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Florida Keys

$133+ Cheap flights from San Diego (SAN) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — EYW
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from San Diego to Florida Keys

Cheapest flights from San Diego to Florida Keys
Explore the most affordable flight options available from San Diego to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:14 pmSAN - MIA
2 stops28h 46mFrontier
Mon 1/125:21 pmMIA - SAN
1 stop9h 15mFrontier
Deal found 12/21$277
This Frontier deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:21 pmSAN - MIA
1 stop7h 14mFrontier
Thu 1/85:21 pmMIA - SAN
1 stop9h 15mFrontier
Deal found 12/22$282
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:14 pmSAN - MIA
2 stops28h 46mFrontier
Tue 1/67:05 amMIA - SAN
1 stop17h 53mFrontier
Deal found 12/21$293
This Expedia deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/251:06 pmSAN - MIA
1 stop13h 29mFrontier
Wed 12/317:05 amMIA - SAN
1 stop8h 06mFrontier
Deal found 12/21$301
This Frontier deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:21 pmSAN - MIA
1 stop7h 14mFrontier
Sat 1/103:11 pmMIA - SAN
1 stop11h 05mFrontier
Deal found 12/22$303
This Frontier deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:21 pmSAN - MIA
1 stop7h 14mFrontier
Fri 1/95:03 pmMIA - SAN
1 stop9h 33mFrontier
Deal found 12/22$317
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:14 pmSAN - MIA
2 stops28h 46mFrontier
Sun 1/115:21 pmMIA - SAN
1 stop9h 28mFrontier
Deal found 12/21$320
This Frontier deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/301:06 pmSAN - MIA
1 stop13h 29mFrontier
Thu 1/85:21 pmMIA - SAN
1 stop9h 15mFrontier
Deal found 12/22$342
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:30 pmSAN - EYW
2 stops12h 13mAmerican Airlines
Tue 12/231:15 pmEYW - SAN
1 stop9h 53mAmerican Airlines
Deal found 12/22$1,215
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:30 pmSAN - EYW
2 stops12h 36mAmerican Airlines
Sat 1/32:52 pmEYW - SAN
1 stop8h 23mAmerican Airlines
Deal found 12/22$1,307
This Delta deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/279:45 pmSAN - EYW
1 stop10h 07mDelta
Fri 1/26:20 pmEYW - SAN
1 stop18h 55mDelta
Deal found 12/22$1,572

Find flight deals from San Diego to Florida Keys

Keep the following information in mind while searching for San Diego to Florida Keys flight deals. Data was last updated December 23, 2025.

Most accurate provider

CheapOair
3 stars

Most trusted provider

CheapOair
3 stars

Round-trip from

$260
(Kiwi.com)

One-way from

$133
(Delta)

Popular in

December

Cheapest in

January

Average price

$541
Provider with most accurate pricing for San Diego-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Miami flights.
Search Deals
From San Diego to Florida Keys
Search Deals
One-way flight from San Diego to Florida Keys
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($22 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from San Diego to Florida Keys that are best for you.

Fly from

San Diego

Fly to

Florida Keys

Route

Depart

Return

Price

San DiegoKey West

SAN - EYW

SANEYW

San Diego

Fri 1/23

1:27 pm-11:56 pm

1 stop7h 29m

Key West

Tue 1/27

1:22 pm-8:36 pm

1 stop10h 14m

$265

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Fri 2/6

7:55 pm-6:37 am

1 stop7h 42m

Miami

Fri 2/20

7:50 am-2:31 pm

1 stop9h 41m

$277

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Sat 1/24

10:40 pm-11:08 am

1 stop9h 28m

Miami

Thu 1/29

4:51 pm-9:56 pm

1 stop8h 05m

$277

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Tue 1/20

10:05 am-9:30 pm

1 stop8h 25m

Miami

Mon 1/26

7:15 am-2:20 pm

1 stop10h 05m

$277

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Fri 1/16

7:35 pm-6:45 am

1 stop8h 10m

Miami

Wed 1/21

5:30 pm-10:45 pm

1 stop8h 15m

$277

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Sat 1/24

11:25 am-9:25 pm

1 stop7h 00m

Miami

Fri 1/30

6:55 am-1:20 pm

2 stops9h 25m

$282

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Fri 2/6

6:50 am-10:25 pm

1 stop12h 35m

Miami

Fri 2/20

6:10 am-12:30 pm

1 stop9h 20m

$282

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Sat 1/24

12:46 pm-10:33 pm

1 stop6h 47m

Miami

Thu 1/29

9:30 am-12:27 pm

Nonstop5h 57m

$297

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Thu 1/22

6:50 am-8:05 pm

2 stops10h 15m

Miami

Fri 1/23

9:00 am-2:50 pm

1 stop8h 50m

$299

San DiegoMiami

SAN - MIA

SANMIA

San Diego

Wed 1/14

7:10 am-8:05 pm

2 stops9h 55m

Miami

Tue 1/27

12:00 pm-6:40 pm

2 stops9h 40m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/21

Showing 1-10 of 35 results
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Best time to book a flight from San Diego to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Florida Keys

What is the cheapest month to book a flight from San Diego to Florida Keys?

Currently, April is the cheapest month in which you can book a flight from San Diego to Florida Keys (average of $160). Flying from San Diego to Florida Keys in July is currently the most expensive (average of $438). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated December 23, 2025.
Read through reviews of airlines operating flights from San Diego to Florida Keys, such as Alaska Airlines, Delta, and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,513 reviews

Comfort

7.8

Overall

8.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Food

7.1

Reviews

1 / 20
2.0
Mediocre

Art,Dec 2025

SAN - OGG

It was a five hour flight and my seat did not recline. I have had three back surgeries and I’m solid bone for my L3 vertebrae all the way to my tailbone. My body has never hurt so much. There was no TV on this flight and only a small can of soda was free.
Alaska Airlines
8.0
Very good
11,513 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Comfort

7.8

Overall

8.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Food

7.1

Reviews

1 / 20
2.0
Mediocre

Art,Dec 2025

SAN - OGG

It was a five hour flight and my seat did not recline. I have had three back surgeries and I’m solid bone for my L3 vertebrae all the way to my tailbone. My body has never hurt so much. There was no TV on this flight and only a small can of soda was free.
Delta
7.9
Good
8,014 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Comfort

7.8

Overall

8.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Food

7.1

Reviews

1 / 20
2.0
Mediocre

Art,Dec 2025

SAN - OGG

It was a five hour flight and my seat did not recline. I have had three back surgeries and I’m solid bone for my L3 vertebrae all the way to my tailbone. My body has never hurt so much. There was no TV on this flight and only a small can of soda was free.
United Airlines
7.4
Good
9,106 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Comfort

7.8

Overall

8.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Food

7.1

Reviews

1 / 20
2.0
Mediocre

Art,Dec 2025

SAN - OGG

It was a five hour flight and my seat did not recline. I have had three back surgeries and I’m solid bone for my L3 vertebrae all the way to my tailbone. My body has never hurt so much. There was no TV on this flight and only a small can of soda was free.
American Airlines
7.2
Good
11,050 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Comfort

7.8

Overall

8.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Food

7.1

Reviews

1 / 20
2.0
Mediocre

Art,Dec 2025

SAN - OGG

It was a five hour flight and my seat did not recline. I have had three back surgeries and I’m solid bone for my L3 vertebrae all the way to my tailbone. My body has never hurt so much. There was no TV on this flight and only a small can of soda was free.
Frontier
5.8
Fair
3,074 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Comfort

7.8

Overall

8.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Food

7.1

Reviews

1 / 20
2.0
Mediocre

Art,Dec 2025

SAN - OGG

It was a five hour flight and my seat did not recline. I have had three back surgeries and I’m solid bone for my L3 vertebrae all the way to my tailbone. My body has never hurt so much. There was no TV on this flight and only a small can of soda was free.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to Florida Keys?

    Most people fly from San Diego (SAN) if they book a flight from San Diego to Florida Keys. San Diego is conveniently located just 2.6 mi from San Diego’s city center.

  • How long is the flight from San Diego to Florida Keys?

    For as low as $265, American Airlines can have you in Florida Keys from San Diego in 7h 29m. There are 2209 mi between San Diego and Florida Keys. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from San Diego to Florida Keys one-way?

    The cheapest airlines for a one-way flight from San Diego to Florida Keys are Frontier ($42), Spirit Airlines ($59), and American Airlines ($125).

  • Can I find deals for flights from San Diego to Florida Keys that include hotel bookings?

    Yes. In addition to deals on San Diego to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Florida Keys.

  • Can I find deals for business class flights from San Diego to Florida Keys?

    Yes. Cheapflights offers flight deals from San Diego to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Florida Keys?

    Currently, April is the cheapest month in which you can book a flight from San Diego to Florida Keys (average of $160). Flying from San Diego to Florida Keys in July is currently the most expensive (average of $438). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Diego to Florida Keys

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Top 2 airlines flying from San Diego to Florida Keys

Discover the top 2 airlines that operate flights from San Diego to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$278Average$458FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$314Average$546FlexibilityNo cancel feeOn-time71%

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