How long is the flight from Mississippi to Buffalo?

A quick flight from Mississippi to Buffalo can take about 5h 49m. Delta provides one of the quickest options available for as low as $290. Mississippi and Buffalo are separated by a distance of 812 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

What are the most popular routes from Mississippi to Buffalo?

The most popular route from Mississippi to Buffalo is Memphis - Buffalo. You may also consider Gulfport Biloxi Regional - Buffalo or Jackson-Evers Intl - Buffalo.

What is the cheapest time of day to fly from MS to BUF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Buffalo as you normally would.

What airport do you fly into for flights to Buffalo from Mississippi?

If you book a flight to Buffalo from Mississippi, you will be flying to Buffalo, which is the city’s only airport. Buffalo (BUF) is located 8.3 mi from the center of Buffalo.

Can I find deals for flights from Mississippi to Buffalo that include hotel bookings?

Yes. In addition to deals on Mississippi to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mississippi to Buffalo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Buffalo.

Can I find deals for business class flights from Mississippi to Buffalo?

Yes. Cheapflights offers flight deals from Mississippi to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$112+ Flights from Mississippi to Buffalo

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Cheap flight deals from Mississippi to Buffalo

Cheapest flights from Mississippi to Buffalo
Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Wed 12/243:46 pmBTR - BUF

1 stop6h 51mDelta

Thu 12/256:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$271

Wed 12/243:46 pmBTR - BUF

1 stop6h 51mDelta

Fri 12/266:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$403

Thu 12/2510:34 amBTR - BUF

2 stops10h 59mDelta

Fri 12/266:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$408

Tue 12/308:17 pmMEM - BUF

2 stops19h 32mMultiple Airlines

Sat 1/37:05 pmBUF - MEM

1 stop21h 03mMultiple Airlines

Deal found 12/14

$445

Tue 12/233:46 pmBTR - BUF

1 stop7h 01mDelta

Thu 12/256:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$474

Thu 12/255:01 pmMEM - BUF

1 stop5h 36mDelta

Sun 12/285:52 pmBUF - MEM

1 stop4h 21mDelta

Deal found 12/17

$483

Thu 12/2510:09 amBTR - BUF

1 stop5h 20mAmerican Airlines

Sun 12/286:00 amBUF - BTR

1 stop7h 38mAmerican Airlines

Deal found 12/16

$506

Mon 12/223:46 pmBTR - BUF

1 stop7h 01mDelta

Thu 12/256:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$510

Thu 12/259:35 amBTR - BUF

2 stops10h 19mUnited Airlines

Fri 12/266:30 amBUF - BTR

2 stops12h 02mUnited Airlines

Deal found 12/16

$517

Sun 12/213:46 pmBTR - BUF

1 stop7h 01mDelta

Thu 12/256:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$520

Thu 12/255:00 amMEM - BUF

2 stops10h 18mAmerican Airlines

Sun 12/2811:32 amBUF - MEM

1 stop7h 20mAmerican Airlines

Deal found 12/17

$523

Sat 12/208:17 pmMEM - BUF

1 stop15h 19mMultiple Airlines

Sat 12/277:05 pmBUF - MEM

1 stop21h 03mMultiple Airlines

Deal found 12/16

$526

Best flights from Mississippi to Buffalo
Discover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

Wed 12/243:46 pmBTR - BUF

1 stop6h 51mDelta

Thu 12/256:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$271

Tue 1/139:55 amMEM - BUF

1 stop5h 49mUnited Airlines

Tue 1/2010:45 amBUF - MEM

1 stop7h 41mUnited Airlines

Deal found 12/16

$290

Fri 1/166:00 amMEM - BUF

1 stop5h 08mAmerican Airlines

Mon 1/1912:58 pmBUF - MEM

1 stop7h 05mAmerican Airlines

Deal found 12/16

$369

Fri 3/2712:20 pmJAN - BUF

1 stop5h 30mSouthwest

Mon 3/3012:30 pmBUF - JAN

1 stop8h 10mSouthwest

Deal found 12/17

$422

Sat 1/107:30 amMEM - BUF

1 stop4h 54mUnited Airlines

Tue 1/2010:45 amBUF - MEM

1 stop7h 41mUnited Airlines

Deal found 12/16

$293

Thu 1/812:34 pmMOB - BUF

1 stop4h 05mDelta

Sun 1/116:00 amBUF - MOB

1 stop6h 45mDelta

Deal found 12/15

$329

Thu 1/812:45 pmMOB - BUF

1 stop5h 40mUnited Airlines

Sun 1/118:30 amBUF - MOB

2 stops10h 54mUnited Airlines

Deal found 12/15

$320

Thu 1/16:14 amMEM - BUF

1 stop5h 03mAmerican Airlines

Mon 1/53:58 pmBUF - MEM

2 stops8h 58mAmerican Airlines

Deal found 12/16

$383

Fri 3/2710:50 amJAN - BUF

1 stop4h 09mDelta

Mon 3/304:57 pmBUF - JAN

1 stop7h 25mDelta

Deal found 12/17

$387

Sat 1/249:00 amMOB - BUF

2 stops10h 29mUnited Airlines

Tue 1/272:49 pmBUF - MOB

1 stop6h 02mUnited Airlines

Deal found 12/16

$354

Fri 1/163:39 pmJAN - BUF

1 stop7h 02mAmerican Airlines

Fri 1/235:27 pmBUF - JAN

1 stop5h 29mAmerican Airlines

Deal found 12/17

$395

Wed 12/243:46 pmBTR - BUF

1 stop6h 51mDelta

Fri 12/266:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$403

Sat 2/75:34 pmGPT - BUF

1 stop5h 19mAmerican Airlines

Thu 2/125:00 amBUF - GPT

2 stops12h 05mAmerican Airlines

Deal found 12/17

$408

Sat 1/317:00 amGPT - BUF

2 stops12h 29mUnited Airlines

Tue 2/39:55 amBUF - GPT

2 stops10h 53mUnited Airlines

Deal found 12/15

$394

Sun 1/187:30 amMEM - BUF

1 stop4h 54mUnited Airlines

Thu 1/225:23 pmBUF - MEM

1 stop5h 36mUnited Airlines

Deal found 12/16

$415

Tue 12/233:46 pmBTR - BUF

1 stop7h 01mDelta

Thu 12/256:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$474

Thu 12/2510:09 amBTR - BUF

1 stop5h 20mAmerican Airlines

Sun 12/286:00 amBUF - BTR

1 stop7h 38mAmerican Airlines

Deal found 12/16

$506

Thu 1/17:10 amBTR - BUF

2 stops8h 24mUnited Airlines

Mon 1/56:30 amBUF - BTR

2 stops13h 53mUnited Airlines

Deal found 12/17

$462

Mon 12/223:46 pmBTR - BUF

1 stop7h 01mDelta

Thu 12/256:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$510

Mon 12/292:18 pmBTR - BUF

1 stop7h 11mAmerican Airlines

Sun 1/41:37 pmBUF - BTR

1 stop7h 20mAmerican Airlines

Deal found 12/17

$510

Thu 1/12:18 pmBTR - BUF

1 stop7h 11mAmerican Airlines

Mon 1/56:24 amBUF - BTR

1 stop8h 24mAmerican Airlines

Deal found 12/17

$513

Thu 12/259:35 amBTR - BUF

2 stops10h 19mUnited Airlines

Fri 12/266:30 amBUF - BTR

2 stops12h 02mUnited Airlines

Deal found 12/16

$517

Wed 12/246:20 amMOB - BUF

1 stop5h 44mDelta

Tue 12/306:00 amBUF - MOB

1 stop6h 31mDelta

Deal found 12/16

$614

Wed 12/2410:53 amMOB - BUF

1 stop6h 38mAmerican Airlines

Tue 12/307:21 pmBUF - MOB

1 stop5h 35mAmerican Airlines

Deal found 12/17

$594

Sat 2/76:05 amGPT - BUF

1 stop6h 04mDelta

Thu 2/126:00 amBUF - GPT

2 stops12h 15mDelta

Deal found 12/17

$710

Fri 1/26:16 pmJAN - BUF

1 stop4h 43mAmerican Airlines

Mon 1/53:58 pmBUF - JAN

2 stops9h 14mAmerican Airlines

Deal found 12/17

$658

Sat 1/36:02 pmMOB - BUF

1 stop4h 45mDelta

Mon 1/56:03 amBUF - MOB

2 stops8h 45mDelta

Deal found 12/17

$724

Wed 12/2412:59 pmMOB - BUF

2 stops9h 34mUnited Airlines

Tue 12/301:59 pmBUF - MOB

2 stops21h 44mUnited Airlines

Deal found 12/17

$736

Sun 12/285:13 amMOB - BUF

1 stop6h 44mAmerican Airlines

Tue 12/307:21 pmBUF - MOB

1 stop5h 35mAmerican Airlines

Deal found 12/15

$748

Fri 1/27:05 amGPT - BUF

1 stop15h 54mAmerican Airlines

Mon 1/57:15 pmBUF - GPT

1 stop5h 57mAmerican Airlines

Deal found 12/16

$760

Last-minute flights from Mississippi to Buffalo
Discover last-minute flight deals from Mississippi to Buffalo. Data last updated December 18, 2025 and is based on user searches.

Wed 12/243:46 pmBTR - BUF

1 stop6h 51mDelta

Thu 12/256:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$271

Wed 12/243:46 pmBTR - BUF

1 stop6h 51mDelta

Fri 12/266:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$403

Thu 12/2510:34 amBTR - BUF

2 stops10h 59mDelta

Fri 12/266:00 amBUF - BTR

1 stop4h 49mDelta

Deal found 12/16

$408

Thu 1/16:14 amMEM - BUF

1 stop5h 03mAmerican Airlines

Mon 1/56:29 pmBUF - MEM

1 stop5h 52mAmerican Airlines

Deal found 12/16

$368

Thu 1/812:45 pmMOB - BUF

1 stop5h 40mUnited Airlines

Sun 1/118:30 amBUF - MOB

2 stops10h 54mUnited Airlines

Deal found 12/15

$320

Thu 1/812:34 pmMOB - BUF

1 stop4h 05mDelta

Sun 1/116:00 amBUF - MOB

1 stop6h 45mDelta

Deal found 12/15

$329

Sat 1/107:30 amMEM - BUF

1 stop4h 54mUnited Airlines

Tue 1/2010:45 amBUF - MEM

1 stop7h 41mUnited Airlines

Deal found 12/16

$293

Tue 1/139:55 amMEM - BUF

1 stop5h 49mUnited Airlines

Tue 1/2010:45 amBUF - MEM

1 stop7h 41mUnited Airlines

Deal found 12/16

$290

Fri 1/165:48 pmMEM - BUF

1 stop4h 45mAmerican Airlines

Mon 1/1912:58 pmBUF - MEM

1 stop5h 10mAmerican Airlines

Deal found 12/17

$369

Fri 1/163:39 pmJAN - BUF

1 stop7h 02mAmerican Airlines

Fri 1/235:27 pmBUF - JAN

1 stop5h 29mAmerican Airlines

Deal found 12/17

$395

Sat 1/249:00 amMOB - BUF

2 stops10h 29mUnited Airlines

Tue 1/272:49 pmBUF - MOB

1 stop6h 02mUnited Airlines

Deal found 12/16

$354

Sat 1/317:00 amGPT - BUF

2 stops12h 29mUnited Airlines

Tue 2/310:45 amBUF - GPT

2 stops10h 03mUnited Airlines

Deal found 12/16

$394

One-way flights from Mississippi to Buffalo
Search for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

Sun 1/1811:44 amMEM - BUF

1 stop7h 19mMultiple Airlines

Deal found 12/16

$112

Sun 1/188:37 amMEM - BUF

2 stops7h 20mAmerican Airlines

Deal found 12/16

$140

Sat 1/105:27 pmMEM - BUF

1 stop5h 29mDelta

Deal found 12/16

$159

Sat 1/106:35 amMEM - BUF

2 stops8h 55mAmerican Airlines

Deal found 12/16

$164

Mon 1/126:45 amMEM - BUF

1 stop6h 25mDelta

Deal found 12/16

$176

Tue 1/66:18 amBTR - BUF

1 stop5h 56mDelta

Deal found 12/16

$179

Mon 1/126:35 amMEM - BUF

2 stops7h 42mAmerican Airlines

Deal found 12/16

$181

Thu 12/257:00 amGPT - BUF

2 stops8h 45mUnited Airlines

Deal found 12/16

$194

Sat 1/109:30 amBTR - BUF

2 stops12h 01mUnited Airlines

Deal found 12/16

$224

Fri 1/25:41 pmMEM - BUF

1 stop4h 47mDelta

Deal found 12/16

$234

Fri 1/27:30 amMEM - BUF

2 stops10h 36mUnited Airlines

Deal found 12/16

$239

Sat 2/219:45 amMEM - BUF

1 stop6h 14mDelta

Deal found 12/15

$240

Find flight deals from Mississippi to Buffalo

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$290 (United Airlines)
One-way from	$112 (Kiwi.com)

Provider with most accurate pricing for Jackson-Evers Intl-Buffalo flight deals.

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From Mississippi to Buffalo

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One-way flight from Mississippi to Buffalo

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Baton RougeBuffalo

BTR - BUF

BTRBUF

Baton Rouge Ryan

Wed 12/24

3:46 pm-11:37 pm

1 stop6h 51m

Buffalo

Thu 12/25

6:00 am-9:49 am

1 stop4h 49m

$271

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Tue 1/13

9:55 am-4:44 pm

1 stop5h 49m

Buffalo

Tue 1/20

10:45 am-5:26 pm

1 stop7h 41m

$290

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Sat 1/10

7:30 am-1:24 pm

1 stop4h 54m

Buffalo

Tue 1/20

10:45 am-5:26 pm

1 stop7h 41m

$293

MobileBuffalo

MOB - BUF

MOBBUF

Mobile

Thu 1/8

12:45 pm-7:25 pm

1 stop5h 40m

Buffalo

Sun 1/11

8:30 am-6:24 pm

2 stops10h 54m

$320

MobileBuffalo

MOB - BUF

MOBBUF

Mobile

Thu 1/8

12:34 pm-5:39 pm

1 stop4h 05m

Buffalo

Sun 1/11

6:00 am-11:45 am

1 stop6h 45m

$329

MobileBuffalo

MOB - BUF

MOBBUF

Mobile

Sat 1/24

9:00 am-8:29 pm

2 stops10h 29m

Buffalo

Tue 1/27

2:49 pm-7:51 pm

1 stop6h 02m

$354

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Fri 1/16

6:00 am-12:08 pm

1 stop5h 08m

Buffalo

Mon 1/19

12:58 pm-7:03 pm

1 stop7h 05m

$369

MemphisBuffalo

MEM - BUF

MEMBUF

Memphis

Thu 1/1

6:14 am-12:17 pm

1 stop5h 03m

Buffalo

Mon 1/5

3:58 pm-11:56 pm

2 stops8h 58m

$383

JacksonBuffalo

JAN - BUF

JANBUF

Jackson-Evers Intl

Fri 3/27

10:50 am-3:59 pm

1 stop4h 09m

Buffalo

Mon 3/30

4:57 pm-11:22 pm

1 stop7h 25m

$387

GulfportBuffalo

GPT - BUF

GPTBUF

Gulfport Biloxi Regional

Sat 1/31

7:00 am-8:29 pm

2 stops12h 29m

Buffalo

Tue 2/3

9:55 am-7:48 pm

2 stops10h 53m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 52 results

...

Best time to book a flight from Mississippi to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mississippi with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Buffalo

No data available for this route at this time. Please check back soon.

Related info for your journey

What airport do you fly into for flights to Buffalo from Mississippi?
If you book a flight to Buffalo from Mississippi, you will be flying to Buffalo, which is the city’s only airport. Buffalo (BUF) is located 8.3 mi from the center of Buffalo.
How long is the flight from Mississippi to Buffalo?
A quick flight from Mississippi to Buffalo can take about 5h 49m. Delta provides one of the quickest options available for as low as $290. Mississippi and Buffalo are separated by a distance of 812 mi. This flight may include one or multiple stops.
What are the most popular routes from Mississippi to Buffalo?
The most popular route from Mississippi to Buffalo is Memphis - Buffalo. You may also consider Gulfport Biloxi Regional - Buffalo or Jackson-Evers Intl - Buffalo.
Can I find deals for flights from Mississippi to Buffalo that include hotel bookings?
Yes. In addition to deals on Mississippi to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mississippi to Buffalo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Buffalo.
Can I find deals for business class flights from Mississippi to Buffalo?
Yes. Cheapflights offers flight deals from Mississippi to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Lockport

Cheektowaga

Batavia

Williamsville

Orchard Park

Eden

Amherst

West Seneca

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Top airline flying from Mississippi to Buffalo

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$258	Average$511	FlexibilityNo cancel fee	On-time71%

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$112+ Cheap flights from Mississippi to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Mississippi to Buffalo with Cheapflights

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Cheap flight deals from Mississippi to Buffalo

Cheapest flights from Mississippi to BuffaloExplore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Find flight deals from Mississippi to Buffalo

Keep the following information in mind while searching for Mississippi to Buffalo flight deals. Data was last updated December 18, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to Buffalo that are best for you.

Best time to book a flight from Mississippi to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mississippi with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Buffalo

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Buffalo from Mississippi?

How long is the flight from Mississippi to Buffalo?

What are the most popular routes from Mississippi to Buffalo?

Can I find deals for flights from Mississippi to Buffalo that include hotel bookings?

How can I find direct flights from Mississippi to Buffalo?

Can I find deals for business class flights from Mississippi to Buffalo?

Traveling to a place near Buffalo?

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Alternative routes for Mississippi to Buffalo

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Cheapest flights from Mississippi to Buffalo
Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.