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$471+ Cheap flights from Des Moines (DSM) to Florence (FLR)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLR
Dec 25 — Jan 11
Thu 12/25
Thu 1/1
1 adult, Economy
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Cheap flight deals from Des Moines to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Florence (FLR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 25, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$471
(Ticket)

Popular in

June

Cheapest in

October

Average price

$1,372
Provider with most accurate pricing for Des Moines-Florence Peretola flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Florence Peretola flights.
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From Des Moines to Florence Peretola
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Highest demand for flights based on searches. 15% potential increase in price ($234 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($43 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Des Moines to Florence

Cheapest flights from Des Moines to Florence
Explore the most affordable flight options available from Des Moines to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 25, 2025.

This lol.travel deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/11:53 pmDSM - FLR
2 stops19h 57mIberia
Sat 12/611:30 amFLR - DSM
2 stops41h 59mIberia
Deal found 11/24$1,282
This United Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:46 pmDSM - FLR
2 stops38h 44mUnited Airlines
Thu 1/19:45 amFLR - DSM
2 stops32h 05mUnited Airlines
Deal found 11/25$1,384
This Air Canada deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/111:26 amDSM - FLR
3 stops19h 09mAir Canada
Sat 12/66:30 amFLR - DSM
3 stops22h 07mAir Canada
Deal found 11/24$1,801

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 25, 2025.
Use the filters below to find and compare flights from Des Moines to Florence that are best for you.

Fly from

Des Moines

Fly to

Florence

Route

Depart

Return

Price

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 1/9

6:48 pm-6:30 pm

2 stops16h 42m

Florence Peretola

Fri 1/16

6:30 am-9:50 pm

2 stops22h 20m

$471

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 1/8

6:48 pm-4:30 pm

2 stops38h 42m

Florence Peretola

Thu 1/15

6:35 am-9:50 pm

2 stops22h 15m

$475

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 2/6

6:48 pm-4:30 pm

2 stops14h 42m

Florence Peretola

Tue 2/10

6:30 am-9:50 pm

2 stops22h 20m

$497

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 1/7

6:48 pm-6:30 pm

2 stops40h 42m

Florence Peretola

Wed 1/14

6:30 am-9:50 pm

2 stops22h 20m

$500

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 1/7

6:48 pm-6:30 pm

2 stops16h 42m

Florence Peretola

Wed 1/14

6:30 am-9:50 pm

2 stops22h 20m

$504

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/25

Compare providers for flights from Des Moines to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Florence in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Florence flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Florence flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Florence flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Florence flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Florence flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florence

How much does it cost to fly round-trip from Des Moines to Florence?

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated November 25, 2025.
See what other customers who have flown with Delta, United Airlines, and Lufthansa from Des Moines to Florence have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,999 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
7,999 reviews
Delta
7.9
Good
7,999 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,046 reviews
Delta
7.9
Good
7,999 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Lufthansa
6.8
Okay
7,594 reviews
Delta
7.9
Good
7,999 reviews

Comfort

7.9

Entertainment

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Florence?

    Airlines like Lufthansa fly from Des Moines to Florence in about 16h 42m. The time it takes to get you to your destination can typically vary by up to . Des Moines and Florence are separated by a distance of 4923 mi.

  • What are the cheapest airlines flying from Des Moines to Florence round-trip?

    Flying on Lufthansa is currently your cheapest option to Florence, with prices starting at $738. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $790 and $923, respectively. Lufthansa is priced at 40% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Florence that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florence.

  • Can I find deals for business class flights from Des Moines to Florence?

    Yes. Cheapflights offers flight deals from Des Moines to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 3 airlines flying from Des Moines to Florence

Discover the top 3 airlines that operate flights from Des Moines to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$738Average$1,366FlexibilityNo cancel feeOn-time76%
United AirlinesCheapest$790Average$1,308FlexibilityNo cancel feeOn-time69%
DeltaCheapest$923Average$1,519FlexibilityNo cancel feeOn-timeN/A

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