$99+ Cheap flights from Mesa, AZ to Buffalo (BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — BUF
jul. 1 — jul. 81
Round-trip
1 adult, Economy
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Find cheap flights from Mesa to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mesa to Buffalo are usually found in March or August, booked 71 days in advance, depart on a Monday or Thursday and return on a Friday
Cheap flight deals from Mesa to Buffalo
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Cheapest flights from Mesa to BuffaloExplore the most affordable flight options available from Mesa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juni 1, 2026.
Explore the most affordable flight options available from Mesa to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juni 1, 2026.
This United Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 8/296:20 am
PHX
- BUF
1 stop7h 36m
United Airlines
ma. 8/315:58 pm
BUF
- PHX
1 stop7h 24m
United Airlines
Deal found 5/31![United Airlines logo]()
$227
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 9/111:05 pm
PHX
- BUF
1 stop6h 10m
Delta
ti. 9/86:25 am
BUF
- PHX
1 stop6h 51m
Delta
Deal found 5/31![Delta logo]()
$237
This United Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 8/411:40 am
PHX
- BUF
1 stop8h 19m
United Airlines
ti. 8/116:55 am
BUF
- PHX
1 stop9h 01m
United Airlines
Deal found 5/31![United Airlines logo]()
$262
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 9/112:35 pm
PHX
- BUF
1 stop9h 05m
Delta
sø. 9/66:00 am
BUF
- PHX
1 stop9h 19m
Delta
Deal found 5/31![Delta logo]()
$267
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 9/411:45 pm
PHX
- BUF
1 stop6h 54m
American Airlines
on. 9/912:56 pm
BUF
- PHX
1 stop7h 05m
American Airlines
Deal found 5/31![American Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 7/2911:40 am
PHX
- BUF
1 stop10h 06m
Delta
to. 8/63:53 pm
BUF
- PHX
1 stop10h 44m
Delta
Deal found 5/30![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 9/1412:35 am
PHX
- BUF
1 stop7h 45m
Southwest
on. 9/2312:35 pm
BUF
- PHX
2 stops8h 35m
Southwest
Deal found 5/31![Southwest logo]()
$305
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 7/305:10 am
PHX
- BUF
1 stop7h 50m
Southwest
ma. 8/1712:30 pm
BUF
- PHX
1 stop12h 50m
Southwest
Deal found 5/28![Southwest logo]()
$308
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 8/1812:35 am
PHX
- BUF
2 stops8h 55m
Southwest
on. 8/263:00 pm
BUF
- PHX
1 stop7h 30m
Southwest
Deal found 5/31![Southwest logo]()
$309
This Frontier deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 6/2411:40 pm
PHX
- BUF
1 stop8h 00m
Frontier
on. 7/12:50 pm
BUF
- PHX
1 stop10h 30m
Frontier
Deal found 5/28![Frontier logo]()
$310
This Booking.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/2212:35 am
PHX
- BUF
1 stop15h 37m
Frontier
ti. 7/79:09 pm
BUF
- PHX
1 stop16h 21m
Frontier
Deal found 5/31![Frontier logo]()
$311
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 7/73:28 pm
PHX
- BUF
1 stop5h 30m
Delta
lø. 7/186:29 am
BUF
- PHX
1 stop6h 15m
Delta
Deal found 5/31![Delta logo]()
$318
Best flights from Mesa to BuffaloDiscover carefully curated flight deals from Mesa to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated juni 1, 2026.
Discover carefully curated flight deals from Mesa to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated juni 1, 2026.
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 7/610:35 pm
PHX
- BUF
1 stop8h 06m
Delta
fr. 7/175:12 pm
BUF
- PHX
1 stop8h 27m
Delta
Deal found 5/31![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 6/272:55 pm
PHX
- BUF
1 stop6h 35m
Southwest
lø. 7/45:45 am
BUF
- PHX
1 stop6h 40m
Southwest
Deal found 5/30![Southwest logo]()
$378
This United Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 8/179:00 am
PHX
- BUF
1 stop9h 07m
United Airlines
on. 8/1910:30 am
BUF
- PHX
2 stops14h 52m
United Airlines
Deal found 5/31![United Airlines logo]()
$444
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 8/1911:05 pm
PHX
- BUF
1 stop6h 10m
Delta
sø. 8/306:00 am
BUF
- PHX
1 stop9h 08m
Delta
Deal found 5/28![Delta logo]()
$297
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 7/206:45 am
PHX
- BUF
1 stop8h 39m
Delta
on. 7/296:29 am
BUF
- PHX
1 stop6h 15m
Delta
Deal found 5/27![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 8/1812:35 am
PHX
- BUF
2 stops8h 55m
Southwest
on. 8/2612:35 pm
BUF
- PHX
2 stops8h 40m
Southwest
Deal found 5/30![Southwest logo]()
$379
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 7/112:55 pm
PHX
- BUF
1 stop6h 40m
Southwest
ti. 7/216:25 am
BUF
- PHX
2 stops17h 20m
Southwest
Deal found 5/27![Southwest logo]()
$380
This Delta deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/2910:35 pm
PHX
- BUF
1 stop8h 05m
Delta
on. 7/83:54 pm
BUF
- PHX
1 stop8h 54m
Delta
Deal found 5/30![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 9/411:10 pm
PHX
- BUF
1 stop7h 45m
Southwest
on. 9/912:00 pm
BUF
- PHX
2 stops9h 10m
Southwest
Deal found 5/31![Southwest logo]()
$404
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 7/711:04 pm
PHX
- BUF
1 stop6h 10m
Delta
ti. 7/146:29 am
BUF
- PHX
1 stop6h 15m
Delta
Deal found 5/31![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 7/112:55 pm
PHX
- BUF
1 stop6h 40m
Southwest
ma. 8/103:55 pm
BUF
- PHX
2 stops9h 00m
Southwest
Deal found 5/27![Southwest logo]()
$404
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 8/2512:35 am
PHX
- BUF
2 stops8h 55m
Southwest
sø. 8/306:45 am
BUF
- PHX
2 stops11h 00m
Southwest
Deal found 5/27![Southwest logo]()
$409
Last-minute flights from Mesa to BuffaloDiscover last-minute flight deals from Mesa to Buffalo. Data last updated juni 1, 2026 and is based on user searches.
Discover last-minute flight deals from Mesa to Buffalo. Data last updated juni 1, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 6/610:55 pm
PHX
- BUF
1 stop6h 28m
Delta
on. 6/109:03 am
BUF
- PHX
1 stop7h 52m
Delta
Deal found 5/28![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 6/123:36 pm
PHX
- BUF
1 stop5h 23m
Delta
ma. 6/156:29 am
BUF
- PHX
1 stop6h 27m
Delta
Deal found 5/28![Delta logo]()
$318
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 6/1211:40 am
PHX
- BUF
1 stop7h 59m
United Airlines
ma. 6/226:04 pm
BUF
- PHX
1 stop8h 33m
United Airlines
Deal found 5/29![United Airlines logo]()
$348
This CheapOair deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/1512:35 am
PHX
- BUF
1 stop15h 37m
Frontier
ti. 7/79:09 pm
BUF
- PHX
1 stop16h 21m
Frontier
Deal found 5/28![Frontier logo]()
$340
This United Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 6/166:00 am
PHX
- BUF
1 stop9h 05m
United Airlines
ti. 6/306:04 pm
BUF
- PHX
1 stop7h 23m
United Airlines
Deal found 5/30![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/2210:57 pm
PHX
- BUF
1 stop6h 26m
Delta
to. 7/26:29 am
BUF
- PHX
1 stop6h 27m
Delta
Deal found 5/28![Delta logo]()
$297
This Booking.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/2212:35 am
PHX
- BUF
1 stop15h 37m
Frontier
ti. 7/79:09 pm
BUF
- PHX
1 stop16h 21m
Frontier
Deal found 5/31![Frontier logo]()
$311
This Frontier deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 6/2411:40 pm
PHX
- BUF
1 stop8h 00m
Frontier
on. 7/12:50 pm
BUF
- PHX
1 stop10h 30m
Frontier
Deal found 5/28![Frontier logo]()
$310
This Travelocity deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 6/2411:40 pm
PHX
- BUF
1 stop8h 00m
Frontier
fr. 7/247:57 pm
BUF
- PHX
1 stop17h 33m
Frontier
Deal found 5/30![Frontier logo]()
$330
This Frontier deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 6/2711:40 pm
PHX
- BUF
1 stop8h 00m
Frontier
on. 7/12:50 pm
BUF
- PHX
1 stop10h 30m
Frontier
Deal found 5/28![Frontier logo]()
$324
This Frontier deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/2911:40 pm
PHX
- BUF
1 stop8h 15m
Frontier
on. 7/82:48 pm
BUF
- PHX
1 stop7h 56m
Frontier
Deal found 5/30![Frontier logo]()
$329
This Booking.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/2911:40 pm
PHX
- BUF
1 stop8h 15m
Frontier
ti. 7/79:09 pm
BUF
- PHX
1 stop16h 21m
Frontier
Deal found 5/30![Frontier logo]()
$332
One-way flights from Mesa to BuffaloSearch for one-way flight options from Mesa to Buffalo. Find affordable one-way fares based on user searches. Data last updated juni 1, 2026.
Search for one-way flight options from Mesa to Buffalo. Find affordable one-way fares based on user searches. Data last updated juni 1, 2026.
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 8/2412:35 am
PHX
- BUF
1 stop7h 45m
Southwest
Deal found 5/28![Southwest logo]()
$99
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 8/1112:20 am
PHX
- BUF
1 stop6h 19m
American Airlines
Deal found 6/1![American Airlines logo]()
$114
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 8/2511:05 pm
PHX
- BUF
1 stop6h 10m
Delta
Deal found 6/1![Delta logo]()
$119
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 7/223:28 pm
PHX
- BUF
1 stop5h 30m
Delta
Deal found 5/29![Delta logo]()
$149
This United Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 11/47:30 pm
PHX
- BUF
2 stops12h 56m
United Airlines
Deal found 5/31![United Airlines logo]()
$154
This Frontier deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 6/2411:40 pm
PHX
- BUF
1 stop8h 00m
Frontier
Deal found 5/30![Frontier logo]()
$155
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 8/2711:35 pm
PHX
- BUF
1 stop7h 43m
American Airlines
Deal found 6/1![American Airlines logo]()
$164
This Frontier deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 6/2711:40 pm
PHX
- BUF
1 stop8h 00m
Frontier
Deal found 5/30![Frontier logo]()
$169
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 9/165:00 am
PHX
- BUF
1 stop7h 40m
American Airlines
Deal found 5/30![American Airlines logo]()
$170
This Frontier deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 6/2011:40 pm
PHX
- BUF
1 stop8h 00m
Frontier
Deal found 5/27![Frontier logo]()
$174
This Priceline deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 6/2611:40 pm
PHX
- BUF
1 stop8h 54m
Frontier
Deal found 5/30![Frontier logo]()
$175
Find flight deals from Mesa to Buffalo
Keep the following information in mind while searching for Mesa to Buffalo flight deals. Data was last updated juni 1, 2026.
Round-trip from | $227 (American Airlines) |
|---|---|
One-way from | $99 (Southwest) |
Popular in | November |
Cheapest in | March |
Average price | $400 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mesa to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated juni 1, 2026.
Use the filters below to find and compare flights from Mesa to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
ma. 7/6
10:35 pm-9:41 am
1 stop8h 06m
Buffalo
fr. 7/17
5:12 pm-10:39 pm
1 stop8h 27m
$297
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
on. 8/19
11:05 pm-8:15 am
1 stop6h 10m
Buffalo
sø. 8/30
6:00 am-12:08 pm
1 stop9h 08m
$297
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
ma. 7/20
6:45 am-6:24 pm
1 stop8h 39m
Buffalo
on. 7/29
6:29 am-9:44 am
1 stop6h 15m
$297
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
ma. 6/29
10:35 pm-9:40 am
1 stop8h 05m
Buffalo
on. 7/8
3:54 pm-9:48 pm
1 stop8h 54m
$369
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
lø. 6/27
2:55 pm-12:30 am
1 stop6h 35m
Buffalo
lø. 7/4
5:45 am-9:25 am
1 stop6h 40m
$378
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
ti. 8/18
12:35 am-12:30 pm
2 stops8h 55m
Buffalo
on. 8/26
12:35 pm-6:15 pm
2 stops8h 40m
$379
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
lø. 7/11
2:55 pm-12:35 am
1 stop6h 40m
Buffalo
ti. 7/21
6:25 am-8:45 pm
2 stops17h 20m
$380
Quickest round-trip
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
ti. 7/7
11:04 pm-8:14 am
1 stop6h 10m
Buffalo
ti. 7/14
6:29 am-9:44 am
1 stop6h 15m
$381
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
fr. 9/4
11:10 pm-9:55 am
1 stop7h 45m
Buffalo
on. 9/9
12:00 pm-6:10 pm
2 stops9h 10m
$404
PhoenixBuffalo
PHX - BUF
PHXBUF
Phoenix Sky Harbor Intl
lø. 7/11
2:55 pm-12:35 am
1 stop6h 40m
Buffalo
ma. 8/10
3:55 pm-9:55 pm
2 stops9h 00m
$404
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Mesa to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Mesa with our price prediction graph.
PHX-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mesa to Buffalo
MS9-BUF
PHX-BUF
What is the cheapest time of day to fly from MS9 to BUF?
Find hourly flight availability from Mesa to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated juni 1, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mesa to Buffalo as you normally would.
How much does it cost to fly round-trip from Mesa to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated juni 1, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Mesa to Buffalo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Mesa to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Buffalo flight routes
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Alternative routes for Mesa to Buffalo
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on juni 1, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mesa to Buffalo by cabin class
Find flights from Mesa to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mesa and Buffalo flights
Browse other Mesa and Buffalo flight options. Last updated on juni 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mesa to Buffalo flights
Consider these flights traveling from Mesa to Buffalo.
Top 6 airlines flying from Mesa to Buffalo
Discover the top 6 airlines that operate flights from Mesa to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated juni 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$125 | Average$310 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$148 | Average$337 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$236 | Average$363 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$262 | Average$466 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$268 | Average$324 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$292 | Average$439 | FlexibilityNo cancel fee | On-time71% |