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Cuzco

$407+ Cheap flights from Panama City (PTY) to Cusco (CUZ)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CUZ
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Panama City to Cuzco

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Cuzco (CUZ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$407
(Mytrip)

Popular in

August

Cheapest in

February

Average price

$401
From Panama City Tocumen Intl to Cusco Velazco Astete
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Highest demand for flights based on searches. 10% potential increase in price ($44 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama City to Cuzco

Cheapest flights from Panama City to Cuzco
Explore the most affordable flight options available from Panama City to Cuzco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Mytrip deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/22:55 amPTY - CUZ
1 stop8h 25mAvianca
Fri 11/712:25 pmCUZ - PTY
1 stop12h 15mAvianca
Deal found 9/10$407
This Priceline deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:55 amPTY - CUZ
1 stop8h 25mAvianca
Sun 11/212:25 pmCUZ - PTY
1 stop12h 35mAvianca
Deal found 9/11$412
This Avianca deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:55 amPTY - CUZ
1 stop8h 25mAvianca
Fri 10/3112:25 pmCUZ - PTY
1 stop12h 15mAvianca
Deal found 9/11$427
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/262:55 amPTY - CUZ
1 stop8h 25mAvianca
Fri 10/3112:25 pmCUZ - PTY
1 stop12h 15mAvianca
Deal found 9/10$496
This Mytrip deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/22:55 amPTY - CUZ
1 stop8h 25mMultiple Airlines
Fri 11/77:02 amCUZ - PTY
2 stops17h 38mMultiple Airlines
Deal found 9/10$568
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:55 amPTY - CUZ
1 stop8h 25mMultiple Airlines
Sun 11/28:52 pmCUZ - PTY
2 stops17h 08mMultiple Airlines
Deal found 9/11$587
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/212:05 pmPTY - CUZ
1 stop7h 50mMultiple Airlines
Wed 10/811:55 pmCUZ - PTY
1 stop10h 47mMultiple Airlines
Deal found 9/11$594
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:15 pmPTY - CUZ
1 stop9h 00mMultiple Airlines
Wed 11/510:32 pmCUZ - PTY
1 stop7h 21mMultiple Airlines
Deal found 9/9$596

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Cuzco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to Cusco that are best for you.

Fly from

Panama City

Fly to

Cuzco

Route

Depart

Return

Price

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Thu 1/22

2:55 am-11:20 am

1 stop32h 25m

Cusco Velazco Astete

Fri 1/30

12:25 pm-12:40 am

1 stop12h 15m

$412

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Sat 10/25

2:55 am-11:20 am

1 stop8h 25m

Cusco Velazco Astete

Fri 10/31

12:25 pm-12:40 am

1 stop12h 15m

$427

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Mon 10/27

5:55 pm-11:20 am

1 stop17h 25m

Cusco Velazco Astete

Fri 10/31

12:25 pm-12:40 am

1 stop12h 15m

$496

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Mon 11/3

9:45 am-11:20 am

1 stop25h 35m

Cusco Velazco Astete

Fri 11/7

12:25 pm-12:40 am

1 stop12h 15m

$547

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Sun 11/2

2:55 am-11:20 am

1 stop8h 25m

Cusco Velazco Astete

Fri 11/7

7:02 am-12:40 am

2 stops17h 38m

$568

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Sun 10/26

5:55 pm-11:20 am

1 stop17h 25m

Cusco Velazco Astete

Sun 11/2

8:52 pm-2:00 pm

2 stops17h 08m

$587

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Thu 10/2

12:05 pm-7:55 pm

1 stop7h 50m

Cusco Velazco Astete

Wed 10/8

11:55 pm-10:42 am

1 stop10h 47m

$594

Panama CityCusco

PTY - CUZ

PTYCUZ

Panama City Tocumen Intl

Sat 11/1

9:15 pm-6:15 am

1 stop9h 00m

Cusco Velazco Astete

Wed 11/5

10:32 pm-5:53 am

1 stop7h 21m

$596

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Panama City to Cuzco

Have a flexible travel schedule? Discover the best time to fly to Cuzco from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Cusco

How far ahead should I book a flight from Panama City to Cusco?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Cuzco. Price data was last updated on August 29, 2025.

Booking 67 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Cusco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Cusco?

Currently, February is the cheapest month in which you can book a flight from Panama City to Cusco (average of $789). Flying from Panama City to Cusco in December is currently the most expensive (average of $1,346). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Cuzco

Get insights into the airlines that provide service to Cuzco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cuzco. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Panama City to Cusco, such as Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Avianca
6.7
Okay
2,436 reviews

Boarding

7.0

Overall

6.7

Entertainment

5.4

Food

5.1

Crew

7.2

Comfort

6.3

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOG - LPB

no meals provided. Staff was nice. no entertainment behind seats
Avianca
6.7
Okay
2,436 reviews
Avianca
6.7
Okay
2,436 reviews

Boarding

7.0

Overall

6.7

Entertainment

5.4

Food

5.1

Crew

7.2

Comfort

6.3

Reviews

1 / 20
8.0
Excellent

Anonymous,Aug 2025

BOG - LPB

no meals provided. Staff was nice. no entertainment behind seats

Related info for your journey

Find useful and relevant information for your journey from Panama City to Cuzco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Cusco?

    Avianca can get you from Panama City to Cusco in just under 32h 25m. Your travel time can differ by up to . Airlines will cover a distance of 1642 mi.

  • What is the cheapest airline to fly from Panama City to Cusco round-trip?

    Currently priced at $358, Avianca will fly you from Panama City to Cusco and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Avianca is currently priced 11% below the average price you’ll pay for this route.

  • Can I find deals for flights from Panama City to Cuzco that include hotel bookings?

    Yes. In addition to deals on Panama City to Cuzco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Cuzco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Cuzco.

  • Can I find deals for business class flights from Panama City to Cuzco?

    Yes. Cheapflights offers flight deals from Panama City to Cuzco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Cusco?

    Currently, February is the cheapest month in which you can book a flight from Panama City to Cusco (average of $789). Flying from Panama City to Cusco in December is currently the most expensive (average of $1,346). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Cuzco

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Lima flights

Top airline flying from Panama City to Cuzco

Discover the top airline that operate flights from Panama City to Cuzco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$358Average$439FlexibilityNo cancel feeOn-time71%

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