$142+ Cheap flights from Missouri to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BUF
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from Missouri to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Buffalo
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Cheapest flights from Missouri to BuffaloExplore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from Missouri to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/110:53 am
MCI
- BUF
1 stop25h 00m
Multiple Airlines
Sun 3/89:25 pm
BUF
- MCI
2 stops14h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:20 pm
STL
- BUF
1 stop13h 32m
Frontier
Sun 2/152:19 pm
BUF
- STL
1 stop17h 32m
Frontier
Deal found 1/31![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/110:53 am
MCI
- BUF
1 stop25h 00m
Frontier
Sun 3/81:00 pm
BUF
- MCI
1 stop28h 23m
Frontier
Deal found 1/31![Frontier logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:24 pm
MCI
- BUF
2 stops21h 25m
Multiple Airlines
Mon 4/138:16 pm
BUF
- MCI
1 stop28h 37m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:40 pm
MCI
- BUF
2 stops13h 25m
Multiple Airlines
Mon 3/99:25 pm
BUF
- MCI
1 stop19h 04m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:45 am
MCI
- BUF
1 stop23h 20m
Frontier
Mon 3/1611:59 am
BUF
- MCI
1 stop6h 26m
Frontier
Deal found 2/2![Frontier logo]()
$255
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:01 pm
SGF
- BUF
1 stop4h 22m
American Airlines
Sat 3/76:00 am
BUF
- SGF
1 stop5h 00m
American Airlines
Deal found 1/31![American Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:31 pm
MCI
- BUF
1 stop18h 46m
Multiple Airlines
Mon 4/138:16 pm
BUF
- MCI
1 stop28h 37m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:45 am
MCI
- BUF
1 stop23h 20m
Frontier
Sun 3/1512:45 pm
BUF
- MCI
1 stop29h 40m
Frontier
Deal found 2/2![Frontier logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:13 pm
STL
- BUF
1 stop15h 00m
Frontier
Sat 4/181:08 pm
BUF
- STL
1 stop22h 22m
Frontier
Deal found 2/2![Frontier logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:24 pm
MCI
- BUF
2 stops21h 35m
Multiple Airlines
Mon 4/138:16 pm
BUF
- MCI
1 stop28h 37m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:45 am
MCI
- BUF
1 stop28h 04m
Multiple Airlines
Wed 4/151:08 pm
BUF
- MCI
1 stop22h 10m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$270
Best flights from Missouri to BuffaloDiscover carefully curated flight deals from Missouri to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from Missouri to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/110:53 am
MCI
- BUF
1 stop25h 00m
Multiple Airlines
Sun 3/89:25 pm
BUF
- MCI
2 stops14h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/110:53 am
MCI
- BUF
1 stop25h 00m
Frontier
Sun 3/81:00 pm
BUF
- MCI
1 stop28h 23m
Frontier
Deal found 1/31![Frontier logo]()
$217
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:01 pm
SGF
- BUF
1 stop4h 22m
American Airlines
Sat 3/76:00 am
BUF
- SGF
1 stop5h 00m
American Airlines
Deal found 1/31![American Airlines logo]()
$260
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:13 pm
STL
- BUF
1 stop6h 49m
United Airlines
Tue 6/237:00 am
BUF
- STL
1 stop6h 11m
United Airlines
Deal found 2/1![United Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:35 am
MCI
- BUF
1 stop4h 09m
Delta
Sat 4/116:15 am
BUF
- MCI
1 stop4h 36m
Delta
Deal found 2/2![Delta logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:20 pm
STL
- BUF
2 stops20h 25m
Frontier
Sun 2/152:19 pm
BUF
- STL
1 stop17h 32m
Frontier
Deal found 1/31![Frontier logo]()
$302
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:23 pm
COU
- BUF
1 stop4h 20m
United Airlines
Sat 5/25:50 pm
BUF
- COU
1 stop5h 08m
United Airlines
Deal found 1/31![United Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:00 am
MCI
- BUF
1 stop5h 50m
Delta
Wed 4/157:37 pm
BUF
- MCI
1 stop5h 13m
Delta
Deal found 2/2![Delta logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:55 pm
STL
- BUF
2 stops16h 35m
Frontier
Sat 4/181:08 pm
BUF
- STL
1 stop22h 22m
Frontier
Deal found 2/2![Frontier logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:24 pm
MCI
- BUF
2 stops21h 35m
Multiple Airlines
Thu 4/1611:25 am
BUF
- MCI
1 stop13h 34m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:42 pm
MCI
- BUF
1 stop4h 13m
Delta
Thu 4/166:05 am
BUF
- MCI
1 stop4h 44m
Delta
Deal found 2/2![Delta logo]()
$341
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/39:55 am
MCI
- BUF
1 stop6h 15m
United Airlines
Tue 4/1410:55 am
BUF
- MCI
1 stop6h 00m
United Airlines
Deal found 2/2![United Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:37 am
MCI
- BUF
1 stop5h 32m
Delta
Sat 4/115:50 pm
BUF
- MCI
1 stop4h 00m
Delta
Deal found 2/2![Delta logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/61:09 pm
STL
- BUF
2 stops20h 40m
Frontier
Sun 3/89:25 pm
BUF
- STL
1 stop10h 37m
Frontier
Deal found 2/2![Frontier logo]()
$348
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/143:15 pm
SGF
- BUF
1 stop4h 36m
United Airlines
Wed 2/186:00 am
BUF
- SGF
2 stops9h 40m
United Airlines
Deal found 1/31![United Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2211:27 am
SGF
- BUF
1 stop6h 11m
American Airlines
Sat 7/258:00 am
BUF
- SGF
1 stop6h 49m
American Airlines
Deal found 2/2![American Airlines logo]()
$439
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:04 pm
STL
- BUF
1 stop4h 55m
Delta
Sat 6/66:25 am
BUF
- STL
1 stop4h 01m
Delta
Deal found 2/2![Delta logo]()
$342
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:59 pm
STL
- BUF
1 stop3h 56m
Delta
Mon 3/167:38 pm
BUF
- STL
1 stop5h 20m
Delta
Deal found 2/1![Delta logo]()
$342
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:04 pm
STL
- BUF
1 stop4h 55m
Delta
Mon 6/89:00 am
BUF
- STL
1 stop5h 17m
Delta
Deal found 2/2![Delta logo]()
$342
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/283:15 pm
SGF
- BUF
2 stops7h 29m
United Airlines
Sat 3/77:00 am
BUF
- SGF
2 stops10h 19m
United Airlines
Deal found 1/31![United Airlines logo]()
$425
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:05 am
MCI
- BUF
1 stop7h 46m
Delta
Wed 4/1512:50 pm
BUF
- MCI
1 stop5h 10m
Delta
Deal found 2/2![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:42 pm
MCI
- BUF
1 stop4h 13m
Delta
Tue 4/1412:06 pm
BUF
- MCI
1 stop4h 59m
Delta
Deal found 2/2![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:42 pm
MCI
- BUF
1 stop4h 13m
Delta
Sun 4/126:15 am
BUF
- MCI
1 stop4h 36m
Delta
Deal found 2/2![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:35 am
STL
- BUF
1 stop4h 08m
Delta
Sun 3/86:15 am
BUF
- STL
1 stop4h 31m
Delta
Deal found 2/1![Delta logo]()
$367
Last-minute flights from Missouri to BuffaloDiscover last-minute flight deals from Missouri to Buffalo. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Buffalo. Data last updated February 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:20 pm
STL
- BUF
1 stop13h 32m
Frontier
Sun 2/152:19 pm
BUF
- STL
1 stop17h 32m
Frontier
Deal found 1/31![Frontier logo]()
$204
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:01 pm
SGF
- BUF
1 stop4h 22m
American Airlines
Sat 3/76:00 am
BUF
- SGF
1 stop5h 00m
American Airlines
Deal found 1/31![American Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/110:53 am
MCI
- BUF
1 stop25h 00m
Multiple Airlines
Sun 3/89:25 pm
BUF
- MCI
2 stops14h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/110:53 am
MCI
- BUF
1 stop25h 00m
Frontier
Sun 3/81:00 pm
BUF
- MCI
1 stop28h 23m
Frontier
Deal found 1/31![Frontier logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:40 pm
MCI
- BUF
2 stops13h 25m
Multiple Airlines
Mon 3/99:25 pm
BUF
- MCI
1 stop19h 04m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/88:40 pm
MCI
- BUF
2 stops14h 25m
Frontier
Mon 3/1611:59 am
BUF
- MCI
1 stop6h 26m
Frontier
Deal found 2/2![Frontier logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:45 am
MCI
- BUF
1 stop23h 20m
Frontier
Mon 3/1611:59 am
BUF
- MCI
1 stop6h 26m
Frontier
Deal found 2/2![Frontier logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:45 am
MCI
- BUF
1 stop23h 20m
Frontier
Sun 3/1512:45 pm
BUF
- MCI
1 stop29h 40m
Frontier
Deal found 2/2![Frontier logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1111:45 am
MCI
- BUF
1 stop23h 20m
Multiple Airlines
Mon 3/1611:59 am
BUF
- MCI
2 stops24h 30m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:24 pm
MCI
- BUF
2 stops21h 25m
Multiple Airlines
Mon 4/138:16 pm
BUF
- MCI
1 stop28h 37m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:45 am
MCI
- BUF
1 stop28h 04m
Multiple Airlines
Wed 4/151:08 pm
BUF
- MCI
1 stop22h 10m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:45 am
MCI
- BUF
1 stop28h 04m
Multiple Airlines
Sun 4/128:59 pm
BUF
- MCI
2 stops19h 37m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$295
One-way flights from Missouri to BuffaloSearch for one-way flight options from Missouri to Buffalo. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from Missouri to Buffalo. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/153:49 pm
STL
- BUF
1 stop17h 13m
Frontier
Deal found 2/1![Frontier logo]()
$142
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:15 pm
STL
- BUF
1 stop4h 58m
Delta
Deal found 2/3![Delta logo]()
$159
This Trip.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:13 pm
STL
- BUF
1 stop15h 00m
Frontier
Deal found 2/2![Frontier logo]()
$165
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
STL
- BUF
1 stop4h 43m
American Airlines
Deal found 2/2![American Airlines logo]()
$194
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:00 am
STL
- BUF
2 stops8h 14m
United Airlines
Deal found 2/3![United Airlines logo]()
$199
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:15 pm
STL
- BUF
2 stops8h 00m
Southwest
Deal found 2/2![Southwest logo]()
$209
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/197:05 am
STL
- BUF
1 stop7h 20m
American Airlines
Deal found 2/2![American Airlines logo]()
$222
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:25 am
STL
- BUF
2 stops6h 48m
United Airlines
Deal found 2/1![United Airlines logo]()
$229
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/154:20 pm
MCI
- BUF
1 stop7h 25m
Southwest
Deal found 2/3![Southwest logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/158:40 pm
MCI
- BUF
2 stops13h 24m
Frontier
Deal found 2/3![Frontier logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/29:50 am
STL
- BUF
3 stops31h 31m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:00 pm
SGF
- BUF
1 stop5h 28m
Delta
Deal found 2/2![Delta logo]()
$390
Find flight deals from Missouri to Buffalo
Keep the following information in mind while searching for Missouri to Buffalo flight deals. Data was last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $198 (Kiwi.com) |
One-way from | $142 (Kiwi.com) |
Popular in | January |
Cheapest in | November |
Average price | $407 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Missouri to Buffalo that are best for you.
Fly from
Missouri
Fly to
Buffalo
Route
Depart
Return
Price
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Sun 3/1
10:53 am-12:53 pm
1 stop25h 00m
Buffalo
Sun 3/8
9:25 pm-10:30 am
2 stops14h 05m
$198
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Sun 3/1
10:53 am-12:53 pm
1 stop25h 00m
Buffalo
Sun 3/8
1:00 pm-4:23 pm
1 stop28h 23m
$217
SpringfieldBuffalo
SGF - BUF
SGFBUF
Springfield-Branson
Sat 2/28
6:01 pm-11:23 pm
1 stop4h 22m
Buffalo
Sat 3/7
6:00 am-10:00 am
1 stop5h 00m
$260
St. LouisBuffalo
STL - BUF
STLBUF
Lambert-St Louis
Fri 2/13
8:20 pm-5:45 pm
2 stops20h 25m
Buffalo
Sun 2/15
2:19 pm-6:51 am
1 stop17h 32m
$302
St. LouisBuffalo
STL - BUF
STLBUF
Lambert-St Louis
Wed 4/15
4:55 pm-10:30 am
2 stops16h 35m
Buffalo
Sat 4/18
1:08 pm-10:30 am
1 stop22h 22m
$315
St. LouisBuffalo
STL - BUF
STLBUF
Lambert-St Louis
Tue 6/16
1:13 pm-9:02 pm
1 stop6h 49m
Buffalo
Tue 6/23
7:00 am-12:11 pm
1 stop6h 11m
$317
ColumbiaBuffalo
COU - BUF
COUBUF
Columbia Regional
Tue 4/28
3:23 pm-8:43 pm
1 stop4h 20m
Buffalo
Sat 5/2
5:50 pm-9:58 pm
1 stop5h 08m
$328
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Wed 4/1
6:35 am-11:44 am
1 stop4h 09m
Buffalo
Sat 4/11
6:15 am-9:51 am
1 stop4h 36m
$330
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Sat 4/4
6:00 am-12:50 pm
1 stop5h 50m
Buffalo
Wed 4/15
7:37 pm-11:50 pm
1 stop5h 13m
$330
Kansas CityBuffalo
MCI - BUF
MCIBUF
Kansas City
Sat 4/4
5:42 pm-10:55 pm
1 stop4h 13m
Buffalo
Thu 4/16
6:05 am-9:49 am
1 stop4h 44m
$341
Showing 1-10 of 34 results
Best time to book a flight from Missouri to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Missouri with our price prediction graph.
MCI-BUF
STL-BUF
SGF-BUF
COU-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Buffalo
USMO-BUF
MCI-BUF
STL-BUF
SGF-BUF
COU-BUF
What is the cheapest month to book a flight from Missouri to Buffalo?
Currently, March is the cheapest month in which you can book a flight from Missouri to Buffalo (average of $136). Flying from Missouri to Buffalo in October is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
Complete your trip
Flights by cabin class
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Alternative routes for Missouri to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Buffalo by cabin class
Find flights from Missouri to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Buffalo flights
Browse other Missouri and Buffalo flight options. Last updated on February 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Buffalo flights
Consider these flights traveling from Missouri to Buffalo.
Top 4 airlines flying from Missouri to Buffalo
Discover the top 4 airlines that operate flights from Missouri to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$143 | Average$314 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$167 | Average$434 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$221 | Average$335 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$411 | FlexibilityNo cancel fee | On-time63% |