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$266+ Cheap flights from Charleston (CHS) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Apr 30 — May 71
Thu 4/30
Thu 5/7
1 adult, Economy
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Cheap flight deals from Charleston to Panama

Cheapest flights from Charleston to Panama
Explore the most affordable flight options available from Charleston to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2026.

This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:50 am
CHS
-
PTY
1 stop12h 47m
United Airlines
Wed 7/110:00 am
PTY
-
CHS
1 stop11h 15m
United Airlines
Deal found 3/27$467
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:08 pm
CHS
-
PTY
2 stops24h 04m
United Airlines
Wed 5/207:55 am
PTY
-
CHS
2 stops15h 04m
United Airlines
Deal found 3/28$478
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:09 pm
CHS
-
PTY
1 stop17h 37m
American Airlines
Wed 5/201:49 pm
PTY
-
CHS
1 stop9h 35m
American Airlines
Deal found 3/28$483
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:50 am
CHS
-
PTY
1 stop8h 24m
United Airlines
Wed 7/17:55 am
PTY
-
CHS
1 stop13h 20m
United Airlines
Deal found 3/27$494
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/161:19 pm
CHS
-
PTY
2 stops15h 45m
United Airlines
Wed 5/209:45 am
PTY
-
CHS
2 stops13h 14m
United Airlines
Deal found 3/30$498
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:40 am
CHS
-
PTY
1 stop10h 32m
United Airlines
Mon 4/2710:00 am
PTY
-
CHS
1 stop10h 59m
United Airlines
Deal found 3/30$499
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:35 am
CHS
-
PTY
1 stop13h 02m
United Airlines
Sun 5/1710:55 pm
PTY
-
CHS
1 stop9h 15m
United Airlines
Deal found 3/27$501
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:04 pm
CHS
-
PTY
2 stops20h 42m
American Airlines
Sun 5/171:49 pm
PTY
-
CHS
2 stops21h 00m
American Airlines
Deal found 3/29$510
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:50 am
CHS
-
PTY
1 stop10h 22m
United Airlines
Wed 7/110:00 am
PTY
-
CHS
1 stop11h 15m
United Airlines
Deal found 3/29$511

Find flight deals from Charleston to Panama

Keep the following information in mind while searching for Charleston to Panama flight deals. Data was last updated March 31, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$467
(United Airlines)

One-way from

$266
(United Airlines)

Popular in

April

Cheapest in

September

Average price

$487
Provider with most accurate pricing for Charleston-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Panama City Tocumen Intl flights.
Search Deals
From Charleston to Panama
Search Deals
One-way flight from Charleston to Panama
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($28 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2026.
Use the filters below to find and compare flights from Charleston to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 6/18

6:50 am-6:37 pm

1 stop12h 47m

Panama City Tocumen Intl

Tue 6/30

10:55 pm-8:51 am

1 stop8h 56m

$467

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 5/11

5:08 pm-4:12 pm

2 stops24h 04m

Panama City Tocumen Intl

Wed 5/20

7:55 am-11:59 pm

2 stops15h 04m

$478
Quickest round-trip

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 9/18

7:39 am-2:10 pm

1 stop7h 31m

Panama City Tocumen Intl

Sat 9/26

3:40 pm-11:05 pm

1 stop6h 25m

$494

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 5/16

6:35 am-4:12 pm

1 stop10h 37m

Panama City Tocumen Intl

Wed 5/20

10:00 am-11:59 pm

2 stops12h 59m

$498

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 6/20

6:50 am-4:12 pm

1 stop10h 22m

Panama City Tocumen Intl

Mon 6/29

10:55 pm-9:48 pm

2 stops21h 53m

$498

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 6/6

6:00 am-7:31 pm

2 stops14h 31m

Panama City Tocumen Intl

Thu 7/2

9:45 am-10:08 am

2 stops23h 23m

$498
Cheapest one-way
Quickest one-way

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 4/5

5:12 pm-6:37 pm

1 stop26h 25m

$266

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sun 4/5

12:57 pm-12:35 am

2 stops36h 38m

$450

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/27

Sorted by cheapest first

Best time to book a flight from Charleston to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Panama

What is the cheapest month to book a flight from Charleston to Panama?

Currently, July is the cheapest month in which you can book a flight from Charleston to Panama (average of $245). Flying from Charleston to Panama in April is currently the most expensive (average of $507). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated March 31, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Charleston to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,364 reviews

Comfort

7.9

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,364 reviews
Delta
7.9
Good
8,364 reviews

Comfort

7.9

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,525 reviews
Delta
7.9
Good
8,364 reviews

Comfort

7.9

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,543 reviews
Delta
7.9
Good
8,364 reviews

Comfort

7.9

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to Panama?

    For a flight from Charleston to Panama, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to Panama?

    United Airlines and American Airlines can get you from Charleston to Panama in just under 7h 31m. Your travel time can differ by up to 5h 16m. Airlines will cover a distance of 1645 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Charleston to Panama that include hotel bookings?

    Yes. In addition to deals on Charleston to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Panama.

  • Can I find deals for business class flights from Charleston to Panama?

    Yes. Cheapflights offers flight deals from Charleston to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Panama?

    Currently, July is the cheapest month in which you can book a flight from Charleston to Panama (average of $245). Flying from Charleston to Panama in April is currently the most expensive (average of $507). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Charleston to Panama

Discover the top 3 airlines that operate flights from Charleston to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$309Average$465FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$363Average$549FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$369Average$513FlexibilityNo cancel feeOn-time69%

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