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$227+ Cheap flights from Roanoke (ROA) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — EYW
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Cheap flight deals from Roanoke to Florida Keys

Keep the following information in mind while searching for Roanoke to Florida Keys flight deals. Data was last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$231
(Kiwi.com)

One-way from

$227
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$353
Provider with most accurate pricing for Roanoke-Miami flight deals.
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Provider most trusted by Cheapflights users for Roanoke-Miami flights.
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From Roanoke to Florida Keys
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One-way flight from Roanoke to Florida Keys
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Highest demand for flights based on searches. 9% potential increase in price ($44 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Roanoke to Florida Keys

Cheapest flights from Roanoke to Florida Keys
Explore the most affordable flight options available from Roanoke to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/28:00 pmROA - MIA
1 stop4h 46mDelta
Wed 12/172:11 pmMIA - ROA
1 stop5h 04mDelta
Deal found 10/28$249
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:03 pmROA - MIA
1 stop5h 05mAmerican Airlines
Mon 11/245:45 amMIA - ROA
1 stop6h 17mAmerican Airlines
Deal found 10/29$264
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/17:59 pmROA - MIA
1 stop4h 47mDelta
Thu 12/186:30 pmMIA - ROA
1 stop5h 41mDelta
Deal found 10/28$274
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:06 pmROA - MIA
1 stop4h 40mAmerican Airlines
Mon 11/178:15 amMIA - ROA
1 stop8h 36mAmerican Airlines
Deal found 10/29$279
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:05 amROA - EYW
2 stops10h 30mAmerican Airlines
Tue 12/97:30 amEYW - ROA
1 stop6h 07mAmerican Airlines
Deal found 10/26$289
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/28:00 pmROA - MIA
1 stop4h 46mDelta
Sun 12/146:00 amMIA - ROA
1 stop4h 40mDelta
Deal found 10/28$309
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:31 pmROA - MIA
1 stop6h 47mAmerican Airlines
Sun 12/146:00 amMIA - ROA
1 stop4h 34mAmerican Airlines
Deal found 10/28$319
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:10 pmROA - MIA
1 stop4h 42mAmerican Airlines
Sun 12/76:00 amMIA - ROA
1 stop4h 34mAmerican Airlines
Deal found 10/28$324
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amROA - MIA
1 stop7h 11mDelta
Mon 11/36:15 pmMIA - ROA
1 stop5h 54mDelta
Deal found 10/27$334
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:59 pmROA - MIA
1 stop4h 30mDelta
Mon 11/106:00 amMIA - ROA
1 stop4h 40mDelta
Deal found 10/28$339
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:42 pmROA - MIA
1 stop5h 09mDelta
Sun 11/25:00 amMIA - ROA
1 stop4h 33mDelta
Deal found 10/27$349
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:35 amROA - EYW
2 stops9h 26mAmerican Airlines
Sat 11/224:53 pmEYW - ROA
1 stop7h 12mAmerican Airlines
Deal found 10/27$349

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Roanoke to Florida Keys that are best for you.

Fly from

Roanoke

Fly to

Florida Keys

Route

Depart

Return

Price

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Thu 1/8

3:45 pm-9:37 pm

1 stop5h 52m

Key West

Sun 1/11

3:46 pm-3:03 pm

1 stop23h 17m

$231

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Sat 4/25

7:50 pm-12:56 am

1 stop5h 06m

Miami

Wed 4/29

6:00 am-10:35 am

1 stop4h 35m

$249

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Thu 2/19

7:50 pm-12:57 am

1 stop5h 07m

Miami

Mon 2/23

7:35 pm-11:49 pm

1 stop4h 14m

$249

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Sat 1/31

5:25 pm-12:51 am

1 stop7h 26m

Miami

Sat 2/7

6:00 am-10:44 am

1 stop4h 44m

$249

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Fri 2/20

7:50 pm-12:57 am

1 stop5h 07m

Miami

Tue 2/24

10:20 am-2:39 pm

1 stop4h 19m

$249

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Wed 12/3

8:00 pm-12:46 am

1 stop4h 46m

Miami

Mon 12/15

6:30 pm-12:11 am

1 stop5h 41m

$249

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Wed 1/7

6:00 am-11:31 am

1 stop5h 31m

Key West

Wed 1/14

6:08 pm-12:06 am

1 stop5h 58m

$249

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Wed 1/7

3:30 pm-11:56 pm

2 stops8h 26m

Key West

Wed 1/14

1:33 pm-10:53 pm

2 stops9h 20m

$259

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Mon 12/1

7:59 pm-12:46 am

1 stop4h 47m

Miami

Wed 12/17

6:00 am-10:40 am

1 stop4h 40m

$274

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Thu 12/4

9:05 am-7:35 pm

2 stops10h 30m

Key West

Tue 12/9

7:30 am-1:37 pm

1 stop6h 07m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 27 results
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Best time to book a flight from Roanoke to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Florida Keys

What is the cheapest month to book a flight from Roanoke to Florida Keys?

Currently, April is the cheapest month in which you can book a flight from Roanoke to Florida Keys (average of $214). Flying from Roanoke to Florida Keys in October is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated October 29, 2025.
Read through reviews of airlines operating flights from Roanoke to Florida Keys, such as Delta, United Airlines, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,992 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,992 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Florida Keys?

    Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly out of when you book flights from Roanoke to Florida Keys.

  • How long is the flight from Roanoke to Florida Keys?

    A quick flight from Roanoke to Florida Keys can take about 5h 06m. Allegiant Air provides one of the quickest options available for as low as $249. The distance from Roanoke to Florida Keys is about 796 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Roanoke to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Roanoke to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Florida Keys.

  • Can I find deals for business class flights from Roanoke to Florida Keys?

    Yes. Cheapflights offers flight deals from Roanoke to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Florida Keys?

    Currently, April is the cheapest month in which you can book a flight from Roanoke to Florida Keys (average of $214). Flying from Roanoke to Florida Keys in October is currently the most expensive (average of $291). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Roanoke to Florida Keys

Discover the top 2 airlines that operate flights from Roanoke to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$378FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$479FlexibilityNo cancel feeOn-time71%

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