$551+ Cheap flights from San Antonio to Florence, SC (SAT - FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
SAT — FLO
Oct 16 — Oct 231
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from San Antonio to FlorenceExplore the most affordable flight options available from San Antonio to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
Explore the most affordable flight options available from San Antonio to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 pm -
1 stop4h 57m
Sun 10/185:09 am -
1 stop6h 52m
Deal found 9/11![American Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:10 am -
1 stop5h 08m
Sat 10/36:24 am -
1 stop5h 12m
Deal found 9/14![American Airlines logo]()
$559
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:25 am -
1 stop6h 29m
Wed 10/212:34 pm -
1 stop6h 50m
Deal found 9/11![American Airlines logo]()
$604
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:09 am -
1 stop4h 45m
Mon 10/192:34 pm -
1 stop6h 50m
Deal found 9/11![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:25 am -
1 stop6h 29m
Tue 10/203:19 pm -
1 stop7h 42m
Deal found 9/11![American Airlines logo]()
$622
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 pm -
1 stop4h 57m
Wed 10/212:34 pm -
1 stop6h 50m
Deal found 9/11![American Airlines logo]()
$645
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:09 am -
1 stop4h 45m
Sat 10/175:09 am -
1 stop6h 52m
Deal found 9/11![American Airlines logo]()
$646
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 pm -
1 stop4h 57m
Tue 10/203:19 pm -
1 stop7h 42m
Deal found 9/11![American Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 pm -
1 stop4h 57m
Sat 10/175:09 am -
1 stop6h 52m
Deal found 9/11![American Airlines logo]()
$687
Best flights from San Antonio to FlorenceDiscover carefully curated flight deals from San Antonio to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
Discover carefully curated flight deals from San Antonio to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:10 am -
1 stop5h 08m
Sat 10/36:24 am -
1 stop5h 12m
Deal found 9/14![American Airlines logo]()
$559
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:05 am -
1 stop7h 04m
Wed 10/215:09 am -
2 stops10h 43m
Deal found 9/11![American Airlines logo]()
$651
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:09 am -
1 stop4h 45m
Tue 10/203:19 pm -
2 stops9h 40m
Deal found 9/11![American Airlines logo]()
$651
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 pm -
1 stop4h 57m
Tue 10/203:19 pm -
1 stop5h 33m
Deal found 9/11![American Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 pm -
1 stop4h 57m
Wed 10/212:34 pm -
2 stops9h 23m
Deal found 9/11![American Airlines logo]()
$692
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:05 am -
1 stop7h 04m
Tue 10/206:30 am -
1 stop6h 55m
Deal found 9/11![American Airlines logo]()
$897
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:00 am -
2 stops8h 54m
Thu 10/155:09 am -
1 stop6h 52m
Deal found 9/11![American Airlines logo]()
$932
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:00 am -
2 stops7h 18m
Fri 10/26:24 am -
1 stop5h 12m
Deal found 9/12![American Airlines logo]()
$984
Last-minute flights from San Antonio to FlorenceDiscover last-minute flight deals from San Antonio to Florence. Data last updated September 16, 2026 and is based on user searches.
Discover last-minute flight deals from San Antonio to Florence. Data last updated September 16, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/287:10 am -
1 stop5h 08m
Fri 10/26:24 am -
1 stop5h 12m
Deal found 9/12![American Airlines logo]()
$943
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:10 am -
1 stop5h 08m
Sat 10/36:24 am -
1 stop5h 12m
Deal found 9/14![American Airlines logo]()
$559
Find flight deals from San Antonio to Florence
Discover tips and strategies to find the most affordable flight options for your journey from San Antonio (SAT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $551 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from San Antonio to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
Use the filters below to find and compare flights from San Antonio to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
San AntonioFlorence
SAT San Antonio - FLO Florence
SATFLO
San Antonio
Tue 9/29
7:10 am-1:18 pm
1 stop5h 08m
Florence
Sat 10/3
6:24 am-10:36 am
1 stop5h 12m
$559
San AntonioFlorence
SAT San Antonio - FLO Florence
SATFLO
San Antonio
Sat 10/17
6:05 am-2:09 pm
1 stop7h 04m
Florence
Wed 10/21
5:09 am-2:52 pm
2 stops10h 43m
$651
San AntonioFlorence
SAT San Antonio - FLO Florence
SATFLO
San Antonio
Tue 10/13
9:09 am-2:54 pm
1 stop4h 45m
Florence
Tue 10/20
3:19 pm-11:59 pm
2 stops9h 40m
$651
San AntonioFlorence
SAT San Antonio - FLO Florence
SATFLO
San Antonio
Fri 10/16
6:00 pm-11:57 pm
1 stop4h 57m
Florence
Tue 10/20
3:19 pm-7:52 pm
1 stop5h 33m
$663
San AntonioFlorence
SAT San Antonio - FLO Florence
SATFLO
San Antonio
Fri 10/16
6:00 pm-11:57 pm
1 stop4h 57m
Florence
Wed 10/21
2:34 pm-10:57 pm
2 stops9h 23m
$692
San AntonioFlorence
SAT San Antonio - FLO Florence
SATFLO
San Antonio
Sun 10/18
6:05 am-2:09 pm
1 stop7h 04m
Florence
Tue 10/20
6:30 am-12:25 pm
1 stop6h 55m
$897
San AntonioFlorence
SAT San Antonio - FLO Florence
SATFLO
San Antonio
Tue 10/13
5:00 am-2:54 pm
2 stops8h 54m
Florence
Thu 10/15
5:09 am-11:01 am
1 stop6h 52m
$932
San AntonioFlorence
SAT San Antonio - FLO Florence
SATFLO
San Antonio
Mon 9/28
5:00 am-1:18 pm
2 stops7h 18m
Florence
Fri 10/2
6:24 am-10:36 am
1 stop5h 12m
$984
Sorted by cheapest first
- Most accurate provider: When it comes to deals on San Antonio-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Antonio-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Antonio-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Antonio-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Antonio-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Antonio to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from San Antonio with our price prediction graph.
SAT-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from San Antonio to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Florence if you plan to visit one of these locationsSumter
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