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Cuzco

$410+ Cheap flights from Panama City (PTY) to Cusco (CUZ)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/31. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CUZ
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Panama City to Cuzco

Cheapest flights from Panama City to Cuzco
Explore the most affordable flight options available from Panama City to Cuzco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/295:50 pm
PTY
-
CUZ
1 stop17h 30m
Avianca
Mon 3/304:45 pm
CUZ
-
PTY
1 stop8h 00m
Avianca
Deal found 1/27$410
This Avianca Connect deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:05 pm
PTY
-
CUZ
1 stop12h 55m
Avianca
Mon 11/305:10 pm
CUZ
-
PTY
1 stop7h 30m
Avianca
Deal found 1/25$416
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/312:55 am
PTY
-
CUZ
1 stop8h 25m
Avianca
Sat 3/75:10 pm
CUZ
-
PTY
1 stop7h 50m
Avianca
Deal found 1/27$494
This Priceline deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:20 am
PTY
-
CUZ
1 stop7h 40m
Avianca
Mon 6/224:45 pm
CUZ
-
PTY
1 stop8h 00m
Avianca
Deal found 1/26$504
This Priceline deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3111:25 am
PTY
-
CUZ
2 stops23h 35m
Avianca
Sat 6/64:45 pm
CUZ
-
PTY
1 stop7h 25m
Avianca
Deal found 1/26$629
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:20 am
PTY
-
CUZ
1 stop7h 40m
Multiple Airlines
Mon 6/2210:30 pm
CUZ
-
PTY
2 stops25h 40m
Multiple Airlines
Deal found 1/26$639
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:50 pm
PTY
-
CUZ
2 stops15h 30m
Avianca
Sun 2/2212:25 pm
CUZ
-
PTY
1 stop12h 35m
Avianca
Deal found 1/27$676

Find flight deals from Panama City to Cuzco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Cuzco (CUZ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$410
(Priceline)

Popular in

June

Cheapest in

February

Average price

$398
Provider with most accurate pricing for Panama City Tocumen Intl-Cusco Velazco Astete flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Cusco Velazco Astete flights.
Search Deals
From Panama City Tocumen Intl to Cusco Velazco Astete
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Cuzco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Panama City to Cusco that are best for you.

Fly from

Panama City

Fly to

Cuzco

Route

Depart

Return

Price

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Sun 5/31

10:05 pm-11:00 am

1 stop12h 55m

Cusco Velazco Astete

Sat 6/6

4:45 pm-10:10 am

1 stop17h 25m

$410

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Thu 2/19

2:55 am-11:20 am

1 stop8h 25m

Cusco Velazco Astete

Sun 2/22

12:25 pm-1:00 am

1 stop12h 35m

$494

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Thu 6/11

3:20 am-11:00 am

1 stop7h 40m

Cusco Velazco Astete

Mon 6/22

4:45 pm-12:45 am

1 stop8h 00m

$504

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Fri 6/12

10:05 pm-6:35 am

3 stops32h 30m

Cusco Velazco Astete

Mon 6/22

4:45 pm-8:55 am

1 stop16h 10m

$712

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Mon 5/25

3:25 am-11:00 am

1 stop7h 35m

Cusco Velazco Astete

Sat 5/30

12:05 pm-10:10 am

2 stops22h 05m

$1,230

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Mon 6/1

7:07 pm-6:35 am

1 stop11h 28m

Cusco Velazco Astete

Mon 6/8

9:45 pm-6:14 am

1 stop8h 29m

$1,231

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Mon 6/1

5:25 pm-11:00 am

1 stop17h 35m

Cusco Velazco Astete

Mon 6/8

4:45 pm-2:55 pm

3 stops22h 10m

$1,413

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

  • Most accurate provider: When it comes to deals on Panama City-Cusco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Cusco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Cusco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Cusco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Cusco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Cuzco

Have a flexible travel schedule? Discover the best time to fly to Cuzco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Cusco

How far ahead should I book a flight from Panama City to Cusco?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Cuzco. Price data was last updated on January 23, 2026.

Booking 58 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Cusco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Cusco?

Currently, April is the cheapest month in which you can book a flight from Panama City to Cusco (average of $316). Flying from Panama City to Cusco in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Cuzco

Get insights into the airlines that provide service to Cuzco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cuzco. Reviews last updated January 27, 2026.
Read through reviews of airlines operating flights from Panama City to Cusco, such as Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Avianca
6.6
Okay
2,487 reviews

Food

5.0

Overall

6.6

Crew

7.2

Comfort

6.2

Boarding

6.9

Entertainment

5.4

Reviews

1 / 20
6.0
Good

Michael,Jan 2026

GYE - BOG

The seats are too small. The leg room is inadequate and uncomfortable!
Avianca
6.6
Okay
2,487 reviews
Avianca
6.6
Okay
2,487 reviews

Food

5.0

Overall

6.6

Crew

7.2

Comfort

6.2

Boarding

6.9

Entertainment

5.4

Reviews

1 / 20
6.0
Good

Michael,Jan 2026

GYE - BOG

The seats are too small. The leg room is inadequate and uncomfortable!

Related info for your journey

Find useful and relevant information for your journey from Panama City to Cuzco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Cusco?

    Avianca can get you from Panama City to Cusco in just under 12h 55m. Your travel time can differ by up to . Airlines will cover a distance of 1642 mi.

  • What is the cheapest airline to fly from Panama City to Cusco round-trip?

    Currently priced at $369, Avianca will fly you from Panama City to Cusco and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Avianca is currently priced 12% below the average price you’ll pay for this route.

  • Can I find deals for flights from Panama City to Cuzco that include hotel bookings?

    Yes. In addition to deals on Panama City to Cuzco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Cuzco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Cuzco.

  • Can I find deals for business class flights from Panama City to Cuzco?

    Yes. Cheapflights offers flight deals from Panama City to Cuzco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Cusco?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Cusco (average of $316). Flying from Panama City to Cusco in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Cuzco

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Lima flights

Top airline flying from Panama City to Cuzco

Discover the top airline that operate flights from Panama City to Cuzco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$369Average$476FlexibilityNo cancel feeOn-time71%

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