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$421+ Cheap flights from Columbus (CMH) to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — FLO
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Cheap flight deals from Columbus to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (CMH) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$421
(American Airlines)
Provider with most accurate pricing for Columbus-Florence flight deals.
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Provider most trusted by Cheapflights users for Columbus-Florence flights.
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From Columbus to Florence
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Find flight deals from Columbus to Florence

Cheapest flights from Columbus to Florence
Explore the most affordable flight options available from Columbus to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This American Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:23 amCMH - FLO
1 stop4h 03mAmerican Airlines
Tue 12/3012:51 pmFLO - CMH
1 stop4h 32mAmerican Airlines
Deal found 11/23$421
This American Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:37 pmCMH - FLO
1 stop4h 01mAmerican Airlines
Sun 1/46:30 pmFLO - CMH
1 stop6h 02mAmerican Airlines
Deal found 11/26$475
This American Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:30 amCMH - FLO
2 stops9h 08mAmerican Airlines
Tue 1/65:36 pmFLO - CMH
1 stop5h 46mAmerican Airlines
Deal found 11/26$480
This American Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:50 pmCMH - FLO
2 stops6h 48mAmerican Airlines
Thu 1/86:15 amFLO - CMH
2 stops7h 54mAmerican Airlines
Deal found 11/26$485
This American Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:30 amCMH - FLO
2 stops9h 08mAmerican Airlines
Sat 1/35:15 amFLO - CMH
2 stops6h 54mAmerican Airlines
Deal found 11/26$517
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/107:25 pmCMH - FLO
1 stop3h 28mAmerican Airlines
Sun 12/145:15 amFLO - CMH
1 stop5h 08mAmerican Airlines
Deal found 11/24$520
This American Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:30 amCMH - FLO
2 stops25h 56mAmerican Airlines
Mon 1/56:30 pmFLO - CMH
2 stops19h 39mAmerican Airlines
Deal found 11/26$542
This American Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:30 amCMH - FLO
2 stops7h 35mAmerican Airlines
Fri 1/25:15 amFLO - CMH
2 stops11h 11mAmerican Airlines
Deal found 11/26$560

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Columbus Airport to Florence that are best for you.

Fly from

Columbus

Fly to

Florence

Route

Depart

Return

Price

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Tue 12/23

8:23 am-12:26 pm

1 stop4h 03m

Florence

Tue 12/30

12:51 pm-5:23 pm

1 stop4h 32m

$421

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 12/31

8:23 am-12:26 pm

1 stop4h 03m

Florence

Fri 1/2

6:30 pm-10:50 pm

1 stop4h 20m

$475

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 12/31

8:23 am-12:26 pm

1 stop4h 03m

Florence

Wed 1/7

5:36 pm-11:22 pm

1 stop5h 46m

$475

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 12/31

6:36 am-12:26 pm

1 stop5h 50m

Florence

Tue 1/6

5:36 pm-9:14 pm

1 stop3h 38m

$475

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 12/31

3:37 pm-7:38 pm

1 stop4h 01m

Florence

Sat 1/3

6:30 pm-12:32 am

1 stop6h 02m

$475

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 12/31

3:37 pm-7:38 pm

1 stop4h 01m

Florence

Sun 1/4

6:30 pm-12:32 am

1 stop6h 02m

$475

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 12/31

3:37 pm-7:38 pm

1 stop4h 01m

Florence

Thu 1/8

6:15 am-5:30 pm

2 stops11h 15m

$480

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/23

Compare providers for flights from Columbus to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbus to Florence in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Columbus Airport-Florence, South Carolina flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Columbus Airport-Florence, South Carolina flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Columbus Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Columbus Airport-Florence, South Carolina flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbus Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbus to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to Florence

What is the cheapest month to book a flight from Columbus Airport to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Columbus Airport to Florence, South Carolina (average of $83). Flying from Columbus Airport to Florence, South Carolina in December is currently the most expensive (average of $138). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Columbus?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Columbus to Florence. 0 airlines have flights to Florence from Columbus on a regular basis. Booking flights from Columbus to Florence should not be difficult; the airport handles an average of 0 inbound flights from Columbus per day.

  • How long is the flight from Columbus Airport to Florence, South Carolina?

    Airlines like American Airlines fly from Columbus Airport to Florence, South Carolina in about 4h 03m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 438 mi.

  • Can I find deals for flights from Columbus to Florence that include hotel bookings?

    Yes. In addition to deals on Columbus to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Florence.

  • Can I find deals for business class flights from Columbus to Florence?

    Yes. Cheapflights offers flight deals from Columbus to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus Airport to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Columbus Airport to Florence, South Carolina (average of $83). Flying from Columbus Airport to Florence, South Carolina in December is currently the most expensive (average of $138). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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