HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$100+ Cheap flights from South Carolina to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Buffalo

Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$181
(JetBlue)

One-way from

$100
(American Airlines)

Popular in

February

Cheapest in

September

Average price

$383
Provider with most accurate pricing for Myrtle Beach Intl-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Buffalo flights.
Search Deals
From South Carolina to Buffalo
Search Deals
One-way flight from South Carolina to Buffalo
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals

Find flight deals from South Carolina to Buffalo

Cheapest flights from South Carolina to Buffalo
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This JetBlue deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1010:39 amCHS - BUF
1 stop8h 23mJetBlue
Wed 6/1110:33 amBUF - CHS
1 stop7h 42mJetBlue
Deal found 4/29$181
This CheapOair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/164:21 pmCLT - BUF
1 stop18h 27mFrontier
Sat 5/174:59 pmBUF - CLT
1 stop23h 40mFrontier
Deal found 4/30$190
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:45 pmCAE - BUF
1 stop3h 29mAmerican Airlines
Sun 5/255:15 amBUF - CAE
1 stop4h 45mAmerican Airlines
Deal found 4/30$199
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:24 pmSAV - BUF
1 stop3h 50mAmerican Airlines
Sat 5/317:11 pmBUF - SAV
1 stop4h 45mAmerican Airlines
Deal found 4/30$201
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/297:40 amCHS - BUF
1 stop5h 03mAmerican Airlines
Mon 6/26:10 amBUF - CHS
1 stop4h 35mAmerican Airlines
Deal found 4/28$218
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/225:30 amCHS - BUF
1 stop6h 35mSouthwest
Sun 8/245:45 amBUF - CHS
1 stop4h 05mSouthwest
Deal found 4/29$237
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/226:24 pmCHS - BUF
1 stop5h 31mDelta
Sun 5/252:10 pmBUF - CHS
1 stop7h 00mDelta
Deal found 4/30$252
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/44:43 pmCLT - BUF
Nonstop1h 47mAmerican Airlines
Sat 7/196:20 amBUF - CLT
Nonstop1h 57mAmerican Airlines
Deal found 4/30$253
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:35 pmGSP - BUF
1 stop3h 39mAmerican Airlines
Wed 5/286:01 amBUF - GSP
1 stop5h 14mAmerican Airlines
Deal found 5/1$257
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/56:00 amMYR - BUF
1 stop5h 00mDelta
Mon 6/96:00 amBUF - MYR
1 stop6h 29mDelta
Deal found 4/30$257
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:15 amGSP - BUF
1 stop4h 51mDelta
Tue 8/194:43 pmBUF - GSP
1 stop4h 48mDelta
Deal found 4/30$267
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/117:30 pmCLT - BUF
1 stop4h 50mSouthwest
Sat 6/145:25 pmBUF - CLT
1 stop3h 55mSouthwest
Deal found 4/30$273

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.

Fly from

South Carolina

Fly to

Buffalo

Route

Depart

Return

Price

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Tue 6/10

10:39 am-7:02 pm

1 stop8h 23m

Buffalo

Wed 6/11

10:33 am-6:15 pm

1 stop7h 42m

$181

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Fri 5/16

4:21 pm-10:48 am

1 stop18h 27m

Buffalo

Sat 5/17

4:59 pm-4:39 pm

1 stop23h 40m

$190

ColumbiaBuffalo

CAE - BUF

CAEBUF

Columbia Metropolitan

Sat 5/24

8:45 pm-12:14 am

1 stop3h 29m

Buffalo

Sun 5/25

5:15 am-10:00 am

1 stop4h 45m

$199

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Sat 5/24

8:24 pm-12:14 am

1 stop3h 50m

Buffalo

Sat 5/31

7:11 pm-11:56 pm

1 stop4h 45m

$201

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 5/29

7:40 am-12:43 pm

1 stop5h 03m

Buffalo

Mon 6/2

6:10 am-10:45 am

1 stop4h 35m

$218

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Tue 6/10

11:55 am-4:05 pm

1 stop4h 10m

Buffalo

Wed 6/11

2:05 pm-10:45 pm

2 stops8h 40m

$242

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 5/22

6:24 pm-11:55 pm

1 stop5h 31m

Buffalo

Sun 5/25

2:10 pm-9:10 pm

1 stop7h 00m

$252

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Fri 7/4

4:43 pm-6:30 pm

Nonstop1h 47m

Buffalo

Sat 7/12

6:20 am-8:17 am

Nonstop1h 57m

$253

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Thu 6/5

6:00 am-11:00 am

1 stop5h 00m

Buffalo

Mon 6/9

6:00 am-12:29 pm

1 stop6h 29m

$257

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Sat 5/24

8:35 pm-12:14 am

1 stop3h 39m

Buffalo

Wed 5/28

6:01 am-11:15 am

1 stop5h 14m

$257

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/1

Showing 1-10 of 52 results
1
2
3
...
6

Best time to book a flight from South Carolina to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Buffalo

What is the cheapest month to book a flight from South Carolina to Buffalo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to BUF?

Find hourly flight availability from South Carolina to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Buffalo as you normally would.

Rainfall in Buffalo by month

Plan your trip to Buffalo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

Temperature in Buffalo by month

Plan your trip to Buffalo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated May 1, 2025.
To help decide which airline to fly from South Carolina to Buffalo, see what other customers have to say about Southwest, Delta and United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,294 reviews

Food

7.1

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,294 reviews
Southwest
8.0
Very good
4,294 reviews

Food

7.1

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,934 reviews
Southwest
8.0
Very good
4,294 reviews

Food

7.1

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,294 reviews

Food

7.1

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
JetBlue
7.3
Good
2,924 reviews
Southwest
8.0
Very good
4,294 reviews

Food

7.1

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,294 reviews

Food

7.1

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from South Carolina?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from South Carolina. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • What are the cheapest airlines to fly from South Carolina to Buffalo one-way?

    $100 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on JetBlue and Frontier, with prices starting from $102 and $106, respectively.

  • What are the most popular routes from South Carolina to Buffalo?

    The most popular flight routes from South Carolina to Buffalo are Charlotte Douglas - Buffalo, Greenville - Buffalo and Charleston - Buffalo.

  • Can I find deals for flights from South Carolina to Buffalo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Buffalo.

  • Can I find deals for business class flights from South Carolina to Buffalo?

    Yes. Cheapflights offers flight deals from South Carolina to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Williamsville
Amherst
West Seneca
Batavia
Orchard Park
Cheektowaga

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to John F Kennedy Intl flights
Dallas/Fort Worth to LaGuardia flights
San Francisco to John F Kennedy Intl flights
Los Angeles to Newark flights
Dallas/Fort Worth to John F Kennedy Intl flights
O'Hare Intl to LaGuardia flights
Dallas/Fort Worth to Newark flights
Los Angeles to LaGuardia flights
San Francisco to Newark flights
Seattle to John F Kennedy Intl flights
Atlanta to LaGuardia flights
O'Hare Intl to John F Kennedy Intl flights
Ontario to John F Kennedy Intl flights
Hobby to John F Kennedy Intl flights
Seattle to Newark flights
Hobby to LaGuardia flights
Atlanta to Newark flights
Miami to John F Kennedy Intl flights
Fort Lauderdale to Newark flights
Atlanta to John F Kennedy Intl flights
Fort Lauderdale to LaGuardia flights
Miami to LaGuardia flights
O'Hare Intl to Newark flights
San Francisco to LaGuardia flights
Miami to Newark flights
Tampa to Newark flights
Orlando to Newark flights
Orlando to LaGuardia flights
Burbank to Newark flights
Fort Lauderdale to John F Kennedy Intl flights
Santa Ana to Newark flights
George Bush Intcntl to John F Kennedy Intl flights
Hobby to Newark flights
Sky Harbor Intl to John F Kennedy Intl flights
Orlando to John F Kennedy Intl flights
Midway to Newark flights
Seattle to LaGuardia flights
Austin to Newark flights
Love Field to LaGuardia flights
George Bush Intcntl to Newark flights
Midway to John F Kennedy Intl flights
Tampa to John F Kennedy Intl flights
San Diego to John F Kennedy Intl flights
Denver to LaGuardia flights
Ontario to Newark flights
George Bush Intcntl to LaGuardia flights
Denver to Newark flights
Denver to John F Kennedy Intl flights
San Diego to Newark flights
West Palm Beach to John F Kennedy Intl flights

Top 5 airlines flying from South Carolina to Buffalo

Discover the top 5 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$197Average$348FlexibilityNo cancel feeOn-time71%
DeltaCheapest$201Average$305FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$201Average$264FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$202Average$370FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$233Average$371FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.