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Florida Keys

$158+ Cheap flights from Panama City, FL (ECP) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
Feb 5 — Feb 121
Thu 2/5
Thu 2/12
1 adult, Economy
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Cheap flight deals from Panama City to Florida Keys

Keep the following information in mind while searching for Panama City to Florida Keys flight deals. Data was last updated January 6, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$297
(Delta)

One-way from

$158
(Delta)

Popular in

January

Cheapest in

August

Average price

$496
Provider with most accurate pricing for Panama City NW Florida Beaches-Miami flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Miami flights.
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From Panama City NW Florida Beaches to Florida Keys
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One-way flight from Panama City NW Florida Beaches to Florida Keys
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Highest demand for flights based on searches. 9% potential increase in price ($41 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Panama City to Florida Keys

Cheapest flights from Panama City to Florida Keys
Explore the most affordable flight options available from Panama City to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 6, 2026.

This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:47 pmECP - EYW
1 stop3h 57mDelta
Wed 6/32:35 pmEYW - ECP
1 stop5h 21mDelta
Deal found 1/5$307
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/104:45 pmECP - MIA
1 stop3h 56mDelta
Tue 2/178:15 amMIA - ECP
1 stop6h 05mDelta
Deal found 1/6$315
This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:47 pmECP - EYW
1 stop3h 57mDelta
Wed 6/37:00 amEYW - ECP
1 stop6h 38mDelta
Deal found 1/5$317
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:34 amECP - EYW
1 stop4h 49mAmerican Airlines
Sat 10/245:12 pmEYW - ECP
1 stop7h 12mAmerican Airlines
Deal found 1/5$327
This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:30 pmECP - EYW
1 stop5h 14mDelta
Tue 6/27:00 amEYW - ECP
1 stop6h 38mDelta
Deal found 1/5$333
This American Airlines deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:21 amECP - MIA
1 stop6h 50mAmerican Airlines
Sat 4/187:00 pmMIA - ECP
1 stop5h 46mAmerican Airlines
Deal found 1/4$334
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/74:45 pmECP - MIA
1 stop7h 06mDelta
Wed 2/117:00 pmMIA - ECP
1 stop4h 38mDelta
Deal found 1/6$335
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/134:34 pmECP - MIA
1 stop6h 09mAmerican Airlines
Tue 2/173:28 pmMIA - ECP
1 stop7h 49mAmerican Airlines
Deal found 1/6$340
This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:30 pmECP - EYW
1 stop5h 14mDelta
Tue 6/27:00 amEYW - ECP
1 stop6h 38mDelta
Deal found 1/5$343
This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:09 pmECP - MIA
1 stop5h 42mDelta
Mon 2/97:25 pmMIA - ECP
1 stop4h 15mDelta
Deal found 1/5$355
This Delta deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:00 amECP - EYW
1 stop4h 25mDelta
Wed 2/116:06 pmEYW - ECP
1 stop5h 32mDelta
Deal found 1/5$357
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:43 pmECP - MIA
1 stop4h 54mAmerican Airlines
Wed 7/16:20 amMIA - ECP
1 stop5h 05mAmerican Airlines
Deal found 1/5$357

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
Use the filters below to find and compare flights from Panama City to Florida Keys that are best for you.

Fly from

Panama City

Fly to

Florida Keys

Route

Depart

Return

Price

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Tue 2/10

7:20 am-2:18 pm

1 stop5h 58m

Miami

Wed 2/11

5:50 am-11:08 am

1 stop6h 18m

$315

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Tue 2/10

4:45 pm-9:41 pm

1 stop3h 56m

Miami

Tue 2/17

8:15 am-1:20 pm

1 stop6h 05m

$315

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Mon 2/9

7:20 am-2:18 pm

1 stop5h 58m

Miami

Thu 2/12

6:00 am-11:25 am

1 stop6h 25m

$355

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Thu 4/23

6:00 am-10:52 am

1 stop3h 52m

Miami

Mon 4/27

7:00 am-10:08 am

1 stop4h 08m

$355

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Wed 2/4

6:00 am-11:25 am

1 stop4h 25m

Key West

Wed 2/11

6:06 pm-10:38 pm

1 stop5h 32m

$357

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Sat 1/31

4:45 pm-12:51 am

1 stop7h 06m

Miami

Tue 2/3

8:15 am-11:08 am

1 stop3h 53m

$375

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Fri 2/20

4:34 pm-11:43 pm

1 stop6h 09m

Miami

Sat 3/21

6:56 pm-11:49 pm

1 stop5h 53m

$377

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Fri 7/3

7:05 pm-12:56 am

1 stop4h 51m

Miami

Sat 7/11

7:00 am-12:39 pm

1 stop6h 39m

$377

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Sun 3/8

6:00 am-12:08 pm

1 stop5h 08m

Miami

Fri 3/13

7:33 pm-11:04 pm

1 stop4h 31m

$377

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Tue 3/10

1:20 pm-9:40 pm

1 stop7h 20m

Miami

Thu 3/12

6:00 am-2:05 pm

2 stops9h 05m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/5

Showing 1-10 of 28 results
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Best time to book a flight from Panama City to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Florida Keys

What is the cheapest month to book a flight from Panama City, Florida to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Florida Keys (average of $161). Flying from Panama City, Florida to Florida Keys in October is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated January 6, 2026.
See what other customers who have flown with Southwest, Delta, and American Airlines from Panama City to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
Delta
7.9
Good
8,018 reviews
Southwest
8.0
Very good
4,248 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
American Airlines
7.2
Good
11,084 reviews
Southwest
8.0
Very good
4,248 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Florida Keys?

    If you book a flight to Florida Keys from Panama City, you will be flying from NW Florida Beaches, which is the city’s only airport. Panama City NW Florida Beaches (ECP) is located 16.0 mi from the center of Panama City.

  • How long is the flight from Panama City, Florida to Florida Keys?

    Delta, American Airlines, and Southwest can get you from Panama City, Florida to Florida Keys in just under 4h 38m. Your travel time can differ by up to 5h 52m. The distance from Panama City, Florida to Florida Keys is about 460 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Panama City, Florida to Florida Keys one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $123. Southwest flights start at $148 while deals on Delta start at $148 one-way.

  • Can I find deals for flights from Panama City to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Panama City to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Florida Keys.

  • Can I find deals for business class flights from Panama City to Florida Keys?

    Yes. Cheapflights offers flight deals from Panama City to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Florida Keys (average of $161). Flying from Panama City, Florida to Florida Keys in October is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama City to Florida Keys

Discover the top airline that operate flights from Panama City to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$306Average$522FlexibilityNo cancel feeOn-timeN/A

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