HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florida Keys

$159+ Cheap flights from Panama City, FL (ECP) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
Dec 20 — Dec 271
Sat 12/20
Sat 12/27
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Florida Keys with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Panama City to Florida Keys

Cheapest flights from Panama City to Florida Keys
Explore the most affordable flight options available from Panama City to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.

This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/111:32 pmECP - EYW
1 stop5h 34mDelta
Tue 12/167:40 amEYW - ECP
1 stop6h 07mDelta
Deal found 11/18$329
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:43 pmECP - EYW
1 stop6h 02mAmerican Airlines
Tue 12/161:33 pmEYW - ECP
2 stops10h 37mAmerican Airlines
Deal found 11/19$334
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:32 pmECP - EYW
1 stop5h 34mDelta
Thu 12/113:02 pmEYW - ECP
1 stop6h 29mDelta
Deal found 11/19$344
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:08 pmECP - EYW
2 stops9h 59mAmerican Airlines
Thu 12/118:00 amEYW - ECP
1 stop7h 13mAmerican Airlines
Deal found 11/19$349
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:00 amECP - MIA
1 stop4h 39mDelta
Tue 12/235:01 pmMIA - ECP
1 stop3h 55mDelta
Deal found 11/19$408
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:02 pmECP - MIA
1 stop4h 46mDelta
Wed 12/316:00 amMIA - ECP
1 stop5h 17mDelta
Deal found 11/19$428
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/221:32 pmECP - EYW
1 stop5h 21mDelta
Wed 11/266:18 pmEYW - ECP
1 stop5h 19mDelta
Deal found 11/18$434
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/227:15 amECP - EYW
2 stops8h 51mAmerican Airlines
Wed 11/264:53 pmEYW - ECP
1 stop7h 56mAmerican Airlines
Deal found 11/18$439
This Southwest deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:15 pmECP - MIA
1 stop6h 40mSouthwest
Thu 1/16:55 amMIA - ECP
2 stops8h 45mSouthwest
Deal found 11/20$447
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:59 pmECP - MIA
1 stop4h 47mDelta
Tue 12/1611:24 amMIA - ECP
2 stops12h 13mDelta
Deal found 11/20$459
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/912:08 pmECP - EYW
2 stops6h 27mAmerican Airlines
Sat 12/134:20 pmEYW - ECP
2 stops8h 44mAmerican Airlines
Deal found 11/19$460
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:26 pmECP - MIA
1 stop4h 48mDelta
Sat 12/138:05 amMIA - ECP
1 stop5h 42mDelta
Deal found 11/20$467

Cheap flight deals from Panama City to Florida Keys

Keep the following information in mind while searching for Panama City to Florida Keys flight deals. Data was last updated November 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$316
(Delta)

One-way from

$159
(Delta)

Popular in

December

Cheapest in

August

Average price

$478
Provider with most accurate pricing for Panama City NW Florida Beaches-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Miami flights.
Search Deals
From Panama City NW Florida Beaches to Florida Keys
Search Deals
One-way flight from Panama City NW Florida Beaches to Florida Keys
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($89 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Panama City to Florida Keys that are best for you.

Fly from

Panama City

Fly to

Florida Keys

Route

Depart

Return

Price

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Sat 1/17

5:14 pm-12:51 am

1 stop6h 37m

Miami

Wed 1/21

7:00 pm-10:40 pm

1 stop4h 40m

$317

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Mon 1/5

6:00 am-11:29 am

1 stop4h 29m

Key West

Mon 1/12

7:10 am-12:45 pm

1 stop6h 35m

$327

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 1/22

12:15 pm-7:40 pm

1 stop6h 25m

Key West

Sun 1/25

6:06 pm-10:40 pm

1 stop5h 34m

$327

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 12/11

1:32 pm-8:06 pm

1 stop5h 34m

Key West

Tue 12/16

7:40 am-12:47 pm

1 stop6h 07m

$329

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Thu 12/11

2:43 pm-9:45 pm

1 stop6h 02m

Key West

Tue 12/16

7:00 am-4:47 pm

2 stops10h 47m

$334

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Tue 3/31

7:45 am-1:04 pm

1 stop4h 19m

Miami

Thu 4/16

3:35 pm-7:36 pm

1 stop5h 01m

$336

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Thu 2/19

6:03 pm-12:51 am

1 stop5h 48m

Miami

Mon 2/23

7:15 am-11:20 am

1 stop5h 05m

$337

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 12/9

1:32 pm-8:06 pm

1 stop5h 34m

Key West

Sat 12/13

6:10 pm-10:37 pm

1 stop5h 27m

$344

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 12/5

1:32 pm-8:06 pm

1 stop5h 34m

Key West

Thu 12/11

3:02 pm-8:31 pm

1 stop6h 29m

$344

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Tue 3/31

5:30 pm-12:57 am

1 stop6h 27m

Miami

Mon 4/13

7:35 pm-10:46 pm

1 stop4h 11m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/20

Showing 1-10 of 28 results
1
2
3

Best time to book a flight from Panama City to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Florida Keys

What is the cheapest month to book a flight from Panama City, Florida to Florida Keys?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Florida Keys (average of $140). Flying from Panama City, Florida to Florida Keys in October is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated November 20, 2025.
See what other customers who have flown with Southwest, Delta, and American Airlines from Panama City to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,251 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
Southwest
8.0
Very good
4,251 reviews
Southwest
8.0
Very good
4,251 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
Delta
7.9
Good
8,002 reviews
Southwest
8.0
Very good
4,251 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
American Airlines
7.2
Good
11,047 reviews
Southwest
8.0
Very good
4,251 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Florida Keys?

    If you book a flight to Florida Keys from Panama City, you will be flying from NW Florida Beaches, which is the city’s only airport. Panama City NW Florida Beaches (ECP) is located 16.0 mi from the center of Panama City.

  • How long is the flight from Panama City, Florida to Florida Keys?

    Delta can get you from Panama City, Florida to Florida Keys in just under 6h 37m. Your travel time can differ by up to . The distance from Panama City, Florida to Florida Keys is about 460 mi.

  • Can I find deals for flights from Panama City to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Panama City to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Florida Keys.

  • Can I find deals for business class flights from Panama City to Florida Keys?

    Yes. Cheapflights offers flight deals from Panama City to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Florida Keys?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Florida Keys (average of $140). Flying from Panama City, Florida to Florida Keys in October is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
Miami to Orlando flights
Tampa to Miami flights
Fort Lauderdale to Tampa flights
Orlando to Miami flights
Tampa to Fort Lauderdale flights
Fort Lauderdale to Orlando flights
Miami to Tampa flights
Orlando to Fort Lauderdale flights
Jacksonville to Miami flights
Pensacola to Miami flights
Pensacola to Fort Lauderdale flights
Miami to Jacksonville flights
Pensacola to Orlando flights
Tampa to Key West flights
Fort Lauderdale to Jacksonville flights
Orlando to Key West flights
Miami to Tallahassee flights
Tallahassee to Miami flights
Jacksonville to Fort Lauderdale flights
Fort Lauderdale to Pensacola flights
Fort Lauderdale to Tallahassee flights
West Palm Beach to Orlando flights
West Palm Beach to Tallahassee flights
Miami to Key West flights
Tampa to Pensacola flights
Jacksonville to Key West flights
Miami to Pensacola flights
West Palm Beach to Tampa flights
Pensacola to Tampa flights
Tampa to West Palm Beach flights
Sarasota to Key West flights
Orlando to Pensacola flights
Orlando to Fort Myers flights
West Palm Beach to Jacksonville flights
Jacksonville to West Palm Beach flights
Orlando to Tallahassee flights
Fort Myers to Key West flights
Gainesville to Miami flights
Panama City to Miami flights
Fort Myers to Orlando flights
Sarasota to Miami flights
Orlando to Valparaiso flights
Tallahassee to Fort Lauderdale flights
Pensacola to Key West flights
Tampa to Panama City flights
Fort Myers to Jacksonville flights
Tampa to Jacksonville flights
Miami to Panama City flights
Miami to Fort Lauderdale flights
Valparaiso to Miami flights

Top 2 airlines flying from Panama City to Florida Keys

Discover the top 2 airlines that operate flights from Panama City to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$468FlexibilityNo cancel feeOn-time71%
DeltaCheapest$306Average$527FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.