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$304+ Cheap flights from Panama to Charleston (CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Dec 4 — Dec 111
Thu 12/4
Thu 12/11
1 adult, Economy
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Cheap flight deals from Panama to Charleston

Keep the following information in mind while searching for Panama to Charleston flight deals. Data was last updated November 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$377
(Delta)

One-way from

$304
(American Airlines)

Popular in

March

Cheapest in

August

Average price

$530
Provider with most accurate pricing for Panama City Tocumen Intl-Charleston flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Charleston flights.
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From Panama to Charleston
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One-way flight from Panama to Charleston
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Highest demand for flights based on searches. 24% potential increase in price ($174 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($43 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Panama to Charleston

Cheapest flights from Panama to Charleston
Explore the most affordable flight options available from Panama to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2025.

This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amPTY - CHS
1 stop7h 08mDelta
Thu 1/17:30 amCHS - PTY
1 stop6h 27mDelta
Deal found 11/2$377
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:53 pmPTY - CHS
1 stop9h 52mAmerican Airlines
Thu 1/18:08 pmCHS - PTY
2 stops17h 45mAmerican Airlines
Deal found 11/2$390
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:55 pmPTY - CHS
1 stop15h 52mAmerican Airlines
Sat 1/36:00 amCHS - PTY
1 stop7h 53mAmerican Airlines
Deal found 11/3$483
This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:50 pmPTY - CHS
3 stops25h 33mMultiple Airlines
Sat 1/311:05 amCHS - PTY
2 stops22h 15mMultiple Airlines
Deal found 11/3$1,965

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Panama to Charleston that are best for you.

Fly from

Panama

Fly to

Charleston

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 12/23

8:00 am-3:08 pm

1 stop7h 08m

Charleston

Thu 1/1

7:30 am-1:57 pm

1 stop6h 27m

$377

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 12/23

2:53 pm-12:45 am

1 stop9h 52m

Charleston

Thu 1/1

8:08 pm-1:53 pm

2 stops17h 45m

$390

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 2/21

4:41 pm-4:03 pm

1 stop23h 22m

Charleston

Wed 2/25

5:07 pm-7:38 pm

1 stop26h 31m

$396

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 1/21

2:27 pm-11:34 am

2 stops21h 07m

Charleston

Sun 1/25

9:27 am-3:38 pm

1 stop6h 11m

$409

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 2/21

4:04 pm-11:59 pm

1 stop7h 55m

Charleston

Wed 2/25

7:40 pm-3:14 pm

2 stops19h 34m

$471

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 12/20

4:55 pm-8:47 am

1 stop15h 52m

Charleston

Sat 1/3

6:00 am-1:53 pm

1 stop7h 53m

$483

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 12/20

4:55 pm-8:47 am

1 stop15h 52m

$304

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 12/20

7:50 pm-9:23 pm

3 stops25h 33m

$382

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Best time to book a flight from Panama to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Charleston

What is the cheapest time of day to fly from PA to CHS?

Find hourly flight availability from Panama to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2025.

One of the essential ways to save on airfare from Panama to Charleston is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 15% on airfare.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated November 4, 2025.
Read through reviews of airlines operating flights from Panama to Charleston, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,040 reviews

Crew

8.0

Food

6.4

Comfort

7.2

Overall

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.
American Airlines
7.2
Good
11,040 reviews
American Airlines
7.2
Good
11,040 reviews

Crew

8.0

Food

6.4

Comfort

7.2

Overall

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.

Related info for your journey

Find useful and relevant information for your journey from Panama to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Charleston from Panama?

    Charleston (CHS), located 10.2 mi from the city center, is the airport you fly into when you book flights from Panama to Charleston.

  • How long is the flight from Panama to Charleston?

    For as low as $377, Delta can have you in Charleston from Panama in 7h 08m. Panama and Charleston are separated by a distance of 1645 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Panama to Charleston that include hotel bookings?

    Yes. In addition to deals on Panama to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Charleston.

  • Can I find deals for business class flights from Panama to Charleston?

    Yes. Cheapflights offers flight deals from Panama to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Walterboro
Isle of Palms
Santee
Mount Pleasant
Edisto Beach

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Alternative routes for Panama to Charleston

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama to Charleston

Discover the top airline that operate flights from Panama to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$397Average$546FlexibilityNo cancel feeOn-time71%

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