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Durham

$117+ Cheap flights from Odessa, TX to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — RDU
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Cheap flight deals from Odessa to Durham

Keep the following information in mind while searching for Odessa to Durham flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$337
(American Airlines)

One-way from

$117
(American Airlines)
Provider with most accurate pricing for Midland Intl-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Midland Intl-Raleigh-Durham flights.
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From Odessa to Durham
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One-way flight from Odessa to Durham
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Find flight deals from Odessa to Durham

Cheapest flights from Odessa to Durham
Explore the most affordable flight options available from Odessa to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/295:00 amMAF - RDU
1 stop6h 33mUnited Airlines
Sat 12/64:48 pmRDU - MAF
1 stop6h 11mUnited Airlines
Deal found 11/1$377
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:45 amMAF - RDU
1 stop4h 45mSouthwest
Mon 12/16:50 pmRDU - MAF
1 stop5h 15mSouthwest
Deal found 11/1$453
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/295:00 amMAF - RDU
2 stops6h 50mSouthwest
Sat 12/62:00 pmRDU - MAF
2 stops6h 50mSouthwest
Deal found 11/1$519
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:45 amMAF - RDU
1 stop4h 45mSouthwest
Sat 11/87:55 amRDU - MAF
1 stop5h 30mSouthwest
Deal found 11/2$947

Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Odessa to Durham that are best for you.

Fly from

Odessa

Fly to

Durham

Route

Depart

Return

Price

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Tue 4/14

12:28 pm-8:13 pm

1 stop6h 45m

Raleigh-Durham

Wed 4/15

7:36 pm-11:45 pm

1 stop5h 09m

$337

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Sat 11/29

5:00 am-12:33 pm

1 stop6h 33m

Raleigh-Durham

Sat 12/6

4:48 pm-9:59 pm

1 stop6h 11m

$377

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Mon 11/24

7:45 am-1:30 pm

1 stop4h 45m

Raleigh-Durham

Mon 12/1

6:50 pm-11:05 pm

1 stop5h 15m

$453

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Tue 12/16

5:00 am-2:07 pm

2 stops8h 07m

$134

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Thu 12/4

5:00 am-2:07 pm

2 stops8h 07m

$149

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Mon 2/9

9:41 am-9:13 pm

2 stops10h 32m

$149

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Thu 1/29

7:00 am-5:44 pm

2 stops9h 44m

$149

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Mon 1/12

7:00 am-5:44 pm

2 stops9h 44m

$149

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Fri 2/20

2:50 pm-10:35 pm

2 stops6h 45m

$165

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Thu 1/1

7:35 am-8:10 pm

2 stops11h 35m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 14 results
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Best time to book a flight from Odessa to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Durham
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to Durham?

    There are many flights that can get you from Odessa to Durham in 6h 45m. Fly via American Airlines to get the fastest option. The distance from Odessa to Durham is about 1365 mi.

  • Can I find deals for flights from Odessa to Durham that include hotel bookings?

    Yes. In addition to deals on Odessa to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Durham.

  • Can I find deals for business class flights from Odessa to Durham?

    Yes. Cheapflights offers flight deals from Odessa to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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