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$126+ Cheap flights from Knoxville to Buffalo (TYS - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BUF
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Knoxville to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$217
(Delta)

One-way from

$126
(American Airlines)

Popular in

May

Cheapest in

March

Average price

$303
From Knoxville McGhee Tyson to Buffalo
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One-way flight from Knoxville McGhee Tyson to Buffalo
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Highest demand for flights based on searches. 6% potential increase in price ($19 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Buffalo

Cheapest flights from Knoxville to Buffalo
Explore the most affordable flight options available from Knoxville to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/129:50 amTYS - BUF
1 stop4h 30mUnited Airlines
Sat 11/155:40 pmBUF - TYS
1 stop5h 15mUnited Airlines
Deal found 9/15$251
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:16 pmTYS - BUF
1 stop5h 20mAmerican Airlines
Sat 11/155:33 pmBUF - TYS
2 stops6h 18mAmerican Airlines
Deal found 9/15$256
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/155:35 pmTYS - BUF
1 stop6h 01mAmerican Airlines
Sun 11/167:40 amBUF - TYS
1 stop4h 50mAmerican Airlines
Deal found 9/14$285
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:37 pmTYS - BUF
1 stop5h 58mAmerican Airlines
Sun 10/195:11 amBUF - TYS
1 stop5h 39mAmerican Airlines
Deal found 9/14$294
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/245:45 amTYS - BUF
1 stop5h 16mDelta
Thu 10/26:00 amBUF - TYS
1 stop3h 44mDelta
Deal found 9/14$304
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:27 pmTYS - BUF
1 stop4h 22mAmerican Airlines
Mon 11/175:20 amBUF - TYS
1 stop5h 32mAmerican Airlines
Deal found 9/14$305
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/67:08 amTYS - BUF
1 stop4h 02mAmerican Airlines
Wed 10/86:00 amBUF - TYS
1 stop4h 50mAmerican Airlines
Deal found 9/14$314
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/165:45 amTYS - BUF
1 stop5h 16mDelta
Tue 9/236:15 amBUF - TYS
1 stop5h 26mDelta
Deal found 9/15$344
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:17 pmTYS - BUF
2 stops15h 19mMultiple Airlines
Sun 10/199:13 pmBUF - TYS
1 stop15h 50mMultiple Airlines
Deal found 9/14$359
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:35 pmTYS - BUF
1 stop6h 00mAmerican Airlines
Mon 11/35:20 amBUF - TYS
1 stop5h 32mAmerican Airlines
Deal found 9/13$384
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:55 pmTYS - BUF
2 stops17h 27mMultiple Airlines
Sun 9/287:41 pmBUF - TYS
1 stop21h 53mMultiple Airlines
Deal found 9/14$386

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Knoxville

Fly to

Buffalo

Route

Depart

Return

Price

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/18

7:30 am-11:51 am

1 stop4h 21m

Buffalo

Sat 2/21

5:55 pm-9:32 pm

1 stop3h 37m

$217

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 11/12

9:50 am-2:20 pm

1 stop4h 30m

Buffalo

Sat 11/15

5:40 pm-10:55 pm

1 stop5h 15m

$251

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 11/12

6:16 pm-11:36 pm

1 stop5h 20m

Buffalo

Sat 11/15

5:33 pm-11:51 pm

2 stops6h 18m

$256

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/18

6:45 am-2:19 pm

2 stops7h 34m

Buffalo

Sat 2/21

1:52 pm-9:07 pm

1 stop7h 15m

$284

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 11/12

6:06 am-12:17 pm

1 stop6h 11m

Buffalo

Fri 11/14

4:26 pm-9:24 pm

1 stop4h 58m

$314

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Mon 10/6

7:08 am-11:10 am

1 stop4h 02m

Buffalo

Wed 10/8

6:00 am-10:50 am

1 stop4h 50m

$314

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 11/1

5:35 pm-11:35 pm

1 stop6h 00m

Buffalo

Mon 11/3

5:20 am-10:52 am

1 stop5h 32m

$384

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 10/8

7:43 pm-11:43 pm

1 stop4h 00m

$126

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 10/17

8:17 pm-8:49 pm

2 stops24h 32m

$154

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sun 12/14

7:59 pm-11:55 pm

1 stop3h 56m

$169

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 16 results
1
2

Best time to book a flight from Knoxville to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Buffalo

What is the cheapest month to book a flight from Knoxville to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $256). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to BUF?

Find hourly flight availability from Knoxville to Buffalo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Buffalo in the afternoon. If you’re flexible enough to do this you can expect to save up to 31% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 15, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Buffalo by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,956 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,956 reviews
Delta
8.0
Very good
7,956 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,956 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Buffalo?

    Delta, United Airlines, and American Airlines can get you from Knoxville to Buffalo in just under 4h 21m. Your travel time can differ by up to 59m. There are 567 mi between Knoxville and Buffalo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Buffalo round-trip?

    Flying on American Airlines is currently your cheapest option to Buffalo, with prices starting at $198. Another option worth looking into is Delta, starting at $232 round trip. These flights start at 36% lower than the current average price 3 months from now.

  • Can I find deals for flights from Knoxville to Buffalo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Buffalo.

  • Can I find deals for business class flights from Knoxville to Buffalo?

    Yes. Cheapflights offers flight deals from Knoxville to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Buffalo (average of $256). Flying from Knoxville to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Top 2 airlines flying from Knoxville to Buffalo

Discover the top 2 airlines that operate flights from Knoxville to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$250FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$307FlexibilityNo cancel feeOn-time71%

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