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$406+ Cheap flights from Houston to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
HOU — FLO
Mar 20 — Mar 271
Fri 3/20
Fri 3/27
1 adult, Economy
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Cheap flight deals from Houston to Florence

Cheapest flights from Houston to Florence
Explore the most affordable flight options available from Houston to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.

This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:00 am
HOU
-
FLO
2 stops10h 21m
American Airlines
Sat 3/75:16 am
FLO
-
HOU
2 stops11h 35m
American Airlines
Deal found 2/16$409
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/712:18 pm
HOU
-
FLO
2 stops10h 39m
American Airlines
Mon 3/165:16 am
FLO
-
HOU
2 stops11h 34m
American Airlines
Deal found 2/17$658
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/712:18 pm
HOU
-
FLO
2 stops10h 39m
American Airlines
Sat 3/145:16 am
FLO
-
HOU
2 stops7h 32m
American Airlines
Deal found 2/17$709
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:00 am
HOU
-
FLO
2 stops10h 50m
American Airlines
Mon 3/165:16 am
FLO
-
HOU
2 stops11h 34m
American Airlines
Deal found 2/17$717
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/612:18 pm
HOU
-
FLO
2 stops10h 39m
American Airlines
Mon 3/165:16 am
FLO
-
HOU
2 stops11h 34m
American Airlines
Deal found 2/17$765
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:00 am
HOU
-
FLO
2 stops10h 50m
American Airlines
Sat 3/145:16 am
FLO
-
HOU
2 stops7h 32m
American Airlines
Deal found 2/17$768
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/612:18 pm
HOU
-
FLO
2 stops10h 39m
American Airlines
Sun 3/155:16 am
FLO
-
HOU
2 stops11h 34m
American Airlines
Deal found 2/17$901
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2512:48 pm
HOU
-
FLO
2 stops10h 09m
American Airlines
Mon 7/62:36 pm
FLO
-
HOU
2 stops10h 16m
American Airlines
Deal found 2/17$980

Find flight deals from Houston to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Houston (HO1) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 18, 2026.

Round-trip from

$409
(American Airlines)

One-way from

$406
(American Airlines)
From Houston to Florence
Search Deals
One-way flight from Houston to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Houston to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
Use the filters below to find and compare flights from Houston to Florence that are best for you.

Fly from

Houston

Fly to

Florence

Route

Depart

Return

Price

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Tue 3/3

6:00 am-5:21 pm

2 stops10h 21m

Florence

Sat 3/7

5:16 am-3:51 pm

2 stops11h 35m

$409

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Sat 3/7

12:18 pm-11:57 pm

2 stops10h 39m

Florence

Mon 3/16

5:16 am-3:50 pm

2 stops11h 34m

$658

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Sat 3/7

12:18 pm-11:57 pm

2 stops10h 39m

Florence

Sat 3/14

5:16 am-11:48 am

2 stops7h 32m

$709

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Thu 3/5

6:00 am-5:50 pm

2 stops10h 50m

Florence

Mon 3/16

5:16 am-3:50 pm

2 stops11h 34m

$717

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Fri 3/6

12:18 pm-11:57 pm

2 stops10h 39m

Florence

Mon 3/16

5:16 am-3:50 pm

2 stops11h 34m

$765

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Thu 3/5

6:00 am-5:50 pm

2 stops10h 50m

Florence

Sat 3/14

5:16 am-11:48 am

2 stops7h 32m

$768

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Fri 3/6

12:18 pm-11:57 pm

2 stops10h 39m

Florence

Sun 3/15

5:16 am-3:50 pm

2 stops11h 34m

$901

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Tue 2/24

6:00 am-5:21 pm

2 stops10h 21m

$406

HoustonFlorence

HOU - FLO

HOUFLO

Houston Hobby

Mon 3/23

12:18 pm-11:57 pm

2 stops10h 39m

$432

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/17

Best time to book a flight from Houston to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Houston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Houston to Florence

What is the cheapest month to book a flight from Houston to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Houston to Florence, South Carolina (average of $38). Flying from Houston to Florence, South Carolina in May is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Houston to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Houston?

    For a flight from Houston to Florence, you will be flying into Florence. Florence (FLO) is just 2.3 mi from the center of the city. Florence is the only Florence airport and it handles 0 inbound flights from Houston per day. 0 airlines have flights to Florence from Houston on a regular basis.

  • How long is the flight from Houston to Florence, South Carolina?

    For as low as $409, American Airlines can have you in Florence, South Carolina from Houston in 10h 21m. Airlines will cover a distance of 963 mi.

  • Can I find deals for flights from Houston to Florence that include hotel bookings?

    Yes. In addition to deals on Houston to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Houston to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Houston to Florence.

  • Can I find deals for business class flights from Houston to Florence?

    Yes. Cheapflights offers flight deals from Houston to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Houston to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Houston to Florence, South Carolina (average of $38). Flying from Houston to Florence, South Carolina in May is currently the most expensive (average of $174). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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