$152+ Cheap flights from St. Louis to Buffalo (STL - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BUF
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Buffalo
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Cheapest flights from St. Louis to BuffaloExplore the most affordable flight options available from St. Louis to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from St. Louis to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:20 pm -
1 stop18h 15m
Sat 12/199:38 pm -
1 stop28h 03m
Deal found 11/4![Frontier logo]()
$246
This CheapOair deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:20 pm -
1 stop25h 23m
Sun 12/206:20 pm -
1 stop7h 21m
Deal found 11/2![Frontier logo]()
$275
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:20 pm -
1 stop6h 04m
Mon 12/72:30 pm -
1 stop10h 42m
Deal found 11/4![Frontier logo]()
$285
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/165:51 pm -
1 stop5h 13m
Tue 1/56:00 am -
1 stop7h 44m
Deal found 11/3![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/103:35 pm -
1 stop5h 50m
Sat 12/1912:35 pm -
2 stops7h 35m
Deal found 11/4![Southwest logo]()
$314
This Priceline deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:20 pm -
1 stop6h 04m
Fri 12/42:30 pm -
1 stop10h 42m
Deal found 11/4![Frontier logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:21 pm -
2 stops41h 47m
Fri 1/89:27 pm -
1 stop23h 23m
Deal found 11/3![Frontier logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:21 pm -
2 stops46h 04m
Fri 1/89:27 pm -
1 stop23h 23m
Deal found 11/3![Frontier logo]()
$340
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/167:00 am -
1 stop5h 29m
Mon 1/46:00 am -
1 stop7h 44m
Deal found 11/3![Delta logo]()
$344
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/203:48 pm -
1 stop7h 07m
Fri 1/86:00 am -
1 stop7h 44m
Deal found 11/3![Delta logo]()
$346
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:25 pm -
1 stop5h 55m
Thu 1/711:30 am -
2 stops6h 05m
Deal found 11/3![Southwest logo]()
$351
Best flights from St. Louis to BuffaloDiscover carefully curated flight deals from St. Louis to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from St. Louis to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1810:13 am -
1 stop6h 41m
Thu 1/216:05 am -
1 stop5h 59m
Deal found 11/1![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:20 am -
1 stop6h 55m
Fri 12/119:05 am -
2 stops11h 05m
Deal found 10/30![Southwest logo]()
$310
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:40 am -
1 stop6h 17m
Wed 12/1610:30 am -
1 stop5h 11m
Deal found 11/3![United Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:32 am -
1 stop3h 52m
Thu 1/710:35 am -
1 stop7h 44m
Deal found 11/3![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:00 am -
1 stop5h 29m
Fri 12/119:15 am -
1 stop5h 15m
Deal found 10/30![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2111:15 am -
1 stop3h 30m
Sun 4/258:30 am -
2 stops8h 15m
Deal found 11/3![Southwest logo]()
$396
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/167:00 am -
1 stop5h 29m
Mon 1/46:00 am -
1 stop7h 44m
Deal found 11/3![Delta logo]()
$344
Last-minute flights from St. Louis to BuffaloDiscover last-minute flight deals from St. Louis to Buffalo. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Buffalo. Data last updated November 4, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:20 pm -
1 stop6h 04m
Mon 12/72:30 pm -
1 stop10h 42m
Deal found 11/4![Frontier logo]()
$285
This Priceline deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:20 pm -
1 stop6h 04m
Fri 12/42:30 pm -
1 stop10h 42m
Deal found 11/4![Frontier logo]()
$320
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:20 pm -
1 stop18h 15m
Sat 12/199:38 pm -
1 stop28h 03m
Deal found 11/4![Frontier logo]()
$246
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/103:35 pm -
1 stop5h 50m
Sat 12/1912:35 pm -
2 stops7h 35m
Deal found 11/4![Southwest logo]()
$314
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/165:51 pm -
1 stop5h 13m
Tue 1/56:00 am -
1 stop7h 44m
Deal found 11/3![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/167:00 am -
1 stop5h 29m
Mon 1/46:00 am -
1 stop7h 44m
Deal found 11/3![Delta logo]()
$344
This CheapOair deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:20 pm -
1 stop25h 23m
Sun 12/206:20 pm -
1 stop7h 21m
Deal found 11/2![Frontier logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:21 pm -
2 stops46h 04m
Fri 1/89:27 pm -
1 stop23h 23m
Deal found 11/3![Frontier logo]()
$340
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:25 pm -
1 stop5h 55m
Thu 1/711:30 am -
2 stops6h 05m
Deal found 11/3![Southwest logo]()
$351
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/203:48 pm -
1 stop7h 07m
Fri 1/86:00 am -
1 stop7h 44m
Deal found 11/3![Delta logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:21 pm -
2 stops41h 47m
Fri 1/89:27 pm -
1 stop23h 23m
Deal found 11/3![Frontier logo]()
$335
One-way flights from St. Louis to BuffaloSearch for one-way flight options from St. Louis to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from St. Louis to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:58 pm -
2 stops39h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Frontier logo]()
$152
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:35 pm -
1 stop5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Southwest logo]()
$155
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:47 pm -
1 stop5h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
2 stops7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![United Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/21:18 pm -
3 stops20h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![United Airlines logo]()
$548
Find flight deals from St. Louis to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $246 (Frontier) |
One-way from | $152 (Kiwi.com) |
Popular in | April |
Cheapest in | February |
Average price | $467 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from St. Louis to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Wed 12/2
7:58 pm-12:19 pm
2 stops39h 21m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$152
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Fri 3/5
9:10 am-5:38 pm
1 stop7h 28m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$230
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Fri 3/5
5:10 am-11:40 am
1 stop5h 30m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$239
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Mon 1/18
10:13 am-5:54 pm
1 stop6h 41m
Buffalo
Thu 1/21
6:05 am-11:04 am
1 stop5h 59m
$309
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Wed 12/16
6:32 am-11:24 am
1 stop3h 52m
Buffalo
Thu 1/7
10:35 am-5:19 pm
1 stop7h 44m
$309
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Wed 12/9
7:00 am-1:29 pm
1 stop5h 29m
Buffalo
Fri 12/11
9:15 am-1:30 pm
1 stop5h 15m
$309
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Wed 12/9
7:20 am-3:15 pm
1 stop6h 55m
Buffalo
Fri 12/11
9:05 am-7:10 pm
2 stops11h 05m
$310
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Wed 12/16
7:00 am-1:29 pm
1 stop5h 29m
Buffalo
Mon 1/4
6:00 am-12:44 pm
1 stop7h 44m
$344
Quickest round-trip
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Thu 11/12
12:47 pm-6:47 pm
1 stop5h 00m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$349
St. LouisBuffalo
STL Lambert-St Louis - BUF Buffalo
STLBUF
Lambert-St Louis
Thu 11/12
6:00 am-2:20 pm
2 stops7h 20m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$354
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Buffalo in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from St. Louis with our price prediction graph.
STL-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Buffalo
What is the cheapest month to book a flight from St. Louis to Buffalo?
Currently, February is the cheapest month in which you can book a flight from St. Louis to Buffalo (average of $337). Flying from St. Louis to Buffalo in April is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Buffalo?
Airfare is below average for this route at the moment.
St. Louis to Buffalo flights typically cost between $337 and $621 in December.The cheapest round-trip price found within the last 5 days was $246 on Frontier (Dec 10-Dec 19).
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated November 4, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from St. Louis to Buffalo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreBhoopal,Nov 2024
STL - BOS
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Buffalo flights
Browse other St. Louis and Buffalo flight options. Last updated on November 4, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on November 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 5 airlines flying from St. Louis to Buffalo
Discover the top 5 airlines that operate flights from St. Louis to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$115 | Average$126 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$252 | Average$388 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$256 | Average$366 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$298 | Average$416 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$302 | Average$443 | FlexibilityNo cancel fee | On-time69% |