$457+ Cheap flights from San Antonio to Florence, SC (SAT - FLO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
SAT — FLO
Jun 1 — Jun 81
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from San Antonio to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Antonio to Florence
Cheapest
Best
Last-minute
One-way
Cheapest flights from San Antonio to FlorenceExplore the most affordable flight options available from San Antonio to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.
Explore the most affordable flight options available from San Antonio to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:06 am
SAT
- FLO
1 stop4h 44m
American Airlines
Mon 5/185:20 am
FLO
- SAT
1 stop4h 55m
American Airlines
Deal found 4/29![American Airlines logo]()
$587
Best flights from San Antonio to FlorenceDiscover carefully curated flight deals from San Antonio to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 2, 2026.
Discover carefully curated flight deals from San Antonio to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 2, 2026.
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:06 am
SAT
- FLO
1 stop4h 44m
American Airlines
Mon 5/185:20 am
FLO
- SAT
1 stop4h 55m
American Airlines
Deal found 4/29![American Airlines logo]()
$587
Last-minute flights from San Antonio to FlorenceDiscover last-minute flight deals from San Antonio to Florence. Data last updated May 2, 2026 and is based on user searches.
Discover last-minute flight deals from San Antonio to Florence. Data last updated May 2, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:06 am
SAT
- FLO
1 stop4h 44m
American Airlines
Mon 5/185:20 am
FLO
- SAT
1 stop4h 55m
American Airlines
Deal found 4/29![American Airlines logo]()
$587
One-way flights from San Antonio to FlorenceSearch for one-way flight options from San Antonio to Florence. Find affordable one-way fares based on user searches. Data last updated May 2, 2026.
Search for one-way flight options from San Antonio to Florence. Find affordable one-way fares based on user searches. Data last updated May 2, 2026.
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:06 am
SAT
- FLO
1 stop4h 44m
American Airlines
Deal found 4/30![American Airlines logo]()
$457
Find flight deals from San Antonio to Florence
Discover tips and strategies to find the most affordable flight options for your journey from San Antonio (SAT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $587 (American Airlines) |
One-way from | $457 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from San Antonio to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
Use the filters below to find and compare flights from San Antonio to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
San AntonioFlorence
SAT - FLO
SATFLO
San Antonio
Thu 5/14
10:06 am-3:50 pm
1 stop4h 44m
Florence
Mon 5/18
5:20 am-9:15 am
1 stop4h 55m
$587
Cheapest one-way
Quickest one-way
San AntonioFlorence
SAT - FLO
SATFLO
San Antonio
Fri 5/8
10:06 am-3:50 pm
1 stop4h 44m
$457
Sorted by cheapest first
- Most accurate provider: When it comes to deals on San Antonio-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Antonio-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Antonio-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Antonio-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Antonio-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Antonio to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from San Antonio with our price prediction graph.
SAT-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from San Antonio to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSumter
Hartsville
Darlington
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Florence flight routes
Other flight options
Other flights from San Antonio
Popular flights