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$544+ Cheap flights from Houston to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/26. Fares are subject to change and may not be available on all flights or dates of travel.
HOU — FLO
Aug 18 — Aug 251
Tue 8/18
Tue 8/25
1 adult, Economy
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Cheap flight deals from Houston to Florence

Cheapest flights from Houston to Florence
Explore the most affordable flight options available from Houston to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 19, 2026.

This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:32 am
HOU
-
FLO
2 stops12h 27m
American Airlines
Wed 9/26:22 am
FLO
-
HOU
2 stops12h 22m
American Airlines
Deal found 7/19$544
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/129:32 am
HOU
-
FLO
2 stops12h 27m
American Airlines
Tue 8/186:22 am
FLO
-
HOU
2 stops12h 22m
American Airlines
Deal found 7/14$687
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2112:15 pm
HOU
-
FLO
2 stops10h 48m
American Airlines
Wed 11/255:15 am
FLO
-
HOU
2 stops7h 25m
American Airlines
Deal found 7/15$723
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/712:14 pm
HOU
-
FLO
2 stops9h 45m
American Airlines
Mon 8/106:22 am
FLO
-
HOU
2 stops10h 04m
American Airlines
Deal found 7/17$873
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/149:32 am
HOU
-
FLO
2 stops12h 27m
American Airlines
Fri 8/216:22 am
FLO
-
HOU
2 stops14h 29m
American Airlines
Deal found 7/16$884
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1111:41 am
HOU
-
FLO
2 stops11h 16m
American Airlines
Sun 10/185:09 am
FLO
-
HOU
2 stops9h 24m
American Airlines
Deal found 7/19$953
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2812:46 pm
HOU
-
FLO
2 stops9h 51m
American Airlines
Fri 7/315:17 am
FLO
-
HOU
2 stops11h 27m
American Airlines
Deal found 7/15$963

Find flight deals from Houston to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Houston (HO1) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 19, 2026.

Round-trip from

$544
(American Airlines)
From Houston to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Houston to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 19, 2026.
Use the filters below to find and compare flights from Houston to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Wed 8/26

9:32 am-10:59 pm

2 stops12h 27m

Florence

Wed 9/2

6:22 am-5:44 pm

2 stops12h 22m

$544

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Wed 8/12

9:32 am-10:59 pm

2 stops12h 27m

Florence

Tue 8/18

6:22 am-5:44 pm

2 stops12h 22m

$687
Quickest round-trip

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Sat 11/21

12:15 pm-12:03 am

2 stops10h 48m

Florence

Tue 11/24

5:15 am-11:40 am

2 stops7h 25m

$723

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Sat 11/21

12:15 pm-12:03 am

2 stops10h 48m

Florence

Wed 11/25

5:15 am-11:40 am

2 stops7h 25m

$723

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Fri 8/7

12:14 pm-10:59 pm

2 stops9h 45m

Florence

Mon 8/10

6:22 am-3:26 pm

2 stops10h 04m

$873

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Fri 8/14

9:32 am-10:59 pm

2 stops12h 27m

Florence

Fri 8/21

6:22 am-7:51 pm

2 stops14h 29m

$884

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/19

Sorted by cheapest first

Best time to book a flight from Houston to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Houston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Houston to Florence

No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Houston to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Houston?

    For a flight from Houston to Florence, you will be flying into Florence. Florence (FLO) is just 2.3 mi from the center of the city. Florence is the only Florence airport and it handles 0 inbound flights from Houston per day. 0 airlines have flights to Florence from Houston on a regular basis.

  • How long is the flight from Houston to Florence, South Carolina?

    For as low as $544, American Airlines can have you in Florence, South Carolina from Houston in 12h 27m. Airlines will cover a distance of 963 mi.

  • Can I find deals for flights from Houston to Florence that include hotel bookings?

    Yes. In addition to deals on Houston to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Houston to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Houston to Florence.

  • Can I find deals for business class flights from Houston to Florence?

    Yes. Cheapflights offers flight deals from Houston to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

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