What are the cheapest airlines to fly from Mesa to Buffalo one-way?

One-way options have recently been found by users for as low as $104 on JetBlue. Other airlines that offer cheap prices include American Airlines from $109 and Frontier from $116 one-way.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

What are the cheapest flights from Mesa to Buffalo?

On average you can expect to pay $769 for a flight from Mesa to Buffalo. The cheapest flight overall is $242 while the most popular route, (Phoenix Sky Harbor Intl - Buffalo) is currently priced at $257.

What are the most popular airlines that fly from Mesa to Buffalo?

Before booking your flight from Mesa to Buffalo check out the most popular airlines for this route: American Airlines, Southwest or United Airlines.

What airport do you fly into for flights to Buffalo from Mesa?

If you book a flight to Buffalo from Mesa, you will be flying to Buffalo, which is the city’s only airport. Buffalo (BUF) is located 8.3 mi from the center of Buffalo. There is 1 flight from Mesa to Buffalo per day from 6 different airlines.

Can I find deals for flights from Mesa to Buffalo that include hotel bookings?

Yes. In addition to deals on Mesa to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mesa to Buffalo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Buffalo.

Can I find deals for business class flights from Mesa to Buffalo?

Yes. Cheapflights offers flight deals from Mesa to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Mesa to Buffalo

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Cheapflights Tip: The best prices from Mesa to Buffalo are usually found in March or August, booked 71 days in advance, depart on a Wednesday or Monday and return on a Thursday

Find flight deals from Mesa to Buffalo

Popular in	December
Cheapest in	March
Average price	$447

Highest demand for flights based on searches. 9% potential increase in price ($40 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).

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Average for round-trip flights in October 2026

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Cheapflights Insights

Everything you need to know about your flight from Mesa to Buffalo

What is the cheapest time of day to fly from MS9 to BUF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mesa to Buffalo as you normally would.

Reviews of airlines servicing Buffalo

Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Mesa to Buffalo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,219 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Southwest

7.9

Good

4,219 reviews

Southwest

7.9

Good

4,219 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Delta

7.8

Good

8,676 reviews

Southwest

7.9

Good

4,219 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

United Airlines

7.3

Good

10,440 reviews

Southwest

7.9

Good

4,219 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

American Airlines

7.0

Good

12,187 reviews

Southwest

7.9

Good

4,219 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Frontier

5.5

Fair

2,515 reviews

Southwest

7.9

Good

4,219 reviews

Reviews

1 / 20

8.0

Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Related info for your journey

What airport do you fly into for flights to Buffalo from Mesa?
If you book a flight to Buffalo from Mesa, you will be flying to Buffalo, which is the city’s only airport. Buffalo (BUF) is located 8.3 mi from the center of Buffalo. There is 1 flight from Mesa to Buffalo per day from 6 different airlines.
What are the cheapest airlines to fly from Mesa to Buffalo one-way?
One-way options have recently been found by users for as low as $104 on JetBlue. Other airlines that offer cheap prices include American Airlines from $109 and Frontier from $116 one-way.
What are the cheapest flights from Mesa to Buffalo?
On average you can expect to pay $769 for a flight from Mesa to Buffalo. The cheapest flight overall is $242 while the most popular route, (Phoenix Sky Harbor Intl - Buffalo) is currently priced at $257.
Can I find deals for flights from Mesa to Buffalo that include hotel bookings?
Yes. In addition to deals on Mesa to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mesa to Buffalo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Buffalo.
Can I find deals for business class flights from Mesa to Buffalo?
Yes. Cheapflights offers flight deals from Mesa to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 6 airlines flying from Mesa to Buffalo

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$127	Average$286	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$153	Average$297	FlexibilityNo cancel fee	On-timeN/A
JetBlue	Cheapest$212	Average$298	FlexibilityNo cancel fee	On-time62%
United Airlines	Cheapest$236	Average$387	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$256	Average$426	FlexibilityNo cancel fee	On-time63%
American Airlines	Cheapest$296	Average$399	FlexibilityNo cancel fee	On-time71%

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Cheap flights from Mesa, AZ to Buffalo (BUF)

Find cheap flights from Mesa to Buffalo with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Mesa to Buffalo

Popular in

Cheapest in

Average price

Cheapflights Insights

What is the cheapest time of day to fly from MS9 to BUF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mesa to Buffalo as you normally would.

Reviews of airlines servicing Buffalo

Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Mesa to Buffalo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

What airport do you fly into for flights to Buffalo from Mesa?

What are the cheapest airlines to fly from Mesa to Buffalo one-way?

What are the cheapest flights from Mesa to Buffalo?

Can I find deals for flights from Mesa to Buffalo that include hotel bookings?

How can I find direct flights from Mesa to Buffalo?

Can I find deals for business class flights from Mesa to Buffalo?

Traveling to a place near Buffalo?

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Alternative routes for Mesa to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.

Other flights to Buffalo

Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.

Complete your trip

Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Mesa to Buffalo by cabin class

Find flights from Mesa to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Mesa and Buffalo flights

Browse other Mesa and Buffalo flight options. Last updated on October 26, 2026.

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Top 6 airlines flying from Mesa to Buffalo

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