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$518+ Cheap flights from Des Moines (DSM) to Florence (FLR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLR
Oct 29 — Nov 51
Wed 10/29
Wed 11/5
1 adult, Economy
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Cheap flight deals from Des Moines to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Florence (FLR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$589
(Air France)

One-way from

$518
(KLM)

Popular in

June

Cheapest in

October

Average price

$1,213
Provider with most accurate pricing for Des Moines-Florence Peretola flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Florence Peretola flights.
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From Des Moines to Florence Peretola
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One-way flight from Des Moines to Florence Peretola
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Highest demand for flights based on searches. 14% potential increase in price ($206 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($50 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Florence

Cheapest flights from Des Moines to Florence
Explore the most affordable flight options available from Des Moines to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2025.

This Air France deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:28 amDSM - FLR
2 stops16h 52mMultiple Airlines
Wed 11/196:40 amFLR - DSM
2 stops17h 32mMultiple Airlines
Deal found 9/28$589
This Expedia deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:28 amDSM - FLR
2 stops16h 52mAir France
Wed 11/196:50 amFLR - DSM
2 stops16h 29mAir France
Deal found 9/28$595
This KLM deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:28 amDSM - FLR
2 stops14h 27mKLM
Wed 11/196:40 amFLR - DSM
2 stops16h 39mKLM
Deal found 9/28$598
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/197:48 amDSM - FLR
2 stops18h 07mDelta
Wed 12/39:50 amFLR - DSM
2 stops19h 44mDelta
Deal found 9/27$604
This Air France deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:52 pmDSM - FLR
2 stops13h 33mMultiple Airlines
Thu 11/206:40 amFLR - DSM
2 stops17h 32mMultiple Airlines
Deal found 9/29$639
This Expedia deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:00 amDSM - FLR
2 stops17h 20mAir France
Thu 11/2012:15 pmFLR - DSM
2 stops17h 18mAir France
Deal found 9/29$645
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:00 amDSM - FLR
2 stops25h 50mDelta
Tue 11/186:40 amFLR - DSM
2 stops21h 35mDelta
Deal found 9/28$648
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/197:48 amDSM - FLR
2 stops20h 32mDelta
Tue 12/212:15 pmFLR - DSM
2 stops38h 28mDelta
Deal found 9/27$708
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/207:48 amDSM - FLR
2 stops18h 07mDelta
Wed 12/39:50 amFLR - DSM
2 stops19h 44mDelta
Deal found 9/27$744
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/207:48 amDSM - FLR
2 stops18h 07mDelta
Tue 12/212:15 pmFLR - DSM
2 stops38h 28mDelta
Deal found 9/27$907

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 29, 2025.
Use the filters below to find and compare flights from Des Moines to Florence that are best for you.

Fly from

Des Moines

Fly to

Florence

Route

Depart

Return

Price

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 11/12

11:28 am-11:20 am

2 stops16h 52m

Florence Peretola

Wed 11/19

6:40 am-4:19 pm

2 stops16h 39m

$589

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 11/12

11:28 am-8:55 am

2 stops14h 27m

Florence Peretola

Wed 11/19

6:40 am-4:19 pm

2 stops16h 39m

$598

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 11/19

7:48 am-8:55 am

2 stops18h 07m

Florence Peretola

Wed 12/3

9:50 am-10:34 pm

2 stops19h 44m

$604

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 11/13

5:52 pm-2:25 pm

2 stops13h 33m

Florence Peretola

Thu 11/20

6:40 am-5:12 pm

2 stops17h 32m

$639

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 11/13

11:00 am-11:20 am

2 stops17h 20m

Florence Peretola

Thu 11/20

12:15 pm-10:33 pm

2 stops17h 18m

$645

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 11/14

11:00 am-7:50 pm

2 stops25h 50m

Florence Peretola

Tue 11/18

6:40 am-4:19 pm

2 stops16h 39m

$648

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 11/13

10:21 am-2:25 pm

2 stops21h 04m

Florence Peretola

Thu 11/20

6:40 am-4:19 pm

2 stops16h 39m

$648

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Mon 3/9

2:48 pm-11:20 am

2 stops38h 32m

Florence Peretola

Sun 3/29

12:25 pm-9:52 pm

2 stops40h 27m

$670

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 11/13

11:28 am-8:55 am

2 stops14h 27m

$518

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 11/13

8:02 am-8:50 am

3 stops17h 48m

$3,232

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/29

Compare providers for flights from Des Moines to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Florence in September.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Florence flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Florence flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Florence flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Florence flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Florence flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florence

How much does it cost to fly round-trip from Des Moines to Florence?

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated September 29, 2025.
See what other customers who have flown with Delta, United Airlines, and Lufthansa from Des Moines to Florence have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,964 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,964 reviews
Delta
8.0
Very good
7,964 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,964 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Lufthansa
6.8
Okay
7,435 reviews
Delta
8.0
Very good
7,964 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Florence?

    Airlines like KLM and Delta fly from Des Moines to Florence in about 14h 27m. The time it takes to get you to your destination can typically vary by up to 3h 40m. Des Moines and Florence are separated by a distance of 4923 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Florence round-trip?

    Flying on United Airlines is currently your cheapest option to Florence, with prices starting at $790. Additional round-trip tickets that might be worth considering are offered by Lufthansa and Delta, with the lowest prices starting at $811 and $955, respectively. United Airlines is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Florence that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florence.

  • Can I find deals for business class flights from Des Moines to Florence?

    Yes. Cheapflights offers flight deals from Des Moines to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florence?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Florence (average of $741). Flying from Des Moines to Florence in June is currently the most expensive (average of $1,292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Des Moines to Florence

Discover the top 3 airlines that operate flights from Des Moines to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$790Average$1,186FlexibilityNo cancel feeOn-time69%
LufthansaCheapest$811Average$1,367FlexibilityNo cancel feeOn-time76%
DeltaCheapest$955Average$1,519FlexibilityNo cancel feeOn-timeN/A

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