$88+ Cheap flights from St. Louis to Charleston (STL - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/2. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Mar 5 — Mar 121
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Charleston are usually found in August or November, booked 49 days in advance, depart on a Monday or Saturday and return on a Thursday
Cheap flight deals from St. Louis to Charleston
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to CharlestonExplore the most affordable flight options available from St. Louis to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from St. Louis to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Thu 3/55:00 pm
CHS
- STL
2 stops19h 49m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:36 pm
STL
- CHS
1 stop19h 02m
Multiple Airlines
Tue 3/35:00 pm
CHS
- STL
2 stops30h 27m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:51 pm
STL
- CHS
1 stop14h 47m
Multiple Airlines
Sun 3/158:07 am
CHS
- STL
2 stops30h 27m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:21 pm
STL
- CHS
1 stop14h 17m
Multiple Airlines
Tue 3/103:01 pm
CHS
- STL
1 stop9h 18m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Thu 5/72:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 2/2![Southwest logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/43:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Wed 3/2512:04 pm
CHS
- STL
2 stops23h 27m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/54:55 pm
STL
- CHS
1 stop15h 43m
Multiple Airlines
Thu 5/73:35 pm
CHS
- STL
2 stops16h 15m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:00 am
STL
- CHS
1 stop6h 05m
United Airlines
Sat 3/144:55 pm
CHS
- STL
1 stop5h 47m
United Airlines
Deal found 2/1![United Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:13 pm
STL
- CHS
2 stops25h 28m
Multiple Airlines
Tue 4/213:01 pm
CHS
- STL
1 stop9h 18m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$292
Best flights from St. Louis to CharlestonDiscover carefully curated flight deals from St. Louis to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from St. Louis to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Thu 3/55:00 pm
CHS
- STL
2 stops19h 49m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$182
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Thu 5/72:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 2/2![Southwest logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:22 pm
STL
- CHS
2 stops20h 18m
Multiple Airlines
Tue 3/33:01 pm
CHS
- STL
1 stop8h 26m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/47:35 am
STL
- CHS
1 stop3h 25m
Southwest
Sat 4/114:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 2/2![Southwest logo]()
$305
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/191:15 pm
STL
- CHS
1 stop4h 00m
Southwest
Tue 4/211:15 pm
CHS
- STL
1 stop5h 40m
Southwest
Deal found 2/2![Southwest logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:51 pm
STL
- CHS
2 stops22h 14m
Multiple Airlines
Thu 3/263:01 pm
CHS
- STL
1 stop17h 01m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$336
Last-minute flights from St. Louis to CharlestonDiscover last-minute flight deals from St. Louis to Charleston. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Charleston. Data last updated February 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:22 pm
STL
- CHS
2 stops20h 18m
Multiple Airlines
Tue 3/33:01 pm
CHS
- STL
1 stop8h 26m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:36 pm
STL
- CHS
1 stop19h 02m
Multiple Airlines
Tue 3/35:00 pm
CHS
- STL
2 stops30h 27m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:36 pm
STL
- CHS
2 stops26h 29m
Multiple Airlines
Mon 3/23:21 pm
CHS
- STL
1 stop9h 38m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Thu 3/55:00 pm
CHS
- STL
2 stops19h 49m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/43:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Wed 3/2512:04 pm
CHS
- STL
2 stops23h 27m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:21 pm
STL
- CHS
1 stop14h 17m
Multiple Airlines
Tue 3/103:01 pm
CHS
- STL
1 stop9h 18m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:51 pm
STL
- CHS
1 stop14h 47m
Multiple Airlines
Sun 3/158:07 am
CHS
- STL
2 stops30h 27m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$230
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:00 am
STL
- CHS
1 stop6h 05m
United Airlines
Sat 3/144:55 pm
CHS
- STL
1 stop5h 47m
United Airlines
Deal found 2/1![United Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/114:51 pm
STL
- CHS
1 stop14h 47m
Multiple Airlines
Sun 3/158:07 am
CHS
- STL
2 stops30h 27m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$313
One-way flights from St. Louis to CharlestonSearch for one-way flight options from St. Louis to Charleston. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from St. Louis to Charleston. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:49 pm
STL
- CHS
2 stops23h 16m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/288:17 pm
STL
- CHS
2 stops42h 48m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:22 pm
STL
- CHS
2 stops20h 18m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/168:22 pm
STL
- CHS
2 stops18h 33m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/48:17 pm
STL
- CHS
2 stops20h 23m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$109
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2810:43 am
STL
- CHS
1 stop5h 55m
American Airlines
Deal found 2/1![American Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:49 pm
STL
- CHS
2 stops24h 51m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$117
Find flight deals from St. Louis to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $182 (Kiwi.com) |
One-way from | $88 (Kiwi.com) |
Popular in | March |
Cheapest in | August |
Average price | $383 |
Good round-trip deal | $360 or less |
Good one-way deal | $216 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from St. Louis to Charleston that are best for you.
Fly from
St. Louis
Fly to
Charleston
Route
Depart
Return
Price
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 3/2
3:49 pm-8:38 am
1 stop15h 49m
Charleston
Thu 3/5
5:00 pm-11:49 am
2 stops19h 49m
$182
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/5
12:05 pm-3:00 pm
Nonstop1h 55m
Charleston
Thu 5/7
2:15 pm-3:30 pm
Nonstop2h 15m
$276
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 2/27
8:22 pm-5:40 pm
2 stops20h 18m
Charleston
Tue 3/3
3:01 pm-10:27 pm
1 stop8h 26m
$298
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sat 4/4
7:35 am-12:00 pm
1 stop3h 25m
Charleston
Sat 4/11
4:40 pm-6:00 pm
Nonstop2h 20m
$305
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sun 4/19
1:15 pm-6:15 pm
1 stop4h 00m
Charleston
Tue 4/21
1:15 pm-5:55 pm
1 stop5h 40m
$314
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 3/10
4:51 pm-4:05 pm
2 stops22h 14m
Charleston
Thu 3/26
3:01 pm-7:02 am
1 stop17h 01m
$336
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 3/2
8:22 pm-4:05 pm
2 stops18h 43m
$95
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 3/31
11:27 am-10:13 pm
2 stops9h 46m
$106
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 2/27
8:22 pm-5:40 pm
2 stops20h 18m
$106
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 3/3
3:49 pm-4:05 pm
3 stops23h 16m
$110
Showing 1-10 of 17 results
Compare providers for flights from St. Louis to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Charleston in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from St. Louis with our price prediction graph.
STL-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Charleston
Prices
More
How far ahead should I book a flight from St. Louis to Charleston?
Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Charleston. Price data was last updated on January 30, 2026.
The price you pay for your flight from St. Louis to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 49 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from St. Louis to Charleston?
Currently, February is the cheapest month in which you can book a flight from St. Louis to Charleston (average of $84). Flying from St. Louis to Charleston in January is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What’s the top layover airport for flights from St. Louis to Charleston?
Share of 1-stop round-trip flights from St. Louis to Charleston chosen by Cheapflights users in the past 12 months, using the same layover each way.
Chicago (ORD) – chosen by Cheapflights users on 33% of 1-stop itineraries from St. Louis to Charleston on Cheapflights.
What’s the cheapest layover airport for flights from St. Louis to Charleston?
Average round-trip fare for 1-stop flights from St. Louis to Charleston, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $326.
What’s the fastest layover option from St. Louis to Charleston?
Shortest average travel time for 1-stop one-way flights from St. Louis to Charleston, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Charlotte (CLT) have the shortest average one-way travel time for 1-stop routes: 3h 42m.
Which airport typically offers the quickest layover for flights from St. Louis to Charleston?
Average layover duration for 1-stop one-way flights from St. Louis to Charleston, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 0h 55m.
The best insider tips for St. Louis to Charleston flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your St. Louis to Charleston trip
Our travel experts
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated February 3, 2026.
Read through reviews of airlines operating flights from St. Louis to Charleston, such as Southwest, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Charleston flight routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from St. Louis
Popular flights
Alternative routes for St. Louis to Charleston
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Charleston by cabin class
Find flights from St. Louis to Charleston, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Charleston flights
Browse other St. Louis and Charleston flight options. Last updated on February 3, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from St. Louis to Charleston
Discover the top 3 airlines that operate flights from St. Louis to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$206 | Average$370 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$246 | Average$378 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$286 | Average$404 | FlexibilityNo cancel fee | On-time63% |