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$399+ Cheap flights from Panama to Charleston (CHS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Mar 15 — Mar 221
Sun 3/15
Sun 3/22
1 adult, Economy
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Cheap flight deals from Panama to Charleston

Cheapest flights from Panama to Charleston
Explore the most affordable flight options available from Panama to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.

This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:00 am
PTY
-
CHS
1 stop11h 12m
United Airlines
Wed 6/311:03 am
CHS
-
PTY
1 stop9h 28m
United Airlines
Deal found 2/8$399
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:14 pm
PTY
-
CHS
2 stops19h 53m
American Airlines
Wed 6/36:18 pm
CHS
-
PTY
2 stops18h 56m
American Airlines
Deal found 2/8$420
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:20 pm
PTY
-
CHS
2 stops21h 35m
American Airlines
Sun 9/137:39 am
CHS
-
PTY
1 stop7h 31m
American Airlines
Deal found 2/8$432
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:14 pm
PTY
-
CHS
2 stops21h 54m
American Airlines
Tue 6/166:18 pm
CHS
-
PTY
2 stops18h 56m
American Airlines
Deal found 2/12$451

Find flight deals from Panama to Charleston

Keep the following information in mind while searching for Panama to Charleston flight deals. Data was last updated February 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$410
(United Airlines)

Popular in

March

Cheapest in

December

Average price

$435
Provider with most accurate pricing for Panama City Tocumen Intl-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Charleston flights.
Search Deals
From Panama to Charleston
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($203 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 13% potential price decrease ($65 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Panama to Charleston that are best for you.

Fly from

Panama

Fly to

Charleston

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

7:55 am-10:12 pm

1 stop13h 17m

Charleston

Tue 6/16

7:00 am-6:37 pm

1 stop12h 37m

$399

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/27

10:00 am-10:12 pm

1 stop11h 12m

Charleston

Wed 6/3

11:03 am-7:31 pm

1 stop9h 28m

$399

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 5/28

10:00 am-10:12 pm

1 stop11h 12m

Charleston

Wed 6/3

11:03 am-7:31 pm

1 stop9h 28m

$410

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/27

1:14 pm-10:07 am

2 stops19h 53m

Charleston

Wed 6/3

6:18 pm-12:14 pm

2 stops18h 56m

$420

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Best time to book a flight from Panama to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Charleston

What is the cheapest month to book a flight from Panama to Charleston?

Currently, December is the cheapest month in which you can book a flight from Panama to Charleston (average of $148). Flying from Panama to Charleston in March is currently the most expensive (average of $726). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Charleston from Panama?

    Charleston (CHS), located 10.2 mi from the city center, is the airport you fly into when you book flights from Panama to Charleston.

  • How long is the flight from Panama to Charleston?

    For as low as $399, United Airlines can have you in Charleston from Panama in 13h 17m. Panama and Charleston are separated by a distance of 1645 mi.

  • Can I find deals for flights from Panama to Charleston that include hotel bookings?

    Yes. In addition to deals on Panama to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Charleston.

  • Can I find deals for business class flights from Panama to Charleston?

    Yes. Cheapflights offers flight deals from Panama to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Charleston?

    Currently, December is the cheapest month in which you can book a flight from Panama to Charleston (average of $148). Flying from Panama to Charleston in March is currently the most expensive (average of $726). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

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