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$408+ Cheap flights from La Crosse to Charleston (LSE - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/31. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — CHS
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from La Crosse to Charleston

Cheapest flights from La Crosse to Charleston
Explore the most affordable flight options available from La Crosse to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:34 am
LSE
-
CHS
1 stop4h 10m
American Airlines
Sat 3/147:10 am
CHS
-
LSE
1 stop4h 52m
American Airlines
Deal found 1/25$430
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1411:35 am
LSE
-
CHS
2 stops10h 26m
American Airlines
Thu 3/195:25 pm
CHS
-
LSE
1 stop7h 11m
American Airlines
Deal found 1/25$493
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:00 am
LSE
-
CHS
2 stops12h 05m
American Airlines
Sat 2/147:10 am
CHS
-
LSE
1 stop4h 45m
American Airlines
Deal found 1/26$525
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:09 am
LSE
-
CHS
1 stop5h 25m
American Airlines
Sat 4/46:08 pm
CHS
-
LSE
1 stop6h 28m
American Airlines
Deal found 1/26$566
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1211:31 am
LSE
-
CHS
1 stop4h 13m
American Airlines
Mon 2/167:10 am
CHS
-
LSE
1 stop4h 51m
American Airlines
Deal found 1/25$588
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2911:35 am
LSE
-
CHS
1 stop4h 09m
American Airlines
Sat 4/46:08 pm
CHS
-
LSE
1 stop6h 28m
American Airlines
Deal found 1/26$606

Find flight deals from La Crosse to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$430
(American Airlines)

One-way from

$408
(American Airlines)
Provider with most accurate pricing for La Crosse-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for La Crosse-Charleston flights.
Search Deals
From La Crosse to Charleston
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One-way flight from La Crosse to Charleston
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from La Crosse to Charleston that are best for you.

Fly from

La Crosse

Fly to

Charleston

Route

Depart

Return

Price

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Wed 3/11

11:34 am-8:46 pm

2 stops8h 12m

Charleston

Sat 3/14

7:10 am-11:02 am

1 stop4h 52m

$436

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Sat 3/14

11:35 am-11:01 pm

2 stops10h 26m

Charleston

Thu 3/19

5:25 pm-11:36 pm

1 stop7h 11m

$493

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Thu 2/12

11:31 am-4:44 pm

1 stop4h 13m

Charleston

Mon 2/16

7:10 am-11:01 am

1 stop4h 51m

$588

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Wed 2/11

6:00 am-11:33 am

1 stop4h 33m

Charleston

Sun 2/15

5:26 pm-11:36 pm

1 stop7h 10m

$621

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Tue 3/31

9:48 am-9:22 pm

2 stops10h 34m

$414

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Mon 3/30

5:09 am-11:34 am

1 stop5h 25m

$442

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Sun 3/29

11:35 am-4:44 pm

1 stop4h 09m

$482

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Sat 3/28

5:09 am-2:14 pm

2 stops8h 05m

$516

La CrosseCharleston

LSE - CHS

LSECHS

La Crosse

Fri 3/27

11:35 am-11:23 pm

1 stop10h 48m

$621

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

  • Most accurate provider: When it comes to deals on La Crosse-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on La Crosse-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from La Crosse to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to Charleston

What is the cheapest month to book a flight from La Crosse to Charleston?

Currently, July is the cheapest month in which you can book a flight from La Crosse to Charleston (average of $231). Flying from La Crosse to Charleston in December is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from La Crosse to Charleston?

    American Airlines can get you from La Crosse to Charleston in just under 8h 12m. Your travel time can differ by up to . The distance from La Crosse to Charleston is about 970 mi.

  • Can I find deals for flights from La Crosse to Charleston that include hotel bookings?

    Yes. In addition to deals on La Crosse to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Charleston.

  • Can I find deals for business class flights from La Crosse to Charleston?

    Yes. Cheapflights offers flight deals from La Crosse to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to Charleston?

    Currently, July is the cheapest month in which you can book a flight from La Crosse to Charleston (average of $231). Flying from La Crosse to Charleston in December is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

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