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$239+ Cheap flights from Roanoke (ROA) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/12. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — EYW
Oct 14 — Oct 211
Tue 10/14
Tue 10/21
1 adult, Economy
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Cheap flight deals from Roanoke to Florida Keys

Keep the following information in mind while searching for Roanoke to Florida Keys flight deals. Data was last updated September 14, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$239
(Delta)

Popular in

April

Cheapest in

September

Average price

$321
From Roanoke to Florida Keys
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One-way flight from Roanoke to Florida Keys
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Highest demand for flights based on searches. 14% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Roanoke to Florida Keys

Cheapest flights from Roanoke to Florida Keys
Explore the most affordable flight options available from Roanoke to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2025.

This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/228:06 pmROA - MIA
1 stop4h 23mDelta
Sat 10/258:11 amMIA - ROA
1 stop6h 51mDelta
Deal found 9/13$249
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/297:05 amROA - MIA
1 stop7h 05mDelta
Sat 10/47:25 pmMIA - ROA
1 stop4h 32mDelta
Deal found 9/12$254
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:00 amROA - EYW
1 stop4h 55mDelta
Tue 10/76:17 pmEYW - ROA
1 stop5h 52mDelta
Deal found 9/12$254
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/152:47 pmROA - EYW
1 stop7h 02mAmerican Airlines
Sat 11/221:33 pmEYW - ROA
2 stops8h 20mAmerican Airlines
Deal found 9/14$271
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/267:03 pmROA - MIA
1 stop4h 53mAmerican Airlines
Mon 10/69:05 amMIA - ROA
1 stop8h 24mAmerican Airlines
Deal found 9/13$279
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/257:05 amROA - MIA
1 stop7h 05mDelta
Wed 10/13:29 pmMIA - ROA
1 stop7h 23mDelta
Deal found 9/12$284
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/159:49 pmROA - EYW
1 stop16h 51mAllegiant Air
Mon 10/203:56 pmEYW - ROA
1 stop16h 27mAllegiant Air
Deal found 9/13$287
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:59 pmROA - MIA
1 stop4h 30mDelta
Tue 10/216:00 amMIA - ROA
1 stop4h 33mDelta
Deal found 9/14$294
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/208:04 amROA - EYW
2 stops10h 55mAmerican Airlines
Wed 9/246:17 pmEYW - ROA
1 stop4h 51mAmerican Airlines
Deal found 9/12$314
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/139:05 amROA - EYW
1 stop4h 36mAmerican Airlines
Tue 12/167:30 amEYW - ROA
1 stop6h 07mAmerican Airlines
Deal found 9/11$319
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/167:05 amROA - MIA
1 stop7h 05mDelta
Thu 9/253:28 pmMIA - ROA
1 stop7h 24mDelta
Deal found 9/14$324
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/98:18 pmROA - MIA
1 stop4h 11mAmerican Airlines
Sun 10/125:18 amMIA - ROA
1 stop5h 24mAmerican Airlines
Deal found 9/12$354

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
Use the filters below to find and compare flights from Roanoke to Florida Keys that are best for you.

Fly from

Roanoke

Fly to

Florida Keys

Route

Depart

Return

Price

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Wed 10/22

8:06 pm-12:29 am

1 stop4h 23m

Miami

Sat 10/25

8:11 am-3:02 pm

1 stop6h 51m

$249

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Sat 11/15

6:00 pm-12:46 am

1 stop6h 46m

Miami

Sun 11/23

7:01 am-12:27 pm

1 stop5h 26m

$249

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Wed 11/19

7:05 am-2:20 pm

1 stop7h 15m

Miami

Tue 12/2

3:30 pm-11:19 pm

1 stop7h 49m

$249

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Mon 9/29

7:05 am-2:10 pm

1 stop7h 05m

Miami

Sat 10/4

7:25 pm-11:57 pm

1 stop4h 32m

$254

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Sat 9/27

7:51 pm-12:23 am

1 stop4h 32m

Miami

Sat 10/25

6:00 am-10:33 am

1 stop4h 33m

$254

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Tue 9/30

6:00 am-11:01 am

1 stop5h 01m

Miami

Sat 10/4

7:25 pm-11:57 pm

1 stop4h 32m

$254

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Tue 9/30

6:00 am-10:55 am

1 stop4h 55m

Key West

Tue 10/7

6:17 pm-12:09 am

1 stop5h 52m

$254

RoanokeKey West

ROA - EYW

ROAEYW

Roanoke

Sat 11/15

2:47 pm-9:49 pm

1 stop7h 02m

Key West

Sat 11/22

1:33 pm-9:53 pm

2 stops8h 20m

$271

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Fri 9/26

7:03 pm-11:56 pm

1 stop4h 53m

Miami

Mon 10/6

9:05 am-5:29 pm

1 stop8h 24m

$279

RoanokeMiami

ROA - MIA

ROAMIA

Roanoke

Fri 10/3

6:00 am-10:51 am

1 stop4h 51m

Miami

Sun 10/5

6:00 am-10:35 am

1 stop4h 35m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 23 results
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Best time to book a flight from Roanoke to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Florida Keys

What is the cheapest month to book a flight from Roanoke to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Roanoke to Florida Keys (average of $328). Flying from Roanoke to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated September 14, 2025.
Read through reviews of airlines operating flights from Roanoke to Florida Keys, such as Delta, United Airlines, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
United Airlines
7.4
Good
8,931 reviews
Delta
8.0
Very good
7,956 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Florida Keys?

    Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly out of when you book flights from Roanoke to Florida Keys.

  • How long is the flight from Roanoke to Florida Keys?

    A quick flight from Roanoke to Florida Keys can take about 4h 23m. Delta provides one of the quickest options available for as low as $249. The distance from Roanoke to Florida Keys is about 796 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Roanoke to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Roanoke to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Florida Keys.

  • Can I find deals for business class flights from Roanoke to Florida Keys?

    Yes. Cheapflights offers flight deals from Roanoke to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Roanoke to Florida Keys (average of $328). Flying from Roanoke to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Roanoke to Florida Keys

Discover the top 2 airlines that operate flights from Roanoke to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$343FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$278Average$484FlexibilityNo cancel feeOn-time71%

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