HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$505+ Cheap flights from Columbus (CMH) to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/20. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — FLO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Columbus to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Columbus to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (CMH) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$505
(American Airlines)
From Columbus to Florence
Search Deals

Find flight deals from Columbus to Florence

Cheapest flights from Columbus to Florence
Explore the most affordable flight options available from Columbus to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:21 pmCMH - FLO
1 stop5h 54mAmerican Airlines
Thu 12/2512:51 pmFLO - CMH
1 stop4h 32mAmerican Airlines
Deal found 9/9$505
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:23 amCMH - FLO
1 stop4h 03mAmerican Airlines
Tue 12/235:15 amFLO - CMH
2 stops9h 16mAmerican Airlines
Deal found 9/9$510
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:00 amCMH - FLO
1 stop4h 53mAmerican Airlines
Mon 9/2912:27 pmFLO - CMH
1 stop6h 00mAmerican Airlines
Deal found 9/10$519
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:21 pmCMH - FLO
1 stop5h 54mAmerican Airlines
Sun 12/216:32 pmFLO - CMH
1 stop3h 56mAmerican Airlines
Deal found 9/9$525
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:01 amCMH - FLO
2 stops10h 04mAmerican Airlines
Thu 12/255:15 amFLO - CMH
1 stop5h 17mAmerican Airlines
Deal found 9/9$555
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:01 amCMH - FLO
2 stops10h 04mAmerican Airlines
Sun 12/216:32 pmFLO - CMH
1 stop3h 56mAmerican Airlines
Deal found 9/9$575
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:01 amCMH - FLO
2 stops10h 04mAmerican Airlines
Tue 12/235:15 amFLO - CMH
2 stops6h 36mAmerican Airlines
Deal found 9/9$592

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Columbus Airport to Florence that are best for you.

Fly from

Columbus

Fly to

Florence

Route

Depart

Return

Price

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 12/20

6:21 pm-12:15 am

1 stop5h 54m

Florence

Tue 12/23

12:51 pm-5:23 pm

1 stop4h 32m

$505

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 12/20

6:21 pm-12:15 am

1 stop5h 54m

Florence

Thu 12/25

12:51 pm-11:48 pm

2 stops10h 57m

$510

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Thu 9/25

6:00 am-10:53 am

1 stop4h 53m

Florence

Mon 9/29

12:27 pm-6:27 pm

1 stop6h 00m

$519

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 12/20

6:21 pm-12:15 am

1 stop5h 54m

Florence

Sun 12/21

6:32 pm-10:28 pm

1 stop3h 56m

$525

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 12/20

4:07 pm-12:15 am

2 stops8h 08m

Florence

Wed 12/24

5:15 am-4:46 pm

2 stops11h 31m

$527

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Fri 12/19

8:01 am-6:05 pm

2 stops10h 04m

Florence

Mon 12/22

6:32 pm-12:32 am

1 stop6h 00m

$555

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Fri 12/19

8:01 am-6:05 pm

2 stops10h 04m

Florence

Thu 12/25

12:51 pm-11:48 pm

2 stops10h 57m

$560

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Columbus to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to Florence

What is the cheapest month to book a flight from Columbus Airport to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Columbus Airport to Florence, South Carolina (average of $366). Flying from Columbus Airport to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Columbus?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Columbus to Florence. 0 airlines have flights to Florence from Columbus on a regular basis. Booking flights from Columbus to Florence should not be difficult; the airport handles an average of 0 inbound flights from Columbus per day.

  • How long is the flight from Columbus Airport to Florence, South Carolina?

    Airlines like American Airlines fly from Columbus Airport to Florence, South Carolina in about 5h 54m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 438 mi.

  • Can I find deals for flights from Columbus to Florence that include hotel bookings?

    Yes. In addition to deals on Columbus to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Florence.

  • Can I find deals for business class flights from Columbus to Florence?

    Yes. Cheapflights offers flight deals from Columbus to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus Airport to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Columbus Airport to Florence, South Carolina (average of $366). Flying from Columbus Airport to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.