$130+ Cheap flights from Mesa, AZ to Buffalo (BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — BUF
Oct 4 — Oct 111
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Buffalo are usually found in March or August, booked 71 days in advance, depart on a Wednesday or Tuesday and return on a Thursday
Cheap flight deals from Mesa to Buffalo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mesa to BuffaloExplore the most affordable flight options available from Mesa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
Explore the most affordable flight options available from Mesa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
This CheapOair deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:12 pm -
1 stop16h 40m
Tue 10/206:51 pm -
1 stop28h 51m
Deal found 9/1![Frontier logo]()
$266
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:00 am -
1 stop6h 10m
Sun 11/14:55 pm -
1 stop8h 10m
Deal found 9/1![Southwest logo]()
$302
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1312:36 am -
1 stop7h 17m
Sat 10/175:50 pm -
1 stop9h 54m
Deal found 8/30![American Airlines logo]()
$306
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:00 am -
1 stop7h 45m
Mon 12/72:40 pm -
1 stop9h 55m
Deal found 9/2![Southwest logo]()
$307
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:30 am -
1 stop7h 23m
Tue 10/62:55 pm -
1 stop7h 38m
Deal found 9/1![American Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1312:35 am -
1 stop6h 50m
Tue 10/204:25 pm -
2 stops9h 10m
Deal found 9/2![Southwest logo]()
$312
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:10 pm -
2 stops15h 20m
Fri 9/251:40 pm -
1 stop10h 55m
Deal found 8/30![Southwest logo]()
$318
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:33 pm -
1 stop6h 10m
Tue 10/610:46 am -
2 stops9h 28m
Deal found 9/2![United Airlines logo]()
$329
Best flights from Mesa to BuffaloDiscover carefully curated flight deals from Mesa to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
Discover carefully curated flight deals from Mesa to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1811:37 am -
1 stop9h 35m
Mon 9/213:53 pm -
1 stop10h 11m
Deal found 9/3![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2612:35 am -
1 stop6h 50m
Tue 10/274:25 pm -
2 stops8h 55m
Deal found 8/31![Southwest logo]()
$312
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/121:00 pm -
1 stop7h 37m
Mon 2/155:50 pm -
1 stop6h 54m
Deal found 9/2![United Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:25 pm -
Nonstop4h 05m
Tue 10/206:20 pm -
Nonstop4h 40m
Deal found 9/1![Southwest logo]()
$317
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:45 am -
2 stops7h 55m
Sun 11/17:20 am -
2 stops9h 05m
Deal found 9/1![Southwest logo]()
$317
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:55 pm -
1 stop9h 55m
Wed 10/144:25 pm -
2 stops8h 55m
Deal found 9/3![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1910:55 pm -
1 stop9h 55m
Mon 10/265:45 pm -
2 stops8h 45m
Deal found 8/30![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:45 am -
2 stops7h 55m
Wed 10/284:25 pm -
2 stops8h 55m
Deal found 9/2![Southwest logo]()
$363
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:10 am -
2 stops6h 55m
Mon 11/97:20 am -
2 stops9h 05m
Deal found 9/3![Southwest logo]()
$363
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:10 pm -
2 stops15h 20m
Sat 9/193:30 pm -
1 stop7h 35m
Deal found 8/30![Southwest logo]()
$385
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:00 pm -
Nonstop4h 05m
Mon 10/197:30 pm -
1 stop7h 00m
Deal found 9/1![Southwest logo]()
$401
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:00 am -
2 stops10h 55m
Mon 11/97:20 am -
2 stops9h 05m
Deal found 9/3![Southwest logo]()
$403
Last-minute flights from Mesa to BuffaloDiscover last-minute flight deals from Mesa to Buffalo. Data last updated September 4, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Buffalo. Data last updated September 4, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:10 pm -
2 stops15h 20m
Fri 9/251:40 pm -
1 stop10h 55m
Deal found 8/30![Southwest logo]()
$318
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:30 am -
1 stop7h 23m
Tue 10/62:55 pm -
1 stop7h 38m
Deal found 9/1![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:33 pm -
1 stop6h 10m
Tue 10/610:46 am -
2 stops9h 28m
Deal found 9/2![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:30 am -
1 stop8h 38m
Sat 10/107:35 pm -
1 stop7h 24m
Deal found 9/2![American Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1312:36 am -
1 stop7h 17m
Sat 10/175:50 pm -
1 stop9h 54m
Deal found 8/30![American Airlines logo]()
$306
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1312:35 am -
1 stop6h 50m
Tue 10/204:25 pm -
2 stops9h 10m
Deal found 9/2![Southwest logo]()
$312
This CheapOair deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:12 pm -
1 stop16h 40m
Tue 10/206:51 pm -
1 stop28h 51m
Deal found 9/1![Frontier logo]()
$266
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:00 am -
1 stop6h 10m
Sun 11/14:55 pm -
1 stop8h 10m
Deal found 9/1![Southwest logo]()
$302
One-way flights from Mesa to BuffaloSearch for one-way flight options from Mesa to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
Search for one-way flight options from Mesa to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
This Booking.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:12 pm -
1 stop16h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/30![Frontier logo]()
$130
This Mytrip deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1910:12 pm -
1 stop16h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Frontier logo]()
$131
This CheapOair deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:12 pm -
1 stop16h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Frontier logo]()
$132
This Expedia deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:14 pm -
1 stop19h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Frontier logo]()
$140
This CheapOair deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1210:12 pm -
1 stop16h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:46 pm -
2 stops19h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:23 pm -
2 stops16h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Frontier logo]()
$147
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 am -
1 stop6h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Southwest logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:25 pm -
2 stops21h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Frontier logo]()
$152
Find flight deals from Mesa to Buffalo
Keep the following information in mind while searching for Mesa to Buffalo flight deals. Data was last updated September 4, 2026.
Round-trip from | $266 (CheapOair) |
|---|---|
One-way from | $130 (Booking.com) |
Popular in | December |
Cheapest in | March |
Average price | $365 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
Use the filters below to find and compare flights from Mesa to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Thu 10/8
11:52 pm-9:29 am
1 stop6h 37m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$154
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Sat 11/14
6:25 am-4:00 pm
1 stop7h 35m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$154
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Sat 10/3
11:05 pm-8:24 am
1 stop6h 19m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$154
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Sat 9/26
9:00 am-8:47 pm
1 stop8h 47m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$154
Quickest round-trip
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Tue 10/27
7:00 am-3:45 pm
1 stop5h 45m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$154
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Fri 9/25
11:52 pm-9:29 am
1 stop6h 37m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$154
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Tue 9/29
6:15 am-5:45 pm
2 stops8h 30m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$159
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Wed 9/23
9:50 am-11:44 pm
2 stops10h 54m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$159
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Thu 11/5
11:25 pm-8:26 am
1 stop7h 01m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$164
PhoenixBuffalo
PHX Phoenix Sky Harbor Intl - BUF Buffalo
PHXBUF
Phoenix Sky Harbor Intl
Sun 11/1
11:45 pm-10:38 am
1 stop8h 53m
Buffalo
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$164
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Mesa to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mesa with our price prediction graph.
PHX-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Buffalo
MS9-BUF
PHX-BUF
How much does it cost to fly round-trip from Mesa to Buffalo?
Airfare is below average for this route at the moment.
Mesa to Buffalo flights typically cost between $296 and $434 in October.The cheapest round-trip price found within the last 5 days was $266 on Frontier (Oct 14-Oct 20).
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 4, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Mesa to Buffalo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Mesa to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 4, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mesa to Buffalo by cabin class
Find flights from Mesa to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mesa and Buffalo flights
Browse other Mesa and Buffalo flight options. Last updated on September 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mesa to Buffalo flights
Consider these flights traveling from Mesa to Buffalo.
Top 6 airlines flying from Mesa to Buffalo
Discover the top 6 airlines that operate flights from Mesa to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$127 | Average$292 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$153 | Average$317 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$234 | Average$324 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$236 | Average$382 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$262 | Average$441 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$296 | Average$406 | FlexibilityNo cancel fee | On-time71% |