$176+ Cheap flights from Odessa, TX to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — RDU
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from Odessa to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Odessa to Durham
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Best
Last-minute
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Cheapest flights from Odessa to DurhamExplore the most affordable flight options available from Odessa to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from Odessa to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:25 am
MAF
- RDU
1 stop8h 50m
Southwest
Sat 2/215:15 pm
RDU
- MAF
1 stop7h 00m
Southwest
Deal found 2/2![Southwest logo]()
$547
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:00 am
MAF
- RDU
1 stop8h 57m
American Airlines
Sat 2/219:08 am
RDU
- MAF
2 stops9h 42m
American Airlines
Deal found 2/3![American Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:00 am
MAF
- RDU
1 stop15h 52m
American Airlines
Wed 2/183:47 pm
RDU
- MAF
1 stop8h 02m
American Airlines
Deal found 2/1![American Airlines logo]()
$675
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:00 am
MAF
- RDU
1 stop16h 52m
American Airlines
Tue 2/174:00 pm
RDU
- MAF
1 stop7h 49m
American Airlines
Deal found 2/3![American Airlines logo]()
$677
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/147:40 am
MAF
- RDU
1 stop6h 20m
United Airlines
Sat 2/216:18 am
RDU
- MAF
1 stop8h 30m
United Airlines
Deal found 2/3![United Airlines logo]()
$732
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:50 am
MAF
- RDU
2 stops10h 25m
Southwest
Tue 2/1710:45 am
RDU
- MAF
2 stops8h 30m
Southwest
Deal found 2/3![Southwest logo]()
$742
Best flights from Odessa to DurhamDiscover carefully curated flight deals from Odessa to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from Odessa to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:25 am
MAF
- RDU
1 stop8h 50m
Southwest
Sat 2/215:15 pm
RDU
- MAF
1 stop7h 00m
Southwest
Deal found 2/2![Southwest logo]()
$547
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:00 am
MAF
- RDU
1 stop8h 57m
American Airlines
Sat 2/219:08 am
RDU
- MAF
2 stops9h 42m
American Airlines
Deal found 2/3![American Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:00 am
MAF
- RDU
1 stop15h 52m
American Airlines
Wed 2/183:47 pm
RDU
- MAF
1 stop8h 02m
American Airlines
Deal found 2/1![American Airlines logo]()
$675
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:00 am
MAF
- RDU
2 stops9h 55m
American Airlines
Tue 2/174:00 pm
RDU
- MAF
1 stop7h 49m
American Airlines
Deal found 2/1![American Airlines logo]()
$680
Last-minute flights from Odessa to DurhamDiscover last-minute flight deals from Odessa to Durham. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from Odessa to Durham. Data last updated February 3, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:00 am
MAF
- RDU
1 stop8h 57m
American Airlines
Sat 2/219:08 am
RDU
- MAF
2 stops9h 42m
American Airlines
Deal found 2/3![American Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:00 am
MAF
- RDU
1 stop15h 52m
American Airlines
Wed 2/183:47 pm
RDU
- MAF
1 stop8h 02m
American Airlines
Deal found 2/1![American Airlines logo]()
$675
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:00 am
MAF
- RDU
1 stop16h 52m
American Airlines
Tue 2/174:00 pm
RDU
- MAF
1 stop7h 49m
American Airlines
Deal found 2/3![American Airlines logo]()
$677
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/147:40 am
MAF
- RDU
1 stop6h 20m
United Airlines
Sat 2/216:18 am
RDU
- MAF
1 stop8h 30m
United Airlines
Deal found 2/3![United Airlines logo]()
$732
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:50 am
MAF
- RDU
2 stops10h 25m
Southwest
Tue 2/1710:45 am
RDU
- MAF
2 stops8h 30m
Southwest
Deal found 2/3![Southwest logo]()
$742
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:25 am
MAF
- RDU
1 stop8h 50m
Southwest
Sat 2/215:15 pm
RDU
- MAF
1 stop7h 00m
Southwest
Deal found 2/2![Southwest logo]()
$547
One-way flights from Odessa to DurhamSearch for one-way flight options from Odessa to Durham. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from Odessa to Durham. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:00 am
MAF
- RDU
1 stop7h 48m
United Airlines
Deal found 2/3![United Airlines logo]()
$176
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:43 am
MAF
- RDU
1 stop4h 57m
United Airlines
Deal found 2/2![United Airlines logo]()
$179
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:25 am
MAF
- RDU
2 stops8h 35m
Southwest
Deal found 2/3![Southwest logo]()
$181
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:13 pm
MAF
- RDU
1 stop6h 45m
United Airlines
Deal found 2/2![United Airlines logo]()
$189
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/710:35 am
MAF
- RDU
2 stops8h 05m
Southwest
Deal found 2/3![Southwest logo]()
$194
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:50 am
MAF
- RDU
2 stops14h 55m
Southwest
Deal found 2/1![Southwest logo]()
$200
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/72:48 pm
MAF
- RDU
1 stop6h 49m
United Airlines
Deal found 2/3![United Airlines logo]()
$214
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:00 pm
MAF
- RDU
2 stops10h 20m
Southwest
Deal found 2/2![Southwest logo]()
$219
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:25 am
MAF
- RDU
1 stop6h 05m
Southwest
Deal found 2/3![Southwest logo]()
$224
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/82:48 pm
MAF
- RDU
1 stop6h 49m
United Airlines
Deal found 2/1![United Airlines logo]()
$231
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2312:22 pm
MAF
- RDU
1 stop7h 24m
American Airlines
Deal found 2/2![American Airlines logo]()
$234
Find flight deals from Odessa to Durham
Keep the following information in mind while searching for Odessa to Durham flight deals. Data was last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $547 (Southwest) |
One-way from | $176 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Odessa to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Odessa to Durham that are best for you.
Fly from
Odessa
Fly to
Durham
Route
Depart
Return
Price
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Tue 2/17
6:25 am-4:15 pm
1 stop8h 50m
Raleigh-Durham
Sat 2/21
5:15 pm-11:15 pm
1 stop7h 00m
$547
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Sat 2/14
5:00 am-2:57 pm
1 stop8h 57m
Raleigh-Durham
Sat 2/21
9:08 am-5:50 pm
2 stops9h 42m
$667
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Sat 2/14
6:00 am-10:52 pm
1 stop15h 52m
Raleigh-Durham
Wed 2/18
3:47 pm-10:49 pm
1 stop8h 02m
$675
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Sat 2/14
5:00 am-3:55 pm
2 stops9h 55m
Raleigh-Durham
Tue 2/17
4:00 pm-10:49 pm
1 stop7h 49m
$680
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Wed 2/25
5:00 am-12:12 pm
1 stop6h 12m
$179
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Sat 2/21
2:56 pm-10:33 pm
1 stop6h 37m
$179
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Sat 2/28
7:00 am-3:40 pm
1 stop7h 40m
$179
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Tue 2/24
9:43 am-3:40 pm
1 stop4h 57m
$179
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Wed 3/4
5:00 am-12:12 pm
1 stop6h 12m
$179
MidlandRaleigh
MAF - RDU
MAFRDU
Midland Intl
Wed 4/22
8:25 am-6:00 pm
2 stops8h 35m
$181
Showing 1-10 of 12 results
Best time to book a flight from Odessa to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Odessa with our price prediction graph.
MAF-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Odessa to Durham
OD3-DU8
MAF-RDU
No data available for this route at this time. Please check back soon.
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