon 9/15

3:50 pm-11:40 am

2 stops22h 50m

$885

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Sun 8/24

8:15 am-1:51 pm

2 stops26h 36m

Key West

Wed 8/27

12:10 pm-10:14 am

3 stops25h 04m

$941

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Fri 9/12

1:12 pm-8:15 am

3 stops40h 03m

Key West

Mon 9/15

8:47 am-12:36 pm

2 stops30h 49m

$998

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Wed 9/10

6:15 am-6:48 pm

1 stop9h 33m

$80

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/22

Showing 1-10 of 12 results
1
2

Best time to book a flight from San Diego to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Florida Keys

What is the cheapest month to book a flight from San Diego to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from San Diego to Florida Keys (average of $328). Flying from San Diego to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated July 23, 2025.
Read through reviews of airlines operating flights from San Diego to Florida Keys, such as Alaska Airlines, Delta, and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,967 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,873 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
JetBlue
7.3
Good
2,911 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Crew

8.5

Entertainment

7.1

Overall

8.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to Florida Keys?

    Most people fly from San Diego (SAN) if they book a flight from San Diego to Florida Keys. San Diego is conveniently located just 2.6 mi from San Diego’s city center.

  • What are the cheapest airlines to fly from San Diego to Florida Keys one-way?

    The cheapest airlines for a one-way flight from San Diego to Florida Keys are Spirit Airlines ($80), Frontier ($118), and JetBlue ($153).

  • Can I find deals for flights from San Diego to Florida Keys that include hotel bookings?

    Yes. In addition to deals on San Diego to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Florida Keys.

  • Can I find deals for business class flights from San Diego to Florida Keys?

    Yes. Cheapflights offers flight deals from San Diego to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from San Diego to Florida Keys (average of $328). Flying from San Diego to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from San Diego to Florida Keys

Discover the top 2 airlines that operate flights from San Diego to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$278Average$458FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$288Average$542FlexibilityNo cancel feeOn-time71%

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