$152+ Cheap flights from Mississippi to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BUF
Mar 16 — Mar 231
1 adult, Economy
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Find cheap flights from Mississippi to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Buffalo
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Cheapest flights from Mississippi to BuffaloExplore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.
Explore the most affordable flight options available from Mississippi to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:14 am
MEM
- BUF
1 stop22h 35m
Multiple Airlines
Thu 4/301:08 pm
BUF
- MEM
1 stop6h 11m
Multiple Airlines
Deal found 2/13![Multiple Airlines logo]()
$201
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:00 pm
BTR
- BUF
1 stop6h 35m
Delta
Sat 4/256:00 am
BUF
- BTR
1 stop4h 46m
Delta
Deal found 2/12![Delta logo]()
$271
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:29 pm
GPT
- BUF
1 stop5h 59m
American Airlines
Wed 4/87:28 pm
BUF
- GPT
1 stop5h 30m
American Airlines
Deal found 2/10![American Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/411:15 am
MEM
- BUF
1 stop23h 24m
Multiple Airlines
Thu 3/51:39 pm
BUF
- MEM
1 stop5h 30m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:00 am
GPT
- BUF
2 stops7h 19m
Delta
Wed 4/86:42 pm
BUF
- GPT
1 stop4h 33m
Delta
Deal found 2/13![Delta logo]()
$276
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:41 am
MOB
- BUF
1 stop6h 13m
American Airlines
Tue 3/106:39 pm
BUF
- MOB
1 stop5h 18m
American Airlines
Deal found 2/10![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
MOB
- BUF
1 stop4h 00m
Delta
Tue 3/107:38 pm
BUF
- MOB
1 stop4h 50m
Delta
Deal found 2/13![Delta logo]()
$294
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:41 pm
MOB
- BUF
1 stop4h 57m
American Airlines
Sun 3/17:41 pm
BUF
- MOB
1 stop5h 10m
American Airlines
Deal found 2/10![American Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:06 pm
MEM
- BUF
2 stops13h 59m
Multiple Airlines
Tue 3/37:17 pm
BUF
- MEM
1 stop16h 03m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/189:25 am
MEM
- BUF
1 stop5h 47m
Delta
Tue 4/216:00 am
BUF
- MEM
1 stop5h 28m
Delta
Deal found 2/13![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:55 am
JAN
- BUF
1 stop5h 42m
Delta
Wed 3/186:00 am
BUF
- JAN
1 stop5h 08m
Delta
Deal found 2/11![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/274:28 pm
BTR
- BUF
1 stop6h 22m
American Airlines
Tue 3/35:29 pm
BUF
- BTR
1 stop5h 32m
American Airlines
Deal found 2/11![American Airlines logo]()
$319
Best flights from Mississippi to BuffaloDiscover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 14, 2026.
Discover carefully curated flight deals from Mississippi to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:39 pm
MEM
- BUF
2 stops16h 34m
Multiple Airlines
Thu 4/301:08 pm
BUF
- MEM
1 stop6h 11m
Multiple Airlines
Deal found 2/13![Multiple Airlines logo]()
$230
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:00 pm
BTR
- BUF
1 stop6h 35m
Delta
Sat 4/256:00 am
BUF
- BTR
1 stop4h 46m
Delta
Deal found 2/12![Delta logo]()
$271
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:29 pm
GPT
- BUF
1 stop5h 59m
American Airlines
Wed 4/87:28 pm
BUF
- GPT
1 stop5h 30m
American Airlines
Deal found 2/10![American Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:00 pm
MEM
- BUF
1 stop4h 00m
Southwest
Tue 4/216:55 pm
BUF
- MEM
1 stop4h 55m
Southwest
Deal found 2/10![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:00 am
BTR
- BUF
2 stops11h 10m
United Airlines
Sat 4/251:52 pm
BUF
- BTR
2 stops8h 22m
United Airlines
Deal found 2/12![United Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/411:15 am
MEM
- BUF
1 stop23h 24m
Multiple Airlines
Thu 3/51:39 pm
BUF
- MEM
1 stop5h 30m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:00 am
GPT
- BUF
2 stops7h 19m
Delta
Wed 4/86:42 pm
BUF
- GPT
1 stop4h 33m
Delta
Deal found 2/13![Delta logo]()
$276
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:41 am
MOB
- BUF
1 stop6h 13m
American Airlines
Tue 3/106:39 pm
BUF
- MOB
1 stop5h 18m
American Airlines
Deal found 2/10![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
MOB
- BUF
1 stop4h 00m
Delta
Tue 3/106:00 am
BUF
- MOB
1 stop6h 55m
Delta
Deal found 2/12![Delta logo]()
$294
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:40 am
MEM
- BUF
2 stops9h 25m
Southwest
Thu 3/57:35 pm
BUF
- MEM
1 stop4h 45m
Southwest
Deal found 2/11![Southwest logo]()
$334
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:41 pm
MOB
- BUF
1 stop4h 57m
American Airlines
Sun 3/17:41 pm
BUF
- MOB
1 stop5h 10m
American Airlines
Deal found 2/10![American Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:06 pm
MEM
- BUF
2 stops13h 59m
Multiple Airlines
Tue 3/37:17 pm
BUF
- MEM
1 stop16h 03m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$316
This United Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:00 pm
BTR
- BUF
2 stops7h 49m
United Airlines
Wed 4/297:00 am
BUF
- BTR
2 stops9h 33m
United Airlines
Deal found 2/13![United Airlines logo]()
$361
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/189:25 am
MEM
- BUF
1 stop5h 47m
Delta
Tue 4/216:00 am
BUF
- MEM
1 stop5h 28m
Delta
Deal found 2/13![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/274:28 pm
BTR
- BUF
1 stop6h 22m
American Airlines
Tue 3/35:29 pm
BUF
- BTR
1 stop5h 32m
American Airlines
Deal found 2/11![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:55 am
JAN
- BUF
1 stop5h 42m
Delta
Wed 3/186:00 am
BUF
- JAN
1 stop5h 08m
Delta
Deal found 2/11![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:00 am
MEM
- BUF
2 stops8h 07m
American Airlines
Tue 4/215:32 pm
BUF
- MEM
1 stop7h 22m
American Airlines
Deal found 2/11![American Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:15 pm
JAN
- BUF
1 stop4h 45m
Southwest
Mon 5/186:15 am
BUF
- JAN
2 stops13h 50m
Southwest
Deal found 2/11![Southwest logo]()
$413
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:21 am
MEM
- BUF
1 stop6h 51m
Delta
Wed 4/227:37 pm
BUF
- MEM
1 stop4h 49m
Delta
Deal found 2/10![Delta logo]()
$327
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/212:10 pm
JAN
- BUF
1 stop5h 31m
Delta
Fri 8/74:30 pm
BUF
- JAN
1 stop4h 34m
Delta
Deal found 2/10![Delta logo]()
$397
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/64:28 pm
BTR
- BUF
1 stop6h 22m
American Airlines
Sun 3/85:29 pm
BUF
- BTR
1 stop5h 26m
American Airlines
Deal found 2/13![American Airlines logo]()
$446
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:45 am
JAN
- BUF
1 stop6h 45m
Delta
Tue 6/167:40 pm
BUF
- JAN
1 stop4h 40m
Delta
Deal found 2/12![Delta logo]()
$404
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2610:03 am
AEX
- BUF
2 stops11h 47m
American Airlines
Mon 3/24:04 pm
BUF
- AEX
2 stops8h 10m
American Airlines
Deal found 2/11![American Airlines logo]()
$450
This United Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:45 pm
BTR
- BUF
2 stops17h 32m
United Airlines
Sun 3/86:07 am
BUF
- BTR
2 stops12h 25m
United Airlines
Deal found 2/13![United Airlines logo]()
$728
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:58 pm
JAN
- BUF
2 stops10h 01m
Delta
Mon 5/187:32 pm
BUF
- JAN
1 stop4h 49m
Delta
Deal found 2/12![Delta logo]()
$413
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2012:43 pm
GPT
- BUF
1 stop4h 56m
American Airlines
Wed 6/247:31 pm
BUF
- GPT
1 stop5h 30m
American Airlines
Deal found 2/11![American Airlines logo]()
$456
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:48 am
AEX
- BUF
1 stop4h 52m
Delta
Mon 3/26:00 am
BUF
- AEX
1 stop6h 07m
Delta
Deal found 2/11![Delta logo]()
$526
Last-minute flights from Mississippi to BuffaloDiscover last-minute flight deals from Mississippi to Buffalo. Data last updated February 14, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Buffalo. Data last updated February 14, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:41 pm
MOB
- BUF
1 stop4h 57m
American Airlines
Sun 3/17:41 pm
BUF
- MOB
1 stop5h 10m
American Airlines
Deal found 2/10![American Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:06 pm
MEM
- BUF
2 stops13h 59m
Multiple Airlines
Tue 3/37:17 pm
BUF
- MEM
1 stop16h 03m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/274:28 pm
BTR
- BUF
1 stop6h 22m
American Airlines
Tue 3/35:29 pm
BUF
- BTR
1 stop5h 32m
American Airlines
Deal found 2/11![American Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/411:15 am
MEM
- BUF
1 stop23h 24m
Multiple Airlines
Thu 3/51:39 pm
BUF
- MEM
1 stop5h 30m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:41 am
MOB
- BUF
1 stop6h 13m
American Airlines
Tue 3/106:39 pm
BUF
- MOB
1 stop5h 18m
American Airlines
Deal found 2/10![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
MOB
- BUF
1 stop4h 00m
Delta
Tue 3/107:38 pm
BUF
- MOB
1 stop4h 50m
Delta
Deal found 2/13![Delta logo]()
$294
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:40 am
MEM
- BUF
2 stops9h 25m
Southwest
Thu 3/57:35 pm
BUF
- MEM
1 stop4h 45m
Southwest
Deal found 2/11![Southwest logo]()
$334
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:15 am
MEM
- BUF
1 stop4h 28m
Delta
Mon 3/94:47 pm
BUF
- MEM
1 stop6h 27m
Delta
Deal found 2/13![Delta logo]()
$410
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/109:57 am
MEM
- BUF
1 stop5h 45m
United Airlines
Tue 3/175:29 pm
BUF
- MEM
1 stop5h 30m
United Airlines
Deal found 2/10![United Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:55 am
JAN
- BUF
1 stop5h 42m
Delta
Wed 3/186:00 am
BUF
- JAN
1 stop5h 08m
Delta
Deal found 2/11![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1312:42 pm
MOB
- BUF
1 stop5h 01m
Delta
Sun 3/157:38 pm
BUF
- MOB
1 stop4h 50m
Delta
Deal found 2/11![Delta logo]()
$423
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:06 am
MEM
- BUF
1 stop8h 19m
American Airlines
Mon 3/235:59 pm
BUF
- MEM
1 stop7h 00m
American Airlines
Deal found 2/12![American Airlines logo]()
$363
One-way flights from Mississippi to BuffaloSearch for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated February 14, 2026.
Search for one-way flight options from Mississippi to Buffalo. Find affordable one-way fares based on user searches. Data last updated February 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/111:14 am
MEM
- BUF
1 stop22h 45m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$152
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:00 am
MEM
- BUF
1 stop7h 05m
American Airlines
Deal found 2/10![American Airlines logo]()
$159
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:53 am
MEM
- BUF
2 stops6h 59m
American Airlines
Deal found 2/11![American Airlines logo]()
$164
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:08 pm
MEM
- BUF
1 stop4h 23m
American Airlines
Deal found 2/10![American Airlines logo]()
$194
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:45 am
MEM
- BUF
2 stops6h 30m
Southwest
Deal found 2/10![Southwest logo]()
$209
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:15 am
MOB
- BUF
1 stop6h 36m
American Airlines
Deal found 2/13![American Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:14 am
MEM
- BUF
3 stops24h 03m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:18 am
BTR
- BUF
1 stop5h 45m
Delta
Deal found 2/13![Delta logo]()
$332
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:00 pm
GPT
- BUF
2 stops8h 56m
United Airlines
Deal found 2/12![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/15:15 am
MOB
- BUF
2 stops9h 10m
American Airlines
Deal found 2/13![American Airlines logo]()
$445
Find flight deals from Mississippi to Buffalo
Keep the following information in mind while searching for Mississippi to Buffalo flight deals. Data was last updated February 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $201 (Kiwi.com) |
One-way from | $152 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Mississippi to Buffalo that are best for you.
Fly from
Mississippi
Fly to
Buffalo
Route
Depart
Return
Price
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Fri 4/24
6:39 pm-12:13 pm
2 stops16h 34m
Buffalo
Thu 4/30
1:08 pm-6:19 pm
1 stop6h 11m
$230
Baton RougeBuffalo
BTR - BUF
BTRBUF
Baton Rouge Ryan
Wed 4/22
4:00 pm-11:35 pm
1 stop6h 35m
Buffalo
Sat 4/25
6:00 am-9:46 am
1 stop4h 46m
$271
GulfportBuffalo
GPT - BUF
GPTBUF
Gulfport Biloxi Regional
Wed 4/1
4:29 pm-11:28 pm
1 stop5h 59m
Buffalo
Wed 4/8
7:28 pm-11:58 pm
1 stop5h 30m
$271
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Wed 3/4
11:15 am-11:39 am
1 stop23h 24m
Buffalo
Thu 3/5
1:39 pm-6:09 pm
1 stop5h 30m
$274
GulfportBuffalo
GPT - BUF
GPTBUF
Gulfport Biloxi Regional
Wed 4/1
6:00 am-2:19 pm
2 stops7h 19m
Buffalo
Wed 4/8
6:42 pm-10:15 pm
1 stop4h 33m
$276
MobileBuffalo
MOB - BUF
MOBBUF
Mobile
Wed 3/4
10:41 am-5:54 pm
1 stop6h 13m
Buffalo
Tue 3/10
6:39 pm-10:57 pm
1 stop5h 18m
$279
MobileBuffalo
MOB - BUF
MOBBUF
Mobile
Wed 3/4
6:00 am-11:00 am
1 stop4h 00m
Buffalo
Tue 3/10
6:00 am-11:55 am
1 stop6h 55m
$294
MobileBuffalo
MOB - BUF
MOBBUF
Mobile
Wed 2/25
5:41 pm-11:38 pm
1 stop4h 57m
Buffalo
Sun 3/1
7:41 pm-11:51 pm
1 stop5h 10m
$309
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Fri 2/27
8:06 pm-11:05 am
2 stops13h 59m
Buffalo
Tue 3/3
7:17 pm-10:20 am
1 stop16h 03m
$316
MemphisBuffalo
MEM - BUF
MEMBUF
Memphis
Sat 4/18
1:00 pm-6:00 pm
1 stop4h 00m
Buffalo
Tue 4/21
6:55 pm-10:50 pm
1 stop4h 55m
$317
Showing 1-10 of 39 results
Best time to book a flight from Mississippi to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mississippi with our price prediction graph.
MEM-BUF
MOB-BUF
BTR-BUF
GPT-BUF
JAN-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Buffalo
USMS-BUF
MEM-BUF
MOB-BUF
BTR-BUF
GPT-BUF
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
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Alternative routes for Mississippi to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 14, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to Buffalo by cabin class
Find flights from Mississippi to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and Buffalo flights
Browse other Mississippi and Buffalo flight options. Last updated on February 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mississippi to Buffalo flights
Consider these flights traveling from Mississippi to Buffalo.
Top airline flying from Mississippi to Buffalo
Discover the top airline that operate flights from Mississippi to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$511 | FlexibilityNo cancel fee | On-time71% |