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$74+ Cheap flights from South Carolina to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
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Cheap flight deals from South Carolina to Buffalo

Cheapest flights from South Carolina to Buffalo
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/510:46 pm
CLT
-
BUF
1 stop12h 03m
Frontier
Sun 3/158:42 pm
BUF
-
CLT
1 stop12h 34m
Frontier
Deal found 2/3$165
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
CLT
-
BUF
1 stop5h 05m
Delta
Tue 3/37:00 am
BUF
-
CLT
1 stop6h 30m
Delta
Deal found 2/3$179
This JetBlue deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2711:52 am
CHS
-
BUF
1 stop6h 43m
JetBlue
Mon 3/26:00 am
BUF
-
CHS
1 stop4h 57m
JetBlue
Deal found 2/2$189
This JetBlue deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:20 am
SAV
-
BUF
1 stop7h 24m
JetBlue
Tue 6/912:25 pm
BUF
-
SAV
1 stop6h 36m
JetBlue
Deal found 2/2$189
This JetBlue deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:10 am
SAV
-
BUF
1 stop6h 24m
JetBlue
Mon 6/812:25 pm
BUF
-
SAV
1 stop6h 36m
JetBlue
Deal found 2/2$194
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:25 am
SAV
-
BUF
1 stop4h 33m
American Airlines
Tue 3/246:39 pm
BUF
-
SAV
1 stop4h 15m
American Airlines
Deal found 2/3$196
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:00 am
CHS
-
BUF
1 stop5h 06m
Delta
Tue 4/2812:50 pm
BUF
-
CHS
1 stop5h 14m
Delta
Deal found 2/2$197
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:59 pm
SAV
-
BUF
1 stop4h 00m
Delta
Wed 6/104:30 pm
BUF
-
SAV
1 stop4h 21m
Delta
Deal found 2/2$197
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:58 pm
CHS
-
BUF
1 stop4h 15m
Delta
Mon 4/67:48 pm
BUF
-
CHS
1 stop4h 28m
Delta
Deal found 2/2$201
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:30 am
SAV
-
BUF
2 stops7h 55m
American Airlines
Sat 3/77:02 pm
BUF
-
SAV
1 stop4h 56m
American Airlines
Deal found 2/3$202
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:20 pm
SAV
-
BUF
1 stop4h 24m
United Airlines
Sun 3/16:07 am
BUF
-
SAV
1 stop4h 41m
United Airlines
Deal found 2/1$203
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/259:09 am
MYR
-
BUF
2 stops27h 45m
Multiple Airlines
Mon 3/211:37 am
BUF
-
MYR
1 stop24h 07m
Multiple Airlines
Deal found 2/1$204

Find flight deals from South Carolina to Buffalo

Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$165
(Kiwi.com)

One-way from

$74
(Frontier)

Popular in

December

Cheapest in

September

Average price

$441
Provider with most accurate pricing for Myrtle Beach Intl-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Buffalo flights.
Search Deals
From South Carolina to Buffalo
Search Deals
One-way flight from South Carolina to Buffalo
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($7 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.

Fly from

South Carolina

Fly to

Buffalo

Route

Depart

Return

Price

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Fri 2/27

11:52 am-6:35 pm

1 stop6h 43m

Buffalo

Mon 3/2

6:00 am-10:57 am

1 stop4h 57m

$189

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Wed 3/4

11:47 am-6:46 pm

1 stop6h 59m

Buffalo

Sun 3/8

6:00 am-10:58 am

1 stop4h 58m

$189

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Tue 3/17

6:25 am-10:58 am

1 stop4h 33m

Buffalo

Tue 3/24

6:39 pm-10:54 pm

1 stop4h 15m

$196

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Wed 4/29

7:05 am-1:54 pm

1 stop6h 49m

Buffalo

Sun 5/3

6:00 am-10:09 am

1 stop4h 09m

$197

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Wed 4/22

10:55 am-3:53 pm

1 stop4h 58m

Buffalo

Sat 4/25

6:00 am-11:20 am

1 stop5h 20m

$197

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Wed 4/1

6:45 pm-11:28 pm

1 stop4h 43m

Buffalo

Sun 4/5

7:40 pm-11:55 pm

1 stop4h 15m

$197

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Wed 6/10

6:30 pm-11:03 pm

1 stop4h 33m

Buffalo

Tue 6/16

3:50 pm-10:04 pm

1 stop6h 14m

$197

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 2/26

11:48 am-6:35 pm

1 stop6h 47m

Buffalo

Sun 3/1

6:00 am-10:58 am

1 stop4h 58m

$197

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Wed 3/4

7:30 am-12:51 pm

1 stop5h 21m

Buffalo

Sat 3/7

7:51 pm-11:58 pm

1 stop4h 07m

$197

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 4/23

6:00 am-11:06 am

1 stop5h 06m

Buffalo

Mon 4/27

6:00 am-10:46 am

1 stop4h 46m

$197

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Buffalo

What is the cheapest month to book a flight from South Carolina to Buffalo?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $79). Flying from South Carolina to Buffalo in August is currently the most expensive (average of $203). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to BUF?

Find hourly flight availability from South Carolina to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.

Unlike in the evening, when flights are generally more expensive, you can save up to 38% on flights from South Carolina to Buffalo by exploring options for tickets in the morning.

What is the cheapest day to fly from South Carolina to Buffalo?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Buffalo. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their South Carolina to Buffalo flight should consider departing on Wednesday at noon when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from South Carolina?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from South Carolina. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • How long is the flight from South Carolina to Buffalo?

    Departing from South Carolina to Buffalo will take you 5h 21m. The distance from South Carolina to Buffalo is about 759 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to Buffalo one-way?

    $87 is the cheapest one-way deal found within the past few days, from Southwest. You may also be able to find cheap deals on American Airlines and JetBlue, with prices starting from $99 and $100, respectively.

  • What are the most popular routes from South Carolina to Buffalo?

    The most popular flight routes from South Carolina to Buffalo are Charlotte Douglas - Buffalo, Charleston - Buffalo and Columbia Metropolitan - Buffalo.

  • Can I find deals for flights from South Carolina to Buffalo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Buffalo.

  • Can I find deals for business class flights from South Carolina to Buffalo?

    Yes. Cheapflights offers flight deals from South Carolina to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Buffalo?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $79). Flying from South Carolina to Buffalo in August is currently the most expensive (average of $203). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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Alternative routes for South Carolina to Buffalo

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Top 5 airlines flying from South Carolina to Buffalo

Discover the top 5 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$80Average$211FlexibilityNo cancel feeOn-time62%
DeltaCheapest$100Average$303FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$179Average$313FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$195Average$331FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$236Average$353FlexibilityNo cancel feeOn-time63%

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