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$177+ Cheap flights from Mississippi to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BUF
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Mississippi to Buffalo

Keep the following information in mind while searching for Mississippi to Buffalo flight deals. Data was last updated September 11, 2025.

Round-trip from

$237
(Delta)

One-way from

$177
(American Airlines)
From Mississippi to Buffalo
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One-way flight from Mississippi to Buffalo
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Find flight deals from Mississippi to Buffalo

Cheapest flights from Mississippi to Buffalo
Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/292:25 pmMEM - BUF
1 stop7h 28mAmerican Airlines
Sun 11/211:20 amBUF - MEM
1 stop13h 42mAmerican Airlines
Deal found 9/11$253
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/295:43 amMOB - BUF
1 stop4h 18mDelta
Tue 11/47:30 pmBUF - MOB
1 stop4h 18mDelta
Deal found 9/11$259
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/242:25 pmMEM - BUF
1 stop5h 22mAmerican Airlines
Tue 10/2811:12 amBUF - MEM
1 stop6h 48mAmerican Airlines
Deal found 9/11$259
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:44 amMEM - BUF
1 stop4h 12mAmerican Airlines
Sun 11/164:26 pmBUF - MEM
1 stop8h 36mAmerican Airlines
Deal found 9/11$265
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:06 pmMEM - BUF
1 stop4h 33mDelta
Tue 10/286:00 amBUF - MEM
1 stop4h 17mDelta
Deal found 9/10$268
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/297:40 amMEM - BUF
2 stops11h 30mSouthwest
Sun 11/25:00 amBUF - MEM
1 stop4h 45mSouthwest
Deal found 9/11$274
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/12:01 pmGPT - BUF
1 stop6h 42mAmerican Airlines
Tue 10/76:42 pmBUF - GPT
1 stop5h 04mAmerican Airlines
Deal found 9/10$279
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/317:00 amMEM - BUF
1 stop8h 58mAmerican Airlines
Sun 11/211:20 amBUF - MEM
1 stop13h 42mAmerican Airlines
Deal found 9/11$287
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/152:55 pmMEM - BUF
1 stop5h 05mUnited Airlines
Tue 11/187:00 amBUF - MEM
1 stop4h 56mUnited Airlines
Deal found 9/10$289
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:27 pmMOB - BUF
1 stop4h 48mAmerican Airlines
Sat 10/183:34 pmBUF - MOB
1 stop7h 21mAmerican Airlines
Deal found 9/10$299
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/144:20 pmMEM - BUF
1 stop6h 39mDelta
Sun 11/166:00 amBUF - MEM
1 stop4h 24mDelta
Deal found 9/10$299
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1512:09 pmBTR - BUF
1 stop4h 43mAmerican Airlines
Sat 10/187:38 pmBUF - BTR
1 stop5h 20mAmerican Airlines
Deal found 9/11$307

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Mississippi to Buffalo that are best for you.

Fly from

Mississippi

Fly to

Buffalo

Route

Depart

Return

Price

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Wed 2/18

10:00 am-5:07 pm

1 stop6h 07m

Buffalo

Sat 2/21

6:00 am-12:43 pm

1 stop7h 43m

$237

JacksonBuffalo

JAN - BUF

JANBUF

Jackson-Evers Intl

Sat 2/28

5:35 pm-11:57 pm

1 stop5h 22m

Buffalo

Tue 3/3

6:50 pm-11:23 pm

1 stop5h 33m

$237

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Wed 10/29

2:25 pm-10:53 pm

1 stop7h 28m

Buffalo

Sun 11/2

11:20 am-12:02 am

1 stop13h 42m

$253

MobileBuffalo

MOB - BUF

MOBBUF

Mobile

Wed 10/29

5:43 am-11:01 am

1 stop4h 18m

Buffalo

Tue 11/4

7:30 pm-10:48 pm

1 stop4h 18m

$259

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Thu 11/13

10:44 am-3:56 pm

1 stop4h 12m

Buffalo

Sun 11/16

4:26 pm-12:02 am

1 stop8h 36m

$265

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Fri 10/24

6:06 pm-11:39 pm

1 stop4h 33m

Buffalo

Tue 10/28

6:00 am-9:17 am

1 stop4h 17m

$268

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Wed 10/29

7:40 am-8:10 pm

2 stops11h 30m

Buffalo

Sun 11/2

5:00 am-8:45 am

1 stop4h 45m

$274

GulfportBuffalo

GPT - BUF

GPTBUF

Gulfport Biloxi Regional

Wed 10/1

2:01 pm-9:43 pm

1 stop6h 42m

Buffalo

Tue 10/7

6:42 pm-10:46 pm

1 stop5h 04m

$279

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Fri 10/31

7:00 am-4:58 pm

1 stop8h 58m

Buffalo

Sun 11/2

11:20 am-12:02 am

1 stop13h 42m

$287

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Fri 10/24

6:00 am-5:47 pm

1 stop10h 47m

Buffalo

Tue 10/28

10:35 am-5:00 pm

2 stops7h 25m

$292

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 37 results
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Best time to book a flight from Mississippi to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Buffalo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Mississippi?

    If you book a flight to Buffalo from Mississippi, you will be flying to Buffalo, which is the city’s only airport. Buffalo (BUF) is located 8.3 mi from the center of Buffalo.

  • How long is the flight from Mississippi to Buffalo?

    A quick flight from Mississippi to Buffalo can take about 6h 07m. Delta provides one of the quickest options available for as low as $237. Mississippi and Buffalo are separated by a distance of 812 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Mississippi to Buffalo one-way?

    One-way options have recently been found by users for as low as $177 on American Airlines. Other airlines that offer cheap prices include Southwest from $219 and Delta from $230 one-way.

  • What are the most popular routes from Mississippi to Buffalo?

    The most popular route from Mississippi to Buffalo is Memphis - Buffalo. You may also consider Mobile - Buffalo or Gulfport Biloxi Regional - Buffalo.

  • Can I find deals for flights from Mississippi to Buffalo that include hotel bookings?

    Yes. In addition to deals on Mississippi to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Buffalo.

  • Can I find deals for business class flights from Mississippi to Buffalo?

    Yes. Cheapflights offers flight deals from Mississippi to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Buffalo (average of $256). Flying from Mississippi to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Top 2 airlines flying from Mississippi to Buffalo

Discover the top 2 airlines that operate flights from Mississippi to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$398FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$436FlexibilityNo cancel feeOn-time71%

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