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$86+ Cheap flights from South Carolina to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BUF
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from South Carolina to Buffalo

Keep the following information in mind while searching for South Carolina to Buffalo flight deals. Data was last updated July 30, 2025.

Round-trip from

$181
(JetBlue)

One-way from

$86
(Priceline)

Popular in

February

Cheapest in

September

Average price

$356
From South Carolina to Buffalo
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One-way flight from South Carolina to Buffalo
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Highest demand for flights based on searches. 0% potential increase in price ($3 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from South Carolina to Buffalo

Cheapest flights from South Carolina to Buffalo
Explore the most affordable flight options available from South Carolina to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This JetBlue deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2611:00 amCHS - BUF
1 stop8h 02mJetBlue
Tue 9/29:45 amBUF - CHS
1 stop8h 19mJetBlue
Deal found 7/29$181
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/216:00 amCHS - BUF
1 stop5h 04mAmerican Airlines
Sat 8/301:46 pmBUF - CHS
1 stop5h 19mAmerican Airlines
Deal found 7/27$218
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/277:39 amSAV - BUF
1 stop3h 47mAmerican Airlines
Sun 8/311:46 pmBUF - SAV
1 stop6h 06mAmerican Airlines
Deal found 7/30$218
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/226:38 pmCHS - BUF
1 stop4h 21mDelta
Sun 8/316:20 amBUF - CHS
1 stop4h 15mDelta
Deal found 7/27$227
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/277:35 amGSP - BUF
1 stop6h 29mAmerican Airlines
Wed 9/32:35 pmBUF - GSP
1 stop4h 39mAmerican Airlines
Deal found 7/30$236
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/96:56 pmMYR - BUF
1 stop5h 01mDelta
Sat 9/206:03 amBUF - MYR
1 stop5h 33mDelta
Deal found 7/28$237
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/38:06 amMYR - BUF
1 stop4h 04mAmerican Airlines
Tue 9/92:35 pmBUF - MYR
2 stops6h 34mAmerican Airlines
Deal found 7/28$242
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/710:49 amCAE - BUF
1 stop4h 42mAmerican Airlines
Tue 10/146:00 amBUF - CAE
1 stop4h 24mAmerican Airlines
Deal found 7/30$249
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2710:23 amCLT - BUF
Nonstop1h 41mAmerican Airlines
Tue 9/22:44 pmBUF - CLT
Nonstop1h 53mAmerican Airlines
Deal found 7/28$253
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/207:40 amCLT - BUF
1 stop4h 20mSouthwest
Sat 8/236:10 amBUF - CLT
1 stop3h 40mSouthwest
Deal found 7/28$258
This CheapOair deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/27:03 pmCLT - BUF
1 stop13h 49mFrontier
Sat 8/99:37 pmBUF - CLT
1 stop14h 05mFrontier
Deal found 7/30$259
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/169:20 amSAV - BUF
2 stops8h 35mSouthwest
Fri 9/1912:25 pmBUF - SAV
1 stop5h 40mSouthwest
Deal found 7/29$259

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.

Fly from

South Carolina

Fly to

Buffalo

Route

Depart

Return

Price

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Tue 8/26

11:00 am-7:02 pm

1 stop8h 02m

Buffalo

Tue 9/2

9:45 am-6:04 pm

1 stop8h 19m

$181

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 8/21

6:00 am-11:04 am

1 stop5h 04m

Buffalo

Sat 8/30

1:46 pm-7:05 pm

1 stop5h 19m

$218

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Wed 8/27

7:39 am-11:26 am

1 stop3h 47m

Buffalo

Sun 8/31

1:46 pm-7:52 pm

1 stop6h 06m

$218

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Fri 8/22

6:38 pm-10:59 pm

1 stop4h 21m

Buffalo

Sun 8/31

6:20 am-10:35 am

1 stop4h 15m

$227

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Wed 8/27

7:35 am-2:04 pm

1 stop6h 29m

Buffalo

Wed 9/3

2:35 pm-7:14 pm

1 stop4h 39m

$236

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Tue 9/9

6:56 pm-11:57 pm

1 stop5h 01m

Buffalo

Sat 9/20

6:03 am-11:36 am

1 stop5h 33m

$237

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Wed 9/3

8:06 am-12:10 pm

1 stop4h 04m

Buffalo

Tue 9/9

2:35 pm-9:09 pm

2 stops6h 34m

$242

ColumbiaBuffalo

CAE - BUF

CAEBUF

Columbia Metropolitan

Tue 10/7

10:49 am-3:31 pm

1 stop4h 42m

Buffalo

Tue 10/14

6:00 am-10:24 am

1 stop4h 24m

$249

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Wed 8/27

10:23 am-12:04 pm

Nonstop1h 41m

Buffalo

Tue 9/2

2:44 pm-4:37 pm

Nonstop1h 53m

$253

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Wed 8/20

7:40 am-12:00 pm

1 stop4h 20m

Buffalo

Sat 8/23

6:10 am-9:50 am

1 stop3h 40m

$258

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 55 results
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Best time to book a flight from South Carolina to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Buffalo

What is the cheapest month to book a flight from South Carolina to Buffalo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to BUF?

Find hourly flight availability from South Carolina to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Buffalo as you normally would.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated July 30, 2025.
Read through reviews of airlines operating flights from South Carolina to Buffalo, such as Southwest, Delta, and United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,896 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
JetBlue
7.3
Good
2,913 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from South Carolina?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from South Carolina. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • What are the cheapest airlines to fly from South Carolina to Buffalo one-way?

    $86 is the cheapest one-way deal found within the past few days, from JetBlue. You may also be able to find cheap deals on Frontier and American Airlines, with prices starting from $95 and $116, respectively.

  • What are the most popular routes from South Carolina to Buffalo?

    The most popular flight routes from South Carolina to Buffalo are Charlotte Douglas - Buffalo, Charleston - Buffalo and Greenville - Buffalo.

  • Can I find deals for flights from South Carolina to Buffalo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Buffalo.

  • Can I find deals for business class flights from South Carolina to Buffalo?

    Yes. Cheapflights offers flight deals from South Carolina to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Buffalo (average of $256). Flying from South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from South Carolina to Buffalo

Discover the top 5 airlines that operate flights from South Carolina to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$160Average$242FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$198Average$281FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$200Average$338FlexibilityNo cancel feeOn-time71%
DeltaCheapest$207Average$297FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$233Average$363FlexibilityNo cancel feeOn-time63%

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