$73+ Cheap flights from St. Louis to Buffalo (STL - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BUF
Sep 4 — Sep 111
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Buffalo
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Best
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Cheapest flights from St. Louis to BuffaloExplore the most affordable flight options available from St. Louis to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
Explore the most affordable flight options available from St. Louis to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1910:35 am -
1 stop24h 43m
Sat 10/241:13 pm -
1 stop21h 27m
Deal found 8/1![Frontier logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:17 pm -
1 stop15h 12m
Sun 9/611:36 am -
1 stop6h 46m
Deal found 8/5![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:35 am -
1 stop24h 43m
Sat 10/171:13 pm -
1 stop21h 27m
Deal found 7/31![Frontier logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:17 pm -
1 stop15h 12m
Sun 9/611:36 am -
1 stop6h 46m
Deal found 8/2![Frontier logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:35 am -
1 stop24h 43m
Mon 10/191:13 pm -
1 stop21h 27m
Deal found 8/3![Frontier logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:35 am -
1 stop24h 43m
Mon 10/121:13 pm -
1 stop21h 27m
Deal found 8/4![Frontier logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:17 pm -
1 stop15h 12m
Wed 9/26:54 pm -
2 stops23h 28m
Deal found 7/31![Frontier logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1210:35 am -
1 stop24h 43m
Mon 10/191:13 pm -
2 stops31h 02m
Deal found 7/31![Frontier logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:39 pm -
2 stops17h 16m
Mon 10/121:13 pm -
1 stop21h 27m
Deal found 7/31![Frontier logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:45 pm -
2 stops14h 44m
Thu 8/277:20 pm -
1 stop23h 02m
Deal found 7/31![Frontier logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:29 pm -
1 stop21h 21m
Thu 10/112:49 pm -
2 stops25h 21m
Deal found 8/1![Frontier logo]()
$214
Best flights from St. Louis to BuffaloDiscover carefully curated flight deals from St. Louis to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
Discover carefully curated flight deals from St. Louis to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:17 pm -
2 stops22h 52m
Sun 9/611:36 am -
1 stop6h 46m
Deal found 8/5![Frontier logo]()
$278
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:45 am -
1 stop3h 25m
Sat 9/58:50 am -
2 stops5h 45m
Deal found 8/1![Southwest logo]()
$327
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:01 am -
1 stop5h 17m
Tue 10/132:55 pm -
1 stop6h 37m
Deal found 8/5![American Airlines logo]()
$335
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:25 am -
1 stop4h 51m
Tue 9/16:00 am -
1 stop6h 17m
Deal found 8/4![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:25 am -
1 stop4h 00m
Mon 10/127:20 pm -
1 stop6h 10m
Deal found 7/31![Southwest logo]()
$335
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:05 am -
1 stop3h 40m
Wed 9/306:50 am -
1 stop6h 50m
Deal found 8/4![Southwest logo]()
$335
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1411:40 am -
1 stop5h 45m
Mon 9/217:10 pm -
1 stop4h 00m
Deal found 8/1![Southwest logo]()
$335
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/81:40 pm -
1 stop6h 30m
Tue 9/1510:35 am -
2 stops7h 10m
Deal found 8/4![Southwest logo]()
$340
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:30 am -
2 stops5h 45m
Sat 10/177:15 am -
2 stops6h 20m
Deal found 7/31![Southwest logo]()
$345
Last-minute flights from St. Louis to BuffaloDiscover last-minute flight deals from St. Louis to Buffalo. Data last updated August 5, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Buffalo. Data last updated August 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:45 pm -
2 stops14h 44m
Thu 8/277:20 pm -
1 stop23h 02m
Deal found 7/31![Frontier logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:45 pm -
2 stops14h 44m
Sat 9/56:54 pm -
1 stop22h 17m
Deal found 8/1![Frontier logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:17 pm -
1 stop15h 12m
Sun 9/611:36 am -
1 stop6h 46m
Deal found 8/2![Frontier logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:17 pm -
1 stop15h 12m
Wed 9/26:54 pm -
2 stops23h 28m
Deal found 7/31![Frontier logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:17 pm -
1 stop15h 12m
Sun 9/611:36 am -
1 stop6h 46m
Deal found 8/5![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:19 pm -
1 stop23h 30m
Mon 9/211:40 pm -
2 stops22h 52m
Deal found 8/1![Frontier logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:29 pm -
1 stop21h 21m
Thu 10/112:49 pm -
2 stops25h 21m
Deal found 8/1![Frontier logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:29 pm -
1 stop21h 21m
Fri 10/21:40 pm -
2 stops44h 55m
Deal found 8/1![Frontier logo]()
$238
One-way flights from St. Louis to BuffaloSearch for one-way flight options from St. Louis to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
Search for one-way flight options from St. Louis to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:17 pm -
1 stop15h 12m
Deal found 8/3![Frontier logo]()
$73
This Trip.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/236:17 pm -
1 stop15h 12m
Deal found 8/2![Frontier logo]()
$88
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1110:35 am -
1 stop24h 43m
Deal found 8/4![Frontier logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/212:29 pm -
2 stops26h 20m
Deal found 8/3![Frontier logo]()
$120
This Jettzy deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jettzy is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:02 pm -
1 stop15h 21m
Deal found 8/1![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:19 pm -
2 stops18h 36m
Deal found 8/3![Frontier logo]()
$133
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:09 pm -
1 stop4h 00m
Deal found 8/1![Delta logo]()
$168
Find flight deals from St. Louis to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $150 (Kiwi.com) |
One-way from | $73 (Kiwi.com) |
Popular in | April |
Cheapest in | January |
Average price | $380 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from St. Louis to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Fri 9/4
6:17 pm-6:09 pm
2 stops22h 52m
Buffalo
Sun 9/6
11:36 am-5:22 pm
1 stop6h 46m
$278
Quickest round-trip
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Sat 8/29
5:45 am-10:10 am
1 stop3h 25m
Buffalo
Sat 9/5
8:50 am-1:35 pm
2 stops5h 45m
$327
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Wed 9/30
11:01 am-5:18 pm
1 stop5h 17m
Buffalo
Tue 10/13
2:55 pm-8:32 pm
1 stop6h 37m
$335
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Sat 8/29
7:25 am-1:16 pm
1 stop4h 51m
Buffalo
Tue 9/1
6:00 am-11:17 am
1 stop6h 17m
$335
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Thu 10/1
5:25 am-10:25 am
1 stop4h 00m
Buffalo
Mon 10/12
7:20 pm-12:30 am
1 stop6h 10m
$335
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Mon 9/28
6:05 am-10:45 am
1 stop3h 40m
Buffalo
Wed 9/30
6:50 am-12:40 pm
1 stop6h 50m
$335
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Mon 9/14
11:40 am-6:25 pm
1 stop5h 45m
Buffalo
Mon 9/21
7:10 pm-10:10 pm
1 stop4h 00m
$335
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Tue 9/8
1:40 pm-9:10 pm
1 stop6h 30m
Buffalo
Tue 9/15
10:35 am-4:45 pm
2 stops7h 10m
$340
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Tue 10/13
8:30 am-3:15 pm
2 stops5h 45m
Buffalo
Sat 10/17
7:15 am-12:35 pm
2 stops6h 20m
$345
Cheapest one-way
Quickest one-way
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Tue 9/8
6:40 am-11:22 am
1 stop3h 42m
$168
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Buffalo in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from St. Louis with our price prediction graph.
STL-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Buffalo
What is the cheapest month to book a flight from St. Louis to Buffalo?
Currently, February is the cheapest month in which you can book a flight from St. Louis to Buffalo (average of $337). Flying from St. Louis to Buffalo in April is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Buffalo?
Airfare is below average for this route at the moment.
St. Louis to Buffalo flights typically cost between $308 and $538 in October.The cheapest round-trip price found within the last 5 days was $150 on Frontier (Oct 19-Oct 24).
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated August 5, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Buffalo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 5, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Buffalo flights
Browse other St. Louis and Buffalo flight options. Last updated on August 5, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on August 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from St. Louis to Buffalo
Discover the top 4 airlines that operate flights from St. Louis to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$115 | Average$126 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$221 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$226 | Average$347 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$298 | Average$416 | FlexibilityNo cancel fee | On-time63% |