HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$446+ Cheap flights from Des Moines (DSM) to Florence (FLR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLR
Nov 12 — Nov 191
Wed 11/12
Wed 11/19
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Florence (FLR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 13, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$538
(Expedia)

One-way from

$446
(Expedia)

Popular in

June

Cheapest in

October

Average price

$870
Provider with most accurate pricing for Des Moines-Florence Peretola flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Florence Peretola flights.
Search Deals
From Des Moines to Florence Peretola
Search Deals
One-way flight from Des Moines to Florence Peretola
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($259 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($46 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Find flight deals from Des Moines to Florence

Cheapest flights from Des Moines to Florence
Explore the most affordable flight options available from Des Moines to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2025.

This 123 Milhas deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure 123 Milhas is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/261:05 pmDSM - FLR
2 stops17h 30mLufthansa
Wed 12/36:30 amFLR - DSM
2 stops22h 07mLufthansa
Deal found 10/12$538
This Flightnetwork deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/261:05 pmDSM - FLR
2 stops17h 30mMultiple Airlines
Wed 12/36:30 amFLR - DSM
3 stops22h 07mMultiple Airlines
Deal found 10/12$541
This Lufthansa deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:50 pmDSM - FLR
2 stops14h 40mLufthansa
Tue 11/181:15 pmFLR - DSM
2 stops15h 17mLufthansa
Deal found 10/12$547
This Expedia deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:50 pmDSM - FLR
2 stops20h 10mLufthansa
Tue 12/25:15 pmFLR - DSM
2 stops35h 22mLufthansa
Deal found 10/11$549
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/278:02 amDSM - FLR
2 stops23h 18mUnited Airlines
Thu 12/46:35 amFLR - DSM
2 stops40h 37mUnited Airlines
Deal found 10/13$554

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
Use the filters below to find and compare flights from Des Moines to Florence that are best for you.

Fly from

Des Moines

Fly to

Florence

Route

Depart

Return

Price

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 11/26

1:05 pm-8:40 pm

2 stops24h 35m

Florence Peretola

Wed 12/3

6:30 am-9:37 pm

2 stops22h 07m

$538

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Wed 11/26

1:05 pm-12:35 pm

3 stops16h 30m

Florence Peretola

Wed 12/3

6:30 am-9:37 pm

3 stops22h 07m

$545

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Fri 11/14

6:50 pm-4:30 pm

2 stops14h 40m

Florence Peretola

Tue 11/18

1:15 pm-9:32 pm

2 stops15h 17m

$547

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 11/27

8:02 am-2:20 pm

2 stops23h 18m

Florence Peretola

Thu 12/4

6:35 am-2:20 pm

2 stops38h 45m

$554

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Sun 2/15

6:45 pm-10:00 pm

2 stops20h 15m

$446

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 11/27

8:02 am-2:20 pm

2 stops23h 18m

$452

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Sun 2/15

8:00 am-1:35 pm

3 stops22h 35m

$458

Des MoinesFlorence

DSM - FLR

DSMFLR

Des Moines

Thu 11/27

11:26 am-12:35 pm

3 stops18h 09m

$521

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/11

Compare providers for flights from Des Moines to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Florence in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Florence flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Florence flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Florence flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Florence flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Florence flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florence

How much does it cost to fly round-trip from Des Moines to Florence?

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated October 13, 2025.
See what other customers who have flown with Delta, United Airlines, and Lufthansa from Des Moines to Florence have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,973 reviews
Delta
8.0
Very good
7,973 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Lufthansa
6.8
Okay
7,479 reviews
Delta
8.0
Very good
7,973 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Florence?

    Airlines like Lufthansa fly from Des Moines to Florence in about 24h 35m. The time it takes to get you to your destination can typically vary by up to . Des Moines and Florence are separated by a distance of 4923 mi.

  • What are the cheapest airlines flying from Des Moines to Florence round-trip?

    Flying on Delta is currently your cheapest option to Florence, with prices starting at $660. Additional round-trip tickets that might be worth considering are offered by United Airlines and Lufthansa, with the lowest prices starting at $790 and $811, respectively. Delta is priced at 45% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Florence one-way?

    The cheapest airlines for a one-way flight from Des Moines to Florence are Lufthansa ($446), United Airlines ($452), and Air Canada ($458).

  • Can I find deals for flights from Des Moines to Florence that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florence.

  • Can I find deals for business class flights from Des Moines to Florence?

    Yes. Cheapflights offers flight deals from Des Moines to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Des Moines to Florence

Discover the top 3 airlines that operate flights from Des Moines to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$660Average$1,519FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$790Average$1,186FlexibilityNo cancel feeOn-time69%
LufthansaCheapest$811Average$1,367FlexibilityNo cancel feeOn-time76%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.