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Florida Keys

$164+ Cheap flights from Panama City, FL (ECP) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
nov. 1 — nov. 81
sáb. 11/1
sáb. 11/8
1 adult, Economy
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Cheap flight deals from Panama City to Florida Keys

Keep the following information in mind while searching for Panama City to Florida Keys flight deals. Data was last updated octubre 2, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$317
(American Airlines)

One-way from

$164
(Delta)

Popular in

December

Cheapest in

August

Average price

$452
Provider with most accurate pricing for Panama City NW Florida Beaches-Miami flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Miami flights.
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From Panama City NW Florida Beaches to Florida Keys
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One-way flight from Panama City NW Florida Beaches to Florida Keys
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Highest demand for flights based on searches. 10% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Panama City to Florida Keys

Cheapest flights from Panama City to Florida Keys
Explore the most affordable flight options available from Panama City to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 2, 2025.

This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/112:43 pmECP - EYW
1 stop6h 02mAmerican Airlines
mar. 12/167:30 amEYW - ECP
1 stop5h 08mAmerican Airlines
Deal found 9/30$317
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/246:40 pmECP - MIA
1 stop5h 06mDelta
mar. 12/27:15 pmMIA - ECP
1 stop18h 50mDelta
Deal found 9/30$317
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/116:00 amECP - MIA
1 stop6h 02mDelta
dom. 11/166:00 amMIA - ECP
1 stop5h 26mDelta
Deal found 10/2$322
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/35:55 pmECP - MIA
1 stop4h 54mAmerican Airlines
mar. 11/115:36 pmMIA - ECP
1 stop6h 39mAmerican Airlines
Deal found 10/1$323
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/111:32 pmECP - EYW
1 stop5h 34mDelta
jue. 12/187:40 amEYW - ECP
1 stop6h 07mDelta
Deal found 9/30$327
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/54:26 pmECP - MIA
1 stop4h 48mDelta
sáb. 12/136:00 amMIA - ECP
1 stop4h 14mDelta
Deal found 10/2$327
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/117:15 amECP - EYW
1 stop7h 57mAmerican Airlines
jue. 12/184:03 pmEYW - ECP
2 stops8h 50mAmerican Airlines
Deal found 9/30$332
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/2911:04 amECP - MIA
1 stop5h 06mDelta
mié. 11/56:00 amMIA - ECP
1 stop3h 44mDelta
Deal found 10/1$342
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/246:17 pmECP - MIA
1 stop3h 52mDelta
dom. 11/25:00 amMIA - ECP
1 stop5h 19mDelta
Deal found 10/2$347
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/277:15 amECP - MIA
2 stops14h 00mAmerican Airlines
sáb. 12/69:30 amMIA - ECP
1 stop5h 43mAmerican Airlines
Deal found 10/2$350
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/215:32 pmECP - MIA
1 stop5h 57mDelta
sáb. 10/256:00 amMIA - ECP
1 stop3h 44mDelta
Deal found 9/30$367
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/215:32 pmECP - MIA
2 stops15h 48mDelta
dom. 10/266:00 amMIA - ECP
1 stop3h 44mDelta
Deal found 9/30$371

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 2, 2025.
Use the filters below to find and compare flights from Panama City to Florida Keys that are best for you.

Fly from

Panama City

Fly to

Florida Keys

Route

Depart

Return

Price

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

jue. 12/11

2:43 pm-9:45 pm

1 stop6h 02m

Key West

mar. 12/16

7:30 am-11:38 am

1 stop5h 08m

$317

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

mar. 3/10

6:00 am-1:04 pm

1 stop6h 04m

Miami

mié. 3/11

4:40 pm-7:38 pm

1 stop3h 58m

$317

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

lun. 11/24

6:40 pm-12:46 am

1 stop5h 06m

Miami

mar. 12/2

7:15 pm-1:05 pm

1 stop18h 50m

$317

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

mar. 11/11

6:00 am-1:02 pm

1 stop6h 02m

Miami

sáb. 11/15

7:00 am-10:26 am

1 stop4h 26m

$322

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

jue. 11/27

5:09 pm-12:46 am

1 stop6h 37m

Miami

sáb. 12/6

7:00 am-12:47 pm

1 stop6h 47m

$322

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

vie. 12/5

12:08 pm-8:56 pm

1 stop7h 48m

Miami

sáb. 12/13

7:10 pm-12:04 am

1 stop5h 54m

$327

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

jue. 12/11

1:32 pm-8:06 pm

1 stop5h 34m

Key West

jue. 12/18

7:40 am-12:47 pm

1 stop6h 07m

$327

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

sáb. 1/31

1:30 pm-9:02 pm

1 stop6h 32m

Miami

sáb. 2/7

7:00 pm-10:42 pm

1 stop4h 42m

$327

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

vie. 12/5

6:49 pm-12:46 am

1 stop4h 57m

Miami

sáb. 12/13

8:05 am-12:47 pm

1 stop5h 42m

$327

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

jue. 11/20

6:40 pm-12:46 am

1 stop5h 06m

Miami

dom. 12/7

6:00 am-9:14 am

1 stop4h 14m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/29

Showing 1-10 of 30 results
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Best time to book a flight from Panama City to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Florida Keys

What is the cheapest month to book a flight from Panama City, Florida to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Florida Keys (average of $328). Flying from Panama City, Florida to Florida Keys in March is currently the most expensive (average of $488). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated octubre 2, 2025.
See what other customers who have flown with Southwest, Delta, and American Airlines from Panama City to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
Delta
8.0
Very good
7,962 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
American Airlines
7.2
Good
11,033 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Florida Keys?

    If you book a flight to Florida Keys from Panama City, you will be flying from NW Florida Beaches, which is the city’s only airport. Panama City NW Florida Beaches (ECP) is located 16.0 mi from the center of Panama City.

  • How long is the flight from Panama City, Florida to Florida Keys?

    American Airlines and Delta can get you from Panama City, Florida to Florida Keys in just under 6h 02m. Your travel time can differ by up to 02m. The distance from Panama City, Florida to Florida Keys is about 471 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Panama City, Florida to Florida Keys one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $164. Southwest flights start at $232 while deals on American Airlines start at $254 one-way.

  • Can I find deals for flights from Panama City to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Panama City to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Florida Keys.

  • Can I find deals for business class flights from Panama City to Florida Keys?

    Yes. Cheapflights offers flight deals from Panama City to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Florida Keys (average of $328). Flying from Panama City, Florida to Florida Keys in March is currently the most expensive (average of $488). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama City to Florida Keys

Discover the top 2 airlines that operate flights from Panama City to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$468FlexibilityNo cancel feeOn-time71%
DeltaCheapest$306Average$535FlexibilityNo cancel feeOn-timeN/A

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