HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$369+ Cheap flights from Houston to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
HOU — FLO
May 10 — May 171
Sun 5/10
Sun 5/17
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Houston to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Houston to Florence

Cheapest flights from Houston to Florence
Explore the most affordable flight options available from Houston to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.

This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:42 pm
HOU
-
FLO
2 stops9h 00m
American Airlines
Sat 4/254:16 pm
FLO
-
HOU
2 stops8h 31m
American Airlines
Deal found 4/6$369
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:42 pm
HOU
-
FLO
2 stops8h 05m
American Airlines
Tue 4/286:15 am
FLO
-
HOU
2 stops14h 36m
American Airlines
Deal found 4/9$651
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:01 am
HOU
-
FLO
2 stops8h 49m
American Airlines
Mon 4/274:16 pm
FLO
-
HOU
2 stops8h 31m
American Airlines
Deal found 4/8$659
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/29:36 am
HOU
-
FLO
2 stops11h 08m
American Airlines
Sun 7/55:17 am
FLO
-
HOU
2 stops7h 59m
American Airlines
Deal found 4/8$903

Find flight deals from Houston to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Houston (HO1) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 10, 2026.

Round-trip from

$369
(American Airlines)
From Houston to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Houston to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Houston to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Tue 4/21

12:42 pm-10:42 pm

2 stops9h 00m

Florence

Sat 4/25

4:16 pm-11:47 pm

2 stops8h 31m

$369
Quickest round-trip

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Thu 4/23

6:01 am-3:50 pm

2 stops8h 49m

Florence

Mon 4/27

4:16 pm-11:47 pm

2 stops8h 31m

$659

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Thu 7/2

9:36 am-9:44 pm

2 stops11h 08m

Florence

Sun 7/5

5:17 am-12:16 pm

2 stops7h 59m

$903

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/6

Sorted by cheapest first

Best time to book a flight from Houston to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Houston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Houston to Florence

What is the cheapest month to book a flight from Houston to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Houston to Florence, South Carolina (average of $38). Flying from Houston to Florence, South Carolina in May is currently the most expensive (average of $167). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Houston to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Houston?

    For a flight from Houston to Florence, you will be flying into Florence. Florence (FLO) is just 2.3 mi from the center of the city. Florence is the only Florence airport and it handles 0 inbound flights from Houston per day. 0 airlines have flights to Florence from Houston on a regular basis.

  • How long is the flight from Houston to Florence, South Carolina?

    For as low as $369, American Airlines can have you in Florence, South Carolina from Houston in 9h. Airlines will cover a distance of 963 mi.

  • Can I find deals for flights from Houston to Florence that include hotel bookings?

    Yes. In addition to deals on Houston to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Houston to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Houston to Florence.

  • Can I find deals for business class flights from Houston to Florence?

    Yes. Cheapflights offers flight deals from Houston to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Houston to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Houston to Florence, South Carolina (average of $38). Flying from Houston to Florence, South Carolina in May is currently the most expensive (average of $167). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Houston to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Dallas/Fort Worth to Charlotte flights
Hobby to Charlotte flights
George Bush Intcntl to Charlotte flights
Dallas/Fort Worth to Charleston flights
Hobby to Charleston flights
Love Field to Charlotte flights
George Bush Intcntl to Charleston flights
Hobby to Savannah flights
Dallas/Fort Worth to Columbia flights
Dallas/Fort Worth to Savannah flights
Austin to Charlotte flights
Dallas/Fort Worth to Myrtle Beach flights
Hobby to Myrtle Beach flights
Austin to Charleston flights
George Bush Intcntl to Savannah flights
Dallas/Fort Worth to Greenville flights
San Antonio to Charlotte flights
Dallas/Fort Worth to Augusta flights
Love Field to Charleston flights
George Bush Intcntl to Myrtle Beach flights
Hobby to Greenville flights
George Bush Intcntl to Greenville flights
Austin to Greenville flights
Austin to Savannah flights
Hobby to Augusta flights
Austin to Myrtle Beach flights
Hobby to Columbia flights
Love Field to Myrtle Beach flights
San Antonio to Savannah flights
Love Field to Savannah flights
San Antonio to Columbia flights
San Antonio to Charleston flights
Love Field to Greenville flights
Dallas/Fort Worth to Hilton Head Island flights
George Bush Intcntl to Augusta flights
George Bush Intcntl to Columbia flights
Austin to Augusta flights
Love Field to Columbia flights
San Antonio to Myrtle Beach flights
El Paso to Charleston flights
Austin to Columbia flights
San Antonio to Greenville flights
El Paso to Columbia flights
George Bush Intcntl to Hilton Head Island flights
El Paso to Savannah flights
El Paso to Myrtle Beach flights
McAllen to Charlotte flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights