$401+ Cheap flights from Charleston (CHS) to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Sep 11 — Sep 181
Round-trip
1 adult, Economy
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Cheapest flights from Charleston to PanamaExplore the most affordable flight options available from Charleston to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 12, 2026.
Explore the most affordable flight options available from Charleston to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 12, 2026.
This Expedia deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:25 pm -
2 stops15h 05m
Sun 11/111:25 am -
3 stops22h 34m
Deal found 8/9![Multiple Airlines logo]()
$559
This Expedia deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:25 pm -
3 stops18h 30m
Sun 11/811:25 am -
3 stops22h 34m
Deal found 8/10![Multiple Airlines logo]()
$566
This Expedia deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:25 pm -
2 stops15h 05m
Sat 10/317:50 pm -
2 stops38h 09m
Deal found 8/9![Multiple Airlines logo]()
$569
This Orbitz deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:41 am -
2 stops24h 49m
Mon 10/53:50 pm -
2 stops17h 29m
Deal found 8/7![Multiple Airlines logo]()
$578
This Orbitz deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:08 am -
3 stops28h 47m
Sun 9/2711:25 am -
3 stops21h 52m
Deal found 8/9![Multiple Airlines logo]()
$591
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:05 am -
1 stop6h 54m
Mon 11/93:30 pm -
1 stop8h 29m
Deal found 8/7![Delta logo]()
$597
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
2 stops14h 31m
Mon 10/53:30 pm -
2 stops17h 57m
Deal found 8/10![United Airlines logo]()
$601
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:00 am -
1 stop7h 16m
Tue 9/291:16 pm -
1 stop7h 20m
Deal found 8/10![American Airlines logo]()
$609
This Travelocity deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:25 pm -
2 stops14h 05m
Mon 11/97:50 pm -
2 stops14h 09m
Deal found 8/10![Multiple Airlines logo]()
$611
Best flights from Charleston to PanamaDiscover carefully curated flight deals from Charleston to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 12, 2026.
Discover carefully curated flight deals from Charleston to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 12, 2026.
This Expedia deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2010:10 am -
3 stops28h 45m
Wed 1/273:50 pm -
2 stops17h 30m
Deal found 8/11![Multiple Airlines logo]()
$567
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:00 am -
1 stop13h 31m
Mon 10/53:30 pm -
2 stops21h 34m
Deal found 8/7![United Airlines logo]()
$601
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:00 am -
1 stop7h 27m
Wed 1/274:46 pm -
1 stop7h 09m
Deal found 8/11![American Airlines logo]()
$602
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:47 pm -
2 stops24h 51m
Mon 11/98:55 am -
1 stop13h 04m
Deal found 8/7![United Airlines logo]()
$601
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2011:55 am -
2 stops26h 50m
Wed 1/278:55 am -
1 stop12h 59m
Deal found 8/10![United Airlines logo]()
$601
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:51 pm -
2 stops19h 23m
Wed 9/309:45 am -
2 stops13h 30m
Deal found 8/9![United Airlines logo]()
$613
Last-minute flights from Charleston to PanamaDiscover last-minute flight deals from Charleston to Panama. Data last updated August 12, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Panama. Data last updated August 12, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:14 pm -
2 stops15h 16m
Sun 9/133:50 pm -
2 stops17h 27m
Deal found 8/10![Multiple Airlines logo]()
$608
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:00 am -
1 stop12h 37m
Thu 9/1710:00 am -
2 stops23h 37m
Deal found 8/10![United Airlines logo]()
$625
This Travelocity deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:08 am -
2 stops24h 22m
Mon 9/143:50 pm -
2 stops17h 27m
Deal found 8/7![Multiple Airlines logo]()
$616
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:00 am -
1 stop12h 37m
Mon 9/219:45 am -
1 stop13h 14m
Deal found 8/8![United Airlines logo]()
$621
This Orbitz deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:08 am -
2 stops24h 22m
Sun 9/273:50 pm -
2 stops17h 27m
Deal found 8/9![Multiple Airlines logo]()
$578
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:51 pm -
2 stops19h 23m
Wed 9/309:45 am -
2 stops13h 30m
Deal found 8/9![United Airlines logo]()
$613
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:00 am -
1 stop12h 37m
Thu 10/13:30 pm -
1 stop29h 51m
Deal found 8/10![United Airlines logo]()
$620
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:00 am -
1 stop7h 16m
Tue 9/291:16 pm -
1 stop7h 20m
Deal found 8/10![American Airlines logo]()
$609
This Expedia deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2511:08 am -
3 stops28h 47m
Tue 9/293:50 pm -
2 stops17h 27m
Deal found 8/10![Multiple Airlines logo]()
$623
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:40 am -
1 stop7h 18m
Sat 10/102:24 pm -
1 stop8h 35m
Deal found 8/10![Delta logo]()
$629
One-way flights from Charleston to PanamaSearch for one-way flight options from Charleston to Panama. Find affordable one-way fares based on user searches. Data last updated August 12, 2026.
Search for one-way flight options from Charleston to Panama. Find affordable one-way fares based on user searches. Data last updated August 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/267:59 pm -
1 stop21h 06m
Deal found 8/8![Multiple Airlines logo]()
$401
Find flight deals from Charleston to Panama
Keep the following information in mind while searching for Charleston to Panama flight deals. Data was last updated August 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $559 (Expedia) |
One-way from | $401 (Kiwi.com) |
Popular in | April |
Cheapest in | March |
Average price | $616 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Charleston to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Wed 1/20
10:10 am-2:55 pm
3 stops28h 45m
Panama City Tocumen Intl
Wed 1/27
3:50 pm-9:20 am
2 stops17h 30m
$567
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Thu 10/1
7:00 am-7:31 pm
1 stop13h 31m
Panama City Tocumen Intl
Mon 10/5
3:30 pm-2:04 pm
2 stops21h 34m
$601
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Mon 11/2
6:47 pm-7:38 pm
2 stops24h 51m
Panama City Tocumen Intl
Mon 11/9
8:55 am-9:59 pm
1 stop13h 04m
$601
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Wed 1/20
11:55 am-2:45 pm
2 stops26h 50m
Panama City Tocumen Intl
Wed 1/27
8:55 am-9:54 pm
1 stop12h 59m
$601
Quickest round-trip
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Wed 1/20
6:00 am-1:27 pm
1 stop7h 27m
Panama City Tocumen Intl
Wed 1/27
4:46 pm-11:55 pm
1 stop7h 09m
$602
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Wed 9/23
7:51 pm-2:14 pm
2 stops19h 23m
Panama City Tocumen Intl
Wed 9/30
9:45 am-12:15 am
2 stops13h 30m
$613
Cheapest one-way
Quickest one-way
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Sat 12/26
7:59 pm-5:05 pm
1 stop21h 06m
$401
Sorted by cheapest first
Best time to book a flight from Charleston to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Charleston with our price prediction graph.
CHS-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Panama
CHS-PA0
CHS-PTY
What is the cheapest month to book a flight from Charleston to Panama?
Currently, March is the cheapest month in which you can book a flight from Charleston to Panama (average of $487). Flying from Charleston to Panama in April is currently the most expensive (average of $809). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated August 12, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Charleston to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Boarding
8.1
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Boarding
8.1
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Boarding
8.1
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Charleston to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Charleston to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Charleston to Panama by cabin class
Find flights from Charleston to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Charleston and Panama flights
Browse other Charleston and Panama flight options. Last updated on August 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Charleston to Panama
Discover the top 3 airlines that operate flights from Charleston to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$363 | Average$551 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$369 | Average$615 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$390 | Average$612 | FlexibilityNo cancel fee | On-timeN/A |