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$148+ Cheap flights from Odessa, TX to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — RDU
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Odessa to Durham

Cheapest flights from Odessa to Durham
Explore the most affordable flight options available from Odessa to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:15 pmMAF - RDU
2 stops19h 26mUnited Airlines
Mon 12/2912:09 pmRDU - MAF
1 stop7h 10mUnited Airlines
Deal found 12/17$712
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:19 amMAF - RDU
1 stop7h 05mAmerican Airlines
Mon 12/295:01 amRDU - MAF
1 stop7h 50mAmerican Airlines
Deal found 12/16$766
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:18 amMAF - RDU
1 stop7h 56mAmerican Airlines
Sun 12/285:05 amRDU - MAF
1 stop5h 44mAmerican Airlines
Deal found 12/16$837

Find flight deals from Odessa to Durham

Keep the following information in mind while searching for Odessa to Durham flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$375
(United Airlines)

One-way from

$148
(United Airlines)
Provider with most accurate pricing for Midland Intl-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Midland Intl-Raleigh-Durham flights.
Search Deals
From Odessa to Durham
Search Deals
One-way flight from Odessa to Durham
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Odessa to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Odessa to Durham that are best for you.

Fly from

Odessa

Fly to

Durham

Route

Depart

Return

Price

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Sat 2/14

2:56 pm-10:33 pm

1 stop6h 37m

Raleigh-Durham

Wed 2/18

4:47 pm-9:44 pm

1 stop5h 57m

$375

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Sat 1/31

12:41 pm-8:43 pm

2 stops7h 02m

Raleigh-Durham

Fri 2/6

9:11 am-4:25 pm

1 stop8h 14m

$397

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Sat 1/31

8:40 am-4:45 pm

2 stops7h 05m

Raleigh-Durham

Fri 2/6

7:05 am-1:50 pm

2 stops7h 45m

$402

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Sat 1/31

8:19 am-4:48 pm

1 stop7h 29m

Raleigh-Durham

Sat 2/7

1:18 pm-8:49 pm

1 stop8h 31m

$437

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Thu 12/25

5:00 am-11:21 am

1 stop5h 21m

$148

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Wed 12/31

11:00 am-5:25 pm

1 stop5h 25m

$148

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Sat 2/14

7:40 am-3:00 pm

1 stop6h 20m

$148

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Wed 1/7

10:37 am-7:05 pm

1 stop7h 28m

$176

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Wed 1/7

7:05 am-1:20 pm

1 stop5h 15m

$176

MidlandRaleigh

MAF - RDU

MAFRDU

Midland Intl

Tue 1/13

10:37 am-7:05 pm

1 stop7h 28m

$176

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 12 results
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Best time to book a flight from Odessa to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Durham
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Odessa to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Odessa to Durham?

    There are many flights that can get you from Odessa to Durham in 6h 37m. Fly via United Airlines to get the fastest option. The distance from Odessa to Durham is about 1365 mi.

  • Can I find deals for flights from Odessa to Durham that include hotel bookings?

    Yes. In addition to deals on Odessa to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Durham.

  • Can I find deals for business class flights from Odessa to Durham?

    Yes. Cheapflights offers flight deals from Odessa to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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