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$72+ Cheap flights from South Carolina to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from South Carolina to Buffalo

Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated September 16, 2025.

Round-trip from

$144
(CheapOair)

One-way from

$72
(Frontier)

Popular in

May

Cheapest in

September

Average price

$300
From South Carolina to Buffalo
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One-way flight from South Carolina to Buffalo
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Highest demand for flights based on searches. 12% potential increase in price ($55 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from South Carolina to Buffalo

Cheapest flights from South Carolina to Buffalo
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This CheapOair deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/38:51 pmCLT - BUF
1 stop21h 23mFrontier
Sun 10/57:41 pmBUF - CLT
1 stop12h 14mFrontier
Deal found 9/14$144
This CheapOair deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/172:14 pmCLT - BUF
1 stop6h 04mFrontier
Sun 10/199:13 pmBUF - CLT
1 stop10h 47mFrontier
Deal found 9/14$152
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:10 amCHS - BUF
1 stop7h 54mJetBlue
Wed 10/297:00 amBUF - CHS
1 stop6h 19mJetBlue
Deal found 9/14$161
This Trip.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:59 pmCLT - BUF
1 stop23h 05mFrontier
Mon 11/39:53 pmBUF - CLT
1 stop15h 39mFrontier
Deal found 9/14$168
This CheapOair deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2012:04 pmCLT - BUF
1 stop8h 14mFrontier
Fri 10/249:13 pmBUF - CLT
1 stop15h 31mFrontier
Deal found 9/14$169
This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:18 pmCLT - BUF
1 stop21h 50mFrontier
Mon 11/39:53 pmBUF - CLT
1 stop15h 39mFrontier
Deal found 9/15$177
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:15 amCHS - BUF
1 stop5h 04mJetBlue
Tue 11/187:00 amBUF - CHS
1 stop6h 19mJetBlue
Deal found 9/15$181
This CheapOair deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/235:34 pmCLT - BUF
1 stop22h 55mFrontier
Sun 10/266:51 pmBUF - CLT
1 stop14h 24mFrontier
Deal found 9/14$193
This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/29:20 pmCLT - BUF
1 stop14h 24mFrontier
Mon 11/39:53 pmBUF - CLT
1 stop15h 39mFrontier
Deal found 9/15$194
This CheapOair deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/202:01 pmCLT - BUF
1 stop27h 26mFrontier
Sun 9/217:41 pmBUF - CLT
1 stop12h 14mFrontier
Deal found 9/14$196
This Priceline deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3011:10 amCHS - BUF
1 stop7h 54mJetBlue
Sat 10/49:33 amBUF - CHS
1 stop10h 02mJetBlue
Deal found 9/15$198
This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/811:10 amCHS - BUF
1 stop7h 54mJetBlue
Sun 10/126:00 amBUF - CHS
1 stop4h 25mJetBlue
Deal found 9/13$199

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.

Fly from

South Carolina

Fly to

Buffalo

Route

Depart

Return

Price

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 11/13

6:15 am-11:19 am

1 stop5h 04m

Buffalo

Tue 11/18

7:00 am-1:19 pm

1 stop6h 19m

$181

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Thu 10/23

5:34 pm-4:29 pm

1 stop22h 55m

Buffalo

Sun 10/26

6:51 pm-9:15 am

1 stop14h 24m

$193

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Fri 11/7

12:18 pm-10:08 am

1 stop21h 50m

Buffalo

Thu 11/13

2:42 pm-11:28 am

2 stops20h 46m

$200

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 11/20

12:06 pm-6:46 pm

1 stop6h 40m

Buffalo

Mon 11/24

11:55 am-6:40 pm

1 stop6h 45m

$205

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 11/20

7:42 pm-11:44 pm

1 stop4h 02m

Buffalo

Mon 11/24

5:43 pm-11:10 pm

2 stops5h 27m

$233

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Fri 12/19

3:25 pm-8:00 pm

1 stop4h 35m

Buffalo

Mon 12/22

6:05 pm-10:20 pm

1 stop4h 15m

$233

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Wed 10/1

11:16 am-5:51 pm

1 stop6h 35m

Buffalo

Sun 10/5

7:00 am-3:14 pm

1 stop8h 14m

$235

ColumbiaBuffalo

CAE - BUF

CAEBUF

Columbia Metropolitan

Sat 10/25

5:32 pm-11:39 pm

1 stop6h 07m

Buffalo

Mon 10/27

2:35 pm-9:20 pm

1 stop6h 45m

$249

ColumbiaBuffalo

CAE - BUF

CAEBUF

Columbia Metropolitan

Tue 10/21

10:52 am-3:31 pm

1 stop4h 39m

Buffalo

Wed 10/29

5:33 pm-11:46 pm

1 stop6h 13m

$249

ColumbiaBuffalo

CAE - BUF

CAEBUF

Columbia Metropolitan

Wed 2/18

7:00 am-11:16 am

1 stop4h 16m

Buffalo

Sat 2/21

2:00 pm-6:58 pm

1 stop4h 58m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Buffalo

What is the cheapest month to book a flight from South Carolina to Buffalo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to BUF?

Find hourly flight availability from South Carolina to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Buffalo as you normally would.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from South Carolina?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from South Carolina. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • How long is the flight from South Carolina to Buffalo?

    Departing from South Carolina to Buffalo will take you 4h 02m. The distance from South Carolina to Buffalo is about 697 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Buffalo one-way?

    $72 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Southwest and JetBlue, with prices starting from $87 and $101, respectively.

  • What are the most popular routes from South Carolina to Buffalo?

    The most popular flight routes from South Carolina to Buffalo are Charlotte Douglas - Buffalo, Charleston - Buffalo and Myrtle Beach Intl - Buffalo.

  • Can I find deals for flights from South Carolina to Buffalo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Buffalo.

  • Can I find deals for business class flights from South Carolina to Buffalo?

    Yes. Cheapflights offers flight deals from South Carolina to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from South Carolina to Buffalo

Discover the top 5 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$135Average$211FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$195Average$336FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$198Average$281FlexibilityNo cancel feeOn-time69%
DeltaCheapest$212Average$302FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$241Average$375FlexibilityNo cancel feeOn-time63%

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