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$81+ Cheap flights from Missouri to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BUF
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Missouri to Buffalo

Keep the following information in mind while searching for Missouri to Buffalo flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$213
(Kiwi.com)

One-way from

$81
(Justfly.com)

Popular in

January

Cheapest in

July

Average price

$346
Provider with most accurate pricing for Lambert-St Louis-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Buffalo flights.
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From Missouri to Buffalo
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One-way flight from Missouri to Buffalo
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Highest demand for flights based on searches. 22% potential increase in price ($116 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Missouri to Buffalo

Cheapest flights from Missouri to Buffalo
Explore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:07 amSTL - BUF
2 stops33h 01mFrontier
Sun 11/166:59 pmBUF - STL
1 stop15h 41mFrontier
Deal found 10/30$213
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:30 pmSTL - BUF
1 stop21h 45mFrontier
Mon 12/83:18 pmBUF - STL
1 stop8h 15mFrontier
Deal found 10/29$231
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/162:12 pmSTL - BUF
1 stop20h 32mFrontier
Thu 11/2011:40 amBUF - STL
1 stop13h 17mFrontier
Deal found 10/28$238
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:55 amSGF - BUF
1 stop4h 24mDelta
Sun 11/166:10 amBUF - SGF
1 stop5h 43mDelta
Deal found 10/28$279
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:40 pmMCI - BUF
1 stop6h 20mSouthwest
Wed 12/316:25 pmBUF - MCI
1 stop4h 25mSouthwest
Deal found 10/28$281
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:55 amMCI - BUF
1 stop5h 05mSouthwest
Thu 12/42:05 pmBUF - MCI
1 stop9h 10mSouthwest
Deal found 10/28$284
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:12 amMCI - BUF
2 stops8h 56mFrontier
Sun 11/162:42 pmBUF - MCI
1 stop20h 35mFrontier
Deal found 10/29$290
This Gotogate deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/162:12 pmSTL - BUF
1 stop20h 32mFrontier
Fri 11/2111:52 amBUF - STL
1 stop13h 05mFrontier
Deal found 10/28$298
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:27 pmSTL - BUF
1 stop27h 41mFrontier
Sat 1/37:05 pmBUF - STL
1 stop15h 35mFrontier
Deal found 10/30$300
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:33 amMCI - BUF
2 stops24h 39mMultiple Airlines
Wed 12/3111:08 amBUF - MCI
1 stop12h 51mMultiple Airlines
Deal found 10/28$302
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:47 pmMCI - BUF
1 stop27h 53mMultiple Airlines
Tue 12/307:58 pmBUF - MCI
2 stops15h 10mMultiple Airlines
Deal found 10/28$312
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:10 amSTL - BUF
1 stop5h 50mSouthwest
Wed 12/36:25 pmBUF - STL
1 stop4h 55mSouthwest
Deal found 10/27$322

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to Buffalo that are best for you.

Fly from

Missouri

Fly to

Buffalo

Route

Depart

Return

Price

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Thu 11/13

11:07 am-9:08 pm

2 stops33h 01m

Buffalo

Sun 11/16

6:59 pm-9:40 am

1 stop15h 41m

$213

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Sun 11/16

2:12 pm-11:44 am

1 stop20h 32m

Buffalo

Thu 11/20

11:40 am-11:57 pm

1 stop13h 17m

$238

SpringfieldBuffalo

SGF - BUF

SGFBUF

Springfield-Branson

Wed 11/12

11:55 am-5:19 pm

1 stop4h 24m

Buffalo

Sun 11/16

6:10 am-10:53 am

1 stop5h 43m

$279

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Wed 12/24

5:42 pm-10:33 pm

1 stop3h 51m

Buffalo

Thu 1/1

6:10 am-9:56 am

1 stop4h 46m

$281

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Thu 11/27

5:55 am-12:00 pm

1 stop5h 05m

Buffalo

Thu 12/4

2:05 pm-10:15 pm

1 stop9h 10m

$284

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Fri 11/14

11:12 am-9:08 pm

2 stops8h 56m

Buffalo

Sun 11/16

2:42 pm-10:17 am

1 stop20h 35m

$290

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Sun 12/21

4:27 pm-9:08 pm

1 stop27h 41m

Buffalo

Sat 1/3

7:05 pm-9:40 am

1 stop15h 35m

$300

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Sat 2/28

6:00 am-11:51 am

1 stop4h 51m

Buffalo

Tue 3/3

5:55 pm-9:22 pm

1 stop4h 27m

$301

Kansas CityBuffalo

MCI - BUF

MCIBUF

Kansas City

Wed 12/24

11:33 am-1:12 pm

2 stops24h 39m

Buffalo

Wed 12/31

11:08 am-10:59 pm

1 stop12h 51m

$302

St. LouisBuffalo

STL - BUF

STLBUF

Lambert-St Louis

Fri 1/16

6:25 am-2:10 pm

1 stop6h 45m

Buffalo

Sun 1/18

6:00 am-11:05 am

1 stop6h 05m

$307

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 46 results
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Best time to book a flight from Missouri to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Buffalo

What is the cheapest month to book a flight from Missouri to Buffalo?

Currently, March is the cheapest month in which you can book a flight from Missouri to Buffalo (average of $133). Flying from Missouri to Buffalo in January is currently the most expensive (average of $336). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to BUF?

Find hourly flight availability from Missouri to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to Buffalo in the evening. If you’re flexible enough to do this you can expect to save up to 50% on your trip compared to booking a flight at noon.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Missouri?

    Most people fly into Buffalo (BUF) if they book a flight to Buffalo from Missouri. Buffalo is conveniently located just 8.3 mi from Buffalo’s city center.

  • How long is the flight from Missouri to Buffalo?

    Airlines like Frontier, Delta, and Southwest fly from Missouri to Buffalo in about 4h 24m. The time it takes to get you to your destination can typically vary by up to 28h 37m. The distance from Missouri to Buffalo is about 867 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Buffalo one-way?

    One-way options have recently been found by users for as low as $81 on Frontier. Other airlines that offer cheap prices include American Airlines from $126 and Delta from $129 one-way.

  • What are the most popular routes from Missouri to Buffalo?

    While some choose either Lambert-St Louis - Buffalo or Springfield-Branson - Buffalo, Kansas City - Buffalo is the most popular route from Missouri to Buffalo.

  • Can I find deals for flights from Missouri to Buffalo that include hotel bookings?

    Yes. In addition to deals on Missouri to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Buffalo.

  • Can I find deals for business class flights from Missouri to Buffalo?

    Yes. Cheapflights offers flight deals from Missouri to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Buffalo?

    Currently, March is the cheapest month in which you can book a flight from Missouri to Buffalo (average of $133). Flying from Missouri to Buffalo in January is currently the most expensive (average of $336). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Top 4 airlines flying from Missouri to Buffalo

Discover the top 4 airlines that operate flights from Missouri to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$167Average$448FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$208Average$398FlexibilityNo cancel feeOn-time71%
DeltaCheapest$238Average$349FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$301Average$408FlexibilityNo cancel feeOn-time63%

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